LOCUS       NM_001368806            7057 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus cytoplasmic polyadenylation element binding protein 2
            (Cpeb2), transcript variant 4, mRNA.
ACCESSION   NM_001368806 XM_006503928
VERSION     NM_001368806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7057)
  AUTHORS   Zhang,M., Yang,C., Ruan,X., Liu,X., Wang,D., Liu,L., Shao,L.,
            Wang,P., Dong,W. and Xue,Y.
  TITLE     CPEB2 m6A methylation regulates blood-tumor barrier permeability by
            regulating splicing factor SRSF5 stability
  JOURNAL   Commun Biol 5 (1), 908 (2022)
   PUBMED   36064747
  REMARK    GeneRIF: CPEB2 m6A methylation regulates blood-tumor barrier
            permeability by regulating splicing factor SRSF5 stability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7057)
  AUTHORS   Jeong,Y., Lee,S. and Choi,I.
  TITLE     Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in
            mouse blastocyst
  JOURNAL   Reproduction 163 (4), 233-240 (2022)
   PUBMED   35133290
  REMARK    GeneRIF: Regulation of Tjp1 mRNA by CPEB2 for tight junction
            assembly in mouse blastocyst.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7057)
  AUTHORS   Reddy,M.A., Amaram,V., Das,S., Tanwar,V.S., Ganguly,R., Wang,M.,
            Lanting,L., Zhang,L., Abdollahi,M., Chen,Z., Wu,X., Devaraj,S. and
            Natarajan,R.
  TITLE     lncRNA DRAIR is downregulated in diabetic monocytes and modulates
            the inflammatory phenotype via epigenetic mechanisms
  JOURNAL   JCI Insight 6 (11), 143289 (2021)
   PUBMED   33945509
  REMARK    GeneRIF: lncRNA DRAIR is downregulated in diabetic monocytes and
            modulates the inflammatory phenotype via epigenetic mechanisms.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7057)
  AUTHORS   Pascual,R., Martin,J., Salvador,F., Reina,O., Chanes,V.,
            Millanes-Romero,A., Suner,C., Fernandez-Miranda,G., Bartomeu,A.,
            Huang,Y.S., Gomis,R.R. and Mendez,R.
  TITLE     The RNA binding protein CPEB2 regulates hormone sensing in mammary
            gland development and luminal breast cancer
  JOURNAL   Sci Adv 6 (20), eaax3868 (2020)
   PUBMED   32440535
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7057)
  AUTHORS   Lai,Y.T., Chao,H.W., Lai,A.C., Lin,S.H., Chang,Y.J. and Huang,Y.S.
  TITLE     CPEB2-activated PDGFRalpha mRNA translation contributes to
            myofibroblast proliferation and pulmonary alveologenesis
  JOURNAL   J Biomed Sci 27 (1), 52 (2020)
   PUBMED   32295602
  REMARK    GeneRIF: CPEB2-activated PDGFRalpha mRNA translation contributes to
            myofibroblast proliferation and pulmonary alveologenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7057)
  AUTHORS   Hagele,S., Kuhn,U., Boning,M. and Katschinski,D.M.
  TITLE     Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2
            bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein
            expression
  JOURNAL   Biochem J 417 (1), 235-246 (2009)
   PUBMED   18752464
  REMARK    GeneRIF: Data identified an interaction of CPEB (cytoplasmic
            polyadenylation-element-binding protein) 1 and CPEB2 with the
            3'-UTR (untranslated region) of HIF-1alpha mRNA.
REFERENCE   7  (bases 1 to 7057)
  AUTHORS   Nakanishi,T., Kumagai,S., Kimura,M., Watanabe,H., Sakurai,T.,
            Kimura,M., Kashiwabara,S. and Baba,T.
  TITLE     Disruption of mouse poly(A) polymerase mGLD-2 does not alter
            polyadenylation status in oocytes and somatic cells
  JOURNAL   Biochem Biophys Res Commun 364 (1), 14-19 (2007)
   PUBMED   17927953
REFERENCE   8  (bases 1 to 7057)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7057)
  AUTHORS   Theis,M., Si,K. and Kandel,E.R.
  TITLE     Two previously undescribed members of the mouse CPEB family of
            genes and their inducible expression in the principal cell layers
            of the hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9602-9607 (2003)
   PUBMED   12871996
REFERENCE   10 (bases 1 to 7057)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
  REMARK    GeneRIF: CPEB2 is expressed postmeiotically in mouse
            spermatogenesis, suggesting a possible role in translational
            regulation of stored mRNAs in transcriptionally inactive haploid
            spermatids.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105174.7.
            
            On Feb 28, 2019 this sequence version replaced XM_006503928.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.5471.1,
                                           SRR11927935.599818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1836              AC105174.7         13513-15348
            1837-2118           AC105174.7         17567-17848
            2119-2208           AC105174.7         18587-18676
            2209-2299           AC105174.7         24846-24936
            2300-2350           AC105174.7         41994-42044
            2351-2374           AC105174.7         49129-49152
            2375-2545           AC105174.7         57691-57861
            2546-2635           AC105174.7         58864-58953
            2636-2754           AC105174.7         61370-61488
            2755-2869           AC105174.7         61631-61745
            2870-3051           AC105174.7         64197-64378
            3052-7057           AC105174.7         65979-69984
FEATURES             Location/Qualifiers
     source          1..7057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.65 cM"
     gene            1..7057
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /note="cytoplasmic polyadenylation element binding protein
                     2"
                     /db_xref="GeneID:231207"
                     /db_xref="MGI:MGI:2442640"
     exon            1..1836
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..3279
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     CPE-binding protein 2"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 2 isoform 4"
                     /protein_id="NP_001355735.1"
                     /db_xref="CCDS:CCDS89916.1"
                     /db_xref="GeneID:231207"
                     /db_xref="MGI:MGI:2442640"
                     /translation="MRDFGFGVLHTALLRSGSPRSSPGGSAYRPFAAGPPATPFGPLS
                     PPPLPVTGFSEAASPFAIPSGGGAASSAAASSSSPLVAHPQAVQDELLLGLTQQPTRP
                     LSGAAAAEQLPSHHPGGGTNAGVTHLLPSQDFKPSLHHPSSSSASSCCCCRTSSPQDF
                     SKRQQQQLSSQKRKELSPPHRPHPPDAKPPPPPPPLHCPGRFSPTPPTPPPPPGPLLQ
                     SAPLAQRSQPFSLPHTQHLPPQDFAQRQRPVDLPQLPQLPPSPPAAPRRRHGGAGSPR
                     QTPAAGEGSAAEPPNAGLPPSTPPVNPAPGSMESPNHPLLNSPSTLLPGAALGTSAFS
                     SLQSPDLPHPGGGGGGGPPGGGGGSASPPPLPGFGTPWSVQTASPPPPQPPPATQQQP
                     PQQPQPPQQPPQPQPPGSSAATPGSGGGAGGSLSAMPPPSPDSENGFYPGLPSSMNPA
                     FFPSFSPVSPHGCAGLSVPAGGGGGGGGFGGPFSAPTVPAPPAMNLPQQQPPAAAPQQ
                     PQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQNSGWGTASMSWG
                     AMHGRDHRRSGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFR
                     TDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLEN
                     SLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNARSYGRRRGRSSLFPIDDSLLDDGHSD
                     QVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHK
                     AESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNL
                     SDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYP
                     KGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKF
                     APFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRWN"
     exon            1837..2118
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2208
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2299
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2350
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2374
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2545
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2635
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2754
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2869
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3051
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..7057
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7035..7040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /note="hexamer: AATAAA"
     polyA_site      7057
                     /gene="Cpeb2"
                     /gene_synonym="A630055H10Rik; Cpe-bp2"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggtg gtgccggagc cggttccggg aggcggcggt ggcctccgtg aggggcggcg
       61 gggccccaag tcggtgcccc ggctcagtca cagtgtccct ttcccattga ccccatcctt
      121 ccaccacggc cgcgccgcca cggctcccgg ggctttctag gcggggcagg ggacggggtg
      181 cgtctcctgc cgcggccgcc ggcctgataa atgcgggact tcgggttcgg ggtgctgcac
      241 actgccctgc tgcgcagcgg cagcccacga tcctcgcccg gcggcagcgc ctaccggccc
      301 ttcgccgccg ggccgcccgc cacgcccttc ggcccgctgt cgccgccgcc gttgcctgtc
      361 accggcttct ccgaggccgc ctcccccttc gccatcccct cgggcggcgg cgcggccagc
      421 tcagccgcag cttcctcttc ctccccgctc gtggcgcatc cccaggccgt gcaggatgag
      481 ctactgctcg ggctgacaca gcagccgacg aggccgctct cgggggcggc ggccgcagag
      541 cagctcccca gccaccaccc cggcggcggc acgaacgcgg gtgtgaccca cctcctcccc
      601 tcccaggact tcaaaccgag tctgcaccac ccctcctcct cctccgcctc ctcctgctgc
      661 tgctgccgca cctcctcccc gcaggacttc agtaagcggc agcagcagca gctgagcagc
      721 cagaagagga aagagttgag cccgccacac cgtccccacc ctccggacgc gaagccgccg
      781 ccgccgccgc cgccgctcca ctgccccggc cgcttcagcc caacaccgcc aacgccgcca
      841 ccaccgcccg ggccgctcct gcagtcggcg ccgctcgccc agcgctctca gccgttcagc
      901 ctcccgcaca cgcagcacct cccgccgcag gacttcgccc agcggcagcg cccggtcgac
      961 ctgccccagc tcccgcagct cccgccctcg ccgcccgcag ctccgcggcg ccgccacgga
     1021 ggcgcgggaa gccctcgcca gaccccggcc gcgggcgagg gcagcgccgc cgagcccccc
     1081 aatgcgggct tgcccccctc gacgccgccg gtgaaccccg cgccgggctc catggagtcg
     1141 cccaaccacc ctctgctcaa cagccccagc accctcctgc ccggcgcggc gctcggcacc
     1201 agcgccttca gcagcctgca gagcccggac ctgccgcacc ccggcggcgg cgggggcggg
     1261 ggaccccccg gagggggagg cggctccgcg tctcccccac cgctgcccgg cttcggcacc
     1321 ccctggtcgg tgcagaccgc gtcgccgccg ccgccccagc ctccgccggc gacccagcag
     1381 cagccacccc agcagccgca gccgccccag cagccgccgc aaccacagcc cccgggctcc
     1441 tcggctgcca ccccgggcag cggcggcggc gcgggcggct ctctgagcgc catgccgccg
     1501 cccagcccgg actcggagaa cggcttctac cccgggctgc catcgtccat gaacccggcc
     1561 ttcttcccga gcttctcgcc ggtgtcgccg cacggctgcg cggggctcag cgtgccggcc
     1621 ggcggtggcg gcggcggcgg cggcttcggc ggcccgttct ctgctcccac ggtgcccgcg
     1681 ccgcccgcca tgaatttacc tcaacagcag ccgccggcgg cggcgccgca gcagccgcag
     1741 agccggaggt cacccgtcag cccgcagctg cagcagcagc accaggctgc cgcagccgcc
     1801 ttcctgcagc agaggaactc gtacaaccac caccagcctc ttctgaaaca gtctccttgg
     1861 agcaaccatc agaacagcgg ttggggcact gcgagcatgt cctggggagc aatgcacggc
     1921 agagatcacc gcaggagcgg caacatgggg atcccaggga ctatgaatca gatatctccg
     1981 ctgaagaagc cgttctcggg taatgttata gcaccaccga aattcactcg ctctactcca
     2041 tcactgactc caaaatcttg gattgaagat aatgtgttca ggacagacaa caatagtaac
     2101 acactcttac ccttacaggt gagatctagt ttgcagttgc cagcttgggg ctcagattca
     2161 ctccaagata gttggtgcac tgcagccgga acatccagaa tagaccagga tcgaagtaga
     2221 atgtatgata gcttgaatat gcactctctg gaaaattccc ttattgatat catgagagca
     2281 gagcacgatc ctctcaaggg tcgtctgagc tatccacatc caggaaccga caatctgtta
     2341 atgttaaatg caaggagtta tgggcgaaga cgaggtcgct cttccctatt tccaatagat
     2401 gatagcttgt tggatgatgg tcacagtgat caagttggtg ttttaaattc accaacatgt
     2461 tattcagctc atcaaaatgg agaacgaatt gaacgcttct ctcgaaaagt ttttgttggt
     2521 gggcttcctc cggatattga tgaagatgag atcactgcca gcttccgaag atttggacct
     2581 ttggtagtag attggcccca caaagcagaa agtaaatcct attttccacc aaaaggctat
     2641 gcattcctcc tctttcaaga agagagctca gtccaggcac tcattgacgc ttgcattgaa
     2701 gaagatggaa agctctactt gtgtgtttcc agccctacta tcaaagacaa acctgttcaa
     2761 atccgtcctt ggaatttaag tgatagtgat ttcgtcatgg atggttctca gcctttggat
     2821 ccccgaaaaa caatttttgt tggaggtgtt cctaggccac taagggctgt ggaacttgct
     2881 atgatcatgg accggctgta tggtggtgtg tgttacgcag gaattgatac agatccagaa
     2941 ctcaaatacc caaaaggtgc tgggcgagtc gctttctcca atcagcagag ctacattgct
     3001 gccatcagtg ctcgatttgt tcagcttcag cacggtgaca ttgataaacg tgtggaggtg
     3061 aagccatatg tgctagatga ccagatgtgt gacgagtgcc agggtgcacg ctgtggtggg
     3121 aaatttgccc cctttttctg tgccaatgtc acctgcctgc agtattactg tgagttttgt
     3181 tgggcaaata tccactctcg tgcaggacgc gagttccata agccattggt gaaggaaggt
     3241 gctgatcgcc cacgtcagat ccacttccgc tggaactaag tatagccaac tggcctcggt
     3301 ctaggaagga aggaaagggt gcatgtggct tactgtgctg aagacactga cgtgcagaag
     3361 aaataagtgc attctcctgc tgctcaccca gctctcgata catgcatcgt tatcagcagc
     3421 caaaacacta caagcctctt gtttttcacc aaaaccctac atctcaggct tactaatttt
     3481 tgtgatattt tcatgttaaa ataaaatgtt tttttgtatt ttctccaagt tatttttata
     3541 tgtaaagtta aaattagata tgagaatgtt ttgcgtaggg gcaacacagt ctgctgctat
     3601 atagtgggtg aagcgtgcac ttatttctta acatgggttt ttaacttcaa gatctgcccc
     3661 agtactttac caaaggtagc aaaataatag tgaagatgga atatgtctgc tacaaatgct
     3721 tatttttatt gttgctgttt tcagtgtgta cataaactaa aaattagggt tgattttgtt
     3781 gctctccatt ttgacttgca agaaataata cctcaagata atctgattta ttagctattt
     3841 ttaaacattt ttaatcacaa gctgtattag ctttgctgct atataggtgt tatgtgtaaa
     3901 tgtcacctat taatacggga ttgaaaacgt tagagacaca ctgcattgcg gatgaaatgc
     3961 aggcagcaca atatggccgg aactgccata gtttagaatg tgaaacaatg catgtttact
     4021 tacctgtgtc caccatatgc atgcactcgg acattaacta acgaggtgag gtattgcaga
     4081 tgttcaaaaa gctctcttga atctaggtag catgaacaaa ttagaaaatt tgtttcttta
     4141 caaaaaagca aacttgcatg cattattgtg acttcaagtt aaaaatgttg tcctacatgt
     4201 gtacaatatg caaattagtt ttagattaga gagtgcagcc attttgtgat ctggtcagta
     4261 gtggaattcg attttatgca gactggatgt aatatttgta atccctgtgc aattttgtga
     4321 tgtgcggttc taattcatgt gcagtgatat agtatagata aaagattgaa taaaagaaaa
     4381 acacaggaat tttaaagaaa gttgatttta gcccctttga tagttcatgg ttaagacatc
     4441 ctttaaaaac caaagatggc cagcacactg ctaaccagtc accgaatgtg agacccatga
     4501 aaagaccata ctttaaaaga ggattttata gaagaacaca gaactttagt gaagtcaaaa
     4561 tggagatggg aaaatataat agatggctag ttgcataaaa tttacctttg atggtgaaat
     4621 ctggcttaaa tttgcttaca tgtttgacct atgtctatgg ggtcttctgt ctaaactggg
     4681 gtcactgttg catggagcat tgttattctt aatggttaag aattgctttt ttaaaacttt
     4741 gatgaaggaa tttcagtaat gactttgctt gcatcttttc ttttttcttt attgagggag
     4801 ttgcgtggaa acatgcacgg ttctgaccta gaacatcgtt cgttcgtggt ggttttcctc
     4861 tttagagcat cctaacagca gctagccgct gtgttaataa tgtaggagtt accctgcagt
     4921 ctaagcaaag caccccacat ggtaaatgtt ggtttttgtt gttgttgtta ttgttgttta
     4981 tttttttaaa tgcagaacta agatttttga ctctaaagag agaaaattgc aagggtatgg
     5041 cccgtgcagc aaacccttgg gacaatcctt cacatgagca aagtactgat ctcaacattg
     5101 gttgtcgatg gtatgctttt ttgtactgta aaaatgcgtg gttcatgtct aactctgctg
     5161 ttttattgtg gttgtggctc aagtttttag tgtttgacgt tgatgctgtt ttcagaggag
     5221 ctctttacta atttatttgt ccgtatccca acctcttcct ccccgtggcc ctccagagtt
     5281 tctggagcat tcttttcacc ctcgccctgc caacccttga tccattttga catttgttgt
     5341 gcactatttt tatatctctg tgagcgattt ttccagcagt cagctatttt atggcatact
     5401 ttttttcact gatgacatct cctttgctat acctcaattt ttggaattta gaaaagaaat
     5461 cagtagtttt gcaatgttaa ttatttagat atttaatttc gcagattttt aaactttatt
     5521 ttcataattt ctgcttaatg tttaaaattg aagagccttt tcatgtatta aataatgaac
     5581 tctaaaataa attatataat aaaataattg gagatgctga aaattatttt cccttcttaa
     5641 acggaagtaa atatttgaaa tgaaggggaa atgaaagaga aacaccttct cctaccaggg
     5701 tgaacgtgac agaaatgctg gtttgtgtca ccttcgttcc tgttaggaca aagctcattg
     5761 gtctaatact gtgtccctcc ctgcctctcc cctacctctg atttgttttg ttttctgttt
     5821 gtttggggat tatttttcct tttatgtact acatttttat tttctaaccg ttaaacactg
     5881 tatttgagtt tttttaattt acagatcata tttattttac tatttttgta gaaaattatt
     5941 aattttgatt gtatttttgt attttcaaag cttcttcatt tgtgttccct aaatgttcat
     6001 attgctgccc aaaagtatga atgactgtgg aggaaaaagt actttaaaaa tccacacttt
     6061 ttgttaagaa ggaaacattt agcatttata tatttgtgta tggaaaacac ttgatatttt
     6121 atccctgttg catctggctg cacgagcctc tcctcaaaga tgccacaaaa cttgaatata
     6181 acacattttg gaaggctgac taacctcgat tctgtgttgt gatgtgcaat actgtttcta
     6241 atgtttgtat aaagatacag tgtaaacctt tttaatgcaa atttattttt ttcattgcat
     6301 attttgcaga ctttatccac agtgtcattt tttactgtca gaaaagatgc cccttttgtc
     6361 attgcaacta ttttttaaac ccagaaatct ttgtactgat gtaaatgatt gtagttattt
     6421 tggatagtgt tttgctaaca aaaggagaga cttttttcat gcatatttct attttgtttt
     6481 tttgggtttt attttatttt aatagtagta aaatacttgg aataattttt catattcttg
     6541 tcattaatat tattttgtat ttttatgtga aaatatataa ttttatgaca ctaattgcta
     6601 aagtttattt tatgttgaat tatttttgga gctgaaatct ttgtaatatt aaagcaacta
     6661 gtttctaatt cccagtttct gtatagaatc gcacaagtgg tttatggagt gtttggattg
     6721 taactataaa tggttctttg atatgcaaat taatattttc agttgatttt attttatatt
     6781 cctaatgggg tgttaaagcc gttttttatt tttttctaaa taaaaagaga acccatgctt
     6841 ttatggacac taggtaaaac gccttcagct taaaattttt gttaaataat ttagtttatt
     6901 ttattgttat cttccaggtg tctaaatctc cagtctgtct gttgtactgg taatttaact
     6961 ctgtaatgga atagtttgct gccaactatt tatattaagt aatttttaaa tatttgtaat
     7021 attgttgact gactaataaa ctattaagtt attggca
//
