LOCUS       NM_027468               5195 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus carboxypeptidase M (Cpm), mRNA.
ACCESSION   NM_027468 XM_917914 XM_994613
VERSION     NM_027468.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5195)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 5195)
  AUTHORS   Amato,C.M. and Yao,H.H.
  TITLE     Developmental and sexual dimorphic atlas of the prenatal mouse
            external genitalia at the single-cell level
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34155146
REFERENCE   3  (bases 1 to 5195)
  AUTHORS   Mould,A., Morgan,M.A., Li,L., Bikoff,E.K. and Robertson,E.J.
  TITLE     Blimp1/Prdm1 governs terminal differentiation of endovascular
            trophoblast giant cells and defines multipotent progenitors in the
            developing placenta
  JOURNAL   Genes Dev 26 (18), 2063-2074 (2012)
   PUBMED   22987638
REFERENCE   4  (bases 1 to 5195)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5195)
  AUTHORS   Chiu,H.S., Szucsik,J.C., Georgas,K.M., Jones,J.L., Rumballe,B.A.,
            Tang,D., Grimmond,S.M., Lewis,A.G., Aronow,B.J., Lessard,J.L. and
            Little,M.H.
  TITLE     Comparative gene expression analysis of genital tubercle
            development reveals a putative appendicular Wnt7 network for the
            epidermal differentiation
  JOURNAL   Dev Biol 344 (2), 1071-1087 (2010)
   PUBMED   20510229
REFERENCE   6  (bases 1 to 5195)
  AUTHORS   Guimaraes,A.O., Motta,F.L., Alves,V.S., Castilho,B.A. and
            Pesquero,J.B.
  TITLE     Multiple RNAs from the mouse carboxypeptidase M locus: functional
            RNAs or transcription noise?
  JOURNAL   BMC Mol Biol 10, 7 (2009)
   PUBMED   19200403
  REMARK    GeneRIF: of the 33 transcripts from the CPM locus, four were
            evaluated with one showing expression patterns that differed
            considerably from the other ones and from the mouse CPM gene,
            suggesting that there may be more than one transcriptional unit in
            this locus
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5195)
  AUTHORS   Sun,X., Wiesner,B., Lorenz,D., Papsdorf,G., Pankow,K., Wang,P.,
            Dietrich,N., Siems,W.E. and Maul,B.
  TITLE     Interaction of angiotensin-converting enzyme (ACE) with
            membrane-bound carboxypeptidase M (CPM) - a new function of ACE
  JOURNAL   Biol Chem 389 (12), 1477-1485 (2008)
   PUBMED   18844448
  REMARK    GeneRIF: spatial proximity between angiotensin-converting enzyme
            and the endogenous CPM enables an angiotensin-converting enzyme
            evoked release of CPM
REFERENCE   8  (bases 1 to 5195)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5195)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 5195)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132139.4.
            
            On or before Jun 7, 2008 this sequence version replaced
            XM_917914.2, XM_994613.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.163490.1, BC100404.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC132139.4         117078-117105
            29-191              AC132139.4         117299-117461
            192-289             AC132139.4         147346-147443
            290-462             AC132139.4         155527-155699
            463-647             AC132139.4         157745-157929
            648-818             AC132139.4         159174-159344
            819-971             AC132139.4         163518-163670
            972-1120            AC132139.4         167541-167689
            1121-5195           AC132139.4         170856-174930
FEATURES             Location/Qualifiers
     source          1..5195
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.19 cM"
     gene            1..5195
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /note="carboxypeptidase M"
                     /db_xref="GeneID:70574"
                     /db_xref="MGI:MGI:1917824"
     exon            1..28
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            29..191
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1363
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /EC_number="3.4.17.12"
                     /codon_start=1
                     /product="carboxypeptidase M precursor"
                     /protein_id="NP_081744.1"
                     /db_xref="CCDS:CCDS48696.1"
                     /db_xref="GeneID:70574"
                     /db_xref="MGI:MGI:1917824"
                     /translation="MDRARLWLGLLLPVVAALDFRYHHQEGMEAFLKSVAQNYSSITH
                     LHSIGKSVRGRNLWVLVVGQTPKEHRVGIPEFKYVANMHGDETVGRELLLHLIDYLVS
                     SYRKDPEITHLIDSTRIHIMPSMNPDGFEAVQKPDCYYSNGRENYNNYDLNRNFPDAF
                     ENNNVTKQPETLAIMEWLKTETFVLSANLHGGALVASYPFDNGVQATGTLLSRSLTPD
                     DDVFQHLAYTYASRNPNMTKGDQCKNKRNFPNGIINGYSWYPLQGGMQDYNYIWAQCF
                     EITLELSCCKYPREEKLPLFWNDNKASLIEYIKQVHLGVKGQVFDQSGAPLPNVIVEV
                     QDRKHICPFRTNKLGEYYLLLLPGSYVINVTVPGHDSYLTKLTIPGKSQPFSALKKDF
                     HLPLRWQPDSISVSNPSCPMIPLYKFMPSHSAATKPSLGVFFMTLLYVFFK"
     exon            192..289
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            290..462
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..647
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..818
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            819..971
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1120
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..5195
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2779
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /note="major polyA site"
     regulatory      5172..5177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5195
                     /gene="Cpm"
                     /gene_synonym="1110060I01Rik; 5730456K23Rik;
                     E030045M14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggcgga gacgcgcgcc tggtactgga catggaccgc gcgcgcctgt ggctggggct
       61 tctgctgccc gtggtggccg ccctggattt ccgatatcac caccaggaag ggatggaggc
      121 gttcctaaag agcgtggctc agaactacag ttcgatcacg cacttgcaca gcatcgggaa
      181 atctgtgaga ggtagaaacc tgtgggttct cgttgtgggg cagactccaa aggaacacag
      241 agtcgggatt ccagaattca aatacgtggc gaatatgcac ggagatgaga ctgtagggcg
      301 agaactgctg ctccacctga tcgactatct ggtgagcagt tacaggaaag acccggaaat
      361 cacgcatctg attgacagca cccggatcca catcatgcct tccatgaacc ccgatggatt
      421 cgaagccgtc cagaagcccg actgttacta cagcaatggc agggaaaact acaataatta
      481 tgacctgaac agaaactttc ctgatgcctt tgagaataac aatgtaacaa agcaacctga
      541 gactctggca atcatggagt ggctgaaaac ggaaacattt gtcctctctg cgaatctcca
      601 tgggggtgcc ctggtggcca gttacccctt tgataatggc gtacaagcta cggggacact
      661 gttgtcccga agcttaaccc cggacgatga cgttttccaa cacctggcct acacctacgc
      721 ctcccggaat cccaacatga caaaaggaga tcagtgtaaa aacaagagga acttccccaa
      781 cgggattatc aacggctact cctggtaccc actgcaaggg ggaatgcaag attacaacta
      841 catctgggcc cagtgctttg aaattaccct ggagctgtcg tgctgtaaat atcctcgcga
      901 ggagaagctg ccgctctttt ggaacgataa caaagcctct ttgatcgaat atataaaaca
      961 ggtgcaccta ggggtaaagg gtcaagtgtt cgatcagagt ggagctccat taccgaatgt
     1021 aatcgtggaa gtccaagaca gaaagcatat ctgcccgttt agaaccaaca agcttggaga
     1081 atactatctg cttctgctgc ccgggtccta cgtgatcaat gttacagtcc ctggacacga
     1141 ctcctacctc acgaagctta ctattccagg gaaatcccag cccttcagtg ctcttaaaaa
     1201 ggattttcac ctcccgctgc gatggcagcc ggattccatc tccgtatcca atccttcgtg
     1261 cccgatgatt ccgctgtaca aattcatgcc aagccactcg gctgccacaa agcctagtct
     1321 gggcgtgttt ttcatgactc ttttgtacgt attttttaaa taaagcaagg tgtgaaactc
     1381 gacttccggg aatcagggat tggttactcc cggttatggc aaccctccct cctgtgggac
     1441 tgcgattggg acagactcca ctgttttcct taagaagaaa accggatgtt tccaaacctg
     1501 gcctagagcg acctgtaacg accaaatcca tcttcagtct ggataaagtg gaggtcactg
     1561 cttagctcat gctgcccaca caaacgccac cccgaaggag tcccaaacac ttgtaagaaa
     1621 gttcagaagc aaaacagata tccctacaag aaaaacaatt tgtctacgga gagccacgtg
     1681 gatcagagcc gcaaggacgg gcactttctg gtcacttgct gtgttacgac ctttcgtgtt
     1741 atttgtagag agctgatatt gtctataagt ggttctcccc aaaggaagaa atttctagat
     1801 aacgggacta agagcattta ctcttgccaa tggtctaagg ccaaatgaga gaaaatggac
     1861 aaacatgtct gatgtgggta cagatgcagt ggcctctgtc tcccgtgcct ttgcccttgc
     1921 cccctgcacc tgatgccaca gtcctacgaa gatgacccct cctgtataac cccagtccct
     1981 tgcctgagcc tcagatgcaa ctccagctgc tcaccagaca cacccacctg actacgatgc
     2041 ctaggaactg cagttcatcc ggttgactgt tgagacgcca tgcaaggctg ttcgattccc
     2101 atatccagtc actggaagct gctgtataca gcctctccag gccagttagc gtccctccgc
     2161 cgctgaccca gctgctgctc atgggtattt tcgccaagtc cgtcttccac acagaacctg
     2221 gggagctggg ctgcccaaag ctctcctgct ccctaaacac aacacagtaa gtgctctcgg
     2281 tcccaggtct ggattctgat tgtgtcacgt cttgtttcct gctcagtaaa actccattcc
     2341 atggggggtt aagagcactg actgctcttc cagaggtcct gaggtcaatt cccagccacc
     2401 acatggtggc tcacagccat ctgtaatggg atccgaggct gccttctggt gtgtctgaag
     2461 acagcaacca tgtagtcata cacgtaaaat aaataaattt tttaaaagga agaattccaa
     2521 gcatcgtctt caacggggaa gcccatggag ttccaggtgg tcaagttcaa ggccgatcct
     2581 tcaaagaagt tcctttgact agtgacttta cagcatcgtg gtgtggaact gctctgtgct
     2641 ggccttctct agcacgccat gagctcttta agacaaggat ctgcttgaga aataatttct
     2701 cagagtctag ccaaaaaaca ggaaataaat ggatggggaa gtgtctcagc taccgctaca
     2761 gacctttcca gaacgctaag gatctgagta attttgtgta aatgcgtttt atgtttggca
     2821 acattcagct tactagtaca cacacacaca catacacact tttcacgtgt atgtcaaaga
     2881 acaaaatcca aagataaatg caaatgggtg agctgtgagg cttgagggaa aggcattagc
     2941 tgttagccaa tctgccttct agaccagaaa acaaattctt acagttcgaa gtaaagtgtc
     3001 ccctgtaaaa gtaactttat tctaacatta gaagaagaga aagctgggcg tgttggcgca
     3061 cacctttaat cccaacactc agaaggcaga ggtgggcgga tgtcttcgtt tacacagaca
     3121 gaccctgtct caaaagtaaa taaattaaaa gaaaaaaaaa aggataaata tcaaacagga
     3181 acattaacag taactccgag gtgcaggttt ctaagtgaca tgcatttccc acaggaagta
     3241 agaacatgcg gggtttgaca ggcgatgaag gcttgagact ctaaagagat acgtgggcac
     3301 cctggtgccc tttcttggtg ccaaacctaa tctatatttt aatatcaata gtctgcatag
     3361 ctttttaacc gcttctaaat ttggaaatag catgagtatc ttgatcattt tatttaaata
     3421 agcattaact tatatcccag aaggcgcgta ttaatagttc aaaaagggat ctgggtatat
     3481 tacatttgaa gtatatatat aagacgaagc caggtgtggt ggtgaactat tatcccagcg
     3541 cttgggaggc tgaggcaaga tcgacacagc tcaaggctag cctggactag ccatcttaga
     3601 aaagcaaaac cagtaagata tgtaagagca aacttggttc gccatcagct ggtgttctga
     3661 gttctgactg gttgaccctt tcctaagatt ccgtgaaagg aaatgagctg ttcgctgagc
     3721 tgctcatggg cctaaccgga gacttggtac tgaaacaact tgcaagtgcc cgtgtcttac
     3781 cagagactgt gccagggctt tgcacagggc cattgagcca cagctacgtc tttattttgt
     3841 tactttttgt tcagacacag catttcacta agctgtgtag cctgcacttg gaactcatag
     3901 taagccaaac tggctttgga tctgcctgcc gtagacgctg gagtagctat tacagacctg
     3961 gtccgctgtg tccatattca ggttacatta cttaaatcag aaatatatat caaaacccag
     4021 tgtaaaaatc actaaaacag ggtgaggggt gtagctcagt gacagtgtac ttagcatatg
     4081 caaaggcttg ggtctaatct ccattaacta cccccaagac aaaacataac caggaaatta
     4141 ttctgttgcc ctctgccagg tagagaaagc agaaggaata cttgggtctg taactgtttt
     4201 gaaagcaata taccttacta aaggtgacct gaaaacggaa atgctggtta ccaaaaacca
     4261 cgtccttttc aaggaaactt tcacaaagtg cctagtttac atgcgtgccc atttttgaat
     4321 tgagatggta aaatcctagc acccaggcag cagaggcagg tggatctctg tgagttcaag
     4381 gccagtcttt tctacagagt tctgggaccg ccagggctac gcagaaaaac ccccgtttca
     4441 aacaagcaaa aacagtccca gttttctcag actctgcctg tactaaaatg gtattaacat
     4501 cagatctgct ttccaatgta tgagctgaag ctgggttgag acgtatctgt ttctaggaaa
     4561 aatatacaaa gccatatagc acacttattt tcctattgca acaggagttt cattctcagt
     4621 ctcggagggg gcatctagtg aaggtttgtg agctcaattc tgccttcctg gtgacctcag
     4681 gtacgggaga gaatgatgct ggattaggtg aagagcatcg ggttcttggt gcctacaaca
     4741 gattcttcac cgagtttgtt ctagacttgc atcactaata agatgctgta ctgtgtctca
     4801 caggccgttt aatcaaacct taagctcaca agccaaccca cagctctgtg cgagagactt
     4861 catgcgggtt tttgtttaac aagcttctaa gtgattcctg ccattaaaag cacagaagca
     4921 gaagctatta aaggtgccca ggttgagtgg tggcagtgct ggaccacgcc tttaatccca
     4981 gtactccaga ggcagaggca gaggggactc tgagttcaaa tccagcctgc ctggtctaca
     5041 cagtgagttc caagacagcc agggctacac agaaaaataa ataaattctc agattatcta
     5101 agattacaac gtttgcttgg gagggaccat gactacctct gagcttattt tatttacatt
     5161 atctgattat caataaagaa tattcatata gtgaa
//
