LOCUS       NM_001081174             951 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus ciliogenesis and planar polarity effector 2 (Cplane2),
            mRNA.
ACCESSION   NM_001081174 XM_205477
VERSION     NM_001081174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Engelhardt,D., Marean,A., McKean,D., Petersen,J. and Niswander,L.
  TITLE     RSG1 is required for cilia-dependent neural tube closure
  JOURNAL   Genesis 62 (3), e23602 (2024)
   PUBMED   38721990
  REMARK    GeneRIF: RSG1 is required for cilia-dependent neural tube closure.
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Langousis,G., Cavadini,S., Boegholm,N., Lorentzen,E., Kempf,G. and
            Matthias,P.
  TITLE     Structure of the ciliogenesis-associated CPLANE complex
  JOURNAL   Sci Adv 8 (15), eabn0832 (2022)
   PUBMED   35427153
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Agbu,S.O., Liang,Y., Liu,A. and Anderson,K.V.
  TITLE     The small GTPase RSG1 controls a final step in primary cilia
            initiation
  JOURNAL   J Cell Biol 217 (1), 413-427 (2018)
   PUBMED   29038301
  REMARK    GeneRIF: RSG1 localizes to the mother centriole in a process that
            depends on tau tubulin kinase 2 (TTBK2), the CPLANE complex protein
            Inturned (INTU), and its own GTPase activity. The data suggest a
            specific role for RSG1 in the final maturation of the mother
            centriole and ciliary vesicle that allows extension of the ciliary
            axoneme.
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY232166.1 and BC147765.1.
            
            On Jun 20, 2009 this sequence version replaced NM_001081174.1.
            
            Sequence Note: There is insufficient transcript evidence to
            determine the extent of the 3' UTR, as of build 37.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC147765.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY232166.1         2-64
            64-951              BC147765.1         1-888
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 73.47 cM"
     gene            1..951
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /note="ciliogenesis and planar polarity effector 2"
                     /db_xref="GeneID:76166"
                     /db_xref="MGI:MGI:1923416"
     exon            1..108
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..258
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..923
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /note="miro domain-containing protein C1orf89 homolog;
                     REM2- and Rab-like small GTPase 1; REM2 and RAB-like small
                     GTPase 1"
                     /codon_start=1
                     /product="ciliogenesis and planar polarity effector 2"
                     /protein_id="NP_001074643.1"
                     /db_xref="CCDS:CCDS38937.1"
                     /db_xref="GeneID:76166"
                     /db_xref="MGI:MGI:1923416"
                     /translation="MARPPMHGSVIVPDWHETVEGKEYLACILRKNRRREFGLLERPV
                     LPPSVVIDTASYKIFVSGKSGVGKTALVAKLAGLEVPIVHHETTGIQTTVVFWPAKLK
                     ASDCVVMFRFEFWDCGESALKKFDHMLPACKENADAFLFLFSFTDRASFEDLPGQLTR
                     VAGEAPGLVKIVIGSKFDQYMHTDVPARDLTAFRQAWELPLFRVKSVPGRRLADGRTL
                     DGRAGLADTAHVLNGLAEQLWHQDQVAAGLLPSSPESAPG"
     exon            259..411
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..536
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..673
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..951
                     /gene="Cplane2"
                     /gene_synonym="6330545A04Rik; b2b2804Clo; b2b2827Clo;
                     Gm723; Rsg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcttcg tggtcagcgt cttgacctga cggaagcagg ctctgctggc aggacagaaa
       61 agaagggcgg gcttttaaat cgtcaccctg ctggcgggga ctgtgaagta ttcggacaca
      121 tccttacctt actggcgtac tcaagcatgg ccagacctcc catgcacggt tcggtgattg
      181 tcccagactg gcatgagacg gtcgagggta aggagtactt agcctgcatc ctgcgcaaga
      241 atcgccggcg ggagtttggg ttgcttgaac gcccggtgct gcccccttcc gtggtcattg
      301 ataccgccag ctataagatc tttgtgtccg ggaagagtgg tgtgggcaag acagcactgg
      361 tggcaaagct ggccggcctg gaagtgccta tagtacacca tgagaccact ggcattcaga
      421 ccactgtggt gttttggcca gccaagctga aggccagcga ctgtgttgtc atgttccgtt
      481 ttgaattctg ggactgtggg gagtctgccc tcaagaagtt tgatcacatg ctgccggctt
      541 gtaaagagaa tgcagatgcc ttcctcttcc tcttttcttt caccgatcgt gcctccttcg
      601 aagaccttcc tggacagttg actcgtgtag ccggtgaagc tcctgggctc gtcaagatag
      661 ttatcgggtc caagtttgat cagtacatgc acacagatgt gccagcgcga gacctcacag
      721 ccttccggca ggcctgggaa ctgcccttgt tccgggtgaa gagtgtgcca gggcggcggc
      781 tggcagacgg acgaacactg gatggcaggg ctgggctagc tgacacagcc catgtgctca
      841 atggccttgc agaacagttg tggcaccagg accaggtggc agccggcctg ctccccagct
      901 ccccagagag tgctcccggc tgaacggtga caacatcctg ggtagaggct g
//
