LOCUS       NM_153166               4366 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus copine V (Cpne5), transcript variant 2, mRNA.
ACCESSION   NM_153166
VERSION     NM_153166.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Astrof,S., Arriagada,C., Saijoh,Y., Francou,A., Kelly,R.G. and
            Moon,A.
  TITLE     Aberrant differentiation of second heart field mesoderm prefigures
            cellular defects in the outflow tract in response to loss of FGF8
  JOURNAL   Dev Biol 499, 10-21 (2023)
   PUBMED   37060937
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Hiver,S., Shimizu-Mizuno,N., Ikawa,Y., Kajikawa,E., Sai,X.,
            Nishimura,H., Takaoka,K., Nishimura,O., Kuraku,S., Tanaka,S. and
            Hamada,H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Goodyer,W.R., Beyersdorf,B.M., Duan,L., van den Berg,N.S.,
            Mantri,S., Galdos,F.X., Puluca,N., Buikema,J.W., Lee,S., Salmi,D.,
            Robinson,E.R., Rogalla,S., Cogan,D.P., Khosla,C., Rosenthal,E.L.
            and Wu,S.M.
  TITLE     In vivo visualization and molecular targeting of the cardiac
            conduction system
  JOURNAL   J Clin Invest 132 (20), e156955 (2022)
   PUBMED   35951416
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4366)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 4366)
  AUTHORS   Ding,X., Jin,Y., Wu,Y., Wu,Y., Wu,H., Xiong,L., Song,X., Liu,S.,
            Fan,W. and Fan,M.
  TITLE     Localization and cellular distribution of CPNE5 in embryonic mouse
            brain
  JOURNAL   Brain Res 1224, 20-28 (2008)
   PUBMED   18614158
  REMARK    GeneRIF: Our results demonstrate that CPNE5 is expressed in both
            neural progenitor cells and the differentiated neurons during the
            neural development, which suggests that CPNE5 might play an
            important role in the development of murine central nervous system.
REFERENCE   9  (bases 1 to 4366)
  AUTHORS   Humphreys,N.E., Xu,D., Hepworth,M.R., Liew,F.Y. and Grencis,R.K.
  TITLE     IL-33, a potent inducer of adaptive immunity to intestinal
            nematodes
  JOURNAL   J Immunol 180 (4), 2443-2449 (2008)
   PUBMED   18250453
REFERENCE   10 (bases 1 to 4366)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC162182.2, AK044042.1 and
            AC167363.3.
            
            On Aug 25, 2009 this sequence version replaced NM_153166.1.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encodes a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2 which is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036971.1, AK044042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC162182.2         162419-162493
            76-2972             AK044042.1         2-2898
            2973-4366           AC167363.3         174837-176230       c
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.14 cM"
     gene            1..4366
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /note="copine V"
                     /db_xref="GeneID:240058"
                     /db_xref="MGI:MGI:2385908"
     exon            1..178
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1865
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     copine-5"
                     /codon_start=1
                     /product="copine-5 isoform 2"
                     /protein_id="NP_694806.1"
                     /db_xref="CCDS:CCDS28592.1"
                     /db_xref="GeneID:240058"
                     /db_xref="MGI:MGI:2385908"
                     /translation="MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSD
                     PLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSK
                     SPDLSKHDFLGQAFCTLGEIVGSSGSRLEKPLTIGTFSLNSRTGKPMPAVSNGGVPGK
                     KCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKT
                     EVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELAR
                     GQSQFNIYEVINPKKKMKKKKYVNSGTVTLLSFAVESESTFLDYIKGGTQINFTVAID
                     FTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKMFPALGFGAKLPPDG
                     RVSHEFPLNGNQENPSCCGIDGILEAYHSSLRTVQLYGPTNFAPVVTHVARNAAAVQD
                     GSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAMVELDGDDVRI
                     SSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSYMKAQGIRPR
                     PPPAAPAQSPPQSPAHSPPGSPVHTHI"
     exon            179..219
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            220..266
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..370
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..410
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            411..487
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            488..547
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            548..611
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..715
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            716..820
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            821..862
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..938
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            939..992
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1054
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1101
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1283
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1411
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1514
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1572
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1646
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..4366
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2973
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
                     /note="major polyA site"
     polyA_site      3021
                     /gene="Cpne5"
                     /gene_synonym="A830083G22Rik"
ORIGIN      
        1 cccagggctg cagccgctcc ggaggaggcg tgaatcgcgc aggaatattg actaatttgg
       61 gtggggtggg gggacggtgg gcgatggagc aacccgagga catggcgtcg ctcagcgagt
      121 tcgactcctt ggcgggcagc atcccggcta ccaaggtgga gatcacggtg tcatgcagga
      181 acctcttgga caaagacatg ttttccaagt ctgacccact gtgtgtcatg tacactcaag
      241 ggatggagaa caagcaatgg cgagagttcg gacgcaccga ggtcatagat aacacgctca
      301 acccggactt cgtgcgcaag ttcattgtgg attacttctt tgaggagaag cagaacctcc
      361 gctttgatct ctacgatgtt gactccaaga gcccggatct atctaaacac gacttcctgg
      421 gccaggcctt ctgtaccctt ggagaaattg tagggtcctc tgggagccgt ctggagaagc
      481 ctctcacgat aggaacattc agcctcaact cccggacagg caagcctatg cccgccgtgt
      541 ctaacggtgg tgtcccaggg aagaaatgtg gtaccatcat cctgtctgca gaggaactga
      601 gcaactgcag ggatgtggcc acaatgcagt tctgtgccaa caagctggat aagaaagatt
      661 tcttcgggaa atctgacccc ttcttggtgt tctacaggag caatgaagac ggaacgttca
      721 ccatctgtca caagacggag gtcatgaaga acaccctcaa cccggtgtgg caaaccttct
      781 ccatccccgt gagggctctg tgcaacggag actatgacag gaccatcaag gtggaggtgt
      841 atgactggga tcgtgacggc agccatgact tcattgggga gttcaccacc agctaccggg
      901 agctggcacg tggccagagt cagttcaaca tctatgaggt gataaatcca aaaaagaaaa
      961 tgaagaaaaa gaaatacgtg aattctggca cggtcaccct gctttccttt gcggtagagt
     1021 cagagagtac cttcctggat tacatcaaag gagggacgca gatcaacttc accgtggcca
     1081 ttgacttcac tgcctctaat gggaatccct cacagtccac gtccctccac tacatgagtc
     1141 cctaccagct gaacgcctac gcgctggcgc tgaccgccgt cggagagatc attcagcatt
     1201 atgacagtga caagatgttc cctgccctgg gcttcggggc caagctgccc cccgacggca
     1261 gggtgtccca tgagtttccc ctgaatggca accaggagaa cccctcctgc tgtggcatcg
     1321 atggcatcct ggaggcctac cacagcagcc tgcgcaccgt gcagctttac ggccccacta
     1381 actttgctcc tgttgtcact cacgtagcca ggaacgccgc agctgtgcag gatggctccc
     1441 agtattctgt gctgctcatc atcactgatg gtgtcatctc ggacatggca cagaccaagg
     1501 aggcaattgt aaatgctgcc aaactcccta tgtcgatcat cattgttggc gtgggccagg
     1561 ccgagttcga tgccatggtg gagctggacg gtgatgacgt gcggatctcc tccaggggga
     1621 agctggctga gcgagacatt gtccagtttg tgcccttcag ggactatgtg gaccgcaccg
     1681 gcaaccacgt actgagcatg gcccgcctgg cccgggatgt tctggctgag attccggacc
     1741 aactggtgtc ctacatgaag gcacagggca tccgcccacg cccgccacct gctgcacccg
     1801 ctcagtcacc cccacagtcc ccagcccact cacctcctgg atcccccgtg cacacgcata
     1861 tctgaagctg agaggaccaa gggcctggag ggtagactga caccctattc tcctcctggt
     1921 cggtttccca gactctgctt ggagggccag cgggaaatgg ggtgtcaggg cctcacccca
     1981 cttcacaccc aaatccaggg gactgtggta tagaagacaa ggggtacaca gattctgggg
     2041 ctgaggggac ccccctagtc catgccggac aactccaaga ctttcttatt cttgcaaccc
     2101 agctgggcct cttccagctc ctgtctcctc ctaccctagt gtctagtgtc cccagtccca
     2161 tgagatcccc tgtcctgttt ccagggaacc ccagactggt agactaccag ggatgcatgt
     2221 gaccctctta gggactccat atgtgagcag atagagcccc tttcctgatc ctcaaaggct
     2281 cagtggtatg ctagaatgtt ctagaatggt cactggagct atcacaggta gcttgtagca
     2341 ctgagatgtc tcctgctcaa cttgggggcc actcacctgc agggcacagg gttagccccc
     2401 acactccaac ttgctcctgc tctctgccct tcagtggcta ggggacaaga gacagggatc
     2461 cctgaatgcc aacctgtccc tagccacatc cagcaggaac ccacccagcc caccctctgc
     2521 tctctgggcc tcagtgtcca cacctccgca atgacaggat ttgtcaggtg gtccagcgtt
     2581 tcctgagcca tcctgagggt acatccattc cacacacagc ctccccacac cttcctcatg
     2641 gccaccattc acacccaggc cagctagact ctggggtcat cctgtcgcat cctgtcaccc
     2701 ccatgcctca gcccttcaaa gctcctgtcc ctgcggtggg aagttagcaa agggcttttc
     2761 acctaaggtc accccaatgg ccaccgtcct ttgtccactg gggcaggtct tgcatgtgtc
     2821 ccttatgccg catggggtct ccacctggca tctcccatcc cacctgcctg tcccgcatgg
     2881 tgatagtgat gttttgactg tctggtcctg tgcctgtctg agactgtctc tgtggaactt
     2941 gccttaaatt gaagtaaacc agttctttta gtagatagac cccccctctc ctttgaaaac
     3001 agctttgctg tttgcctagc atctatctct ctgctgcctt ggttcttccg tccggccatg
     3061 ttcctgtcag actctgtaag aggcatgggg gggggggtgc atggcgagga ttgaaaccca
     3121 ccacccacaa acatatgtaa gcagagtctg tgagccatca gggactgtga tggaggcatg
     3181 gttgcctaga gccccttccc ggtcctcaga ggctcagtgg tatgctagaa tgttctagat
     3241 gtggatctct agcctcacta gagctgtcac gagtagcttg tgacattgag aggtctcctg
     3301 ctcaactcgg aagccactca cctgccgggc acatgaccag agcctggacg ccaacatgag
     3361 agacagtgag cacacacaca cactcaggtc tatagtctgg cttcagacag tgttaagagg
     3421 caggagcaag gggagagaat gagagcagac tccagtagag agatgtttga gacgagcagg
     3481 ggtgttgagg ggagcccaag agaaatgagc agggagccat gctgatgcca gggtgaagag
     3541 gactctggta gtttgggata agtttgtgcc aggtaggagc ctagtgtgtt tgacgggagg
     3601 caagcacgcg ggtgtgatag gagctaacca aggaagagaa tgcaggcgat ggggtcaggg
     3661 tggaggccaa aatgcacagg gccttgtggt tcatggcaag gcatctgacg tttgctctag
     3721 agggttgtag ccattaagga agtaagagag acgagcacgt gacccaaacc tccccaacac
     3781 atggatcgct atcaccgtgg atcatggttt cttcatctct caacaaacat ctactgagaa
     3841 tccattccag gcctgtgcag aggtcagagg cacttggctc agtccccagt gtctccctct
     3901 gggctaaatc agccaccaca aagtagcaat gccagccagc ttgaagggat gggagtggtg
     3961 gcactaagag acactctggc ccataccgga tgacccccca cccggggtgt ggccaccata
     4021 gtgtcaggtg gggtacatgt gtgcacagat ggtgacattg gcaggctctg tgggtggacc
     4081 acgcaggact tatgtgactt cagggacacg gtaagcatct tccgtggtcc ctttctacag
     4141 gtcagggcct tcaccaatgt ggagcatggg agcaaggaca tacgcgcatg cgcacagcac
     4201 atactgcgca cgctgtccca tcagccctct aggcagccat tctgaggctg tacccaagag
     4261 gaattcggta ccaattaccc tccagctcgg ggcttgttta cttctgatga cttcatggta
     4321 aattagagct gactcacgat tgtctctata atcagatgct ctgcga
//
