LOCUS       NP_079626                419 aa            linear   ROD 09-FEB-2025
DEFINITION  carboxypeptidase A1 preproprotein [Mus musculus].
ACCESSION   NP_079626 XP_284174
VERSION     NP_079626.2
DBSOURCE    REFSEQ: accession NM_025350.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Lu,P., Xu,J., Shen,X., Sun,J., Liu,M., Niu,N., Wang,Q. and Xue,J.
  TITLE     Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic
            organogenesis
  JOURNAL   Cell Rep 43 (2), 113703 (2024)
   PUBMED   38265933
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Gittes,G.K. and Rutter,W.J.
  TITLE     Onset of cell-specific gene expression in the developing mouse
            pancreas
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 1128-1132 (1992)
   PUBMED   1371010
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Siegel,D., Irving,N.G., Friedman,J.M. and Wainwright,B.J.
  TITLE     Localization of the cystic fibrosis transmembrane conductance
            regulator (Cftr) to mouse chromosome 6
  JOURNAL   Cytogenet Cell Genet 61 (3), 184-185 (1992)
   PUBMED   1385049
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Steinmeyer,K., Klocke,R., Ortland,C., Gronemeier,M., Jockusch,H.,
            Grunder,S. and Jentsch,T.J.
  TITLE     Inactivation of muscle chloride channel by transposon insertion in
            myotonic mice
  JOURNAL   Nature 354 (6351), 304-308 (1991)
   PUBMED   1659665
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052661.1 and AC155656.10.
            
            On or before Oct 22, 2004 this sequence version replaced
            XP_284174.1, NP_079626.1.
            
            Summary: This gene encodes carboxypeptidase A, a zinc-dependent
            metalloprotease that cleaves peptide bonds at the C-terminus of
            protein substrates. The encoded preproprotein undergoes proteolytic
            activation to generate a mature, functional enzyme. This gene is
            expressed in pancreas, the encoded protein is a major component of
            digestive enzymes secreted by pancreas and plays an important role
            in the process of digestion. This gene is located in a cluster of
            related carboxypeptidase genes on chromosome 6. [provided by
            RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052661.1, AK003088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     Protein         1..419
                     /product="carboxypeptidase A1 preproprotein"
                     /EC_number="3.4.17.1"
                     /calculated_mol_wt=45673
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1730
     Region          26..100
                     /region_name="Propep_M14"
                     /note="Carboxypeptidase activation peptide; pfam02244"
                     /db_xref="CDD:460505"
     mat_peptide     111..419
                     /product="Carboxypeptidase A1. /id=PRO_0000004348"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TPZ8.1)"
                     /calculated_mol_wt=34693
     Region          117..417
                     /region_name="M14_CPA"
                     /note="Peptidase M14 carboxypeptidase subfamily A/B-like;
                     Carboxypeptidase A subgroup; cd03870"
                     /db_xref="CDD:349442"
     Site            order(179,182,237,254..255,306,358,360,380)
                     /site_type="active"
                     /db_xref="CDD:349442"
     Site            order(181..182,237,273,306..308,349,354,356..359,380,389)
                     /site_type="active"
                     /note="inhibitor binding interface [active]"
                     /db_xref="CDD:349442"
     CDS             1..419
                     /gene="Cpa1"
                     /gene_synonym="0910001L12Rik; Cpa"
                     /coded_by="NM_025350.4:247..1506"
                     /db_xref="CCDS:CCDS19977.1"
                     /db_xref="GeneID:109697"
                     /db_xref="MGI:MGI:88478"
ORIGIN      
        1 mkrllvlsvl laavfgnenf vghqvlrisa tdeaqvqkvr eleelehlkl dfwrdparag
       61 lpidvrvpfp tiqsvkafle yhdisyeimi edvqslldee kqqmsafqar alstdafnya
      121 tyhtldeiye fmdllvtehp qlvskiqigs tfegrpinvl kfstggtnrp aiwidtgihs
      181 rewvtqasgv wfakkitkdy gqeptltail dnmdifleiv tnpdgfvyth ktnrmwrktr
      241 shtegslcvg vdpnrnwdaa fgmpgassnp csetyrgkfp nsevevksiv dfvtshgnik
      301 afisihsysq lllypygyts epapdkeeld qlaksavtal tslhgtkfky gsiidtiyqa
      361 sgstidwtys qgikysftfe lrdtglrgfl lpasqiipta eetwlallti mdhtvkhpy
//
