LOCUS       NM_029706               1503 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus carboxypeptidase B1 (Cpb1), mRNA.
ACCESSION   NM_029706 XM_130814
VERSION     NM_029706.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 1503)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1503)
  AUTHORS   Soggia,A., Ramond,C., Akiyama,H., Scharfmann,R. and Duvillie,B.
  TITLE     von Hippel-Lindau gene disruption in mouse pancreatic progenitors
            and its consequences on endocrine differentiation in vivo:
            importance of HIF1-alpha and VEGF-A upregulation
  JOURNAL   Diabetologia 57 (11), 2348-2356 (2014)
   PUBMED   25186293
REFERENCE   5  (bases 1 to 1503)
  AUTHORS   Hale,M.A., Swift,G.H., Hoang,C.Q., Deering,T.G., Masui,T.,
            Lee,Y.K., Xue,J. and MacDonald,R.J.
  TITLE     The nuclear hormone receptor family member NR5A2 controls aspects
            of multipotent progenitor cell formation and acinar differentiation
            during pancreatic organogenesis
  JOURNAL   Development 141 (16), 3123-3133 (2014)
   PUBMED   25063451
REFERENCE   6  (bases 1 to 1503)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1503)
  AUTHORS   Chatterjee,S., Lardinois,O., Bonini,M.G., Bhattacharjee,S.,
            Stadler,K., Corbett,J., Deterding,L.J., Tomer,K.B., Kadiiska,M. and
            Mason,R.P.
  TITLE     Site-specific carboxypeptidase B1 tyrosine nitration and
            pathophysiological implications following its physical association
            with nitric oxide synthase-3 in experimental sepsis
  JOURNAL   J Immunol 183 (6), 4055-4066 (2009)
   PUBMED   19717511
  REMARK    GeneRIF: CPB1 colocalization, coupling, and proximity to NOS-3 in
            the sinus-lining cells of spleen red pulp could explain the
            site-specific tyrosine nitration and inactivation of CPB1
REFERENCE   8  (bases 1 to 1503)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
REFERENCE   9  (bases 1 to 1503)
  AUTHORS   Suzuki,T., Li,W., Zhang,Q., Novak,E.K., Sviderskaya,E.V.,
            Wilson,A., Bennett,D.C., Roe,B.A., Swank,R.T. and Spritz,R.A.
  TITLE     The gene mutated in cocoa mice, carrying a defect of organelle
            biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3
            gene
  JOURNAL   Genomics 78 (1-2), 30-37 (2001)
   PUBMED   11707070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ831426.1, AK003061.1, AK008678.1 and AC158937.5.
            
            On Jan 23, 2016 this sequence version replaced NM_029706.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138762.1, AK003061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               BQ831426.1         13-129
            118-767             AK003061.1         53-702
            768-783             AK008678.1         436-451
            784-1392            AK003061.1         717-1325
            1393-1393           AC158937.5         40127-40127
            1394-1496           AK003061.1         1327-1429
            1497-1503           AC158937.5         40231-40237
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.29 cM"
     gene            1..1503
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /note="carboxypeptidase B1"
                     /db_xref="GeneID:76703"
                     /db_xref="MGI:MGI:1923953"
     exon            1..148
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1331
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /EC_number="3.4.17.2"
                     /note="carboxypeptidase B1 (tissue)"
                     /codon_start=1
                     /product="carboxypeptidase B precursor"
                     /protein_id="NP_083982.1"
                     /db_xref="CCDS:CCDS17263.1"
                     /db_xref="GeneID:76703"
                     /db_xref="MGI:MGI:1923953"
                     /translation="MLLLLALVSVALAHASEENFDGNRVFRVSVHDEDDVSLIQELAN
                     TKQIDFWKPDSATQVKPLTTVDFHVKAEDVVDVENFLEENEVLYEVLISNVKHILESQ
                     FDSHTRASGHSYTKYNNWETIEAWIQQVANDNPDLVSKRVIGTTFEGRNMYVLKIGKD
                     RPNKPAFFIDCGFHAREWISPAFCQWFVREAVRTYKQEIHMKRLLDELDFYVLPVVNI
                     DGYVYTWAKDRMWRKTRSTTAGSSCFGVDPNRNFDAGWCEVGASRSPCSDTYCGPTPE
                     SEKETKALADFIRQNLSSIKAYLTVHSYSQMMLYPYSYDYKLPENYEELNALVKGAAK
                     ELSTLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGFFGFLLPESQI
                     RQTCEETMLAVKYIANYVLEHPY"
     exon            149..224
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..349
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            350..449
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..551
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..653
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            654..764
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..855
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1058
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1143
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1503
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1501
                     /gene="Cpb1"
                     /gene_synonym="0910001A18Rik; 1810063F02Rik;
                     2210008M23Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcagagtgga gaagaacaga aagaacactc cgggctataa aagcaagaag aacccaggtt
       61 gcccagtaat tcagacaggc accatgttgc tgctactggc cctggtgagt gtggccctgg
      121 ctcatgcttc tgaggagaac tttgatggca accgggtgtt ccgtgtcagt gtacatgatg
      181 aagatgacgt cagcttaatt caggaactag ccaacaccaa acagattgat ttctggaaac
      241 cagattctgc tacacaagtg aaacctctta ctacagttga ctttcatgtt aaagcagaag
      301 atgtcgttga tgtggagaac tttctcgagg agaatgaagt tctctatgag gtattgataa
      361 gcaacgtgaa acatattctg gaatcccagt ttgacagcca cacccgtgca agtggacaca
      421 gctacaccaa gtacaacaac tgggaaacga tagaggcatg gattcaacaa gttgccaatg
      481 ataatccaga ccttgtttct aagagagtca ttggaaccac atttgaagga cgtaacatgt
      541 atgttctcaa gattggcaaa gatagaccaa ataagcctgc cttcttcatc gactgtggtt
      601 tccacgcaag agagtggatt tctcctgcat tctgtcagtg gtttgtgaga gaggctgtcc
      661 gtacctataa acaagagatc cacatgaaac gacttcttga cgaactggac ttttatgttc
      721 tgcctgtggt caacattgac ggctatgtct acacatgggc taaggaccga atgtggagaa
      781 aaacccgctc tactacggct ggaagttcct gctttggtgt agaccccaac agaaattttg
      841 atgctggctg gtgtgaagtg ggagcttctc ggagtccctg ctctgacact tactgtggac
      901 caactccaga gtcagaaaaa gagacaaagg ccctggcaga tttcatccgc cagaacctct
      961 cctccatcaa ggcctatctg accgtccact cctactcaca gatgatgctc tatccttact
     1021 cctacgacta taagctgccc gagaactatg aggagctgaa tgccctggtg aaaggtgcag
     1081 caaaggagct ttccactctg catggcacca agtacacata tggcccagga gctacaacga
     1141 tctatcctgc tgctggggga tctgacgact gggcttatga tcagggaatc aaatattcct
     1201 ttacctttga actccgggat aaaggcttct ttggctttct gcttcctgag tctcagatcc
     1261 gccaaacctg tgaggagaca atgcttgcag tcaagtacat tgccaattat gtcctagagc
     1321 atccatatta gtgaagaatc tggattgcct tattttaaaa ttcttactgt tcattccttg
     1381 tctgatgtga cttcgtttgt ttggaggttt gcagattcta atctttctca taattttctt
     1441 gatgtaatga ccaattggac ccctgaaaac atcttaataa aatcctatca ttattggaaa
     1501 aca
//
