LOCUS       NM_007754               9152 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus carboxypeptidase D (Cpd), mRNA.
ACCESSION   NM_007754 XM_912145
VERSION     NM_007754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9152)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9152)
  AUTHORS   Singh,U., Yu,Y., Kalinina,E., Konno,T., Sun,T., Ohta,H.,
            Wakayama,T., Soares,M.J., Hemberger,M. and Fundele,R.H.
  TITLE     Carboxypeptidase E in the mouse placenta
  JOURNAL   Differentiation 74 (9-10), 648-660 (2006)
   PUBMED   17177860
REFERENCE   4  (bases 1 to 9152)
  AUTHORS   Lu,Y. and Cederbaum,A.I.
  TITLE     Enhancement by pyrazole of lipopolysaccharide-induced liver injury
            in mice: role of cytochrome P450 2E1 and 2A5
  JOURNAL   Hepatology 44 (1), 263-274 (2006)
   PUBMED   16799984
REFERENCE   5  (bases 1 to 9152)
  AUTHORS   O'Malley,P.G., Sangster,S.M., Abdelmagid,S.A., Bearne,S.L. and
            Too,C.K.
  TITLE     Characterization of a novel, cytokine-inducible carboxypeptidase D
            isoform in haematopoietic tumour cells
  JOURNAL   Biochem J 390 (Pt 3), 665-673 (2005)
   PUBMED   15918796
  REMARK    GeneRIF: The isolation and characterization of CPD from several
            haematopoietic tumour cells are reported.
REFERENCE   6  (bases 1 to 9152)
  AUTHORS   Kalinina,E.V. and Fricker,L.D.
  TITLE     Palmitoylation of carboxypeptidase D. Implications for
            intracellular trafficking
  JOURNAL   J Biol Chem 278 (11), 9244-9249 (2003)
   PUBMED   12643288
  REMARK    GeneRIF: Palmitoylation of carboxypeptidase D has a role in
            intracellular trafficking
REFERENCE   7  (bases 1 to 9152)
  AUTHORS   Kalinina,E., Varlamov,O. and Fricker,L.D.
  TITLE     Analysis of the carboxypeptidase D cytoplasmic domain: Implications
            in intracellular trafficking
  JOURNAL   J Cell Biochem 85 (1), 101-111 (2002)
   PUBMED   11891854
  REMARK    GeneRIF: CPD localization to the TGN requires both static retention
            involving the C-terminal domain and phosphorylation at a CK2 site,
            which regulates the binding of adaptor proteins.
REFERENCE   8  (bases 1 to 9152)
  AUTHORS   Ishikawa,T., Murakami,K., Kido,Y., Ohnishi,S., Yazaki,Y., Harada,F.
            and Kuroki,K.
  TITLE     Cloning, functional expression, and chromosomal localization of the
            human and mouse gp180-carboxypeptidase D-like enzyme
  JOURNAL   Gene 215 (2), 361-370 (1998)
   PUBMED   9714835
REFERENCE   9  (bases 1 to 9152)
  AUTHORS   Riley,D.A., Tan,F., Miletich,D.J. and Skidgel,R.A.
  TITLE     Chromosomal localization of the genes for human carboxypeptidase D
            (CPD) and the active 50-kilodalton subunit of human
            carboxypeptidase N (CPN1)
  JOURNAL   Genomics 50 (1), 105-108 (1998)
   PUBMED   9628828
REFERENCE   10 (bases 1 to 9152)
  AUTHORS   Xin,X., Varlamov,O., Day,R., Dong,W., Bridgett,M.M., Leiter,E.H.
            and Fricker,L.D.
  TITLE     Cloning and sequence analysis of cDNA encoding rat carboxypeptidase
            D
  JOURNAL   DNA Cell Biol 16 (7), 897-909 (1997)
   PUBMED   9260933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ130378.1, AK137737.1 and AL645479.19.
            
            On Jul 3, 2007 this sequence version replaced NM_007754.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85391.1, AK137737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ130378.1         2-23
            23-4371             AK137737.1         2-4350
            4372-9152           AL645479.19        5525-10305          c
FEATURES             Location/Qualifiers
     source          1..9152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.05 cM"
     gene            1..9152
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /note="carboxypeptidase D"
                     /db_xref="GeneID:12874"
                     /db_xref="MGI:MGI:107265"
     exon            1..785
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..4176
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /EC_number="3.4.17.22"
                     /note="gp180; metallocarboxypeptidase D"
                     /codon_start=1
                     /product="carboxypeptidase D precursor"
                     /protein_id="NP_031780.2"
                     /db_xref="CCDS:CCDS25071.1"
                     /db_xref="GeneID:12874"
                     /db_xref="MGI:MGI:107265"
                     /translation="MASGRDERPPWRLGRLRLLPPPPLLLLLLLLRSSAQAAHIKKAE
                     ATTTTVGGSEAAEGQFDHYYHEAALGEALEAAAAAGPPGLARLFSIGSSVEGRPLWVL
                     RLTAGLGPPPTAAAGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYR
                     RGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRS
                     FPDQFSTGEPPSLDEVPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTG
                     LYSKTSDDEVFRYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQ
                     DYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVT
                     GSGLENATISVAGINHNITTGRFGDFHRLLVPGTYNLTALSTGYMPLTINNIMVKEGP
                     ATEMDFSLRPTVMSVMPGSTEAVTTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDM
                     EIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNE
                     VVGRELLLNLIEYLCKNFGTDPEVTDLVRSTRIHLMPSMNPDGYEKSQEGDSISVVGR
                     NNSNNFDLNRNFPDQFVPITEPTQPETIAVMSWVKAYPFVLSANLHGGSLVVNYPYDD
                     NEQGVATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKDMYLNEYFPHGITNGASWYN
                     VPGGMQDWNYLQTNCFEVTIELGCVKYPFENELPKYWEQNRRSLIQFMKQVHQGVKGF
                     VLDATDGRGILNATLSVAEINHPVTTYKAGDYWRLLVPGTYKITASARGYNPVTKNVT
                     VRSEGAVQVNFTLVRSSADANNESKKGRGHSTSTDDTSDPTSKEFEALIKHLSAENGL
                     EGFMLSSSSDLALYRYHSYKDLSEFLRGLVMNYPHITNLTTLGQSVEYRHIWSLEISN
                     KPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKRNPVVTQLVDRTRIVIV
                     PSLNPDGRERAQEKDCTSKTGHTNAHGKDLDTDFTSNASQPETKAIIENLIQKQDFSL
                     SIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNNSDENIP
                     GGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLPALWAENKKSLLSM
                     LVEVHKGVHGLVKDKAGKPISKAVIVLNEGIKVYTKEGGYFHVLLAPGVHNINAIADG
                     YQQQHTQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCIC
                     SIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH"
     exon            786..1033
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1176
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1346
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1696
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1888
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2056
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2166
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2269
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2412
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2582
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2906
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3102
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3238
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3370
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3466
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3531
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3663
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3849
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3949
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..9152
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6977..6982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6995
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /note="major polyA site"
     regulatory      7914..7919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /note="hexamer: TATAAA"
     polyA_site      7932
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
                     /note="major polyA site"
     polyA_site      7999
                     /gene="Cpd"
                     /gene_synonym="D830034L15Rik"
ORIGIN      
        1 ggagccgctg gagcggagcg gtattagcgg cgttgctgga agatggcgag cggccgggat
       61 gagcggccgc cctggcggct gggacgcctg cgtctgctgc cgccgccacc gctgctgctg
      121 ctgctgctgc tactgaggag ctcggcccag gcggcgcaca tcaagaaggc tgaggcgacc
      181 acgacaaccg ttggcggctc cgaggcggcc gagggccagt ttgaccacta ctaccacgaa
      241 gcggcgctgg gcgaggcgct ggaagcggcg gcggccgcgg ggccacccgg cctggcgcgt
      301 ctcttcagca tcggcagctc ggtggagggc cggccgctgt gggtgctgcg cctcacagcg
      361 ggcctggggc cgccgcccac cgccgccgcg gggctggacg ccgcggggcc gctgctgccc
      421 ggccggccgc aggtgaagct ggtgggtaac atgcacggcg acgagacggt gtcacgccag
      481 gtgttggtct acctggcccg cgagctggcg tcgggctacc gccgcgggga cccgcgcctg
      541 gtccgcctgc tcaacaccac cgacgtgtat ttgctgccca gcctgaaccc ggatggcttc
      601 gaacgtgccc gcgagggtga ctgcggcctc ggcgacagcg gcccgcctgg gaccagcggc
      661 cgtgacaaca gccgaggccg cgacctcaac cgcagcttcc ctgaccagtt cagcaccggc
      721 gagccacctt ccctggatga ggtgccggag gtgcgcgccc tcatcgactg gatccgcagg
      781 aacaagtttg tgctttctgg aaatcttcat ggtggctcag tggtagcaag ctatcctttt
      841 gatgattctc ccgagcataa gaccactgga ctctatagca aaacctccga tgatgaagtc
      901 tttagatact tggcaaaagc ttatgcctct aaccacccta taatgaaaac tggcgaaccc
      961 cattgtccag gagatgaaga cgagactttc aaagatggga tcacgaatgg cgcgcactgg
     1021 tatgacgtgg aaggtggtat gcaagattac aattatgtat gggccaactg ttttgagatc
     1081 acattagaat tgtcttgctg caagtaccca cctgcttctc agcttcgaca agaatgggag
     1141 aataatcgtg agtctttgat cacattgatt gaaaaggtcc acattggaat taaaggattt
     1201 gttaaagatt ccgtaacagg ctctgggtta gagaacgcaa ccatttcagt ggctggtatt
     1261 aatcataaca tcacaacggg aagatttggt gatttccaca gattacttgt tcctggaact
     1321 tacaatctta cggcgctttc aactgggtat atgccattga ccattaataa tataatggtg
     1381 aaagaagggc cagctacaga gatggatttc tcccttcggc caactgtgat gtcagtaatg
     1441 cctggttcaa ctgaggctgt aacaactcct ggcacagttg ctgttcctaa tatccctcct
     1501 ggaacaccat cctcccatca gccaattcag cctaaagact ttcaccacca ccattttccc
     1561 gacatggaaa tcttcttgag aagatttgcc aatgaatatc ctaatatcac ccgtctttat
     1621 tctctgggga aatccgtaga gtcaagagaa ctgtatgtga tggagatatc tgataaccca
     1681 ggtgtccatg aaccaggtga accagaattt aagtatattg gaaatatgca tggaaatgaa
     1741 gtggttggaa gagagctgct attgaatctc attgaatacc tctgcaagaa ttttggaaca
     1801 gaccctgaag taacagattt ggttcgcagc acaagaattc accttatgcc atccatgaat
     1861 cctgatggat atgaaaagtc ccaggaagga gattcgatca gtgtagttgg cagaaacaac
     1921 agcaacaact ttgacctaaa ccggaatttc ccagaccagt ttgttccaat cacagaacct
     1981 acccaaccag aaactatcgc tgtgatgagc tgggtgaagg cctacccgtt tgtgctgtca
     2041 gccaatctgc acgggggttc cctggtggtt aactaccctt atgatgataa tgagcaagga
     2101 gttgccacgt acagcaagtc accagatgat gctgtatttc agcaaatagc actttcttat
     2161 tccaaggaaa attcgcagat gttccaaggt agaccttgca aggacatgta tctcaatgag
     2221 tattttcctc atgggataac aaacggagct agttggtata acgtcccagg tggtatgcag
     2281 gactggaact atttacagac aaattgcttt gaagtaacta tcgaactcgg ttgtgtgaaa
     2341 tatccatttg agaatgaact gccaaagtac tgggagcaaa atcgaagatc tctaatccag
     2401 tttatgaaac aggttcatca gggtgtcaaa ggatttgtcc ttgatgccac agatggtagg
     2461 ggcatattaa atgccaccct cagtgttgct gaaattaatc acccagtgac cacttacaaa
     2521 gctggagatt actggcgcct cttggtccca gggacataca aaatcacagc atctgcccga
     2581 gggtataacc ctgtcaccaa gaacgtgacc gtcaggagtg aaggtgctgt tcaggtcaac
     2641 ttcacccttg ttcgatcttc agcagatgca aacaatgagt caaagaaagg cagggggcat
     2701 agcaccagca ctgacgacac cagcgaccca acttctaagg agtttgaagc attaatcaaa
     2761 cacctttcgg ctgagaatgg cttggaaggc ttcatgttaa gctcgtcctc agacctggct
     2821 ctgtatcgat accattcata caaagactta tccgagttcc tgagaggact tgtaatgaac
     2881 tacccgcaca ttacaaacct taccactttg ggacagagtg ttgagtatcg tcacatttgg
     2941 tccctggaga tctccaataa gcccaacata tcagaacctg aagaaccgaa gattcgtttt
     3001 gttgctggta tccatggaaa cgctccagtt ggaactgaac tgctcttggc tctggcagaa
     3061 tttctttgcc tgaattacaa aaggaaccca gttgttaccc aattggttga caggactaga
     3121 attgtgattg ttccctctct gaatccagat gggcgagagc gtgctcaaga gaaagactgc
     3181 acctcaaaga ctgggcacac aaatgctcat ggcaaagacc tggacacaga ctttacaagt
     3241 aatgcttctc agcctgagac caaagccatc atcgaaaact tgattcaaaa gcaggacttc
     3301 agtctttcca ttgccttaga tggtggttct gtgctggtca catatccgta tgataaacca
     3361 gtgcagacag tggaaaacaa agaaacttta aagcatttgg catctcttta tgcaaataac
     3421 catccatcaa tgcacatggg tcagcccagt tgcccaaata attcagatga gaacatacct
     3481 ggaggagtga tgcggggagc cgagtggcac agtcacctgg gcagcatgaa ggattatagt
     3541 gtcacctatg gccattgccc agaaatcacg gtatacacaa gctgctgcta cttcccaagt
     3601 gcagctcagc tccctgccct atgggcagag aacaagaagt ctctccttag catgctggtg
     3661 gaggtccaca aaggagtcca cgggttagta aaagacaagg ctggtaaacc aatctcgaaa
     3721 gcagtcattg tactcaatga aggaataaaa gtatacacaa aggagggggg ttatttccat
     3781 gtgctcctag ctcctggagt ccataacatc aacgcaattg ctgatgggta ccagcagcag
     3841 cacacacagg tctttgtgca tcatgatgca gccagttctg tggtaatagt ctttgataca
     3901 gataaccgga tatttggttt gccaagggaa ctcgtggtaa ctgtgtcagg tgccactatg
     3961 tcagcactga tcctaacggc ttgcatcatt tggtgcatct gctccatcaa gtctaataga
     4021 cacaaagatg gcttccaccg gctgcggcag catcatgatg aatatgaaga tgaaattcgc
     4081 atgatgtcaa ctggctctaa gaagtccctc ctaagccatg agttccagga tgaaacggac
     4141 acagaggagg aaacattata ttctagcaaa cattgaaaag cacggtttgc atatctccct
     4201 gtatacgtac caggcaaaat gacagctctt cttgggagac actgcagtaa gaagagaaat
     4261 tccttccgcc ttcaaagagc tttgggaagt tagcctgcta aattcatact ctctgaatgt
     4321 cacaggcagt tttgaacttc ccttccttaa agtactctta accttttctt taaaaaaaaa
     4381 aatctgattt ctatttatgc agcagaagat ggggcagccg ctttgtttcc ctttttaatt
     4441 taagacgagc tgttcagaga ctctatagag acagcataaa gccagctagt agatgttgta
     4501 tcttgcacat cagacattta ctagtggctt tagttttgtt ctctttaatt taaaggccaa
     4561 aagaatccag aaacattaag gcagggacac cagtcagact ctgacacaaa gctttaaaaa
     4621 ctcgagattt ttctccatct actgaggagt tctcttctcc agttagcaca tagctggggt
     4681 ttctcttatt caggtctaat ggaggctgga tgatgcttag acagatctga cattaggaaa
     4741 tggaataaac gggcttccgt atttgtcttt ctacctgttt ccaagctggg tcagaactgg
     4801 tgggctgtgc tctcagcagg attttactac ctctcttgta aggtttagca aagttctaga
     4861 tatctttatc ctagaggaga actcactggc tttgctgtgg aggcaccaga tgtcccatga
     4921 gtagaggtga aagggagatg gagcagaagc aaggacgttg tctgtcttat cctggtaaaa
     4981 cccataggtg ctgctgcttt atctgtgaag cactcattct cctaggaacg cctgttcctt
     5041 agcatttcct acatttcagc ccttctgtgt gtacacctgc ggtttccata tgacccacac
     5101 ctaaaggttc tgaattctac tgctgaaact atctaaaagt ggaagaaacc tacttgcaca
     5161 ttctcagtac acttggatcc aaaatgtcta cacttgatgc tccggcccaa gcctctgccc
     5221 tgtgatggca tactgtcatg gagatagtgt ggcctctgca catgggcctc caaaagtaat
     5281 tcagtccttt gtcctatgat tcccttgaca gtctttttct ttttcttttt ttgatcaagc
     5341 aattatgtta aaattttcag ttctaagctt tgaaatatgg ttctttccat gtaaaaaagt
     5401 caactgaagg actgccatgt gatagaacat tggtatgaag gtgtcctctt caatgccagt
     5461 caggcctaaa agattggtat tttattgtgt ctgtctgaat gctgttcagt ggaatgatgc
     5521 tttttgtaag tgtgagtctt accaatgacg taacagttta atatctttga atgtttttaa
     5581 tggccaagtt gctgctgaac ttgtactaaa tcaggggatc acaaaactag ctcttacctt
     5641 tccaaactgc attcatgcca ttgatgtatc agttacccta aggctcgact cacccaggtc
     5701 actcggccac acttggtgag gaatgcaccc aagtggctgt gtaaagttga gatcttagtt
     5761 gatggaaggg gctaatgaga tcttggtatc tgttagtcac ggtcacttag gtggcttagg
     5821 tccagctgtt ctggaatctg tcctggtatc agcatatctg aaccttgctt ctctgcatga
     5881 acagaacaat tagtggcagt taatgctaat gaagagcaca tgactccatc tcttccggta
     5941 atgctttgtt ttcctaaatg atgtgtattg ttctttttca gctttatttt taaaagtgcc
     6001 aagtcagaaa accaacaagt ggcctgtggc tgggccctgc ttgggacaaa tagaaaccaa
     6061 gttcatgtga cagccttcac gttactagag ttcactaaag gacactttcc acttgttctc
     6121 tggcattaag tgtgtcttta acagttcatc tcagcagtca caggccatgc cttggtcaca
     6181 ggccatgcct tcttaagtat gtatgaaacc tttttagaga tgaatatata gaatagttct
     6241 cttagtcatc ttttcctgaa atgaaaccca aattctgctc taagttttga gtctttaatg
     6301 aacttctaat gtactgaggc ggaaaatccg gcctccccag cctgccacct atgaacatga
     6361 atgtacaaga cccatgacta caagactttg ttcttagccc agccttcttt gggttgtgaa
     6421 accgatctaa tcctacacta cttcggcagc cgaggacact gaagccatat ggggtgggca
     6481 gtgcatgcct ccagtgtttc tcctggagac cttccatttc ttcagagtcc tggactcaag
     6541 tgtcacagta ttagaagttt gccccagtct gagatgtgcc tttcctttgc tcacaaggtg
     6601 ttgctttgtc ctcgtgatga gtttataagc cttcttccct ccctgctcct taacaaaaac
     6661 aatgtgatgg atcggtgatg ttcacagttc tccctgtgcg gatgcacttg tgctcatagg
     6721 gtttggtaag atgatctcaa gtaactacac cagctttggt gtagcagtga actccgggtg
     6781 gtgctgggat ctgatccaac gaaaaacact tgccattctc accgaagaga actggctttg
     6841 ggactctgtt aactttgggg aaggaaacat tgtatgtttg gctcagtgtg cttggctggt
     6901 taatctttgg taatttcacc tgaatgagat ttgatgaatt aatgaatatt gaatttaaaa
     6961 ctaattatga gtgaaaaata aaagggtcgt gcttatgtct gaacttgctg cgtttctgag
     7021 ctagcaccag ctcaccagga accacggctc aatactccat tcatttccac ctgtccccag
     7081 cattagaggt ttctcgtctg ccagactcac actcctgcca ggtttggtcc ctgctctctc
     7141 agaagcttct tggctatgaa catgtcatgg tgtcctgcag tgtgggtctc tggtggattg
     7201 ttttatggta gcacccaagt atcttccccc aatttttcct ttattgttat tactaaaatt
     7261 ccactaatgg ttaaatattc aatgatcttt ctgtctagca acttgttgat aactttaggt
     7321 ttctgatttg ttttaattat agcagttttg gggggtgaat agggccttcg attaatgtca
     7381 attgaatttg ggtttctagt tttttgaaga aaaccctccc aaatacactt ttcctttata
     7441 cttggaaaaa cttcattaat agttccactt aactctcaaa gtattatcct ggttgatttt
     7501 gaaatttgaa aataggttac cattttgagg caattagata aaaattatgt aaatacagac
     7561 aattacaatg tttataaata gtgtaacatg aatgtactag ctacattcaa tgctgcagat
     7621 tttttggaag tgtgacatgg tattttttta tgttcctttt acctcttttt ttttccaaat
     7681 acttccccag atccaaaatt ctccacaaca atttctatga cataacaccc atttgtctta
     7741 agtgcttcag tcttttgttt tatttcatgc actgtgcctt caaaatgaaa acttaaaagg
     7801 gactttaaaa gaattgaata gtagttttaa aaagttaatc tgtgtaattt atgtgaaatc
     7861 taactgtact gaggtccttt gttttttata tgtaaacaga tctactaatc ctgtataaaa
     7921 gttattttat gatgtttgtc tttctttgtg tgttgtctca taagctttat tcaaaaacag
     7981 tagacggtta ctgctcaaat cctgaaagtt ttaagcttag tttttctacc taacttgaag
     8041 agaaaatagt accagaggca ggatatgggg aaccacctat aaagtgttcc catctttatg
     8101 aattgactta cagaaggttt tgtttcagaa gtgactgttt acatagcagc cacaactgtg
     8161 cagcatccag aatgatgcgt tcaggagcac cacacacagt agccacacag ggctttacca
     8221 cggcacagcc cactccacag gtatcctatg tgctgccttt cagatcagga acgcccaaga
     8281 ggcttataga cccatgctac atggtgaagc acagttagaa tgacctgtcc tggcatctca
     8341 ggcatgaccg tgatgaagtc agtgtcccct ggttatttaa caagttcccc caaaattgct
     8401 gctctaatgg gttgggaatg tagagctatg taagaaacat gggctgtgct gacagggaac
     8461 tcttggtcca gacaagagaa gcagagacag ccataggctg tgcttcagtg gcatttggcc
     8521 tctctcagaa gtctcctgag gaagttctga gaggtttcag tctgggccac ttgtgataga
     8581 tgtcatttgc aatgtgacct tggattgcaa gaatctcaga gcaggctcag catctcagcc
     8641 tcatgtctgt taaggaacca actggaagag aatgggaggt gggttgagga gatggagtca
     8701 gcgtggtgtt tggctccaag ctgagtacct agagtagcca gtgtccttcc cttcctttgt
     8761 tgtttcctgg tctgcttggt ggtatgttgt cagccatctg aactgagatc tcttaaaggc
     8821 catcttttta atttagaaga catttagata agaaaacttc ctggaacttg cttccactct
     8881 gtggttcact aggttgcctg aaatatgata aaagttttaa ttttccaggt gcttcatact
     8941 tgtttttagg tgagattaga ctatccatgt tacttcgtag aggcttggtt taactgttgg
     9001 aaatcctatc gtgagtttta gcactttttc atgcttgaag ctagatgtct tttggttgtt
     9061 tttataaaca taatctacta attgtgctca gtttttcgga tgtctaggaa ttgttaccag
     9121 caatgtaaat acagtggcca ttgctcacat gc
//
