LOCUS       NM_146223               2859 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus complexin 3 (Cplx3), mRNA.
ACCESSION   NM_146223
VERSION     NM_146223.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Lux,U.T., Meyer,J., Jahn,O., Davison,A., Babai,N., Giessl,A.,
            Wartenberg,A., Sticht,H., Brose,N., Reim,K. and Brandstatter,J.H.
  TITLE     Light-dependent regulation of neurotransmitter release from rod
            photoreceptor ribbon synapses involves an interplay of Complexin 4
            and Transducin with the SNARE complex
  JOURNAL   Front Mol Neurosci 17, 1308466 (2024)
   PUBMED   38481472
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Roque,M., Alves Rodrigues de Souza,D., Rangel-Sosa,M.M.,
            Altounian,M., Hocine,M., Deloulme,J.C., Barbier,E.L., Mann,F. and
            Chauvet,S.
  TITLE     VPS35 deficiency in the embryonic cortex leads to prenatal cell
            loss and abnormal development of axonal connectivity
  JOURNAL   Mol Cell Neurosci 120, 103726 (2022)
   PUBMED   35367368
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Pal,S., Dwivedi,D., Pramanik,T., Godbole,G., Iwasato,T.,
            Jabaudon,D., Bhalla,U.S. and Tole,S.
  TITLE     An Early Cortical Progenitor-Specific Mechanism Regulates
            Thalamocortical Innervation
  JOURNAL   J Neurosci 41 (32), 6822-6835 (2021)
   PUBMED   34193558
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Martinez,M.E. and Hernandez,A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Doyle,D.Z., Lam,M.M., Qalieh,A., Qalieh,Y., Sorel,A., Funk,O.H. and
            Kwan,K.Y.
  TITLE     Chromatin remodeler Arid1a regulates subplate neuron identity and
            wiring of cortical connectivity
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34011608
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Hoerder-Suabedissen,A., Wang,W.Z., Lee,S., Davies,K.E.,
            Goffinet,A.M., Rakic,S., Parnavelas,J., Reim,K., Nicolic,M.,
            Paulsen,O. and Molnar,Z.
  TITLE     Novel markers reveal subpopulations of subplate neurons in the
            murine cerebral cortex
  JOURNAL   Cereb Cortex 19 (8), 1738-1750 (2009)
   PUBMED   19008461
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Strenzke,N., Chanda,S., Kopp-Scheinpflug,C., Khimich,D., Reim,K.,
            Bulankina,A.V., Neef,A., Wolf,F., Brose,N., Xu-Friedman,M.A. and
            Moser,T.
  TITLE     Complexin-I is required for high-fidelity transmission at the
            endbulb of Held auditory synapse
  JOURNAL   J Neurosci 29 (25), 7991-8004 (2009)
   PUBMED   19553439
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Reim,K., Regus-Leidig,H., Ammermuller,J., El-Kordi,A.,
            Radyushkin,K., Ehrenreich,H., Brandstatter,J.H. and Brose,N.
  TITLE     Aberrant function and structure of retinal ribbon synapses in the
            absence of complexin 3 and complexin 4
  JOURNAL   J Cell Sci 122 (Pt 9), 1352-1361 (2009)
   PUBMED   19386896
  REMARK    GeneRIF: Results show that complexin 3 and complexin 4 are
            essential regulators of transmitter release at retinal ribbon
            synapses.
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Xue,M., Stradomska,A., Chen,H., Brose,N., Zhang,W., Rosenmund,C.
            and Reim,K.
  TITLE     Complexins facilitate neurotransmitter release at excitatory and
            inhibitory synapses in mammalian central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 105 (22), 7875-7880 (2008)
   PUBMED   18505837
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Reim,K., Wegmeyer,H., Brandstatter,J.H., Xue,M., Rosenmund,C.,
            Dresbach,T., Hofmann,K. and Brose,N.
  TITLE     Structurally and functionally unique complexins at retinal ribbon
            synapses
  JOURNAL   J Cell Biol 169 (4), 669-680 (2005)
   PUBMED   15911881
  REMARK    GeneRIF: The novel CPXs III and IV may contribute to the unique
            release efficacy of retinal sensory neurons.(cOMPLEXIN III, MOUSE)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122528.3 and BC033343.1.
            
            On Aug 26, 2009 this sequence version replaced NM_146223.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033343.1, AK044211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC122528.3         63838-63886
            50-2859             BC033343.1         1-2810
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.11 cM"
     gene            1..2859
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /note="complexin 3"
                     /db_xref="GeneID:235415"
                     /db_xref="MGI:MGI:2384571"
     exon            1..301
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /inference="alignment:Splign:2.1.0"
     exon            302..389
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /inference="alignment:Splign:2.1.0"
     exon            390..2859
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /note="hexamer: AATAAA"
     polyA_site      1473
                     /gene="Cplx3"
                     /gene_synonym="CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l"
                     /note="major polyA site"
ORIGIN      
        1 gtgaggaggg ttttgggaag gtagggacca gtgctcaaag cgtggggcgc gagctcgcaa
       61 ccggagctgt ccccgggact tagtgctgaa gtaggcgctg acgaaccagg cgcctggtgc
      121 ggtggtcaga aaagaccatg gcgttcatgg tgaagtccat ggtgggtggc caactgaaga
      181 acctcacagg gagcctgggg ggcggcgagg acaaggggga cggagacaag tctgcagccg
      241 aagcacaggg catgagccga gaagagtacg aggagtatca gaagcaactg gtggaggaga
      301 agatggagcg agatgcacag ttcacacaga ggaaggcaga gcgggccaca ctgcgaagtc
      361 acttcagaga caaataccgt ctgcccaaga acgaaacaga tgaaagccag atccagctgg
      421 caggcggaga tgtggagctg cctcgggagc tagccaagat gatcgaggag gatacggagg
      481 aagaggagga taaggcctct gtgctcgggc agctggccag cctccctggc ctagacctca
      541 gctcactcaa ggacaaagcc cagactacac taggggacct caagcaatca gctgagaagt
      601 gccatatcat gtgaccactt ccccctggat tctcctctag gatggccaga gggctggtcc
      661 acatgagggc taagagagtg agtgtctcaa cttccggata cctccagtcc attttggact
      721 ctgctttccc tgccccagcc tagcctgagc cgtctcgtcc atgtccagct ctagctctgg
      781 tctctctctc tctctctctc tctctctctc tctctctctc tctctcttta ttgtcagcaa
      841 agttcccatt cttccctctc tccctccgct gcctggaaag tttccccgag ttgatagaat
      901 tagcccaacc ctttctgggt acagcctcct gttcttcaca caagagcact cacaagagga
      961 cacagaagcc ctggctcatt tgccacagat gcatcctggc acacacagac acacgtctcc
     1021 tgggctccca gcccctccag ataccagcac ccagaggccc ttaggagagc ctctgggcac
     1081 acagaagacc tgctcttatc cctaccttta tgatcctaga agcttttctt ctttctgggt
     1141 tttaccatct gtaaaatggg aatggactga gtgatttcca aaattctctc ctgattggca
     1201 ttcctggcca ctcagaatag agcccacatc ccttcttggg cagggcagca gctgcagtcc
     1261 cagcatcaca cagctgccac tgtgggttct gggagctgag caatgctgtg tgaggggcag
     1321 agtgccaggg atggagctgg cactgaacag tagctccagg cctcctctgg gcccagggct
     1381 gagccaaact gtgttctgtt cctgtagaat tctctggatt ccatagttgg aatttcctct
     1441 tctcgttcag tgaaaaataa aaattccaaa tgacgtggct atcttcccac ttcctgctga
     1501 cttggggttc acaggcccca ggcctgccct tttgagggac ctcatctgct tcttcacctg
     1561 cagcttcaga ggattctagg agagaatcag ggctgcaggt gagggtgggg cctcactgag
     1621 ggagcagatg ccctttggcc agatgaagtt aagtctaagc actaagagtg aggagggtgt
     1681 ggcagccatc tggatggaga ggtacacggg aagatggagc ttagggtgtt cctgagacta
     1741 gagaaagggc tgtctctgac acctgtcctg tactttcccc tcacctaaga gatggagaat
     1801 gaaacagaga aaaaaagcat cattgtgctc caacctggct ctgctctgca tccctgagcc
     1861 tatgttaaat gaagagttct cctccccaag aataatacgt gtttcaaaga gtagccattt
     1921 gtcccccacc cccacctcct tggtagtgct gggggaccca gggcctcaca cactgcatac
     1981 taaggcaaat ggtctgccac tcagccacac ccacagcccc tccccccaca caccatgctg
     2041 cttatcagct gttgtaacac attctttaaa gtaacagagg ctgaggagcc agcagtcatg
     2101 ctacactgag tgagacctgg tggtgaagac agtgttagtc ccacctcaca gggaggtggc
     2161 ctgagatggc aagctggtgt cctcaaagtt tgtgtttagg cagtgtgttt cagtttctgc
     2221 cgggttttct tctctctctg tgttccccct ccccctcccc cctctccctt tctctctctg
     2281 tatgtgtgtt agttggtatt attgtcattt tgttttcttt cagacagaat ctcatgtagc
     2341 tcaggctagc ctcaaactcc taggtaggca ggaatgatct tgggcttctg atcatcttgc
     2401 ctcaacttcc caagtaccct gcttacagga acaggctatc acatgtaact tctgctgtgc
     2461 ttcgaaccta accaaggcct ttgtacatgt taggcacgca ccaacaggct gcatccttct
     2521 cctgtgtttg gtggtgtttt taaatttaat tactctatgt gtatgaatat ttgtctgcac
     2581 acatgtcttt gctcatgtgt gcttggtgac caaggaggtc agaacaaggc gtcagatgcc
     2641 ctgtgcctgg agttacagat ggttttgagt tgtcatgtgg gtgctgagaa ttgaatctgt
     2701 gtctggaaaa gcactgagcc ctctctccag cccctttgtc ttagagatgg gatctcacta
     2761 tgtagcccaa gctagcctcc caagtgctag gattacagat gtgcagcaac actatgtatg
     2821 actttaatga ggaataaaaa gggggaaaaa agttcttaa
//
