LOCUS       NM_007753               1458 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus carboxypeptidase A3, mast cell (Cpa3), mRNA.
ACCESSION   NM_007753
VERSION     NM_007753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Waern,I., Akula,S., Allam,V.S.R.R., Taha,S., Feyerabend,T.B.,
            Abrink,M. and Wernersson,S.
  TITLE     Disruption of the mast cell carboxypeptidase A3 gene does not
            attenuate airway inflammation and hyperresponsiveness in two mouse
            models of asthma
  JOURNAL   PLoS One 19 (4), e0300668 (2024)
   PUBMED   38578780
  REMARK    GeneRIF: Disruption of the mast cell carboxypeptidase A3 gene does
            not attenuate airway inflammation and hyperresponsiveness in two
            mouse models of asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Li,Y., Di,C., Song,S., Zhang,Y., Lu,Y., Liao,J., Lei,B., Zhong,J.,
            Guo,K., Zhang,N. and Su,S.
  TITLE     Choroid plexus mast cells drive tumor-associated hydrocephalus
  JOURNAL   Cell 186 (26), 5719-5738 (2023)
   PUBMED   38056463
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Lin,C.J., Herisson,F., Le,H., Jaafar,N., Chetal,K., Oram,M.K.,
            Flynn,K.L., Gavrilles,E.P., Sadreyev,R.I., Schiffino,F.L. and
            Tanzi,R.E.
  TITLE     Mast cell deficiency improves cognition and enhances
            disease-associated microglia in 5XFAD mice
  JOURNAL   Cell Rep 42 (9), 113141 (2023)
   PUBMED   37713312
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Plum,T., Binzberger,R., Thiele,R., Shang,F., Postrach,D., Fung,C.,
            Fortea,M., Stakenborg,N., Wang,Z., Tappe-Theodor,A., Poth,T.,
            MacLaren,D.A.A., Boeckxstaens,G., Kuner,R., Pitzer,C., Monyer,H.,
            Xin,C., Bonventre,J.V., Tanaka,S., Voehringer,D., Vanden Berghe,P.,
            Strid,J., Feyerabend,T.B. and Rodewald,H.R.
  TITLE     Mast cells link immune sensing to antigen-avoidance behaviour
  JOURNAL   Nature 620 (7974), 634-642 (2023)
   PUBMED   37438525
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Jippo,T., Mizuno,H., Xu,Z., Nomura,S., Yamamoto,M. and Kitamura,Y.
  TITLE     Abundant expression of transcription factor GATA-2 in proliferating
            but not in differentiated mast cells in tissues of mice:
            demonstration by in situ hybridization
  JOURNAL   Blood 87 (3), 993-998 (1996)
   PUBMED   8562971
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Hara,T., Harada,N., Mitsui,H., Miura,T., Ishizaka,T. and
            Miyajima,A.
  TITLE     Characterization of cell phenotype by a novel cDNA library
            subtraction system: expression of CD8 alpha in a mast cell-derived
            interleukin-4-dependent cell line
  JOURNAL   Blood 84 (1), 189-199 (1994)
   PUBMED   8018917
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Zon,L.I., Gurish,M.F., Stevens,R.L., Mather,C., Reynolds,D.S.,
            Austen,K.F. and Orkin,S.H.
  TITLE     GATA-binding transcription factors in mast cells regulate the
            promoter of the mast cell carboxypeptidase A gene
  JOURNAL   J Biol Chem 266 (34), 22948-22953 (1991)
   PUBMED   1744088
REFERENCE   9  (bases 1 to 1458)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Stevens,R.L., Sugarbaker,D.J.,
            Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of cDNAs that encode human mast cell carboxypeptidase A,
            and comparison of the protein with mouse mast cell carboxypeptidase
            A and rat pancreatic carboxypeptidases
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9480-9484 (1989)
   PUBMED   2594780
REFERENCE   10 (bases 1 to 1458)
  AUTHORS   Reynolds,D.S., Stevens,R.L., Gurley,D.S., Lane,W.S., Austen,K.F.
            and Serafin,W.E.
  TITLE     Isolation and molecular cloning of mast cell carboxypeptidase A. A
            novel member of the carboxypeptidase gene family
  JOURNAL   J Biol Chem 264 (33), 20094-20099 (1989)
   PUBMED   2584208
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY113342.1, J05118.1 and
            BY584193.1.
            
            On Apr 1, 2010 this sequence version replaced NM_007753.1.
            
            Summary: This gene encodes a member of the carboxypeptidase A
            family of zinc metalloproteases and preproprotein that is
            proteolytically processed to generate a mature protein product.
            This product is released by mast cells and may be involved in the
            degradation of endogenous proteins and the inactivation of
            venom-associated peptides. Homozygous knockout mice for this gene
            exhibit impaired mast cell development. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088906.1, J05118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY113342.1         2-5
            5-1446              J05118.1           1-1442
            1447-1458           BY584193.1         396-407
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.25 cM"
     gene            1..1458
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /note="carboxypeptidase A3, mast cell"
                     /db_xref="GeneID:12873"
                     /db_xref="MGI:MGI:88479"
     exon            1..78
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            79..154
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            155..279
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            280..382
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            383..484
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            485..586
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            587..697
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            698..788
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            789..991
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1076
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1453
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /note="hexamer: AATAAA"
     polyA_site      1453
                     /gene="Cpa3"
                     /gene_synonym="MC-CPA"
                     /note="major polyA site"
ORIGIN      
        1 aagaaaaaac atgaggttct tcttgcttat ggctgtcatc tacactacac ttgcaattgc
       61 tcctgtccac tttgacaggg agaaggtatt ccgtgtgaaa ctccagaatg aaaagcacgc
      121 cagtgtcttg aagaacttga cccaaagcat tgagctcgac ttctggtatc cagatgctat
      181 ccatgatatt gctgtgaata tgactgtgga tttccgagtt agtgagaagg aatctcagac
      241 catccagtca accttggaac aacataaaat ccattatgaa attctgatac atgacctaca
      301 agaagagata gagaaacagt ttgatgtgaa agatgaaatc gcaggcaggc acagttatgc
      361 aaaatacaat gactgggaca agattgtttc ttggactgaa aaaatgttag aaaaacatcc
      421 tgagatggtt tcaaggatta aaattggatc aactgttgaa gataatccat tatatgtcct
      481 caagattggg aaaaaagatg gagaaagaaa ggctatcttt atggactgtg gcattcatgc
      541 acgtgaatgg atttctccag ctttctgtca gtggtttgtc tatcaggcaa ccaagagtta
      601 tggaaaaaat aaaatcatga ccaaactctt ggaccggatg aatttttacg ttctgcctgt
      661 attcaatgta gacggataca tttggtcatg gacacaggat cgaatgtgga gaaaaaaccg
      721 ttccaggaac caaaactcca cctgcattgg cactgacctc aacaggaact ttgatgtctc
      781 gtgggactct tctccaaaca ccaacaaacc atgcctcaat gtctacaggg gacctgcacc
      841 agagtctgag aaagagacaa aagctgtcac caacttcatt cgaagccatc tgaactcaat
      901 caaggcttat atcactttcc attcctactc gcagatgcta ttaattcctt atggctacac
      961 attcaaactg cctcctaacc accaggacct attgaaagtt gcaaggattg ccacggatgc
     1021 tctctcaact agatatgaaa cccgttacat ctacggccca atagcatcca caatttacaa
     1081 gacttcaggc tcttccttag actgggttta tgacctgggc atcaaacaca catttgcctt
     1141 tgagcttcgt gataaaggaa agtctgggtt tcttcttcca gaatcccgga taaagccaac
     1201 atgtaaagaa accatgcttt ctgtcaaatt tattgccaag tatatcctca agaatacttc
     1261 ctaatgaatt gcccttgttt tgaaacgtgc taatcaatgc ttgggtggag tctctccctg
     1321 gaaagacaac ctcctacatc acctggattc atccttctct tgctcatgaa gtcctgcatt
     1381 attttcttct tgtttctatt tactcccaac agccccactt taaaaagccc caataaagct
     1441 ttaagtaaat ccaaaaaa
//
