LOCUS       NM_170684               2421 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus copine VII (Cpne7), mRNA.
ACCESSION   NM_170684 XM_916516
VERSION     NM_170684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Lee,Y.S., Park,Y.H., Hwang,G., Seo,H., Ki,S.H., Bai,S., Son,C.,
            Roh,S.M., Park,S.J., Lee,D.S., Lee,J.H., Seo,Y.M., Shon,W.J.,
            Jeon,D., Jang,M., Kim,S.G., Seo,B.M., Lee,G. and Park,J.C.
  TITLE     Cpne7 deficiency induces cellular senescence and premature aging of
            dental pulp
  JOURNAL   Aging Cell 23 (3), e14061 (2024)
   PUBMED   38105557
  REMARK    GeneRIF: Cpne7 deficiency induces cellular senescence and premature
            aging of dental pulp.
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Paget-Blanc,V., Pfeffer,M.E., Pronot,M., Lapios,P., Angelo,M.F.,
            Walle,R., Cordelieres,F.P., Levet,F., Claverol,S., Lacomme,S.,
            Petrel,M., Martin,C., Pitard,V., De Smedt Peyrusse,V., Biederer,T.,
            Perrais,D., Trifilieff,P. and Herzog,E.
  TITLE     A synaptomic analysis reveals dopamine hub synapses in the mouse
            striatum
  JOURNAL   Nat Commun 13 (1), 3102 (2022)
   PUBMED   35660742
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Liu,C.Y., Tsai,C.J., Yasugaki,S., Nagata,N., Morita,M., Isotani,A.,
            Yanagisawa,M. and Hayashi,Y.
  TITLE     Copine-7 is required for REM sleep regulation following cage change
            or water immersion and restraint stress in mice
  JOURNAL   Neurosci Res 165, 14-25 (2021)
   PUBMED   32283105
  REMARK    GeneRIF: Copine-7 is required for REM sleep regulation following
            cage change or water immersion and restraint stress in mice.
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Choung,H.W., Lee,D.S., Park,Y.H., Lee,Y.S., Bai,S., Yoo,S.H.,
            Lee,J.H., You,H.K. and Park,J.C.
  TITLE     The effect of CPNE7 on periodontal regeneration
  JOURNAL   Connect Tissue Res 60 (5), 419-430 (2019)
   PUBMED   30734591
  REMARK    GeneRIF: The effect of CPNE7 on periodontal regeneration.
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Park,Y.H., Lee,Y.S., Park,J.S., Kim,S.H., Bae,H.S. and Park,J.C.
  TITLE     Expression of CPNE7 during mouse dentinogenesis
  JOURNAL   J Mol Histol 50 (3), 179-188 (2019)
   PUBMED   30863901
  REMARK    GeneRIF: these results illustrate the dynamic expression of CPNE7
            during tooth development and suggest its important function in
            entire stages of tooth development
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Liu,C., Maejima,T., Wyler,S.C., Casadesus,G., Herlitze,S. and
            Deneris,E.S.
  TITLE     Pet-1 is required across different stages of life to regulate
            serotonergic function
  JOURNAL   Nat Neurosci 13 (10), 1190-1198 (2010)
   PUBMED   20818386
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162900.1, AU079878.1 and BF458951.1.
            
            On Apr 18, 2006 this sequence version replaced NM_170684.1.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encodes a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.288409.1,
                                           SRR1660811.104202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AK162900.1         2-218
            218-708             AU079878.1         137-627
            709-900             AK162900.1         710-901
            901-2400            AK162900.1         1520-3019
            2401-2421           BF458951.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.06 cM"
     gene            1..2421
                     /gene="Cpne7"
                     /note="copine VII"
                     /db_xref="GeneID:102278"
                     /db_xref="MGI:MGI:2142747"
     exon            1..291
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1797
                     /gene="Cpne7"
                     /note="copine 7 protein"
                     /codon_start=1
                     /product="copine-7"
                     /protein_id="NP_733785.1"
                     /db_xref="CCDS:CCDS22748.1"
                     /db_xref="GeneID:102278"
                     /db_xref="MGI:MGI:2142747"
                     /translation="MSGDSERAVAPGVVPAPCASKVELRLSCRHLLDRDPLTKSDPSV
                     VLLQQAQGQWLQVDRTEVVKSSLHPVFSKVFTVDYYFEGVQKLRFEVYDTHGPSGLTC
                     QDDDFLGGMECTLGQIVAQKKMTRPLLLRFGRNAGKSTITVIAEDISGNNGYVELSFQ
                     ARKLDDKDLFSKSDPFLELYRVNDDGSEQLVYRTEVVKNNLNPVWEPFKVSLNSLCSC
                     EETRPLKCLVWDYDSRGKHDFIGDFTTTFAEMQKAFEEEQQAQWDCVNAKYKQKKRNY
                     KNSGVVILADLKLHRVHSFLDYIMGGCQIHCTVAIDFTASNGDPRNSCSLHHINPYQP
                     NEYLRALVAVGEVCQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQG
                     VVEAYQNCLPKVQLYGPTNVAPIISKVARMAAAEESTGEASQYYILLILTDGVVTDMS
                     DTREAIVRASHLPMSVIIVGVGNADFTDMQILDGDDGVLRSPRGEPALRDIVQFVPFR
                     ELKNASPAALAKCVLAEVPKQVVEYYSHKELPPRSLGAQTGEAAASSAP"
     exon            292..474
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            475..549
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            550..624
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..708
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            709..798
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            799..900
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            901..987
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1047
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1181
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1236
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1288
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1422
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1659
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2405
                     /gene="Cpne7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpne7"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="Cpne7"
                     /note="major polyA site"
ORIGIN      
        1 gctctgtggc ggccgcccga gacacgtgtg cccgcgcccg gcgggcgtgc ggggaagcgc
       61 ggccacgcct ggtccggcca ccatttctcc ggcgcccacc ggttcgagtg cggagcctga
      121 agcatgagcg gcgactcgga gcgcgcggtg gccccggggg tggtgcctgc accctgcgcc
      181 tcgaaggtgg agctgcggct gagctgccgg cacctgctgg accgggaccc attgaccaag
      241 tccgacccca gcgtggtgct gctgcagcag gcacagggcc agtggctaca ggtggacaga
      301 acagaggtgg tgaagagcag cctgcatcct gtgttctcca aggtcttcac tgtcgactac
      361 tacttcgagg gggtgcagaa gctacggttt gaggtgtatg acacccacgg gcctagtggg
      421 ctgacttgcc aggatgatga cttcctaggg ggcatggagt gtaccctggg tcaaattgtg
      481 gcccagaaga agatgacacg gccattgctg ttgcgattcg gcaggaatgc tggcaagtcc
      541 accatcacgg tgatagcaga ggacatctct gggaacaacg gctatgtgga gctctccttc
      601 caggcccgga aactggatga caaggacctc ttcagcaagt cggacccctt cctagagctg
      661 tatcgggtta atgacgacgg gagtgagcag ctcgtgtaca ggacagaggt agtgaagaac
      721 aatcttaacc cagtgtggga acccttcaag gtgtccctga attcactctg cagctgcgag
      781 gagacacggc ctctgaagtg cctggtctgg gactatgact cccgaggaaa gcatgacttc
      841 attggcgact tcaccaccac gttcgcagag atgcagaagg cctttgagga ggagcagcag
      901 gcccagtggg actgtgtgaa tgccaagtac aaacagaaga agcgcaatta caagaattcc
      961 ggggtggtga tcctggcaga cctgaagctc cacagggtcc actccttcct ggattacatc
     1021 atgggtggct gccagatcca ctgtacggta gccatcgact tcacagcctc caacggtgac
     1081 ccgaggaaca gctgctccct ccaccacatc aacccttacc agcccaacga gtacctgagg
     1141 gcattggtgg cagtgggcga ggtctgccag gattatgaca gtgacaagcg gttttctgct
     1201 ctgggatttg gagcccggat ccctcccaag tatgaggtgt cccacgactt tgccatcaat
     1261 ttcaaccctg aggacgatga gtgtgaagga atccagggcg tggtggaggc ctaccagaac
     1321 tgcctgccga aggttcagct ctacggcccc accaacgtgg cacccatcat ctctaaggtg
     1381 gcccgcatgg cagcggctga ggagagcaca ggagaggctt ctcaatatta catactgctg
     1441 atcctcacgg acggtgtggt gacggatatg tcggacactc gagaggccat tgtgcgtgcc
     1501 tcccacctgc ccatgtctgt catcattgtt ggggtgggca acgctgactt cacagatatg
     1561 caaatcttag acggggatga tggagtcctg cgttccccac ggggcgagcc tgcactccgg
     1621 gacatcgttc agtttgtgcc cttccgtgag ctaaagaacg catcccccgc agcactggcc
     1681 aagtgtgtgt tggccgaggt gccaaagcag gtggttgaat actacagcca caaggagctg
     1741 cctcctcgaa gccttggcgc ccagactgga gaggctgctg ccagctcagc gccatgagga
     1801 tgtcagggga gggagcagta cgtccgtcca tctatggcat ctcccgtgcc cccagaaatc
     1861 ctcagaaact gatcacccag cccaggcctc ccagccctgc tcctgtgttc tgctggcctg
     1921 cgtcagtggc ctggtcccca acatgaagag atctaggcct tgtggcttga cagaaattag
     1981 cagctccccc agctctgggc ctccctgcac ccaacaggca aggagcaggg tgttctgaaa
     2041 gaaatggggc tgcaaagatg ctctcccctc ttgcttgagg tcactctcct gtcaatcata
     2101 gcaccacttc agaagagccc tcaagcccag cttggcccag agagatgggt gggatcgctc
     2161 ctgttataat cctggcagct cagctatgga aagggtggtg aaggggtggt cgacctggac
     2221 aatcttgcca tttgatcgtg tggagagagg aagtacccca agccttgagg acacccatat
     2281 ctgggcactt tgtccccata ggtttctctg tcctgtctgg tgcctctcca acctgtaccc
     2341 acacctggag cctgcggggc ctgggagaca gcttagggtg taataaagta tccctcattc
     2401 tcacaaaaaa aaaaaaaaaa a
//
