LOCUS       NM_007756               2217 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus complexin 1 (Cplx1), mRNA.
ACCESSION   NM_007756
VERSION     NM_007756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2217)
  AUTHORS   Liu,M., Wang,C., Huo,L., Cao,J., Mao,X., He,Z., Hu,C., Sun,H.,
            Deng,W., He,W., Chen,Y., Gu,M., Liao,J., Guo,N., He,X., Wu,Q.,
            Chen,J., Zhang,L., Wang,X., Shang,C. and Dong,J.
  TITLE     Complexin-1 enhances ultrasound neurotransmission in the mammalian
            auditory pathway
  JOURNAL   Nat Genet 56 (7), 1503-1515 (2024)
   PUBMED   38834904
  REMARK    GeneRIF: Complexin-1 enhances ultrasound neurotransmission in the
            mammalian auditory pathway.
REFERENCE   2  (bases 1 to 2217)
  AUTHORS   Grasso,E.M., Terakawa,M.S., Lai,A.L., Xue Xie,Y., Ramlall,T.F.,
            Freed,J.H. and Eliezer,D.
  TITLE     Membrane Binding Induces Distinct Structural Signatures in the
            Mouse Complexin-1C-Terminal Domain
  JOURNAL   J Mol Biol 435 (1), 167710 (2023)
   PUBMED   35777466
REFERENCE   3  (bases 1 to 2217)
  AUTHORS   Kisseleff,E., Vigouroux,R.J., Hottin,C., Lourdel,S., Thomas,L.,
            Shah,P., Chedotal,A., Perron,M., Swaroop,A. and Roger,J.E.
  TITLE     Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced
            Retinal Ganglion Cells3
  JOURNAL   eNeuro 8 (5) (2021)
   PUBMED   34518365
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2217)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2217)
  AUTHORS   Courtney,N.A., Bao,H., Briguglio,J.S. and Chapman,E.R.
  TITLE     Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons
            independent of complexin
  JOURNAL   Nat Commun 10 (1), 4076 (2019)
   PUBMED   31501440
  REMARK    GeneRIF: the C2B domain of syt1, independent of complexin, is the
            molecular clamp that arrests synaptic vesicles prior to
            Ca(2+)-triggered fusion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2217)
  AUTHORS   Freeman,W. and Morton,A.J.
  TITLE     Differential messenger RNA expression of complexins in mouse brain
  JOURNAL   Brain Res Bull 63 (1), 33-44 (2004)
   PUBMED   15121237
  REMARK    GeneRIF: We studied the mRNA distribution of CPLXI and CPLXII in
            mouse brain. We show that while CPLXs are expressed in distinct
            cell populations they do not segregate with particular
            neurotransmitters or different classes of transmitter action
REFERENCE   7  (bases 1 to 2217)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   8  (bases 1 to 2217)
  AUTHORS   Reim,K., Mansour,M., Varoqueaux,F., McMahon,H.T., Sudhof,T.C.,
            Brose,N. and Rosenmund,C.
  TITLE     Complexins regulate a late step in Ca2+-dependent neurotransmitter
            release
  JOURNAL   Cell 104 (1), 71-81 (2001)
   PUBMED   11163241
REFERENCE   9  (bases 1 to 2217)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   10 (bases 1 to 2217)
  AUTHORS   Takahashi,S., Yamamoto,H., Matsuda,Z., Ogawa,M., Yagyu,K.,
            Taniguchi,T., Miyata,T., Kaba,H., Higuchi,T., Okutani,F. et al.
  TITLE     Identification of two highly homologous presynaptic proteins
            distinctly localized at the dendritic and somatic synapses
  JOURNAL   FEBS Lett 368 (3), 455-460 (1995)
   PUBMED   7635198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY278933.1, AK159026.1 and BY594213.1.
            
            On Apr 22, 2009 this sequence version replaced NM_007756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158166.1, SRR1660815.102689.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY278933.1         1-42
            43-2184             AK159026.1         2-2143
            2185-2217           BY594213.1         412-444
FEATURES             Location/Qualifiers
     source          1..2217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.17 cM"
     gene            1..2217
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /note="complexin 1"
                     /db_xref="GeneID:12889"
                     /db_xref="MGI:MGI:104727"
     exon            1..139
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /inference="alignment:Splign:2.1.0"
     exon            140..243
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..617
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /note="CPX I; synaphin-2; complexin I"
                     /codon_start=1
                     /product="complexin-1"
                     /protein_id="NP_031782.3"
                     /db_xref="CCDS:CCDS39206.1"
                     /db_xref="GeneID:12889"
                     /db_xref="MGI:MGI:104727"
                     /translation="MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQA
                     EEERKAKYAKMEAEREVMRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIP
                     PGCGDEPEEEDESILDTVIKYLPGPLQDMFKK"
     exon            244..419
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /inference="alignment:Splign:2.1.0"
     exon            420..2192
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Cplx1"
                     /gene_synonym="921-S"
                     /note="major polyA site"
ORIGIN      
        1 gtcatgcggg acgcgggcgg gggcgcctct gagtgacgcg ccctcctcgc ggtgtccttc
       61 agccgccgca gcagcacaga gcgccacatg gaccccgccg gcctgagagc gcgctgctgt
      121 tgatcgtcca ccttggaagg cagaagaccc tgaccacact tgaatgtgaa atctgacccc
      181 gggagtggct cctgaggaac caagccatca ccatggagtt cgtgatgaaa caagccctgg
      241 gaggggccac caaggacatg gggaagatgc ttgggggtga tgaggaaaag gaccccgatg
      301 ctgctaagaa ggaggaagag cggcaggagg cactgcggca ggcagaggag gagcgcaaag
      361 caaagtacgc caagatggag gcagaacgtg aggtcatgcg gcagggtata agagacaagt
      421 atggcatcaa gaagaaggag gagcgtgagg ctgaggctca ggcagccatg gaggccaact
      481 cggaaggcag cctgactcga cccaagaagg ctatcccacc gggctgtggc gatgagccag
      541 aggaggaaga tgagagcatc ctggacactg tcatcaagta cctgcctggg ccactgcagg
      601 acatgttcaa gaagtaatga tattgggtca gcaccaggag ccctgcccac tgtacagacc
      661 cccgcggagt ctccccccaa caagggatgt tgggagcaga tgcagccccc ctacccccgc
      721 aaaaataagc catagtccta gatctatcct gcccatgtcc cccctcgcgc ctcgggagcc
      781 tctggccacc cctccccata ctgccatcac tgaccccacc aggcaagggt gtgaccctca
      841 ggcccctgtg ctgtgcatcc ttgccttcgg gtggttggac ccctccttac taatcttaag
      901 ttcaccatcc ccacagagcc tgcccaaggt caggccccga gggccagccc tgaccacccc
      961 tggatgggtg gctaccagtc agggcctaaa ctcaggagca cagccatagt ggggtgggac
     1021 ttggggaatg agcagtgggt gcttggggcc cccagccctt ccctgagtcc attgccccag
     1081 tttctggact tgttggacct gctggaccat tcgctctgtc ttcctgtctg tgagctacca
     1141 ccctagtctt ccccagcagc ctttgcatat tttgtccagc tgtctctttc tctgttgctc
     1201 tgcaaggttt ggcttaagaa ttccatggcc agaggaaaca cagcaataga tttggagcgg
     1261 gtggtctcag acacacttgg agtcccttga catcgtctgt aatgcacttt ccagagtccc
     1321 atctttccct gatcccacct ctccctggtg gcctcctgtc ctcttcatgt gggcaggcag
     1381 tctcctagga tcttcctggc tttacccctg gacacctacc ctccaaatgc ccgtcttcct
     1441 aaaagccctg ggttctggtg attcccgccc gtgcagagca gacagagggc cgcataatca
     1501 agtgtcccac cctctccact attcctcctc tgaagggctg acagtggccg gtaaatgcaa
     1561 gctcctgggc ttgggctgtg gtgttttgtt ctgtgtgtgg cccaggggca gtatgaccca
     1621 actactcccc ctttgcccag ccagcagcca ttgttcttca tatttgttta atttacatca
     1681 taatatgttg aatctcaggt aaatgaggtc tgtatttggt aagttttatc ttgacagaaa
     1741 ggccagcctg gtcttcccat aacccttcct gtccacagta aaactgaatt aagtgtccat
     1801 gagttttggg ccaggtgtgt ggcttagcat tgaccttcat gaccttacat agctctttag
     1861 agaagccata acaattagac tgcaatacta ttcagaatgc cctctgccca aagagatgaa
     1921 gcatgctcgg cccacagtac cttgctcacc tgggccattc tctgcgcctc tggctggttt
     1981 tcatgaattg agaagccagc tctgagcaga tggccctctc ttgagtcaat cctgcatcct
     2041 gttcctagcg catggggcac cgggcgctga gcttagaata gcccatgtgt tacctgtctg
     2101 tctgtcctcg tgcctgcacc tcctgcatgt cagaggcctc acattttctc tctgagggaa
     2161 tcacagccaa taaacagtga tttcacaccg tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
