LOCUS       NM_009946               4928 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus complexin 2 (Cplx2), transcript variant 1, mRNA.
ACCESSION   NM_009946 XM_983209
VERSION     NM_009946.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Wang,L., Hu,L., Wang,X., Geng,Z., Wan,M., Hao,J., Liu,H., Fan,Y.,
            Xu,T. and Li,Z.
  TITLE     Long non-coding RNA LncCplx2 regulates glucose homeostasis and
            pancreatic beta cell function
  JOURNAL   Mol Metab 80, 101878 (2024)
   PUBMED   38218537
  REMARK    GeneRIF: Long non-coding RNA LncCplx2 regulates glucose homeostasis
            and pancreatic beta cell function.
REFERENCE   2  (bases 1 to 4928)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   3  (bases 1 to 4928)
  AUTHORS   Malsam,J., Barfuss,S., Trimbuch,T., Zarebidaki,F., Sonnen,A.F.,
            Wild,K., Scheutzow,A., Rohland,L., Mayer,M.P., Sinning,I.,
            Briggs,J.A.G., Rosenmund,C. and Sollner,T.H.
  TITLE     Complexin Suppresses Spontaneous Exocytosis by Capturing the
            Membrane-Proximal Regions of VAMP2 and SNAP25
  JOURNAL   Cell Rep 32 (3), 107926 (2020)
   PUBMED   32698012
  REMARK    GeneRIF: Complexin Suppresses Spontaneous Exocytosis by Capturing
            the Membrane-Proximal Regions of VAMP2 and SNAP25.
REFERENCE   4  (bases 1 to 4928)
  AUTHORS   Tsuru,E., Oryu,K., Sawada,K., Nishihara,M. and Tsuda,M.
  TITLE     Complexin 2 regulates secretion of immunoglobulin in
            antibody-secreting cells
  JOURNAL   Immun Inflamm Dis 7 (4), 318-325 (2019)
   PUBMED   31691534
  REMARK    GeneRIF: data suggest that CPLX2 inhibits spontaneous secretion of
            IgM and IgG1 from splenic antibody-secreting cells (ASCs). This
            study provides new insight into the mechanism of antibody secretion
            of ASCs.
REFERENCE   5  (bases 1 to 4928)
  AUTHORS   Courtney,N.A., Bao,H., Briguglio,J.S. and Chapman,E.R.
  TITLE     Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons
            independent of complexin
  JOURNAL   Nat Commun 10 (1), 4076 (2019)
   PUBMED   31501440
  REMARK    GeneRIF: the C2B domain of syt1, independent of complexin, is the
            molecular clamp that arrests synaptic vesicles prior to
            Ca(2+)-triggered fusion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4928)
  AUTHORS   Morton,A.J. and Edwardson,J.M.
  TITLE     Progressive depletion of complexin II in a transgenic mouse model
            of Huntington's disease
  JOURNAL   J Neurochem 76 (1), 166-172 (2001)
   PUBMED   11145989
REFERENCE   7  (bases 1 to 4928)
  AUTHORS   Huang,G.Z., Ujihara,H., Takahashi,S., Kaba,H., Yagi,T. and Inoue,S.
  TITLE     Involvement of complexin II in synaptic plasticity in the CA1
            region of the hippocampus: the use of complexin II-lacking mice
  JOURNAL   Jpn J Pharmacol 84 (2), 179-187 (2000)
   PUBMED   11128041
REFERENCE   8  (bases 1 to 4928)
  AUTHORS   Takahashi,S., Ujihara,H., Huang,G.Z., Yagyu,K.I., Sanbo,M., Kaba,H.
            and Yagi,T.
  TITLE     Reduced hippocampal LTP in mice lacking a presynaptic protein:
            complexin II
  JOURNAL   Eur J Neurosci 11 (7), 2359-2366 (1999)
   PUBMED   10383625
REFERENCE   9  (bases 1 to 4928)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   10 (bases 1 to 4928)
  AUTHORS   Takahashi,S., Yamamoto,H., Matsuda,Z., Ogawa,M., Yagyu,K.,
            Taniguchi,T., Miyata,T., Kaba,H., Higuchi,T., Okutani,F. et al.
  TITLE     Identification of two highly homologous presynaptic proteins
            distinctly localized at the dendritic and somatic synapses
  JOURNAL   FEBS Lett 368 (3), 455-460 (1995)
   PUBMED   7635198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BN000502.1 and AC242674.2.
            
            On Apr 15, 2014 this sequence version replaced NM_009946.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.3972478.1, CX241609.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-762               BN000502.1         1-762
            763-779             AC242674.2         19158-19174
            780-1007            BN000502.1         763-990
            1008-1226           BN000502.1         1066-1284
            1227-1252           AC242674.2         19622-19647
            1253-1384           BN000502.1         1311-1442
            1385-1554           AC242674.2         19780-19949
            1555-4928           BN000502.1         1443-4816
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 28.59 cM"
     gene            1..4928
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /note="complexin 2"
                     /db_xref="GeneID:12890"
                     /db_xref="MGI:MGI:104726"
     exon            1..227
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /inference="alignment:Splign:2.1.0"
     exon            228..346
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..720
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /note="CPX II; synaphin-1; complexin II"
                     /codon_start=1
                     /product="complexin-2"
                     /protein_id="NP_034076.1"
                     /db_xref="CCDS:CCDS36667.1"
                     /db_xref="GeneID:12890"
                     /db_xref="MGI:MGI:104726"
                     /translation="MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQ
                     EEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIP
                     AGCGDEEEEEEESILDTVLKYLPGPLQDMFKK"
     exon            347..522
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /inference="alignment:Splign:2.1.0"
     exon            523..4928
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4907..4912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /note="hexamer: AAGAAA"
     polyA_site      4928
                     /gene="Cplx2"
                     /gene_synonym="921-L; Gm34843"
                     /note="major polyA site"
ORIGIN      
        1 gttttgaatt tcccttctgg aagagaagct gtacggcgtc agggcctggc tgaggggcgt
       61 gattggaggg cgccttaggc atccgcccgc ccgcggcagc agcctcggcc ccagcttgcc
      121 tggcggagtt acaccaggca gcggcgcgag ctggctgagc acacggcacc gcctgctgga
      181 gtcagccgga gccctgcagt ggcttagacg gttgctggga ccaccaggtg ggctcatttc
      241 ccaaaggcag accagccagg agtgctgaat gcgaattcag ccacgggcta gagagcatta
      301 accaaagcct gcaggatgga cttcgtcatg aagcaagccc tcggaggggc caccaaggac
      361 atggggaaga tgctgggggg agaggaggag aaggacccag acgcacagaa gaaggaggag
      421 gagcggcagg aggccctgag gcagcaggag gaagagcgca aggcgaaaca cgcccgcatg
      481 gaagccgagc gcgagaaggt ccggcagcag atccgagaca agtatgggct gaagaagaag
      541 gaagagaaag aggcagagga gaaggcagcc ctggaacagc cctgcgaggg aagcctgacc
      601 cgacccaaga aggccatccc tgcaggctgt ggggacgagg aggaggagga agaggagagc
      661 atcctggaca cagtgctcaa atatctgcca gggccgctgc aggacatgtt caagaagtaa
      721 cccatcctcc tccggcccct tccacgttat gacttttttt tttttttttt tttttttttg
      781 gtgttcttag tctttctttt ctttttattc agttaagtct cagttccaaa ggggaaaacc
      841 ttagtcgacc tctgccccct taccctagtc agggactcct cccctctgca gtccctgaca
      901 gacccttcat cccagggttt ctagtcctgt ttcactccca agtagcttga aaaaggaagg
      961 aggaggagga ggaggaggag gaggaggagg aggaggagga ggaggagaag gagaaggaga
     1021 aggagaagga gaaggagaag gagaaggaga aggagaagga gaaggagaag gagaaggaga
     1081 aggagaagga gaaggagaag gagaaggaga aggagaagga gaaggagaag gagaagaaga
     1141 agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagaaga
     1201 agaagaagaa gatagcttta ctctagcagg gggcattgaa cccagagcca aaggcattgg
     1261 ttgtccctcc agaagaagcc catggtctat gttaatgtgg tgacactccc ccccatacat
     1321 tccttcatgc tccccactgc caggaggacc actgtcccca gccagccaaa gtaatgacac
     1381 attccagcct tgcccagcat gctgaccttt ggcctctgaa ccccccagtg ggagtccagg
     1441 tcagggcaga ggcactgagt ggtctggctc caggaaggct attcagaggg agcctgtcct
     1501 ggagagccta gccctgagag gctctagctg ggtctggcca ggttagaatc tgggcaggag
     1561 gcttgggctc tcctcttttc ctcttcctgg tgccgctgct ggccaggagc acacctctcc
     1621 ccaacccgac ctaaagaagc acggccccgg ccaagccact ccttccaaat ggatcctctt
     1681 tggactttag cacatctgtg gaggaaccca gggcagggca acacccttat ttctctctca
     1741 tctgacttag gtcctgggac cccactgcca ggctaggccc gagtttgccc agccaagggg
     1801 ctgcccagac ccccagaaaa tacttggagc catcgggcag tggtggcctg tgccatgagg
     1861 ctcctcattg gcacatccaa actgccccca tttcctgtcc accctccttc cctccatgtc
     1921 ctgtccatgt gcttccaagt ccccattgtc cccaggagga ctcttcttgg ccaaagcccc
     1981 caaacagctg gggagaagcc aattgccacc tgacaaaaga ctgtccattc atcccactgg
     2041 ccaagggtca gctctcctct gggatgtata ggactggtat gtgtcctcac gtaccacctt
     2101 gtcaaggctt cctgctctgt gacttgtgga gaaatggaga gacagagggg gaggcgcaaa
     2161 tgagggatga gcgtgtgagt ccccacacac tgggtaatgc acggcaggcc catcctacat
     2221 ctcgatgcga ctgtgtcttg agattgcatg tgtgtgtgtt agctctgtgt tgcaggctgt
     2281 gtatctgatg tgcctcgtgc atatgtgttt gtgggatgta gtgtgcctga gtcccagttc
     2341 attttctcgg tatgtgctag ccatctcgtg tgctttcaga ttgcatgtgc tagcttgtat
     2401 atgcatgtac ttgcaaaacg gcatgtgtgt caagagtgac aggttacatg ttagctgtag
     2461 acatgtgtgc ttgagacaac tgtcacgtgg gctaagactg gtgttcatgt gtgtgggtct
     2521 aaaccaggaa gtcgtatgca taagtcgtac aacttctttc tcagagagca agaattggag
     2581 taagatgctt cctccccacc ctgagacggt tagtcacaga tggccacatc tgacaggaaa
     2641 ccttactttg gcctagagtc ctcccaccct tgggggtttc ctacctgagg tcctcagaat
     2701 gctactggga cagacccagg cagtacccta ggaagccatg ctgggcccct accagggcct
     2761 atcccaaaag caggggcccg ggagggggcg acttgccctc ccccgaagcc cctgtcccac
     2821 tggccccagt ttgcattctg caggttttcc attttagtgg acttacgctt ttatttcaga
     2881 gaagacagac gtcttccctg tccgtttcca atagttaaag ccatatcagt tagaccgcaa
     2941 tactttaaag ataagactaa acaatccata tgtgtaggga accagaaaag tcccctggtc
     3001 tctccctcct ctaaggagca gggccttggc agctccagct cccgggactt accctcctcc
     3061 cacccccacc ctcttgggcc cctgtgtcat cccacagggg gctagtgttt gtgtctatgt
     3121 ctgtggtggg gagccatctt gcacccctat tgtctgcttg tttctgtttc ttatcctggg
     3181 caggatggtc attcttcaga gccttggggt cctgggccag agacaggcag ggaccagtcc
     3241 aggggccctg ggcctcccta gaccctgagt gtgacttccc cttccccaac ccccaccccc
     3301 tcacacacac cttgaaggca gggaaggaca ctagtgtttt aaaggcctaa cccttcacag
     3361 atagacctca aaggtaatga acggcacagt acaaagcatc agatgggtag tggagaccaa
     3421 gacctggaga gatgcaaata ggcaaggaaa cccagccacg caagaacccg aatggtcctg
     3481 agagagccca gacccttcaa ctgaagtcct tggtggtttc catggctcct ctgagcccag
     3541 agcgagctca gggcttttca gcctcaccca gtgcccccca ggcggggctg gcttagtcta
     3601 gatttatgtc tcctttctat gcccagacag cagattctga ggtcctttga aggtggaggt
     3661 aagagaattt ctacttgata catacctggt tccacccaca caaagcccag ggagatgtaa
     3721 tgattgatat ttctgacata gcctgggcta tagggagaaa acaacaggca accctggaag
     3781 gatgctgtgt accacacatg catgggaggg cagaacttgg gtacttgagc attggaaagg
     3841 atacatatac acacatagca catacatgca cacattcact cacatacata tacacacata
     3901 catacatcca tatatataca cacacatata tatacataca tatacacata cataaacata
     3961 catatacaca cacatatata tacatacata cacacatata tatacaaaca tatacacaca
     4021 tatgtacaca tacacacaca tacatacaca catgcacaca cacagcatgg aagatggctg
     4081 gagtgggatg aggcacatca ctgacaggca tgtgtgctct ttgggaaggt catcaggctc
     4141 ctacacctgg aaatcaccag cagtgaaaag aaagagcgct tctctgggcc tctgtgaaga
     4201 tgacacagga tatccagggt acatgtcccc catttcagct ccagagagtg agcccttagc
     4261 agcaaagctc cacagcgctt ccttccatgg aagtaggagc tctataggcc atcccaggta
     4321 ggtaaatgag aacaggaacg agaagcccag agacccctca cacatggcag agctggtgag
     4381 caaaccagcc atctaaaggc ccatggctag agtaaggggg gctaagcatg gggcttccag
     4441 ccccgagagt gcccactatg aagtgagcag agttgcccac ccacaactcc ccttccatct
     4501 tcctgtggtt tggccagccc ctgacctcac tgggagacct ggggatcaga ctccctccca
     4561 tgggggatgc ctcccggcca atgtcccctg ctctagtccc cattcctaat gccctgccct
     4621 ttcaccaggg agagagacct gaggtgctcc tgctggcccc gggatgggag tgggaagtcc
     4681 cactgagacc caggtgagat ggaccatcct gctcatgtag gggaacctct ttcccacaac
     4741 tgtgctgtgt ccttgttgct ctgcttcctt taaatgtgtc agtctctggg ggaggggagg
     4801 gccacgcccc ccgaactccc ttgaacctga ccaaaagcca tggccgtgct ccccactttg
     4861 tatgatgcaa atgctaagat gatgtacaaa accaaccatg atgacaaaga aaaagacctt
     4921 gtacagca
//
