LOCUS       NM_019775               1503 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus carboxypeptidase B2 (Cpb2), mRNA.
ACCESSION   NM_019775
VERSION     NM_019775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Meijers,J.C.M., van der Harst,J., Marx,P.F., Sahbaie,P., Clark,D.J.
            and Morser,J.
  TITLE     Brain Expression of CPB2 and Effects of Cpb2 Deficiency in Mouse
            Models of Behavior
  JOURNAL   Thromb Haemost 124 (1), 4-19 (2024)
   PUBMED   37532120
  REMARK    GeneRIF: Brain Expression of CPB2 and Effects of Cpb2 Deficiency in
            Mouse Models of Behavior.
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Zhou,Q., Zhao,L., Shao,Z., Declerck,P., Leung,L.L.K. and Morser,J.
  TITLE     Both plasma basic carboxypeptidases, carboxypeptidase B2 and
            carboxypeptidase N, regulate vascular leakage activity in mice
  JOURNAL   J Thromb Haemost 20 (1), 238-244 (2022)
   PUBMED   34626062
  REMARK    GeneRIF: Both plasma basic carboxypeptidases, carboxypeptidase B2
            and carboxypeptidase N, regulate vascular leakage activity in mice.
REFERENCE   3  (bases 1 to 1503)
  AUTHORS   Ni,R., Neves,M.A.D., Wu,C., Cerroni,S.E., Flick,M.J., Ni,H.,
            Weitz,J.I., Gross,P.L. and Kim,P.Y.
  TITLE     Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)
            attenuates fibrin-dependent plasmin generation on
            thrombin-activated platelets
  JOURNAL   J Thromb Haemost 18 (9), 2364-2376 (2020)
   PUBMED   32506822
  REMARK    GeneRIF: Activated thrombin-activatable fibrinolysis inhibitor
            (TAFIa) attenuates fibrin-dependent plasmin generation on
            thrombin-activated platelets.
REFERENCE   4  (bases 1 to 1503)
  AUTHORS   Basu,S., Liang,H.P.H., Hernandez,I., Zogg,M., Fields,B., May,J.,
            Ogoti,Y., Wyseure,T., Mosnier,L.O., Burns,R.T., Carlson,K. and
            Weiler,H.
  TITLE     Role of thrombomodulin expression on hematopoietic stem cells
  JOURNAL   J Thromb Haemost 18 (1), 123-135 (2020)
   PUBMED   31628891
REFERENCE   5  (bases 1 to 1503)
  AUTHORS   Wyseure,T., Yang,T., Zhou,J.Y., Cooke,E.J., Wanko,B., Olmer,M.,
            Agashe,R., Morodomi,Y., Behrendt,N., Lotz,M., Morser,J., von
            Drygalski,A. and Mosnier,L.O.
  TITLE     TAFI deficiency causes maladaptive vascular remodeling after
            hemophilic joint bleeding
  JOURNAL   JCI Insight 4 (19), 128379 (2019)
   PUBMED   31465300
  REMARK    GeneRIF: TAFI deficiency causes maladaptive vascular remodeling
            after hemophilic joint bleeding.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1503)
  AUTHORS   Swaisgood,C.M., Schmitt,D., Eaton,D. and Plow,E.F.
  TITLE     In vivo regulation of plasminogen function by plasma
            carboxypeptidase B
  JOURNAL   J Clin Invest 110 (9), 1275-1282 (2002)
   PUBMED   12417566
  REMARK    GeneRIF: role of pCPB as a modulator of the pivotal functions of
            plasminogen in fibrinolysis and cell migration in vivo.
REFERENCE   7  (bases 1 to 1503)
  AUTHORS   Nagashima,M., Yin,Z.F., Zhao,L., White,K., Zhu,Y., Lasky,N.,
            Halks-Miller,M., Broze,G.J. Jr., Fay,W.P. and Morser,J.
  TITLE     Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is
            compatible with murine life
  JOURNAL   J Clin Invest 109 (1), 101-110 (2002)
   PUBMED   11781355
REFERENCE   8  (bases 1 to 1503)
  AUTHORS   Ong,K., Horsfall,W., Conway,E.M. and Schuh,A.C.
  TITLE     Early embryonic expression of murine coagulation system components
  JOURNAL   Thromb Haemost 84 (6), 1023-1030 (2000)
   PUBMED   11154109
REFERENCE   9  (bases 1 to 1503)
  AUTHORS   Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N.,
            Campbell,W. and Okada,H.
  TITLE     Pro-carboxypeptidase R is an acute phase protein in the mouse,
            whereas carboxypeptidase N is not
  JOURNAL   J Immunol 165 (2), 1053-1058 (2000)
   PUBMED   10878383
REFERENCE   10 (bases 1 to 1503)
  AUTHORS   Marx,P.F., Wagenaar,G.T., Reijerkerk,A., Tiekstra,M.J., van
            Rossum,A.G., Gebbink,M.F. and Meijers,J.C.
  TITLE     Characterization of mouse thrombin-activatable fibrinolysis
            inhibitor
  JOURNAL   Thromb Haemost 83 (2), 297-303 (2000)
   PUBMED   10739389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA048136.1, AK004045.1 and
            CO807338.1.
            
            On Aug 14, 2009 this sequence version replaced NM_019775.2.
            
            Summary: This gene encodes carboxypeptidase B, a zinc-dependent
            metalloprotease that cleaves peptide bonds at the C-terminus of
            protein substrates. The encoded preproprotein undergoes proteolytic
            activation to generate a mature, functional enzyme, and secreted
            into plasma. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF164524.1, BC089577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AA048136.1         1-27
            28-1473             AK004045.1         1-1446
            1474-1503           CO807338.1         508-537
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 39.73 cM"
     gene            1..1503
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /note="carboxypeptidase B2"
                     /db_xref="GeneID:56373"
                     /db_xref="MGI:MGI:1891837"
     exon            1..139
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1337
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /EC_number="3.4.17.20"
                     /note="carboxypeptidase R; carboxypeptidase B2 (plasma);
                     carboxypeptidase U; thrombin-activable fibrinolysis
                     inhibitor; thrombin-activatable fibrinolysis inhibitor"
                     /codon_start=1
                     /product="carboxypeptidase B2 preproprotein"
                     /protein_id="NP_062749.2"
                     /db_xref="CCDS:CCDS27277.1"
                     /db_xref="GeneID:56373"
                     /db_xref="MGI:MGI:1891837"
                     /translation="MKLHGLGILVAIILYEQHGFAFQSGQVLSALPRTSRQVQLLQNL
                     TTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVDSVKAHLNVSRIPFNVLMNNVEDLIE
                     QQTFNDTVSPRASASYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSFEKYPLYVL
                     KVSGKEQRIKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENLYTRLLRHVDFYI
                     MPVMNVDGYDYTWKKNRMWRKNRSAHKNNRCVGTDLNRNFASKHWCEKGASSSSCSET
                     YCGLYPESEPEVKAVADFLRRNIDHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSL
                     VASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYG
                     FLLPERYIKPTCAEALAAISKIVWHVIRNT"
     exon            140..215
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            216..340
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            341..449
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            450..551
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            552..656
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            657..767
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            768..861
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1064
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1152
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1477
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /note="hexamer: AATAAA"
     polyA_site      1477
                     /gene="Cpb2"
                     /gene_synonym="1110032P04Rik; 4930405E17Rik; CPR; Cpu;
                     TAFI"
                     /note="major polyA site"
ORIGIN      
        1 gaaggctctt aggcaattag ttacctggga ctttctcccc aagggcttgc tcacaagtca
       61 ctgttgggat gaagcttcat ggccttggaa tcctggtagc catcatcctc tatgagcagc
      121 atggcttcgc ctttcagagt ggccaggttt tatctgctct tccaagaacc tccaggcaag
      181 ttcaactact tcagaatctt actacaacgt atgaggtcgt tctctggcag ccagtgacag
      241 ctgaattcat cgagaagaaa aaggaagtcc acttttttgt gaatgcgtct gatgtcgaca
      301 gtgtcaaagc gcatttaaat gtgagcagaa ttccatttaa cgttctgatg aacaacgtgg
      361 aggacctaat tgaacagcag actttcaatg acacggtcag cccccgcgcc tccgcttcat
      421 actatgagca gtatcactcg ctaaatgaaa tctattcctg gatagaagtc ataactgaac
      481 agcatcctga catgctccag aaaatctaca tcggatcatc attcgagaag tacccacttt
      541 atgttttaaa ggtctcagga aaggaacaaa gaatcaaaaa tgccatctgg atcgactgtg
      601 gaatccatgc cagagaatgg atttcacctg ctttctgttt gtggttcata ggctacgtga
      661 cacaattcca tgggaaagaa aatctgtata ccagacttct gaggcacgtg gatttctaca
      721 tcatgcccgt gatgaacgtg gatggctatg actacacgtg gaaaaagaat cgaatgtgga
      781 ggaagaaccg ctctgctcac aagaacaacc gctgcgtggg cacagacctg aacaggaact
      841 tcgcttccaa acactggtgt gagaaaggtg cgtcaagttc ctcctgctct gaaacctact
      901 gtggacttta tcctgagtct gagccagagg tgaaggcagt ggctgacttc ttgagaagaa
      961 atatcgacca cattaaagct tacatcagta tgcactcata ctcccaacaa atactgtttc
     1021 cctattccta taacagaagc aaaagcaagg accacgaaga actgtctcta gtggccagcg
     1081 aagcagttcg tgcaattgaa agtattaata aaaacaccag gtacacacac ggcagtggct
     1141 cagaaagttt atatctagct cctggaggtt ctgacgattg gatctatgat ttgggcatca
     1201 aatattcgtt tacaattgag ctccgagata caggcagata cggattcttg ctgcctgaga
     1261 gatacatcaa acccacttgt gcagaagctt tggccgccat ctctaaaata gtttggcatg
     1321 tcatcaggaa cacttaatgc cctaacctcc gctctcatta tttttatttt attgatttca
     1381 gcaacactta actgttgcat tagcttctaa gttgaatcag tttccttggt tttgttgaag
     1441 aataaaaagc acactacttt gagcttaaga gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaa
//
