LOCUS       NM_153507               2328 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus copine II (Cpne2), mRNA.
ACCESSION   NM_153507
VERSION     NM_153507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Perestenko,P., Watanabe,M., Beusnard-Bee,T., Guna,P. and
            McIlhinney,J.
  TITLE     The second C2-domain of copine-2, copine-6 and copine-7 is
            responsible for their calcium-dependent membrane association
  JOURNAL   FEBS J 282 (19), 3722-3736 (2015)
   PUBMED   26175110
  REMARK    GeneRIF: The second C2-domain of copine-2 is responsible for
            calcium-dependent membrane association.
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2328)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   4  (bases 1 to 2328)
  AUTHORS   Perestenko,P.V., Pooler,A.M., Noorbakhshnia,M., Gray,A., Bauccio,C.
            and Jeffrey McIlhinney,R.A.
  TITLE     Copines-1, -2, -3, -6 and -7 show different calcium-dependent
            intracellular membrane translocation and targeting
  JOURNAL   FEBS J 277 (24), 5174-5189 (2010)
   PUBMED   21087455
REFERENCE   5  (bases 1 to 2328)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC031801.1.
            
            On Nov 21, 2002 this sequence version replaced NM_153507.1.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encodes a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031801.1, AK160238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.55 cM"
     gene            1..2328
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /note="copine II"
                     /db_xref="GeneID:234577"
                     /db_xref="MGI:MGI:2387578"
     exon            1..166
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            167..384
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1851
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /codon_start=1
                     /product="copine-2"
                     /protein_id="NP_705727.1"
                     /db_xref="CCDS:CCDS22543.1"
                     /db_xref="GeneID:234577"
                     /db_xref="MGI:MGI:2387578"
                     /translation="MAYIPDGGAPTAGAIPLGSQCCVCKVELSVSGQNLLDRDVTSKS
                     DPFCVLFIEDNGRWMEFDRTETAVNNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSS
                     AQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGVITIAAQELSDNRVITLS
                     LAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLC
                     DGDLEKPIQVMCYDYDSNGGHDFIGEFQTSVLQMSEARDGVPLEIECINPKKQRKKKS
                     YKNSGIIILRSCKIHRNYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMG
                     TNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVD
                     GIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQQTATQYFILLIITDGVISDM
                     EETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDNRRLRSHTGEEAARDIVQFVPF
                     REFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA"
     exon            385..564
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            565..639
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            640..711
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..795
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            796..885
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            886..984
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1071
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1131
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1265
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1320
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1372
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1506
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1743
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2302
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /note="major polyA site"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="Cpne2"
                     /gene_synonym="3322401K10Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgcagccggg gcccgaggag ggccagcccc agcccgggcg agcgcacgag tgggtacggc
       61 cgcgcgggta gcgccctgag cctgtcccgc gccgccgccc ggccgacagc acagcgcccg
      121 gggatgcccc ggcggcccgg agcacgctga ggctgcggaa agcgcgactg ccaggaactg
      181 ttgctgctgc cgccaccaac ccccatggcc tacattccgg atgggggtgc tcctaccgct
      241 ggggccatcc ccttgggttc tcagtgctgt gtgtgcaaag tggagctgtc agtgagtggc
      301 cagaacctgc tggaccggga tgtcacctcc aagtctgacc ctttctgtgt cctctttata
      361 gaagacaatg gcaggtggat ggagttcgac agaacagaaa cagccgtcaa caacctcaac
      421 ccagccttct ccaagaagtt cgtgctggac taccacttcg aggaggtgca gaagctcaag
      481 ttcgccctgt ttgaccagga caagtccagt gcccagttgg atgagcatga tttcctgggc
      541 cagttctcct gcagcctggg cacgattgtc tccagcaaga agatcactag gcctctgctg
      601 ctgatgaatg acaagccagc ggggaagggc gtaatcacga ttgcagccca agagctgtca
      661 gacaaccgag tcatcacact gagcctggct ggcaggaaac tggataagaa ggacctcttt
      721 gggaagtcag acccttttct tgagttttac aagccaggag atgatggcaa atggatgctg
      781 gtccatagga ccgaggtgat taagtacacc ctggacccgg tgtggaaacc attcactgtc
      841 ccgttggtgt ccttgtgtga tggcgacctg gagaagccca tccaggttat gtgctacgac
      901 tatgacagta atggaggcca tgacttcatc ggcgagttcc agacctctgt gctgcagatg
      961 agcgaggctc gggatggtgt cccgctggag atagagtgca tcaaccccaa gaagcagagg
     1021 aagaagaaaa gctacaagaa ctcgggcatc attattctga gatcatgcaa gatacaccga
     1081 aactactcat tcctggacta cattctggga ggctgccagc tcatgttcac cgttggaata
     1141 gacttcacag cctccaatgg gaatcccctc gacccttctt ctctccatta tatcaacccc
     1201 atgggcacca atgaatactt gtcagccatc tgggcagtgg gacagatcat tcaggactac
     1261 gacagtgata agatgttccc tgctctggga tttggggccc agttaccacc agactggaag
     1321 gtgtcccatg agttcgctat caacttcaac cccactaacc ctttctgctc aggcgtggat
     1381 ggcatcgccc aggcgtactc agcctgtctg ccccacattc gcttctatgg ccccacaaac
     1441 ttctccccga tcgtcaacca tgtggcccgg tttgcagccc aggccaccca gcagcagaca
     1501 gcaacgcagt acttcatcct cctcatcatc accgacgggg tcatcagtga catggaggag
     1561 actcggcacg ccgtggtgca ggcctccaag ctgcccatgt ccatcatcat cgtgggtgtg
     1621 ggcaatgctg actttgcagc catggagttt ctagacgggg acaaccgtcg actgcgctca
     1681 cacacaggcg aggaggcggc ccgagatatc gtgcagttcg tgcccttccg agagttccgc
     1741 aacgcagcaa aagaaacgct ggctaaagcg gtgttggcgg agctgcctca gcaagtagtg
     1801 cagtatttca agcataaaaa cctgcccccc accaactcag agcctgcctg agcccatgcc
     1861 cagccgcagc atgccagctg agcccccggc ctccccagga acatgcacgt tcaccccgct
     1921 tcctcgtggg tggctttttt ttttttttta aaaccagtcc acgttttcat tttttacaac
     1981 tggacctcca cccacaactt ccccagccca gctgggctcc ctttgtcaga gtcaatggat
     2041 gatgcttcca ggacaaatcg gcttcctctc cccaccctcc tgccactcta agtattgaat
     2101 gtactttgta taattttagt ggaattattg ttattaaaga gaataaaatt tttacaatca
     2161 taactggctt tttctaagta actagctgca agaaggaatg tatatccctt actgcatact
     2221 ttgtatggtg gtctgctgtt tttatacttg tgactgtgtt ctatttgtaa aactcagggt
     2281 aataaaggag tttcagatgt tgaaaaaaaa aaaaaaaaaa aaaaaaaa
//
