LOCUS       NM_170588               3478 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus copine I (Cpne1), transcript variant 1, mRNA.
ACCESSION   NM_170588
VERSION     NM_170588.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3478)
  AUTHORS   Song,Y., Song,B., Yu,Z., Li,A., Xia,L., Zhao,Y., Lu,Z. and Li,Z.
  TITLE     Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 316 (2023)
   PUBMED   38062811
  REMARK    GeneRIF: Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer.
REFERENCE   2  (bases 1 to 3478)
  AUTHORS   Cao,J., Cao,R., Liu,Y. and Dai,T.
  TITLE     CPNE1 mediates glycolysis and metastasis of breast cancer through
            activation of PI3K/AKT/HIF-1alpha signaling
  JOURNAL   Pathol Res Pract 248, 154634 (2023)
   PUBMED   37454492
  REMARK    GeneRIF: CPNE1 mediates glycolysis and metastasis of breast cancer
            through activation of PI3K/AKT/HIF-1alpha signaling.
REFERENCE   3  (bases 1 to 3478)
  AUTHORS   Chen,L., Pan,L., Zeng,Y., Zhu,X. and You,L.
  TITLE     CPNE1 regulates myogenesis through the PERK-eIF2alpha pathway
            mediated by endoplasmic reticulum stress
  JOURNAL   Cell Tissue Res 391 (3), 545-560 (2023)
   PUBMED   36525128
  REMARK    GeneRIF: CPNE1 regulates myogenesis through the PERK-eIF2alpha
            pathway mediated by endoplasmic reticulum stress.
REFERENCE   4  (bases 1 to 3478)
  AUTHORS   Zhang,L., Tan,W., Song,X., Wang,S., Tang,L., Chen,Y., Yu,H.,
            Jiang,P. and Liu,J.
  TITLE     Methylprednisolone Attenuates Lipopolysaccharide-Induced Sepsis by
            Modulating the Small Nucleolar RNA Host Gene 5/Copine 1 Pathway
  JOURNAL   DNA Cell Biol 40 (11), 1396-1406 (2021)
   PUBMED   34767734
  REMARK    GeneRIF: Methylprednisolone Attenuates Lipopolysaccharide-Induced
            Sepsis by Modulating the Small Nucleolar RNA Host Gene 5/Copine 1
            Pathway.
REFERENCE   5  (bases 1 to 3478)
  AUTHORS   Hernandez Cordero,A.I., Gonzales,N.M., Parker,C.C., Sokolof,G.,
            Vandenbergh,D.J., Cheng,R., Abney,M., Sko,A., Douglas,A.,
            Palmer,A.A., Gregory,J.S. and Lionikas,A.
  TITLE     Genome-wide Associations Reveal Human-Mouse Genetic Convergence and
            Modifiers of Myogenesis, CPNE1 and STC2
  JOURNAL   Am J Hum Genet 105 (6), 1222-1236 (2019)
   PUBMED   31761296
  REMARK    Erratum:[Am J Hum Genet. 2020 Jan 2;106(1):138. doi:
            10.1016/j.ajhg.2019.12.008.. PMID: 31901248]
REFERENCE   6  (bases 1 to 3478)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   7  (bases 1 to 3478)
  AUTHORS   Greene,N.D., Leung,K.Y., Wait,R., Begum,S., Dunn,M.J. and Copp,A.J.
  TITLE     Differential protein expression at the stage of neural tube closure
            in the mouse embryo
  JOURNAL   J Biol Chem 277 (44), 41645-41651 (2002)
   PUBMED   12200422
REFERENCE   8  (bases 1 to 3478)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   9  (bases 1 to 3478)
  AUTHORS   Tomsig,J.L. and Creutz,C.E.
  TITLE     Biochemical characterization of copine: a ubiquitous
            Ca2+-dependent, phospholipid-binding protein
  JOURNAL   Biochemistry 39 (51), 16163-16175 (2000)
   PUBMED   11123945
REFERENCE   10 (bases 1 to 3478)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833786.8.
            
            On Jul 8, 2022 this sequence version replaced NM_170588.3.
            
            Summary: This gene encodes a protein that contains two N-terminal
            type II C2 domains and an integrin A domain-like sequence in the
            C-terminus. Its activity is also upregulated in mouse embryos. This
            gene and the gene for RNA binding motif protein 12 overlap at map
            location 2 H2. Two alternatively spliced variants that encode the
            same isoform have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152323.1, SRR13422598.983795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL833786.8         162498-162639       c
            143-191             AL833786.8         154061-154109       c
            192-317             AL833786.8         130051-130176       c
            318-497             AL833786.8         129775-129954       c
            498-572             AL833786.8         129612-129686       c
            573-644             AL833786.8         129464-129535       c
            645-725             AL833786.8         129286-129366       c
            726-815             AL833786.8         129044-129133       c
            816-902             AL833786.8         128859-128945       c
            903-989             AL833786.8         128641-128727       c
            990-1049            AL833786.8         128487-128546       c
            1050-1183           AL833786.8         128268-128401       c
            1184-1238           AL833786.8         128111-128165       c
            1239-1290           AL833786.8         126949-127000       c
            1291-1424           AL833786.8         124888-125021       c
            1425-1661           AL833786.8         124511-124747       c
            1662-3478           AL833786.8         122557-124373       c
FEATURES             Location/Qualifiers
     source          1..3478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.34 cM"
     gene            1..3478
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /note="copine I"
                     /db_xref="GeneID:266692"
                     /db_xref="MGI:MGI:2386621"
     exon            1..142
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            143..191
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1802
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /codon_start=1
                     /product="copine-1"
                     /protein_id="NP_733467.1"
                     /db_xref="CCDS:CCDS16960.1"
                     /db_xref="GeneID:266692"
                     /db_xref="MGI:MGI:2386621"
                     /translation="MAHCVTLVQLSVSCEHLIDKDIGSKSDPLCVLLQDVGGAWAELC
                     RTERVRNCSSPEFSKTLQIEYHFETVQKLRFGIYDIDNKTPELGDDDFLGGAECSLGQ
                     IVSSQTLTLPLMLKPGKPAGRGTITVSAQELKDSRVVTMEVEARNLDKKDFLGKSDPF
                     LEFFRQGDGKWQLAYRTEVVKNNLNPTWKRFSVSLQHFCGGDLSTPIQVRCSDYDSDG
                     SHDLIGTFHTTLAQLQAVPAEFECVHPEKQQRKKNYRNSGTVRVKTCRVETEYSFLDY
                     VMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLTALWSVGSVVQDYDSDKL
                     FPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAP
                     IINHVARFAAQAAQQRSASQYFVLLLLTDGAVTDVEATCKAVVDASKLPMSVIIVGVG
                     GADFEVMEQLDADGGPLRTRSGEAAARDIVQFVPYRRFQNAPRETLAQTVLAEVPTQM
                     VSYFRAQGWAPLKAPPTPGKGPAQAPQA"
     exon            192..317
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            318..497
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            498..572
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            573..644
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            645..725
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            726..815
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            816..902
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            903..989
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1049
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1183
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1238
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1290
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1424
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1661
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..3478
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3456..3461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /note="hexamer: AATAAA"
     polyA_site      3478
                     /gene="Cpne1"
                     /gene_synonym="1810028N16Rik; mKIAA4108"
                     /note="major polyA site"
ORIGIN      
        1 attttgtgaa gcggctgtgg aggtgttggc tgcagtgggc tccgggaaag ccgttcgggc
       61 tggggctgtc ggccgcaggg ctgaggcact cgcgcggggg gtaactcggg tctgggttct
      121 ggtgccgcgc aagctctccc cggattgact tggcctctgc ttcttaagaa aatacatctc
      181 ttgttttaca gatggctcat tgcgtgacct tggtccagct ctccgtgtcc tgtgaacatc
      241 tcattgacaa ggacattggc tccaagtctg acccactctg cgtcctttta caggatgtgg
      301 gcggggcctg ggccgagctt tgccggactg aacgtgttcg caactgctca agccctgagt
      361 tctccaagac tctgcagata gaataccact ttgagactgt ccagaagctg cgctttggaa
      421 tctatgacat agacaacaag acaccagagc tgggggatga cgacttcctg gggggagctg
      481 aatgttccct aggtcagatt gtatccagcc agacgctgac cttacccttg atgttgaagc
      541 ctgggaagcc tgcagggcgg ggaaccatca cagtttcagc tcaggagcta aaggacagcc
      601 gtgtagtaac catggaggtg gaagctagaa acctagataa gaaggacttc ctagggaaat
      661 ctgacccatt cttggagttc ttccggcaag gcgatgggaa gtggcagctg gcatacagaa
      721 ccgaggtagt caagaacaac ctgaacccta cctggaagcg cttctcagtc tctctgcagc
      781 atttctgtgg cggggacctc agcacgccca ttcaggtgcg ctgctcagac tatgacagtg
      841 acggctcaca tgatctcatt ggtaccttcc atactacctt ggcccaactg caagcagtcc
      901 cggctgagtt tgaatgtgtc caccctgaaa agcagcagag aaagaaaaac tacaggaact
      961 ctggaactgt ccgtgtcaag acttgccggg tggagacaga gtattccttc ctggactatg
     1021 tgatgggagg ctgccagatc aactttactg tgggtgtgga cttcactggc tccaatggcg
     1081 acccatcctc acctgactcc ctgcattatc tgagccctac aggagtcaac gagtatctga
     1141 cagctctgtg gagcgtgggc agcgtggttc aagactatga ctcagacaag ctatttcctg
     1201 catttggttt tggagcccag gtgccccctg attggcaggt ctcacatgag tttgccttga
     1261 acttcaatcc cagtaatccg tattgtgcag gcatccaggg tatcgtcgat gcctaccgtc
     1321 aagccctgcc ccaagttcgt ctctatggcc ccaccaactt tgcacccatc atcaaccacg
     1381 tggccaggtt tgcagcccaa gctgcacagc agaggtcggc ctcgcaatac ttcgtgctgt
     1441 tgcttttgac tgacggtgct gtgacagatg tggaggccac atgtaaggca gtggtggacg
     1501 cctcaaagct gcccatgtcc gtgatcatcg tgggtgtggg cggtgcggat tttgaggtca
     1561 tggaacagct ggatgcagat ggtggccctc tccgcacgcg ctctggagaa gcagcggccc
     1621 gagacatagt gcagttcgtg ccttatcgac gatttcagaa tgctccccgg gagacactcg
     1681 cacagaccgt actcgccgaa gtgcccactc agatggtttc ctacttcaga gcccaaggct
     1741 gggccccgtt aaaggcacct ccaaccccag gcaagggccc cgcacaggcc ccacaggcat
     1801 aggcacccgt ggaggagtag gctccaatca gtcctcagcc tgcagcctgc tccatcctca
     1861 gggcagggac caagcgtgca cattctttcc atttcatagt tgatactttt atatgtactg
     1921 ctgctgctgc tctttgacat tgcctgcctg cctggcacct tttcattcag gaaagaaaga
     1981 ctagtaaaga tatcactcct ttcaaaatta tagactgcta gagagagcca cacttgcttt
     2041 gaccttgggc ttgttgagta gatccctttg gtctaataac cccattcaag gattatgttt
     2101 atgtctattc gcttcagtca catactttga aaagacaaag tttgaataat taagtaaact
     2161 tgtggttgtc ctttcctccg gggcgagctg aactggggct gactatgaac acgatggaag
     2221 gtgctacagt gtaagaggta gcaaatgaga gaagacaatg ttttagagta agggctgtta
     2281 gacttcctgt gctagctctg tccctctgtt tcttggggac atttgtgtag cccaggctgg
     2341 cctgcagttt accatcctgc ggcaacctta gagatgctag aattacaggt gtatgctacc
     2401 gtgcctggag tatagtcttg atttttttac ttttttaata tatgctctca tatagcccag
     2461 gctggcccta cattttgttg ccaaggataa cttgaattcc tgctccttcc tatttgagct
     2521 tcccaaatgc taggattata agcatgcctc aacagttgcc ctttaccagc tcaacagttt
     2581 gatagctttt ttttaatata atgaatgatt taatgcatgt tcatttgggg aaaactttat
     2641 aggacacatc ctaaccactt tgcccagact gccttttaca ttttacaact caaggtcctg
     2701 gagtagctgg aactacagtt cagtgtctgg tttagcaaaa ctggttttgt ttgcagactg
     2761 gggggagggg agctcctaaa tgcaggtatc agtattatat aaaaatagaa aatgggaaca
     2821 aagattggtg gctcatggtt ataatcccaa cactcagaag tctgaggcag gagggttgct
     2881 ctgagtttga tgtgaatttg aggtacacga ggagtttcag gtcagacaga acaactttaa
     2941 aagcaaacat gtgtgctgtt tgtatctggt ttgcatttat attgggtgcc ttatccacca
     3001 gaacttactg cctcctcttt ttcattatct gtccttttgt aagaatatac cagagtttag
     3061 cagttccctt cccaacagag attcgattta ctgtgattac acacattttt gaagagttgg
     3121 tttttcagta tggaaatgag agattgcagg tgatatttgc agtgttagca gttattacag
     3181 gctgccttct gtagaggggt gatctgacct ctgataacct gtgggtcacc ttccttcccc
     3241 agatctcatt tctagtttcc atttatttct ctatattatt tcatacacat ttccttctca
     3301 gtaacctgtt cacaaactgt atgttagagc ttttattttg ttcttgacat gttgaaagta
     3361 tttttccctc atctgttact gtttcatgtt tttatattcc atatgtaaaa ttatttttat
     3421 atatgttacc cttttaaaaa atatatctat gtatcaataa aattaatata tccacctc
//
