LOCUS       NM_001081351            5662 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cadherin-like and PC-esterase domain containing 1
            (Cped1), transcript variant 1, mRNA.
ACCESSION   NM_001081351 XM_898270
VERSION     NM_001081351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5662)
  AUTHORS   Gomez,A.E., Addish,S., Alvarado,K., Boatemaa,P., Onyali,A.C.,
            Ramirez,E.G., Rojas,M.F., Rai,J., Reynolds,K.A., Tang,W.J. and
            Kwon,R.Y.
  TITLE     Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone
            Mineral Density Locus
  JOURNAL   Curr Osteoporos Rep 21 (2), 173-183 (2023)
   PUBMED   36943599
  REMARK    GeneRIF: Multiple Mechanisms Explain Genetic Effects at the
            CPED1-WNT16 Bone Mineral Density Locus.
            Review article
REFERENCE   3  (bases 1 to 5662)
  AUTHORS   Maynard,R.D., Godfrey,D.A., Medina-Gomez,C. and
            Ackert-Bicknell,C.L.
  TITLE     Characterization of expression and alternative splicing of the gene
            cadherin-like and PC esterase domain containing 1 (Cped1)
  JOURNAL   Gene 674, 127-133 (2018)
   PUBMED   29935354
  REMARK    GeneRIF: Some of the first data describing expression and
            alternative splicing of Cped1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117213.3, AC133955.4 and AC115039.7.
            
            On Mar 14, 2023 this sequence version replaced NM_001081351.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151018.1, SRR10223970.8359.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1116              AC117213.3         64743-65858
            1117-1300           AC117213.3         95702-95885
            1301-1407           AC117213.3         130092-130198
            1408-1483           AC117213.3         138676-138751
            1484-1616           AC117213.3         163829-163961
            1617-1785           AC117213.3         167488-167656
            1786-1928           AC133955.4         63537-63679
            1929-2001           AC133955.4         65059-65131
            2002-2169           AC133955.4         66332-66499
            2170-2274           AC133955.4         67627-67731
            2275-2432           AC133955.4         76304-76461
            2433-2503           AC133955.4         79922-79992
            2504-2554           AC133955.4         82735-82785
            2555-2741           AC133955.4         88019-88205
            2742-2910           AC133955.4         89594-89762
            2911-3028           AC133955.4         159587-159704
            3029-3165           AC133955.4         166479-166615
            3166-3386           AC133955.4         177520-177740
            3387-3488           AC133955.4         177983-178084
            3489-3576           AC133955.4         178706-178793
            3577-3723           AC133955.4         181671-181817
            3724-5662           AC115039.7         124566-126504       c
FEATURES             Location/Qualifiers
     source          1..5662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.86 cM"
     gene            1..5662
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /note="cadherin-like and PC-esterase domain containing 1"
                     /db_xref="GeneID:214642"
                     /db_xref="MGI:MGI:2444814"
     exon            1..1116
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             868..3948
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cadherin-like and PC-esterase domain-containing
                     protein 1 isoform a"
                     /protein_id="NP_001074820.1"
                     /db_xref="CCDS:CCDS39435.1"
                     /db_xref="GeneID:214642"
                     /db_xref="MGI:MGI:2444814"
                     /translation="MVCRPGFLCRRRFCPRPFLVGLVVAICLFYQTLTLRGTKKIAAD
                     VSGTVPHTPSQTQASRCEEGYRQDKQCFLLSASTQETRKIEESIERHFGSLSRRAVLH
                     RPPSSSRAQLQIHQHLLAQHGYSVVTVEERLGGGLGPELLDQGGLNSWDLFICLPSRE
                     ADGKPCIPREHMCRLSLHQRVNVLPEIQPQLCRREGLCEITRRFPEFRLPVSSSVCLD
                     QETQSRLRVSSHLSKAEKPHVWKPRDWHRKQLNLTTVVAPHEAISRAEELSVILKAYV
                     LVTSLRPLRAFIHSTGTVWSPPKKKRFTVKLQMFFETFLRTSSPLQALDSMKEAISKL
                     LLVAEVFSDASTLGPKTFNRCIQCFQLLTFDVGYGDSGYPVVLQVHEHLHFHDDENFS
                     AEDQNAENIILRDTFDFLFSNASSLSMVSEMLQRRDSAGAFVDGNYEKELNQCLSFEE
                     IHSIRTFVKELGSLGQFQLLFPSSVPGIRSLMGEFYDMATPGSVLSQYWSLLNVFEQF
                     WLMNKKAQLQPLEWNSPTRNETIEEPPRSLEGIQSGKDAAPRVLFENKDIHCSDEEDV
                     LCHIKKIITHPRLELSPEFNPKIKEYYCEVPFDVLTVRIGAETSKCQCKAHLQEQAGP
                     SFATYPLGIGMNRISVLVVDESHAGGAALTTYKLTIYREDRPSLPFFEDFTACGFVQD
                     CDLLIHPEETCGLQPISAEYIKAISQPEIESCPSGDTKGQWIVPCLTCSDNRTCDWRE
                     ITWQPHNCQHNILTKPELQQCLQGRKILFIGDSTNRGMMYYLIERLNETLQEWQKLHG
                     TKLYPSVNGGKSPISYSYYPQFWIRPSLRPAFEKALEHLLQRSQPLENTDQTVLVVGG
                     VQWLNSNHLQIIHKVLKRENLLNILVIIKTLGIGFHLPVDGVHFLTQGEVRNLYKENL
                     SILETAKKYGYEVVDTFTITMGRHKEFLQGNCGCHFHEVVKSKLSRQHHVIKMKRSKN
                     HIVGKYFSSQSKLKQHNSVPNLHSPYHVRGPINQVCAEILLSRMCASQRSAQAP"
     exon            1117..1300
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1407
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1483
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1616
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1785
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1928
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2001
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2169
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2274
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2432
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2503
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2554
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2741
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2910
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3028
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3165
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3386
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3488
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3576
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3723
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..5662
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5643..5648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5662
                     /gene="Cped1"
                     /gene_synonym="6720481P07; A430107O13Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggctctcggc cctgtgtgca gctggcacgc gcgtgtctcc gcgagtctgc gcgtgtctgt
       61 ccgtgcgtga gagtgagatg aagcggagtc ctacgcctgg gtgtttcctt ccaagtgatt
      121 ttgatcagca atccattagg ggatcatgaa aaaaaaaaaa tctggctaaa aggatgaaaa
      181 ctgagtaagt acacagaact ttgaacttga aacggaatga gaccaaacgc aagcaaagcc
      241 ctgacagtaa ccacatacag ccaaactgct atcccccttt tttatgttaa aagccgtgaa
      301 tgctagcagc aaagtggcaa tttaaaactg aacgaaagga agcagcagtt ctacaacata
      361 aaaggctggg agcgggatgg ctttaaaacc ggagggaaaa tgagaaactg ctaggacaac
      421 ctggccggcg cccagctgtg caacaggcac ttcgcgttaa atcgactgcg tcttcggctg
      481 gtttctgcct ccagacccgc tttacggtgc tttctttttg ccccaaaaga ggagacaagc
      541 tgaactcctg actttaagaa tgttgtggaa gtaaggcatt accggaagga actcttggta
      601 gctggggatg cattcggatg atttcttata actatcttta ttttgacatc ttaaaaaaaa
      661 atctggccag tcacttctta ctgtccttca tttaagggct attaaccacc tctgaccgct
      721 gggtcctatg aatctttggc atgaaccttc ggaaagtttt caagcggaga tggggcgaac
      781 ttgattggaa ttgtgtaaaa agaagacaga tgtgtgtttt tttcacactg acaacgtggc
      841 caggggccaa gtgatcctgg actggtcatg gtctgtcgac ccgggttcct ttgtcgccgg
      901 cgattttgcc cccgaccttt cctggtgggt ttggtggtgg cgatctgtct cttttaccag
      961 accctgacac tccgagggac taagaagatt gcagcggacg tctctggcac tgtcccacac
     1021 acaccctctc aaactcaggc tagcagatgt gaagaaggat accggcagga caaacaatgc
     1081 ttccttctct ctgcgagtac ccaggaaacc aggaagattg aagaatcgat tgagagacac
     1141 ttcggcagtc tcagcagaag ggccgtcctc cacaggcctc cttcctccag cagagcacag
     1201 cttcagatac accagcacct tcttgctcag catggataca gcgttgtcac tgtggaagaa
     1261 aggcttggtg gtggtctagg tccggagctg ctggaccaag gtggtttgaa ctcctgggat
     1321 ctgttcattt gcctgccttc tagggaagct gatgggaaac cctgcatacc cagggagcac
     1381 atgtgtcgac taagcctaca tcaaagggta aatgtgttac cagaaataca gcctcagctt
     1441 tgcaggagag aaggcttgtg tgaaataacc agaagatttc cagaatttcg acttccagtg
     1501 agttcctctg tgtgcctgga tcaggagaca cagtcacggc tgagggtttc cagtcatctc
     1561 tcaaaagcag agaagccaca tgtatggaaa cctcgggact ggcaccgcaa acagttgaat
     1621 ctgactacag tcgttgcccc gcacgaagca atctccagag cagaagagct atctgtgatt
     1681 cttaaggcat atgtgttggt gacctcctta aggcctttgc gggccttcat tcattcaact
     1741 ggcacggtat ggagcccacc aaagaagaaa cgcttcactg tcaagctgca gatgtttttt
     1801 gagacattcc tgaggaccag ttcgcctctg caagcactgg acagcatgaa ggaagccatt
     1861 agcaagctcc tgttggtagc tgaggtgttt agtgacgcat ctactctggg accaaagacc
     1921 ttcaatagat gtatacagtg ttttcagctt ttaacctttg atgttggtta tggagattca
     1981 ggatatcctg tggtgctcca ggtacatgaa catttacatt ttcacgatga tgagaatttc
     2041 agcgcggagg accaaaatgc ggaaaatatt attttaaggg atactttcga cttcctcttc
     2101 tccaatgcgt cttcactgtc catggtttct gagatgttgc agaggcgtga ctcagcaggt
     2161 gcattcgtgg acggaaacta tgaaaaggaa ttaaatcagt gcctgtcatt cgaggaaatt
     2221 cactcaatta ggacttttgt aaaggaactt gggagtttgg gacaattcca actgctcttc
     2281 ccgtccagtg ttcctgggat tcggtctctg atgggtgaat tttatgatat ggcaactcct
     2341 ggctcagtcc tgtcgcagta ctggtccctt ttaaatgtat ttgaacaatt ttggctcatg
     2401 aataaaaagg cacagctaca gccactggaa tggaattctc cgacaagaaa tgagaccatt
     2461 gaggaaccac ccaggtcact ggaaggaatc caaagtggaa aagatgcagc tccacgagtt
     2521 ttgttcgaaa ataaagatat acattgcagt gatgaggaag atgtgctctg ccatatcaag
     2581 aagatcatca cccacccccg tttagaactc agtcccgagt ttaatccgaa gatcaaagag
     2641 tattactgtg aagtgccatt cgatgtgcta actgtgagga tcggagcaga gacctcaaag
     2701 tgtcagtgca aggcgcacct gcaggagcag gcagggccaa gttttgccac ctatcctctg
     2761 ggaataggaa tgaacagaat ctctgtgctt gtggtggacg agtctcacgc agggggtgcc
     2821 gccctaacca cgtataaact caccatctat agagaagatc gcccgagtct gcccttcttc
     2881 gaggacttca cagcgtgcgg ctttgtacaa gattgtgact tattgattca cccagaagaa
     2941 acctgtgggt tgcagcctat ttctgcagaa tacattaaag ccatttcaca gcctgaaata
     3001 gagagttgtc catctgggga cactaaaggc cagtggattg tgccctgcct tacttgttca
     3061 gacaacagga cctgtgactg gagagaaata acctggcaac cacacaactg ccaacacaac
     3121 attctaacca agccagaact tcaacagtgc ctacaaggaa gaaagattct tttcatagga
     3181 gattccacca acagagggat gatgtactat ctaatcgaga gactgaatga aacacttcag
     3241 gagtggcaga aactgcatgg cactaaactc taccccagtg tcaatggtgg gaagagtccg
     3301 atcagttact cctactatcc ccagttctgg ataaggcctt cattgagacc agcatttgag
     3361 aaagcacttg aacatctctt gcaaagatca cagcccctag agaatactga ccagacggta
     3421 ttggttgttg gtggtgtcca gtggcttaat tccaatcacc tgcaaattat tcacaaggtt
     3481 ttaaagaggg aaaatttgct gaatattcta gtgatcatca aaacattggg gattggattt
     3541 cacctgccgg tggacggggt gcacttccta acccagggtg aagtacggaa cttatataaa
     3601 gaaaatctga gcattctgga aactgccaaa aagtatggct atgaagtagt agacacattc
     3661 actatcacaa tgggacggca caaagaattt ctgcagggca attgtggatg ccattttcat
     3721 gaggtagtga aatcaaagtt atccagacag caccacgtta tcaagatgaa aagatccaag
     3781 aaccatattg tggggaagta cttcagtagt caaagcaaac taaaacaaca caattctgtc
     3841 ccaaatcttc attcaccgta tcatgtcaga ggcccgataa accaggtttg tgctgaaatc
     3901 ctgctcagca gaatgtgtgc gagtcagagg tctgcgcagg cgccttgaaa gagagccgat
     3961 tgcgcagact ccctggagga gagccgaatt cactgttgga gatgaacctt tcacctcaac
     4021 ctgagaacca aatgagcctc acacgtactc tgcaatgact gtacaatcac cagcacaagc
     4081 gcgcacagcc aagcacacag ctcacaaaaa gcacaatgac acatttttct catgaccgca
     4141 cacacccaca agtgaccttg agtatccgtt agtttcaggt cgaagcacag agctgtacgg
     4201 agatcacttg aagtgtgatc tcaaagtatg accacgtgga ccaggtactg gactgcaacg
     4261 ataaacagaa agacagaaat acaacagcat ggagataggc gcatgcgggt tctgtgctct
     4321 cctctccaaa ggttcactga tgtaagaatg ttgaagaagc aaatacattc cgcacttaag
     4381 aaaagatagc actgaagttc tctactggga gaagtggagt acttatggtg gtttgaactt
     4441 tgtgcatcca atgcttatga aaagcatgtc ttcttatgct tttaaaatgg tacaatggaa
     4501 gggaaagaac aggagtgatt ctctacagtg gaattcaaaa gagcaatagg aagcaatgtt
     4561 acattcaact ctgagttcct gtgtgttcca caaagatccc cccaccccta gctgcctgtg
     4621 agcttagatg gggagcacag tctaaatgga tggtatgcat aattgtaaag tgtgggacaa
     4681 agtgaagttc cctgtctgtc actttgtata tttgtggatg ctgttactaa ggtagctttc
     4741 gcttgtccct ataggcctgt ttaatttaag acaacagtta catttcagat attgtgcaaa
     4801 gaactgcaga attctcaaat gtaaaagcat gaagcattac tatgtgacta gtacccgtat
     4861 tcttctgtga acaaatgtat ttaattcaaa ttagaatagg catacaagtt tttttaatga
     4921 aaattgtgat ataagaatga agcgtaccta attccatcat tgaaaacttt ttcttccgtc
     4981 tttttagata caagatggta aatttcctta ttataccaat tctttgttgt gagataacat
     5041 ctcactgcca tggtgggttt taaaggatga tttgggcata aagaaaggaa gctgagagga
     5101 ataattcagt gtgtagctga gattactaaa tatacaaata cctcaagttc attgccataa
     5161 aaaataaacc tattgaccca tcaattattt agaatgaata cccacctcct tcaaatgctc
     5221 tatttttgta tacatatata ttttataaga acataaacat gaatttatat ttaactgttt
     5281 aaaattatat ttaaatacaa atatcacttg atataaacat tatatgcatt tagaaatgga
     5341 ctttttgaac aatggtactg aattaactta aaatgaaata tttttcatat gtacacctat
     5401 attccaacac tgtttttaga ttttctgttc ctttaccctg atataatatg ttagcagttg
     5461 atgcagctgc tccatcagat gtccatagac tgagtattca cccacattgt ccacttagtg
     5521 ctaagccttt tgtaactcac tctcctgata actctggaaa ccctctgact cgagtcagtc
     5581 gggcattttc ctgttcacca ctaaaataat gctagatttt ggatccactg taatgtatta
     5641 tcaataaatg tctagctggt aa
//
