LOCUS       NM_001024698            1340 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus carboxypeptidase A2, pancreatic (Cpa2), mRNA.
ACCESSION   NM_001024698 XM_133021
VERSION     NM_001024698.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Desanlis,I., Paul,R. and Kmita,M.
  TITLE     Transcriptional Trajectories in Mouse Limb Buds Reveal the
            Transition from Anterior-Posterior to Proximal-Distal Patterning at
            Early Limb Bud Stage
  JOURNAL   J Dev Biol 8 (4), 31 (2020)
   PUBMED   33297480
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Cao,J., Spielmann,M., Qiu,X., Huang,X., Ibrahim,D.M., Hill,A.J.,
            Zhang,F., Mundlos,S., Christiansen,L., Steemers,F.J., Trapnell,C.
            and Shendure,J.
  TITLE     The single-cell transcriptional landscape of mammalian
            organogenesis
  JOURNAL   Nature 566 (7745), 496-502 (2019)
   PUBMED   30787437
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Scavuzzo,M.A., Hill,M.C., Chmielowiec,J., Yang,D., Teaw,J.,
            Sheng,K., Kong,Y., Bettini,M., Zong,C., Martin,J.F. and Borowiak,M.
  TITLE     Endocrine lineage biases arise in temporally distinct endocrine
            progenitors during pancreatic morphogenesis
  JOURNAL   Nat Commun 9 (1), 3356 (2018)
   PUBMED   30135482
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Vanhorenbeeck,V., Jenny,M., Cornut,J.F., Gradwohl,G.,
            Lemaigre,F.P., Rousseau,G.G. and Jacquemin,P.
  TITLE     Role of the Onecut transcription factors in pancreas morphogenesis
            and in pancreatic and enteric endocrine differentiation
  JOURNAL   Dev Biol 305 (2), 685-694 (2007)
   PUBMED   17400205
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Wells,J.M., Esni,F., Boivin,G.P., Aronow,B.J., Stuart,W., Combs,C.,
            Sklenka,A., Leach,S.D. and Lowy,A.M.
  TITLE     Wnt/beta-catenin signaling is required for development of the
            exocrine pancreas
  JOURNAL   BMC Dev Biol 7, 4 (2007)
   PUBMED   17222338
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1340)
  AUTHORS   Georgia,S. and Bhushan,A.
  TITLE     p27 Regulates the transition of beta-cells from quiescence to
            proliferation
  JOURNAL   Diabetes 55 (11), 2950-2956 (2006)
   PUBMED   17065330
REFERENCE   9  (bases 1 to 1340)
  AUTHORS   van Eyll,J.M., Passante,L., Pierreux,C.E., Lemaigre,F.P.,
            Vanderhaeghen,P. and Rousseau,G.G.
  TITLE     Eph receptors and their ephrin ligands are expressed in developing
            mouse pancreas
  JOURNAL   Gene Expr Patterns 6 (4), 353-359 (2006)
   PUBMED   16446123
REFERENCE   10 (bases 1 to 1340)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB610349.1, CO428705.1 and
            BP772440.1.
            
            On Jul 19, 2016 this sequence version replaced NM_001024698.2.
            
            Summary: This gene encodes a member of the carboxypeptidase A
            family of zinc metalloproteases. The encoded preproprotein
            undergoes proteolytic processing that removes the N-terminal
            activation peptide to generate a functional enzyme. This gene is
            expressed by the pancreatic exocrine cells which secrete the enzyme
            during digestion. This gene is located in a cluster of
            carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849378 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               BB610349.1         2-504
            504-804             CO428705.1         349-649
            805-1340            BP772440.1         30-565              c
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     gene            1..1340
                     /gene="Cpa2"
                     /note="carboxypeptidase A2, pancreatic"
                     /db_xref="GeneID:232680"
                     /db_xref="MGI:MGI:3617840"
     exon            1..88
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1277
                     /gene="Cpa2"
                     /EC_number="3.4.17.15"
                     /codon_start=1
                     /product="carboxypeptidase A2 preproprotein"
                     /protein_id="NP_001019869.1"
                     /db_xref="CCDS:CCDS19974.1"
                     /db_xref="GeneID:232680"
                     /db_xref="MGI:MGI:3617840"
                     /translation="MRLTPLLVALFGYIYCQETFVGDQVLEVIPNDEEQIKTLLQLEA
                     EEHLELDFWKSPSVPRQTVHVRVPFASIQDVKVFLESQGITYSIMIEDVQVLLDQERE
                     EMLFNQQRERGTNFNFGAYHTLEEIYQEMDNLVAENPGLVSKVNIGSSFENRPMNVLK
                     FSTGGDKPAIWLDAGIHAREWVTQATALWTANKIASDYGTDPAITSLLNTLDVFLLPV
                     TNPDGYVFSQTSNRMWRKTRSKRSGSFCVGVDPNRNWDANFGGPGASSNPCSDSYHGP
                     SPNSEVEVKSIVDFIKSHGKVKAFITLHSYSQLLMFPYGYKCAKPDDFNELDEVAQRA
                     AQSLKRLHGTSYKVGPICSVIYQASGGSIDWAYDLGIKYSFAFELRDTGYYGFLLPAK
                     QILPTAEETWLGLKTIMEHVRDHPY"
     exon            89..170
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            171..305
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..401
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..503
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..602
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..713
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..804
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1004
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1089
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1325
                     /gene="Cpa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpa2"
                     /note="hexamer: ATTAAA"
     polyA_site      1325
                     /gene="Cpa2"
                     /note="major polyA site"
ORIGIN      
        1 ggactctggg aaaagcattg accatgaggt tgaccccgtt attggttgcc ctatttgggt
       61 atatctactg tcaagaaaca tttgtgggag atcaagttct tgaggtgatc ccgaatgatg
      121 aagagcaaat taagactctg ctgcaactgg aggccgaaga gcaccttgag cttgattttt
      181 ggaaatcccc cagcgtcccc aggcagacag tccatgtccg agttcctttt gccagcatcc
      241 aggacgtcaa agttttcctg gagtcccagg ggattactta ttccatcatg atcgaagatg
      301 ttcaagttct gttggatcaa gagcgtgaag agatgctgtt caaccagcaa agagagcgtg
      361 gcactaactt caactttggg gcctaccata ccctggaaga gatttaccaa gaaatggata
      421 acctcgtggc tgagaaccct ggtctagtga gcaaagtgaa tatcggttca tcttttgaaa
      481 atcggcccat gaatgtgctc aagttcagca ccggaggaga caagccagcc atctggcttg
      541 atgcggggat ccacgctcga gagtgggtta cgcaagctac tgcactgtgg acagcaaata
      601 agattgcgtc tgattatggg actgatccag ccatcacttc tcttctcaat actctggatg
      661 tcttcctgct gcctgtcacg aaccctgatg gatatgtgtt ctcccaaacc tccaatcgta
      721 tgtggcgaaa gacccggtct aaacggtcgg gaagcttctg tgttggtgtg gatcctaatc
      781 ggaactggga cgcaaatttc ggaggacctg gagccagtag caacccttgc tctgattcat
      841 accatggacc cagtcccaat tctgaagttg aagtgaaatc catagtggac ttcatcaaga
      901 gccacgggaa agtcaaagcg ttcattaccc ttcacagcta ttcccaactg ctcatgttcc
      961 cctatggcta taaatgtgcc aagccagatg actttaatga gctggatgaa gtggcccaaa
     1021 gggctgccca gtctttgaaa agactccacg gcaccagtta caaagtggga cccatctgtt
     1081 ctgtcatcta ccaggccagt ggcggaagca tcgactgggc ttatgacctt ggcatcaaat
     1141 actcatttgc ctttgaactg agagacacag gctactatgg cttcctcctg ccagccaagc
     1201 agatcttgcc cacagcagaa gagacctggc ttggcctgaa gaccatcatg gagcacgtac
     1261 gagaccaccc ctactaggga catacagaac agatgaacac tattaaaatc tctgtggtat
     1321 aagcaaaaaa aaaaaaaaaa
//
