LOCUS       NM_027926               2738 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus carboxypeptidase A4 (Cpa4), mRNA.
ACCESSION   NM_027926
VERSION     NM_027926.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Gao,W., Guo,N., Zhao,S., Chen,Z., Zhang,W., Yan,F., Liao,H. and
            Chi,K.
  TITLE     Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through
            activating PI3K-AKT-mTOR signaling
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32347291
  REMARK    GeneRIF: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy
            through activating PI3K-AKT-mTOR signaling.
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Inagawa,M., Nakajima,K., Makino,T., Ogawa,S., Kojima,M., Ito,S.,
            Ikenishi,A., Hayashi,T., Schwartz,R.J., Nakamura,K., Obayashi,T.,
            Tachibana,M., Shinkai,Y., Maeda,K., Miyagawa-Tomita,S. and
            Takeuchi,T.
  TITLE     Histone H3 lysine 9 methyltransferases, G9a and GLP are essential
            for cardiac morphogenesis
  JOURNAL   Mech Dev 130 (11-12), 519-531 (2013)
   PUBMED   23892084
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Tanco,S., Zhang,X., Morano,C., Aviles,F.X., Lorenzo,J. and
            Fricker,L.D.
  TITLE     Characterization of the substrate specificity of human
            carboxypeptidase A4 and implications for a role in extracellular
            peptide processing
  JOURNAL   J Biol Chem 285 (24), 18385-18396 (2010)
   PUBMED   20385563
  REMARK    GeneRIF: CPA4 functions in neuropeptide processing and regulation
            in the extracellular environment
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Hald,J., Hjorth,J.P., German,M.S., Madsen,O.D., Serup,P. and
            Jensen,J.
  TITLE     Activated Notch1 prevents differentiation of pancreatic acinar
            cells and attenuate endocrine development
  JOURNAL   Dev Biol 260 (2), 426-437 (2003)
   PUBMED   12921743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155656.10, AK030705.1 and
            AK003823.1.
            
            On Jul 19, 2016 this sequence version replaced NM_027926.2.
            
            Summary: This gene encodes a member of the carboxypeptidase A
            family of zinc metalloproteases that could be involved in the
            histone hyperacetylation pathway. The encoded preproprotein
            undergoes proteolytic processing that removes the N-terminal
            activation peptide to generate a functional enzyme. This gene is
            located in a cluster of carboxypeptidase genes on chromosome 6.
            [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061206.1, AK030705.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC155656.10        33133-33139
            8-2068              AK030705.1         1-2061
            2069-2099           AK003823.1         960-990
            2100-2100           AC155656.10        56543-56543
            2101-2691           AK003823.1         992-1582
            2692-2692           AC155656.10        57135-57135
            2693-2738           AK003823.1         1584-1629
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     gene            1..2738
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /note="carboxypeptidase A4"
                     /db_xref="GeneID:71791"
                     /db_xref="MGI:MGI:1919041"
     exon            1..93
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            94..175
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            176..310
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            311..406
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..508
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            509..613
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..724
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            725..815
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1015
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1100
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..2738
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2049..2054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2069
                     /gene="Cpa4"
                     /gene_synonym="1110019K20Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtatgtgac tggcgccctt gagacatgaa gtggctactg ttctttgggg ccctgattgg
       61 ggcaggcatc tgcggccgag ataaattctt tggggaccaa gtttttagga ttaatgtcag
      121 aaatggagac gagatcagaa aactgactga gctagtgaat tctgaccact taaagctcag
      181 tgtctggaaa tctccctcca cttttgatcg gcccgtggat attctcgtcc cttctgtcag
      241 cttgctccca gtcaagtcct tcctgaagtc ccagggttta gactactccg tgacaattga
      301 ggacctccag gcccttttag ataacgaaga tgaagaaatg cagcacaatg aagggataga
      361 gcggagtggt gacttcaact acggagctta ccatcccctg gaggctattt accacgagat
      421 ggacagtatt gccacagact ttcctgagct ggtgagcaga gtgaagattg gagagacatt
      481 tgaaaagcgg cccatgtatg ttctaaagtt cagcacggga ggaggcaaga agcggccagc
      541 catttggttg aatgcaggca tccatgcccg tgagtggatc tcacaggcca cagccatctg
      601 gacagcgagg aagattgtaa ctgattataa aaaggacccg gctatcacct ccatcttgaa
      661 gaaagtggat attttcttgt tgcccgtggc caatcctgat ggatatgtgt acacgcaaag
      721 ccagaaccga ttatggagaa agacgcggtc ccggaaccca ggaagccgct gtgttggagc
      781 cgatccaaac agaaactgga atgctagttt tgcaggagag gggaccagtg ataacccttg
      841 ctctgaagtg taccatggct cccaccccaa ttctgaagtg gaggtgaaat cggtggtgga
      901 tttcattcaa aagcatggga acttcaaatg cttcattgac ctgcatagct actcacagct
      961 gctgatgtat ccctatgggt acacagtcaa gaaggccccg gatgctgagg agctggacga
     1021 tgtggcgagg aatgcagccc aagccctggc ttctctctcg ggcactaagt accgagtggg
     1081 cccaacttgc accaccgtct atccagctag tgggagcagc gttgactggg catacgacaa
     1141 tggcatcaag tatgctttca catttgagct gagagacact gggtactacg gcttcctctt
     1201 gccagccagc cagatcatcc ccaccgcgga ggagacctgg ctagggctga agaccatcat
     1261 ggaacatgtt cgggaccacc tctactagtc aaagaacact tacattttac ctctaagcca
     1321 ccacttagtt taacatcact tcttcacgga taggtcggag ccttctgagt cggcagagaa
     1381 ctcagctgcc tcctcttcag catcgcttca cagagatcac acctcctggt agtgagcacg
     1441 tgagggacac ttcttccgtg gagtggtcgg tcccgctgct ctactgacct ttggtgtata
     1501 tacctctcta ttcacgcagc tggttaggcg ggccacagag gtcatgactt cctggtggcc
     1561 tatggctacc tcacctttag aactttgatg gtcctctagt ctttacctgt agccttgggt
     1621 agggcaccat gggaggtgcc aggggagaca gtgcctgtct tcagaactct gtaatttctc
     1681 cttcaaacat gttctctctt tttatttatt tattttttct tttagacagg gtcttactat
     1741 tttgcccatg ctagcctgaa gctcctgggg tcaaactgta cccttccccg cctcctcctt
     1801 gccccatctt cccagtagtg gtatgcagct caggaacaca cttttctttg aggaaacaaa
     1861 tcctattaga ccatcatcat tgctctttct agctgcgtat tcttcctatt cctcctcctc
     1921 ctcctcctca tcatcatcat catggagaca ggatctcttt atgtagccat gactgtcctg
     1981 gagcttgcta tatagaccaa gctggccttg aacttacaga gatctgcctg gctctgcctt
     2041 cagcatacat taaagatgta ttatcaccat acctggctca tcttaattct tttctgttgg
     2101 ctcgagcaca cagtcaagct cttgtccatt acaaggctca gtgttcaggt gatgcccttt
     2161 gctttttaaa ccgtcttttc tttatatgtg gtgttactgg gatcctctaa gagggtcagt
     2221 tagttatgtt gtaggcaagg ctctcagggg tcatggggaa acggggctag attgcaggga
     2281 cagattagca ccatctgtcc tcttggcctc accaccactc tgccttttga actcacttca
     2341 aagattttga cctcacccca caggtcctaa atcatcccta gagcctggat aatctcaggg
     2401 cctcagcaca ctccagctcc ggctctggtg tgccctgcgt ttcaggctcc tggtttctgt
     2461 cctcctgtgt ttaatgttac tttctatttt gcatcctgaa ccctgagtac ctacctgaaa
     2521 caagacttcg tcaacagcta gacacttcct gttctctcct tagcacatac tgtctgccct
     2581 gtttgtgttg tggtttttgt gtttttgttt tcttgtgggt attttttttt ttctttttct
     2641 gttttcaatc atgtctataa atcttaacct tctgcctagg atttgggcag catctggtgt
     2701 gtcctcataa gccaataaat attcaatatg ggtctcct
//
