LOCUS       NM_001290827            5908 bp    mRNA    linear   ROD 07-SEP-2024
DEFINITION  Mus musculus cytoplasmic polyadenylation element binding protein 3
            (Cpeb3), transcript variant 3, mRNA.
ACCESSION   NM_001290827 XM_006526828
VERSION     NM_001290827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5908)
  AUTHORS   Lamacova,L., Jansova,D., Jiang,Z., Dvoran,M., Aleshkina,D.,
            Iyyappan,R., Jindrova,A., Fan,H.Y., Jiao,Y. and Susor,A.
  TITLE     CPEB3 Maintains Developmental Competence of the Oocyte
  JOURNAL   Cells 13 (10), 850 (2024)
   PUBMED   38786074
  REMARK    GeneRIF: CPEB3 Maintains Developmental Competence of the Oocyte.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5908)
  AUTHORS   Chen,C.C., Han,J., Chinn,C.A., Rounds,J.S., Li,X., Nikan,M.,
            Myszka,M., Tong,L., Passalacqua,L.F.M., Bredy,T., Wood,M.A. and
            Luptak,A.
  TITLE     Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and
            polyadenylation of its target mRNAs and enhances object location
            memory
  JOURNAL   Elife 13, e90116 (2024)
   PUBMED   38319152
  REMARK    GeneRIF: Inhibition of Cpeb3 ribozyme elevates CPEB3 protein
            expression and polyadenylation of its target mRNAs and enhances
            object location memory.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5908)
  AUTHORS   Winkler,I., Engler,J.B., Vieira,V., Bauer,S., Liu,Y.H., Di
            Liberto,G., Grochowska,K.M., Wagner,I., Bier,J., Bal,L.C.,
            Rothammer,N., Meurs,N., Egervari,K., Schattling,B., Salinas,G.,
            Kreutz,M.R., Huang,Y.S., Pless,O., Merkler,D. and Friese,M.A.
  TITLE     MicroRNA-92a-CPEB3 axis protects neurons against inflammatory
            neurodegeneration
  JOURNAL   Sci Adv 9 (47), eadi6855 (2023)
   PUBMED   38000031
  REMARK    GeneRIF: MicroRNA-92a-CPEB3 axis protects neurons against
            inflammatory neurodegeneration.
REFERENCE   4  (bases 1 to 5908)
  AUTHORS   Chen,J., Li,L., Liu,T.Y., Fu,H.F., Lai,Y.H., Lei,X., Xu,J.F.,
            Yu,J.S., Xia,Y.J., Zhang,T.H., Yang,D.J. and He,Y.L.
  TITLE     CPEB3 suppresses gastric cancer progression by inhibiting
            ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies
  JOURNAL   Oncogene 41 (41), 4591-4605 (2022)
   PUBMED   36068334
  REMARK    GeneRIF: CPEB3 suppresses gastric cancer progression by inhibiting
            ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies.
REFERENCE   5  (bases 1 to 5908)
  AUTHORS   Hwang,J.Y., Monday,H.R., Yan,J., Gompers,A., Buxbaum,A.R.,
            Sawicka,K.J., Singer,R.H., Castillo,P.E. and Zukin,R.S.
  TITLE     CPEB3-dependent increase in GluA2 subunits impairs excitatory
            transmission onto inhibitory interneurons in a mouse model of
            fragile X
  JOURNAL   Cell Rep 39 (10), 110853 (2022)
   PUBMED   35675768
  REMARK    GeneRIF: CPEB3-dependent increase in GluA2 subunits impairs
            excitatory transmission onto inhibitory interneurons in a mouse
            model of fragile X.
REFERENCE   6  (bases 1 to 5908)
  AUTHORS   Wang,X.P. and Cooper,N.G.
  TITLE     Characterization of the transcripts and protein isoforms for
            cytoplasmic polyadenylation element binding protein-3 (CPEB3) in
            the mouse retina
  JOURNAL   BMC Mol Biol 10, 109 (2009)
   PUBMED   20003455
  REMARK    GeneRIF: show that CPEB3 expression is increased in a
            time-dependent manner during the course of postnatal development,
            and CPEB3 is localized mostly in the inner retina, including
            retinal ganglion cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5908)
  AUTHORS   Huang,Y.S., Kan,M.C., Lin,C.L. and Richter,J.D.
  TITLE     CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and
            translational control of AMPA receptor GluR2 mRNA
  JOURNAL   EMBO J 25 (20), 4865-4876 (2006)
   PUBMED   17024188
  REMARK    GeneRIF: CPEB3 is a sequence-specific translational regulatory
            protein.
REFERENCE   8  (bases 1 to 5908)
  AUTHORS   White,R.A., Boydston,L.A., Brookshier,T.R., McNulty,S.G.,
            Nsumu,N.N., Brewer,B.P. and Blackmore,K.
  TITLE     Iron metabolism mutant hbd mice have a deletion in Sec15l1, which
            has homology to a yeast gene for vesicle docking
  JOURNAL   Genomics 86 (6), 668-673 (2005)
   PUBMED   16289749
REFERENCE   9  (bases 1 to 5908)
  AUTHORS   Theis,M., Si,K. and Kandel,E.R.
  TITLE     Two previously undescribed members of the mouse CPEB family of
            genes and their inducible expression in the principal cell layers
            of the hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9602-9607 (2003)
   PUBMED   12871996
  REMARK    GeneRIF: CPEB3 is expressed in the principal cell layers of the
            hippocampus
REFERENCE   10 (bases 1 to 5908)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161513.1, AK044639.1 and AC113124.9.
            
            On Mar 20, 2014 this sequence version replaced XM_006526828.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093274.1, SRR7345562.3092999.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-827               AK161513.1         39-865
            828-1287            AK044639.1         892-1351
            1288-1356           AC113124.9         151361-151429       c
            1357-3486           AK044639.1         1352-3481
            3487-5908           AC113124.9         33590-36011         c
FEATURES             Location/Qualifiers
     source          1..5908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.08 cM"
     gene            1..5908
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /note="cytoplasmic polyadenylation element binding protein
                     3"
                     /db_xref="GeneID:208922"
                     /db_xref="MGI:MGI:2443075"
     exon            1..177
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            178..1196
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2339
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /note="isoform a is encoded by transcript variant 3;
                     CPE-binding protein 3"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 3 isoform a"
                     /protein_id="NP_001277756.1"
                     /db_xref="CCDS:CCDS29775.1"
                     /db_xref="GeneID:208922"
                     /db_xref="MGI:MGI:2443075"
                     /translation="MQDDLLMDKSKTQPQSQQQQRQQQQQQQQLQPEPGAAEAPSTPL
                     SSEIPKPEDSSAVPALSPASAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPTA
                     PGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIG
                     LAQTQHHQQPPPPAPQPPQPAQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMT
                     SKPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVG
                     VGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLP
                     FQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRM
                     GINFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDAFLDDSHGDQALSSGLSSPTRCQN
                     GERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLL
                     FQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPR
                     KTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIA
                     AISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCE
                     YCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS"
     exon            1197..1356
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1413
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1437
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1605
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1695
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1814
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1929
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2111
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..5908
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5881..5886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /note="hexamer: AATAAA"
     polyA_site      5904
                     /gene="Cpeb3"
                     /gene_synonym="4831444O18Rik; CPE-BP3; mKIAA0940"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgga ccgtccccgc tagaggctgc acagcccgcc gggacccccg ccgccgtgcc
       61 cgccgccgcc gggccggcgc cctcccgttt ccttcctcca gggggaaaaa aaaatgtcct
      121 tcgggccgct gtccgggaag cggcagcatg tggcgctccg ctgtcagtag caacaagctg
      181 cgcaaaccat gcaggatgat ttactgatgg acaaaagcaa aacccagccc cagtctcagc
      241 agcagcagcg gcagcagcag cagcagcagc aacagctcca gcccgagccc ggcgcagctg
      301 aagccccgtc cacgcccctc tcctcagaga tccccaagcc cgaagacagt agcgcagtgc
      361 cggccctcag ccccgcctcg gctccgccag cccccaacgg ccccgacaag atgcagatgg
      421 agtcgccgct cctgccgggc ttgagtttcc atcagccccc tcagcagccg ccgccgccgc
      481 aggagcccac ggcgcccgga gcgtcgctgt cgccgtcctt cggcagcacc tggtccacag
      541 gcactacaaa cgcggtggag gacagcttct tccaggggat caccccagtc aacgggacca
      601 tgctcttcca aaacttcccg caccacgtca acccggtctt cggaggcacc ttctcgccgc
      661 agatcggcct ggcgcagacc cagcaccatc agcagcctcc accgcccgcg ccgcagccgc
      721 cgcagcccgc gcagcccccg caggcgcagc cctcgcagca acgccgctcg cccgccagcc
      781 ccagccaggc gccctatgcg cagaggagcg ccgctgccta cggccaccag cccatcatga
      841 ccagcaagcc gtcctcatcc tcggcggtcg cggctgctgc ggccgcggcc gctgcctctt
      901 cggcctcgtc cagctggaac acgcaccaga gcgtgaacgc cgcctggagt gctccgtcca
      961 acccgtgggg tggcctgcag gcgggccgag accctcgccg cgcggtcggc gtgggcgtgg
     1021 gtgtaggtgt gggggtaccc tccccgctta accccatctc gccgctcaaa aagcccttct
     1081 ccagcaatgt gatcgctcca cccaagttcc ctcgtgcagc cccgctcacc tccaagtcct
     1141 ggatggagga taacgctttc cggaccgata atggtaacaa tctgttgcct tttcaggacc
     1201 ggagtaggcc ctatgacact tttaacttgc actccttgga gaactcctta atggatatga
     1261 taaggactga ccatgagcct ctgaaaggta aacactaccc tcccagtggc ccaccaatga
     1321 gtttcgctga tataatgtgg aggaatcatt ttgcaggacg catgggaata aatttccacc
     1381 atccaggaac agataacatt atggcactta acaccaggag ctatgggcgg agacgaggtc
     1441 ggtcttctct ctttcccttt gaagacgcct tcttggatga cagccatggt gatcaggcct
     1501 tatcgtctgg cttaagttct cctactcgat gtcaaaatgg ggaacgagtg gaacgctact
     1561 ctagaaaggt gtttgttgga ggccttcctc ctgacatcga tgaagatgag atcactgcca
     1621 gctttcgcag gtttggaccc cttgtggtgg actggcctca taaagccgag agcaaatcgt
     1681 acttccctcc taaaggctat gctttcctgc tgttccagga ggagagctca gtgcaagctc
     1741 tgatagatgc ctgcctggag gaggatggga aactgtacct gtgtgtgtcc agcccaacca
     1801 tcaaggataa accggtgcaa atccgaccgt ggaacctaag tgacagtgac tttgtaatgg
     1861 atggctctca gcctttggac cccagaaaaa ctatctttgt tgggggagtt ccacgacccc
     1921 ttcgagctgt tgaactggca atgataatgg accgtttgta cggtggtgtt tgctatgctg
     1981 gcattgacac agacccagag ctgaagtacc cgaaaggtgc tgggcgtgtt gcgttctcca
     2041 atcagcagag ctacattgca gccatcagtg cgcgctttgt gcaacttcaa cacaacgaca
     2101 ttgacaaacg ggtggaagtg aagccgtacg tgctggatga tcagatgtgt gacgagtgtc
     2161 agggcacacg ctgcgggggg aagtttgccc cattcttctg tgccaacgtc acctgtctgc
     2221 agtactactg tgaatactgc tgggccagca tccactcccg agccggccgt gagttccaca
     2281 aaccgctggt gaaggaggga ggcgaccgcc cccggcacgt cccgttccgc tggagctgag
     2341 ccccaggccg ccacagctac aagtactgga gtagatcaca aggaggaaga gagggcactg
     2401 cctcagggct cacggtgttc tggaaatctg tgcattcgtt ctcgattttt aaagaagaaa
     2461 tgggtctttt tattattatt attatcattt acagtcatat tactgaactc aacgtccagt
     2521 ataatgcaga atcacagagt gtgtaacggt acccatttgc acctttgact cacaccttgt
     2581 ctgcttggta ccttgatttc ttatacctga cctgtctgtc acctccacag ttccgtagac
     2641 tgccattctc atccgcagcc gtcaggttga cgtctgtgac tctgtgtttg atgtcgtgtt
     2701 gtcgttgctc tgattggtct tgactggagc acgcttattt tcagagactt agagagtcac
     2761 ccctaggaca agacttacca aaggccacac atgtacgtag aggccgacgt agcaaacact
     2821 ttacaatcag cactcaatag tggggtcacg tagagtaagg ttagccctta atgaaaataa
     2881 gcctgtagtt gctctgtact ttgacgtgta tggatacctc acaagctggg tctttcattt
     2941 tccttcatgt ttgatttttt gttttgctga ggatttgggt tagatctttt agtgttatgt
     3001 aaatttatgc tgcaatagct tttgctgcta ttaaaatggt attgttgata ccataatact
     3061 ctattcagga taaggtatca attaaaaaca aaaaacaaga acccaacaac acacttttgt
     3121 ggtttaggga tagagccagc tgccggaggg agatcatatg agaccagaga gagccatcgg
     3181 aggccgccgt tcctgactgc atgtttactt aatgcggttg ctgcatgcaa taaattttat
     3241 atccaatgtc tagtataaaa ccttcccaca gtgcacaaat taagaatcta tataagctat
     3301 aaaatactca tttttttaaa aagaatttct ttttcactca aagacttggt aatctgtggg
     3361 aggaaggcat gcctcagtgg gtggactgcc cgtggacagc gagagcctgt aacagggcga
     3421 ccagtattac aaccaataga caacctagtg taggatgctc ttccagtaac cctggggggg
     3481 ggggggggat gaagtactgc ggtgctctgt tacatattgt gcaatttatt ttatatagta
     3541 aagtgattat gtctaactgt gatcaaacgt aactgtttga agccgtgtca gccgtggatg
     3601 agcgtgacca ttcataactg gtgtattaac acacgagctc cgagttagga cctctcctgg
     3661 tgcttgcacc acttcaccca gcttcagacc ttgtccagac agccaaagag ctcagcttac
     3721 aaacactaag aacacacaca gtgtctagaa taagtcggca gactgacacg gaggcacata
     3781 gctaaggagg ccacgtaagg gtgatgctaa agaaatgtct gcaccaagcg agccagcctg
     3841 ggcagagggg ccttctgtga gacggtcact gcttagttcc ctggatgcat cctgtatagc
     3901 ttgactagag tgaagccctg ctcgtgctag cgcggacctt ttagtgttca ctcctgggct
     3961 gcagagagta acggagacac gtggtgattg caagactctg taacgcttgc tttttaaacc
     4021 cttcttcctt tgttttgcat tctggggaca atctgactgg atgtggcact gcagagtaga
     4081 cagaagtcaa tgtgtctttt gtgctgtgat gtccttgttc tgtcttgaag ttactgttgt
     4141 gtggttttgt tatagttggt tctttttttt ctctttttct ctccagtgtt taattgtgaa
     4201 tactggctct ccagctacag tttgttttca aaaaaaaaaa aatggagaaa cagaatagtt
     4261 ttttactgaa ttaaaagatg cctattagac ccctccccct ttcgggtttc ccctggaccc
     4321 tttggtaata ctgctttcct gcagcccaga tgtgctttgc tttgctttgg ttcctttttc
     4381 tatgtttgtg ttttactttg ttttcatctg tatgggaaat tttgttacgc actactactt
     4441 tttatattct agaacgtttt caaaagttgg ctgatgattt tcgcttgttt gtttctaagg
     4501 aaaaaggcat gctttctgac tgacatgatc ttttgcaata cctcaatttt gaaatatagg
     4561 aaagaaaatg atattttcta agtaagttta ttcagaaaat atatattaat ttaattctgc
     4621 aagaaaatga tttaacagat gggtaacttt atttttttca tgcttatttg tgttttttga
     4681 aaatgaagaa gttagagctt tataactata atattaaaga tcatatctaa cctacagaaa
     4741 tctacctaat tatgtgaaac atgcaaatgt ttggaagaag cacccctctt tcatgtacta
     4801 aaataaccct gagctctaga ggagccagaa gactgcgcag tgtaagctag cgcgaaggcc
     4861 acagtgtcgc agagaccagg ttgtcagaga ctccacttgg tgctgagggc tgtgactgag
     4921 gaaactgctt tcccttaatt tgtatattta taatcaagtg ttgatcgtgt gactggccag
     4981 gactgtgaaa gagctcttct gtttgtattt ttttaaagag aactttttta gtttattaaa
     5041 ttataacatg ttcccttttg ttttgtaaat aaatgtgccc cccccccaag ttcttaatgt
     5101 tatattaaaa gagagggtcc ttcaaaaaaa ttatttttta aaaaaaacac agaggtgttc
     5161 tgccctgcaa cttgactggg aagcccctgg gtaacacagg tcctgctgtg gcctttcctt
     5221 gatgggacac ttgaactagt ggattttttg aaggctgtaa ctaacctcga ctctttgttg
     5281 ttatgtgcaa tactgtttgt actgtttgta taaaaaatag aaaaaaaaga caagaaaaaa
     5341 ggcctaaacc tttattgcag acttattttc attgcagact ttagacattg tgactcacag
     5401 aactcatttt ctactgtcaa atatgtacct ttccctcatg ctggtatttt ttcaatagta
     5461 acgtagcctt tgtactgaga caaattttca ttgttatttt tagaaagatt ttttgctaag
     5521 aaaaaaaatt aaacatattt acatattttt cattttattt cgtattttct ttaaggagtg
     5581 ctttctcaat cattactaga gttgtttctg ggagggactt tcatatctgg tcaacgtcat
     5641 aatattattt tgtattttta cttggaataa attaatttta tgatgctaat tctttaaagg
     5701 tttatttttt tcatttcagt tatttttgaa gctaaaaacc tttgtaatat tgttactaaa
     5761 gtgtctagtt ttttgaaatg caaagcttta tgtattaact tgccgatgtg gtttacaata
     5821 tgacaagggt ggaaacggtt ggttctgtaa cgtgactggg actgtaacgg acaattggat
     5881 aataaaacga cagaatgagc agaacgtg
//
