LOCUS       NM_007755               3138 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytoplasmic polyadenylation element binding protein 1
            (Cpeb1), transcript variant 2, mRNA.
ACCESSION   NM_007755
VERSION     NM_007755.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Kunitomi,C., Romero,M., Daldello,E.M., Schindler,K. and Conti,M.
  TITLE     Multiple intersecting pathways are involved in CPEB1
            phosphorylation and regulation of translation during mouse oocyte
            meiosis
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38785133
  REMARK    GeneRIF: Multiple intersecting pathways are involved in CPEB1
            phosphorylation and regulation of translation during mouse oocyte
            meiosis.
REFERENCE   2  (bases 1 to 3138)
  AUTHORS   Zhang,Z., Liu,R., Zhou,H., Li,Q., Qu,R., Wang,W., Zhou,Z., Yu,R.,
            Zeng,Y., Mu,J., Chen,B., Guo,X., Sang,Q. and Wang,L.
  TITLE     PATL2 regulates mRNA homeostasis in oocytes by interacting with
            EIF4E and CPEB1
  JOURNAL   Development 150 (12) (2023)
   PUBMED   37218508
  REMARK    GeneRIF: PATL2 regulates mRNA homeostasis in oocytes by interacting
            with EIF4E and CPEB1.
REFERENCE   3  (bases 1 to 3138)
  AUTHORS   Takahashi,N., Franciosi,F., Daldello,E.M., Luong,X.G., Althoff,P.,
            Wang,X. and Conti,M.
  TITLE     CPEB1-dependent disruption of the mRNA translation program in
            oocytes during maternal aging
  JOURNAL   Nat Commun 14 (1), 416 (2023)
   PUBMED   36697412
  REMARK    Erratum:[Nat Commun. 2023 Feb 6;14(1):646. doi:
            10.1038/s41467-023-36396-1.. PMID: 36746956]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3138)
  AUTHORS   Wang,Y., Yasmin,L., Li,L., Gao,P., Xu,X., Sun,X. and Godbout,R.
  TITLE     DDX1 vesicles control calcium-dependent mitochondrial activity in
            mouse embryos
  JOURNAL   Nat Commun 13 (1), 3794 (2022)
   PUBMED   35778392
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3138)
  AUTHORS   Feng,S., Li,J., Wen,H., Liu,K., Gui,Y., Wen,Y., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing
            in germ cells
  JOURNAL   Nat Commun 13 (1), 3588 (2022)
   PUBMED   35739118
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3138)
  AUTHORS   Welk,J.F., Charlesworth,A., Smith,G.D. and MacNicol,A.M.
  TITLE     Identification and characterization of the gene encoding human
            cytoplasmic polyadenylation element binding protein
  JOURNAL   Gene 263 (1-2), 113-120 (2001)
   PUBMED   11223249
REFERENCE   7  (bases 1 to 3138)
  AUTHORS   Luitjens,C., Gallegos,M., Kraemer,B., Kimble,J. and Wickens,M.
  TITLE     CPEB proteins control two key steps in spermatogenesis in C.
            elegans
  JOURNAL   Genes Dev 14 (20), 2596-2609 (2000)
   PUBMED   11040214
REFERENCE   8  (bases 1 to 3138)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
REFERENCE   9  (bases 1 to 3138)
  AUTHORS   Gebauer,F. and Richter,J.D.
  TITLE     Mouse cytoplasmic polyadenylylation element binding protein: an
            evolutionarily conserved protein that interacts with the
            cytoplasmic polyadenylylation elements of c-mos mRNA
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14602-14607 (1996)
   PUBMED   8962099
REFERENCE   10 (bases 1 to 3138)
  AUTHORS   Takagaki,Y., Seipelt,R.L., Peterson,M.L. and Manley,J.L.
  TITLE     The polyadenylation factor CstF-64 regulates alternative processing
            of IgM heavy chain pre-mRNA during B cell differentiation
  JOURNAL   Cell 87 (5), 941-952 (1996)
   PUBMED   8945520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY720025.1, Y08260.1, BC144948.1, AK077799.1 and CO803180.1.
            
            On Nov 17, 2011 this sequence version replaced NM_007755.4.
            
            Transcript Variant: This variant (2) uses a different splice in the
            coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136088.1, Y08260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                BY720025.1         4-85
            83-1516             Y08260.1           2-1435
            1517-1845           BC144948.1         1419-1747
            1846-3057           AK077799.1         474-1685
            3058-3138           CO803180.1         548-628
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..3138
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:12877"
                     /db_xref="MGI:MGI:108442"
     exon            1..125
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1796
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 2"
                     /protein_id="NP_031781.1"
                     /db_xref="CCDS:CCDS40007.1"
                     /db_xref="GeneID:12877"
                     /db_xref="MGI:MGI:108442"
                     /translation="MAFSLEEAAGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSL
                     DFSKVCTTPINRGIHDQLPDFQDSEETVTSRMLFPTSAQESPRGLPDANGLCLGLQSL
                     SLTGWDRPWSTQDSDSSAQSSTQSVLSMLQNPLGNVLGKAPLSFLSLDPLGSDLDKFP
                     APSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGN
                     GPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGASVWPSWDLLGAPKDPFSIER
                     EARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFG
                     SLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYY
                     FKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILN
                     DLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPY
                     LEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN"
     exon            126..300
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..489
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..713
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..966
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1080
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1185
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1322
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1521
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1616
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1697
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..3111
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /note="hexamer: AATAAA"
     polyA_site      3111
                     /gene="Cpeb1"
                     /gene_synonym="Cpe-bp1; Cpeb; mCPEB; mCpeb-1"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcgct gcaaaaatag tgcccacgtg tgtgcgcgtc ccgcgccgca cagacccgcc
       61 ggcccgcgcg cccgcccgcc cgccagtccc ttagggccac gccggacccc atggctttct
      121 ctctggaaga agcagcagga agaataaagg attgctggga caaccaagaa gttcctgcac
      181 tctctacatg tagcaatgcc aatatctttc gaaggataaa tgccattttg gatgattcac
      241 tggacttcag taaagtctgt acaacaccta taaatcgagg aattcatgat cagttgccag
      301 acttccagga ctctgaagaa acagttacaa gcaggatgct tttccccacc tctgcgcaag
      361 aatctccccg tggcctccca gatgcaaatg gcttgtgcct tggcctgcag tccctcagtc
      421 tgactggctg ggaccgaccc tggagcaccc aggactcaga ctcctcagcc cagagcagca
      481 cacagtcagt attaagcatg ctccaaaatc cactgggaaa tgtcttagga aaagccccct
      541 tgagcttcct gtctctggat ccccttgggt ctgacttgga caagttccca gcaccctcag
      601 ttagaggatc tcgcctggac acccggccca tcctggactc ccgttctagc agcccctctg
      661 actcagacac gagtggcttc agctctggat cagaccatct ctcagatttg atttcaagcc
      721 ttcgcatttc ccctcctctg ccctttcttt ctatgacggg aaatggtccc agagaccctc
      781 taaagatggg cgttgggtcc cgaatggacc aagaacaagc tgctcttgct gcagttgctc
      841 cctctccaac cagtgctcca aagagatggc caggagcttc tgtgtggcca tcttgggacc
      901 ttcttggagc tcctaaagac ccattcagca tagagagaga ggctagactc caccggcagg
      961 ctgcagctgt gaatgaagct acgtgtacct ggagtggcca gcttcctccc cggaactata
     1021 agaaccccat ctactcatgc aaggtgttcc taggaggcgt tccttgggat attacagaag
     1081 ctggattggt taacaccttc cgtgtttttg gctctctgag tgtggagtgg cctggtaagg
     1141 atggcaagca cccccggtgt cctcccaaag gtaatatgcc taaagggtat gtgtatttgg
     1201 tgtttgaact agagaagtcc gtccgggcct tgcttcaggc ttgttctcat gacccgctga
     1261 gcccagatgg cctgagtgaa tattatttca agatgtccag ccgaaggatg cgctgcaaag
     1321 aggtacaggt aatcccttgg gtcttggctg acagcaactt tgtctggagc ccatctcaga
     1381 ggctggatcc cagcaggacg gtgtttgttg gtgccttgca cgggatgctc aatgctgagg
     1441 ctctggctgc catcttgaat gacctatttg gtggagtggt gtatgctggg attgacacag
     1501 ataagcacaa gtaccccatt gggtctggtc gtgtgacttt caataaccaa cgtagttatc
     1561 tgaaagcagt caccgctgct tttgtggaga tcaaaaccac caagtttacc aagaaggttc
     1621 agattgaccc ctatctagaa gattctctgt gtcttatctg cagctcacaa cctggtcctt
     1681 tcttctgccg agatcaggtc tgcttcaagt acttttgcag aagctgctgg cactggcgac
     1741 acagcatgga aggcctacgc caccatagcc ccctaatgag gaaccagaag aactgagatt
     1801 ccagctagag gagctggcct tgcccagtgt cctgtggtgc caaaggctgt caagtcaggc
     1861 agcaactcgc tgcacaggcg ccatgggagc tagctttgcg cagacaaggg agaatcgtag
     1921 tcacctttgt acttgctaac tctgtctttg tttctgcact aattaatgca caatgagttt
     1981 tgtcaggtct tgttttcagt ggggtgtgcc agagcaagga ccctcggctc accctcaagc
     2041 aattgtagtt ttcccagatt ctagttcctc attttgcaaa tgaaaataac aacaacaacc
     2101 actgtgtcca gaaggtctga cacagatgcc tacacttggg tttatttatt aaagcgcttt
     2161 ttacattcct tgcaatactg atggtggtga tgcgcaggtc tcattggttc gttcattctg
     2221 cagttgccat acagtgcctt tccattgatt taacccccac ctgaacggca tcaattgagt
     2281 gttcagctgg tgttttttac tgtaacaaac aaaggagact ttgctcttca tttaaaccaa
     2341 atcatatttc atagtttacg ctcgagggtt tttactggtt cctttttaca ctccttaaaa
     2401 cagtttttaa gtcgtttgga acaatatatt tttttttctt tcttggcagc ttttaacatt
     2461 atagcaaatt tgtgtctggg ggactgctgg tcacagttgc aaatcaaagc atttgtaacc
     2521 aagagaaaaa ttattttatt taaaactgga ccggaggaaa agtctgagca gctgctgtat
     2581 atagttttaa atggtttgtg gcaccttatg ttgcacttat gttgggggag ggttgataga
     2641 agtttttaat cacagtcaca ggactttttc ttttgtaact gagcttaaaa attaaaaaaa
     2701 aaaaaaaaag ggctgctttt tggtgggggc aggtgaaggc tcacaggagc cctttctctt
     2761 agaggggcaa atacccttcc ttacaacttt tatttgacga atgtatgaat caacagttac
     2821 agttgacaaa gacgctactg gaattgaaaa cttgactttt ctttttaatt taacgattac
     2881 ttgcctctct tagggaagct gtgtgccaaa gagccagtgt cataacccct ccctcctgct
     2941 gagctgatgt tgcattgttg catatcccag ctactctgtg ggttttgtga agctgtgtgt
     3001 gaagtctcta cctcattgtt gtatatgcag gcaagactgc actctcctac agatgtgtgg
     3061 agtaagctgt ggtgtaattt ttttggcaca taataaacac gttgcagcag aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaa
//
