LOCUS       NM_026252               7655 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus cytoplasmic polyadenylation element binding protein 4
            (Cpeb4), transcript variant 1, mRNA.
ACCESSION   NM_026252 XM_484003
VERSION     NM_026252.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7655)
  AUTHORS   Sun,M., Huang,X., Ruan,X., Shang,X., Zhang,M., Liu,L., Wang,P.,
            An,P., Lin,Y., Yang,J. and Xue,Y.
  TITLE     Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by
            chronic cerebral ischemia through phosphorylation of Ehf
  JOURNAL   J Cereb Blood Flow Metab 44 (9), 1655-1673 (2024)
   PUBMED   38513137
  REMARK    GeneRIF: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced
            by chronic cerebral ischemia through phosphorylation of Ehf.
REFERENCE   2  (bases 1 to 7655)
  AUTHORS   Arasaki,Y. and Hayata,T.
  TITLE     The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in
            osteoclast differentiation
  JOURNAL   J Cell Physiol 239 (4), e31197 (2024)
   PUBMED   38284484
  REMARK    GeneRIF: The RNA-binding protein Cpeb4 regulates splicing of the
            Id2 gene in osteoclast differentiation.
REFERENCE   3  (bases 1 to 7655)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7655)
  AUTHORS   de Diego-Garcia,L., Brennan,G.P., Auer,T., Menendez-Mendez,A.,
            Parras,A., Martin-Gil,A., Mitra,M., Olla,I., Villalba-Benito,L.,
            Gil,B., Alves,M., Lau,K., Delanty,N., Beausang,A., Cryan,J.,
            Brett,F.M., Farrell,M.A., O'Brien,D.F., Mendez,R.,
            Carracedo-Rodriguez,G., Henshall,D.C., Lucas,J.J. and Engel,T.
  TITLE     CPEB4-CLOCK crosstalk during temporal lobe epilepsy
  JOURNAL   Epilepsia 64 (10), 2827-2840 (2023)
   PUBMED   37543852
  REMARK    GeneRIF: CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 7655)
  AUTHORS   Zeng,W., Zhang,W., Tse,E.H.Y., Liu,J., Dong,A., Lam,K.S.W.,
            Luan,S., Kung,W.H., Chan,T.C. and Cheung,T.H.
  TITLE     Restoration of CPEB4 prevents muscle stem cell senescence during
            aging
  JOURNAL   Dev Cell 58 (15), 1383-1398 (2023)
   PUBMED   37321216
  REMARK    GeneRIF: Restoration of CPEB4 prevents muscle stem cell senescence
            during aging.
REFERENCE   6  (bases 1 to 7655)
  AUTHORS   Huang,Y.S., Kan,M.C., Lin,C.L. and Richter,J.D.
  TITLE     CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and
            translational control of AMPA receptor GluR2 mRNA
  JOURNAL   EMBO J 25 (20), 4865-4876 (2006)
   PUBMED   17024188
REFERENCE   7  (bases 1 to 7655)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7655)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 7655)
  AUTHORS   Theis,M., Si,K. and Kandel,E.R.
  TITLE     Two previously undescribed members of the mouse CPEB family of
            genes and their inducible expression in the principal cell layers
            of the hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9602-9607 (2003)
   PUBMED   12871996
  REMARK    GeneRIF: CPEB4 is expressed in the principal cell layers of the
            hippocampus
REFERENCE   10 (bases 1 to 7655)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162101.1, CF182456.1, BC079599.1 and AI845839.1.
            
            On Mar 19, 2014 this sequence version replaced NM_026252.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.285291.1,
                                           SRR1660825.118974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1932              AK162101.1         30-1961
            1933-2653           CF182456.1         20-740
            2654-7639           BC079599.1         438-5423
            7640-7655           AI845839.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..7655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.66 cM"
     gene            1..7655
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /note="cytoplasmic polyadenylation element binding protein
                     4"
                     /db_xref="GeneID:67579"
                     /db_xref="MGI:MGI:1914829"
     exon            1..2473
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1349..3538
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CPE-binding protein 4"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 4 isoform 1"
                     /protein_id="NP_080528.2"
                     /db_xref="CCDS:CCDS24514.1"
                     /db_xref="GeneID:67579"
                     /db_xref="MGI:MGI:1914829"
                     /translation="MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAF
                     INNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQ
                     EAGILPETEKAKAEENPGDSSSENSNGKEKLRIESPVLTGFDYQEATGLGTSTQPLTS
                     SASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGF
                     GGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRSAAFNQLPHLAN
                     NLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPL
                     KKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPERPRTFDMHSLESSLID
                     IMRAENDSIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLH
                     SGLGSPHCFTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAES
                     KSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDS
                     DFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGA
                     GRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPF
                     FCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN"
     exon            2474..2555
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2606
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2630
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2804
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2894
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3013
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3128
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3310
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..7641
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7622..7627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /note="hexamer: AATAAA"
     polyA_site      7641
                     /gene="Cpeb4"
                     /gene_synonym="Cpe-bp4; Cpeb-4; mCPEB-4"
                     /note="major polyA site"
ORIGIN      
        1 ggactcagcc gcggctgcgg gacctgggca ccggaggcag tggcggcggc ggcggcggcg
       61 gcagcggcga cagcagagga agacgaggag gaagaaggaa gaaaaagaag agccagacgg
      121 agtccgcaac gacgacagct gggactgcgg gaccggggaa aagcggcggc ggcggcggcc
      181 cagcaaccgt gaggagaaac aaaagccttc taaattatag tttccaatca gtctagggga
      241 aaagagagcg cgagccgagg ggggaggctt ttctcctgta gagtaactac ggtagcgggg
      301 ttttcctttt tgtccatccc ccttccccct ccccccggcg gagaatcgaa ctgagagaac
      361 tgaacaaacc gcccctgggt cccatgaggg aaaaaaatcc cggagccgca gagaggggaa
      421 gaggcagaaa ccgcaggacc ttccaggtcg cccccttgct ccccgcaccc ccgggccgcc
      481 agcttgccct tgtccagtct cgctaatccc tcctgatcgc gacacccccc agagggagaa
      541 acgggtgttt ccaacccctt tcatggggga aaggaggccg aggggagccc aagaacagca
      601 aacgcagcaa gatctgcacc cggagcccaa ggaacagccc cagaggccca cactgcaccc
      661 tacaaaagaa cagaaacagg accaggaaca gcagaaatct ccctgcaatc atctttcctt
      721 tagtcaaggc tgatttcctc tttggcaacc agaaattcac ctcccgcccc agataaccta
      781 atataatcta tctatatata aatatataat atataatgtt cttaaattat tcctgatttt
      841 tttaaccaag ctgccaagaa aagaacgtat tcacccctta atcctattct aatttttatg
      901 tgaatctaaa ctgctgagga agaccatatg tgattgttaa attttatata tatatatttt
      961 tactccgcac aatgcttatt cttctatatc catagatgct tgagaagctg tgtttttgtc
     1021 attcatgaac attttccttt ggaaaaagaa agcgcctatt ttactaacca aagacttgat
     1081 ttttaccttt ttcctttttt attccttcct tgaaataagc ccaattggat tcatatcaat
     1141 attttaagag gttttttttt ttaggttctt ttccattcag agagaccaga attccaaatc
     1201 agagatacgt agggtgataa gctgtgatct ttgagttagc tataaataag atacttcaag
     1261 caaacatatt tgagatacag gggaggaaag acgtgagaca ttaggttgtc ttttttttat
     1321 tgtgagattc tgatcctaaa aataataaat gggggattac gggtttggag tgctagtgca
     1381 aagcaatact gggaataaat ctgcttttcc agtccgattc catccacatc tgcagcctcc
     1441 acaccatcac caaaatgcca cccccaaccc tgctgctttt ataaataata acacagctgc
     1501 caatggcagc agtgctgggt cagcctggct ctttcctgcc ccggctactc ataacattca
     1561 ggatgagatc ttggggtcag aaaaagcaaa aagtcaacag caagaacaac aagacccttt
     1621 agaaaagcaa cagctctccc cgagtccagg tcaggaagct ggaatactgc ctgaaactga
     1681 aaaggcaaaa gctgaagaaa atccagggga cagttcttca gaaaacagca acggaaaaga
     1741 aaaactacgc attgaatcac cagtgttgac agggtttgat taccaagaag ccaccggtct
     1801 cgggacttcc acccaaccct tgacatccag tgcatcgtcc cttactggtt tcagtaactg
     1861 gtcagcagcg atagcacctt cttcctccac tataatcaat gaagatgcaa gtttctttca
     1921 ccagggaggg gtccctggcg cttcagctaa taatggtgct ctcttgtttc aaaattttcc
     1981 ccatcatgtc agccctggct ttggtggtag cttctcccct cagatcgggc ctctctccca
     2041 gcaccatcct catcaccccc atttccagca ccatcacagc cagcatcagc agcagaggag
     2101 gtctcctgcc agtccccacc ccccaccttt cacacataga agtgctgctt ttaaccagct
     2161 gcctcatttg gcgaataatc ttaacaaacc tccttctcca tggagcagct accagagtcc
     2221 ttctccaacc ccctcttctt cctggagccc aggaggtggc ggctacggtg gctggggagc
     2281 atctcaaggc cgggatcacc gcagagggct gaacggtgga ataacacccc tgaactcaat
     2341 ctcacctttg aagaaaaatt tcgcaagcaa tcatattcag ctccagaagt atgctcgccc
     2401 tagctcagcc tttgctccaa aatcctggat ggaagatagc ttgaacaggg ctgacaacat
     2461 ttttcctttt ccggaacgcc ccaggacgtt tgacatgcac tcactggaga gctcactcat
     2521 tgacataatg agagctgaaa atgattccat taaaggtcgt ctaaactatt catacccagg
     2581 atccgatagt tctctgctta ttaatgcaag gacttatggg cgaaggagag gtcagtcttc
     2641 attgtttccg atggaagatg gattcctgga tgatggccgt ggggatcaac ctcttcatag
     2701 tggtctgggg tcacctcact gcttcactca ccagaatggg gagagagtgg aacgatactc
     2761 tcgcaaagtg tttgtgggtg gattgcctcc tgatattgat gaagatgaga tcacagctag
     2821 tttccgtcgc tttggccctt tgattgtgga ttggcctcat aaggcagaga gcaaatctta
     2881 ttttccacca aaaggctatg cattcctgct gtttcaagat gaaagttctg ttcaggctct
     2941 cattgatgca tgtattgaag aagatggaaa actttacctg tgtgtatcaa gtccaaccat
     3001 caaggataaa ccagtgcaga tccggccctg gaatctcagt gacagtgact ttgtgatgga
     3061 tggctcacag ccacttgacc cacggaaaac aatatttgtt ggtggtgttc ctcgaccatt
     3121 acgagctgtg gagcttgcaa tgataatgga tcggctgtat ggaggcgtct gctatgctgg
     3181 aatcgatact gacccagagc tcaaataccc aaaaggagct ggaagagtcg cgttttctaa
     3241 tcaacagagt tacatagctg ctatcagtgc ccgctttgtt cagctgcagc atggagagat
     3301 agataaacgg gtggaggtta agccatatgt cttggatgac cagctgtgtg atgaatgtca
     3361 aggggcccgt tgtgggggga aatttgctcc atttttctgt gctaatgtta cctgtctgca
     3421 gtattactgt gaatattgct gggctgctat tcactctcgt gctggcagag aattccacaa
     3481 gcccctggtg aaggaaggtg gtgaccgccc tcggcatatt tcattccgct ggaactgaag
     3541 aatgaatgac tccagagctc atttgcaggc ctcagaagaa gtgccctctt ttgttaattc
     3601 caactcttcc tcagcctctt cacactggca tgtcctgcac agcagtgtgt aactatcagt
     3661 ggtagaatga aaagaacaac ctacaacata ggtattttgt agactctcgt gtcactgcaa
     3721 acagtatgtt caactccatt tcacattgcc attatgttgc atgcaggttt taattctctt
     3781 gttttgctgg aggccaagag gatctaaact tgctgtagca ttttcttaga ggagagaaat
     3841 attaacagag aaatgagaca atattttgag gttttaattg ctggtaatga tataacatat
     3901 aagaaaactt tattgagata atcaccaaca gtaacactat catctgttct gacacagtct
     3961 cccccaggaa agtgctcttg ccagttcttt tctttcattc cttctctctc tcttttctat
     4021 ccctttttat tctttaacag caatggagga agttaacagt tattaacagg aaagagtatg
     4081 tcagagcaag caaatgcatg agcaagattg agcagtgtaa ccataagagc tttgaggctg
     4141 atgatagctt gatcatgcct caaatgcctt catacaacag aaaaaataaa gtaggcagag
     4201 ctgagtttgt tttctttgaa ataattctta aaattccgaa tgtaagaatt gggtgacttt
     4261 actactgagg ggagtgcgcg tatttattta actgacttcc taatcacggc cccaggaaac
     4321 ctaccaaagc tagaattaat gatttctggt ggggaacaga agaacaaata cataaatttt
     4381 atttttgtta ttatatataa actctatatc ctaatttact aacagtcatc aggtgtcagc
     4441 ctttgctctc cattttgaca ttaaaaacaa cgtatctaga catacctcaa ggatatcatt
     4501 tttgactttg tgttacacta cacttgtagc caaaactgga agattaaaaa caacatacag
     4561 atcggctgcc cattggcctt gttttccatt tgaagttact ttggaatcct gtaatttagt
     4621 tgtaacatag aaaatgtggg ggggaaaggt taaaaaaaaa agtcaagtag ttgcaaagtg
     4681 ttttgcactg ttgaactaag taattgtgta aatctgtgca aaagtccgta tggttatctt
     4741 actcttccta taaggtacaa taacatacac tttccgaact tagcatggga catagtgttt
     4801 gaagtgccaa cttcatcaag taatgcatgc tttattataa atacaaccct agctttgaaa
     4861 gatgttctta tgttttgaac agtctgcttc gggggtaaat ttaaaatagt ctcttgaagc
     4921 cccggtcatg gaagtaactt ttggtttaat tgacattctc ttattaaatg ccctaccgta
     4981 gttcaaagga ttactatcag tgtgcaaagc atttaacagc agcagtctaa gtgcagtctt
     5041 gctagctgtg ctgcctaaca gtaccatctt ggatccttca gaaccaaaga cttgcctgca
     5101 gtgctgtcac cgcctggctg gtgacccttc tgctgtctgt aggaaaagca gccctttatt
     5161 tttaacacag gctttaatga actacacctg ttaagttcca aaggtcaaaa tggaggcact
     5221 tgctgtctaa gagtccaaca gaaagaggga gccactgtca aagaatcccc tgctaacaga
     5281 acagcggagc agctgtgtgg tggagggtgc tgtctctcgt gtagctggtc agggacgttt
     5341 tttgtttttt tcttttctcc tgaactacat gattctaatt ggaatgttca tttgcctctt
     5401 tttcttcctt taatgcttgt aggtggcttg gggtgtgcta ttgtgctggt cctactcagt
     5461 aaacaggtgt gatgagttaa caagaactaa cactgcttga gaactagctt tgagtaatac
     5521 ttttcccttt gtacacggcc tgctgaattc cggtacagtg tctgtagctg acttattttg
     5581 tcatgcacat gatgtacatt tgttatgcac tacttttgta taccttgttt ttccaacagt
     5641 gaacattttt aggcacactt ttcactgacg ggatatctct ttatgcaata cctcaatttt
     5701 tcatattgca aagagtagct ttttgtactt ttattactga gagatcttca tatacttcat
     5761 tttttaatat aaataatttt aataaatttt attttcttat attctgcttt ttatacattt
     5821 cagtgctctg catacatttt aaattatgaa tgttgtgcac tggcaatgct attttagagt
     5881 ctgcagagaa gagaaagcat gttgcttaaa catccttccc cagcaccagc tactggtgta
     5941 cctataattt aagaaatagt ctatgtaaag tcacaaatta atgaaaaaaa ttcgcatgaa
     6001 aatgacaaaa taacactgta gttcctaaaa aaaattaaat gcataaccat agggtagaaa
     6061 tttaaaataa caaaattgtc tacagcttct tactaagttt tttaaattat tcataaaatg
     6121 cagacatttt gggtgaatgt ttaatcattt ttaatcttaa ttaattgatg ttacatgttt
     6181 gattcagaga tgtctgctct tttaaattct atataataaa acaaaatcgc ctgccacagg
     6241 acaggtttgt aatgttagta tgcatgacta atgtaagaaa ttgttattct gctaatattt
     6301 acttgtgatt gtgtgacaag cgtgtttaca gatgatttgg ttccacttct ttacagggca
     6361 taaacaatga ttatctatta ctctgaactt tatgattaca tgtccttcag attacatggg
     6421 attgtagctg ggagttacca tgtaactcaa acattattaa catgtaatta gtttacaggt
     6481 tttagggtat cacttcaatt taccaagcat gtagttctag cgcactagca tggcaccagc
     6541 catgtattta caatgtagtt acagagtaat tacatggtta tttttgcaat gtaaaataaa
     6601 gtgtttctga ttattttcta tgtaaaggac cccccaccct acccgtgccc cctggctttg
     6661 gtataatata tttacttctc catacacaga cctctgcaga atgcaacata aaacttgcag
     6721 tgaatgaact tagcatttta tgagagtgct gttggaaaga cttgataatt cacccctttt
     6781 tgttttgaag agttgaatct tctgttaaaa ggtgatttaa aacttgaatg tgatgaattg
     6841 tggcaagctc actccagtta tgtgcaatac ttatctcaca ctttggaaga tctttgcagt
     6901 gtaattcttt gtttttaatt gcagacatta aaaaatgtca ttttctactg ttaagagtaa
     6961 tcctctttct tgctggtgtt tctaaagaaa agaatcagaa atcaatcttt ctactaatgt
     7021 aaatttgaga ttatttttaa aaatggaata aaagaggttt tggtcatttg ctttatttta
     7081 ttatcttatt ttaaagctac tgtgattgat agcattgtaa gaattgggac aatattgtat
     7141 tcaactgttt tattttttat atttttaaaa tttaaagtat aattagtttt tataatttca
     7201 tcagattttt gttatatttt tttggaagtg aaacttttag caagtgggtg tctagttttt
     7261 actaatccct aatttttcca gtgtattgct catattatca gaagggaacg ttatttaagt
     7321 gcgtcagtta attgtactac ttggctgaat ttccatatag tttttactgt gtatggggag
     7381 gttgtagtat ttattctagc attttaaata agggtaattc attttttatt aaagtcattt
     7441 tcacgttaag ttcctatttt tgtatgttct actcttaagt tatataacac agtttctttt
     7501 ttaaaagagt tcatttgttg aagtgctagt ggaaaattaa tgttattaaa tagtttgcaa
     7561 atgactattt ataccagtat gcatataatt tttaaatatt tgtaatgtga gatgttgaat
     7621 gaataaaact tttaactcag aaaaaaaaaa aaaaa
//
