LOCUS       NM_030703               1792 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase N, polypeptide 1 (Cpn1), mRNA.
ACCESSION   NM_030703 XM_978873
VERSION     NM_030703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Zhou,Q., Zhao,L., Shao,Z., Declerck,P., Leung,L.L.K. and Morser,J.
  TITLE     Both plasma basic carboxypeptidases, carboxypeptidase B2 and
            carboxypeptidase N, regulate vascular leakage activity in mice
  JOURNAL   J Thromb Haemost 20 (1), 238-244 (2022)
   PUBMED   34626062
  REMARK    GeneRIF: Both plasma basic carboxypeptidases, carboxypeptidase B2
            and carboxypeptidase N, regulate vascular leakage activity in mice.
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Woodworth,M.B., Greig,L.C., Liu,K.X., Ippolito,G.C., Tucker,H.O.
            and Macklis,J.D.
  TITLE     Ctip1 Regulates the Balance between Specification of Distinct
            Projection Neuron Subtypes in Deep Cortical Layers
  JOURNAL   Cell Rep 15 (5), 999-1012 (2016)
   PUBMED   27117402
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Greig,L.C., Woodworth,M.B., Greppi,C. and Macklis,J.D.
  TITLE     Ctip1 Controls Acquisition of Sensory Area Identity and
            Establishment of Sensory Input Fields in the Developing Neocortex
  JOURNAL   Neuron 90 (2), 261-277 (2016)
   PUBMED   27100196
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Davis,D.A., Singer,K.E., De La Luz Sierra,M., Narazaki,M., Yang,F.,
            Fales,H.M., Yarchoan,R. and Tosato,G.
  TITLE     Identification of carboxypeptidase N as an enzyme responsible for
            C-terminal cleavage of stromal cell-derived factor-1alpha in the
            circulation
  JOURNAL   Blood 105 (12), 4561-4568 (2005)
   PUBMED   15718415
  REMARK    GeneRIF: carboxypeptidase N regulates the biologic activity of
            SDF-1alpha by reducing the chemokine-specific activity
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Matthews,K.W., Drouin,S.M., Liu,C., Martin,J.F., Skidgel,R.A. and
            Wetsel,R.A.
  TITLE     Expression of the third complement component (C3) and
            carboxypeptidase N small subunit (CPN1) during mouse embryonic
            development
  JOURNAL   Dev Comp Immunol 28 (6), 647-655 (2004)
   PUBMED   15177117
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Matthews,K.W. and Wetsel,R.A.
  TITLE     Characterization of mouse carboxypeptidase N small active subunit
            gene structure
  JOURNAL   J Immunol 166 (10), 6196-6202 (2001)
   PUBMED   11342641
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N.,
            Campbell,W. and Okada,H.
  TITLE     Pro-carboxypeptidase R is an acute phase protein in the mouse,
            whereas carboxypeptidase N is not
  JOURNAL   J Immunol 165 (2), 1053-1058 (2000)
   PUBMED   10878383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF326477.1.
            
            On Oct 23, 2009 this sequence version replaced NM_030703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326477.1, AB021969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1673              AF326477.1         1-1673
            1674-1792           AF326477.1         1675-1793
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.68 cM"
     gene            1..1792
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /note="carboxypeptidase N, polypeptide 1"
                     /db_xref="GeneID:93721"
                     /db_xref="MGI:MGI:2135874"
     exon            1..455
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            456..652
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            653..808
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            809..991
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1103
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1243
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1343
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1462
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1792
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /note="hexamer: ATTAAA"
     polyA_site      1792
                     /gene="Cpn1"
                     /gene_synonym="0610011F20Rik; CPN"
                     /note="major polyA site"
ORIGIN      
        1 tccttccaaa agggcttcca gatttaggag gaggaagaga aatgagcccg gagggtattg
       61 tggctatcct ggggccacag gaataattcc cagcatagca gaggcgggtc cccagtctcc
      121 tgcaggtgcg gcgagtgcaa ggctggttac tctgtgctct ggatccagac tggcaaagga
      181 ttgcttagag agcgggaggg cacatttcag agccccttag aagctccgcg agatgccaga
      241 cctgccctca gccttcctgc ccctcctcct cctctccaag tttgttaccc cggtgacctt
      301 tcgtcaccac cgctacgacg acctcgtgcg gacgctgtac aaggtgcaca accaatgccc
      361 ggacatcacg cggctctaca acatcgggcg cagtgtgaag gggaggtacc tctacgtgct
      421 ggagtttagc gactaccctg ggatccatga acccttggaa ccggaagtca agtatgtggg
      481 aaacatgcac gggaacgaag tgctgggccg cgagctgctt ctgcagctgt cggaattcct
      541 ctgcgaggag ttccggaacc gaaaccagcg tatcctgcgc ctcattcagg acacgcgcat
      601 tcacatcctg ccttccatga accctgacgg ctacgaggtg gctgctgccc agggcccaaa
      661 catgtctggg tatctggttg gtaggaacaa tgcaaatggg gtggacctga accgcaactt
      721 cccggatctc aacacctact tctactacaa ctccaagaac ggtggcccta accaccacct
      781 gcccctcccc gacaactgga aaagtcaggt ggaaccagag acccgggcgg tgatccagtg
      841 gattcgctcc ttgaacttcg ttctctcagc caatatgcac ggcggggctg tggtggccaa
      901 ttacccatat gacaagtcac ttgagcatag gtttcgaggt ccccatcgca cctccaattc
      961 cccgacacct gatgacgagc tcttccagac gctggccaag gtctactcct acgcccatgg
     1021 atggatgcac caaggttgga actgtgggga ctactttcca gacggcatca ccaacggggc
     1081 gtcctggtat tctctcagca agggaatgca agacttcaat tatctccaca ctaactgctt
     1141 tgagatcacg ctcgagctga gttgcgacaa gtttccccgg caagaggagc tgcagaggga
     1201 gtggctgggt aaccgggaag ccttaatcca gttcttggaa caggtccacc agggcatcaa
     1261 gggaatggtg ttggatgaga actctaacaa cctcacgggg gctgtcattt ccgtcaccgg
     1321 catcaaccac gacgtcactt caggtgaaca tggggattat ttccggctgc tgctcccggg
     1381 tacttactct gtcactgcca aggcaccagg gtacgacccc aaaacagtga ctgtgacggt
     1441 gggacctgcg ggaccaacag tggttgactt ccaactcaag cgaagctcat ctcaggtgta
     1501 ccctgtgcag agagctcccg gccgagggca gggaggcagg gcaaagcagc cccggacatc
     1561 cagaaagaaa gacccagcaa cgaaacggca taggggtcct gcatgaagcc agcacccagg
     1621 accacacaca gcgaggccat ccctgctctc aaaccccttg atcacgcttc tcttttatta
     1681 tctgggacag atttagacac agacacatac agaacacctc ccagtgtctc tgtctgcccc
     1741 gggatccagc cttccttagg ccagcattaa aggagtccga atcttctaga aa
//
