LOCUS       NM_001409648            4514 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus ceruloplasmin (Cp), transcript variant 7, mRNA.
ACCESSION   NM_001409648
VERSION     NM_001409648.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Anderson,B.D., Lee,T., Bell,B., Song,Y. and Dunaief,J.L.
  TITLE     Low ceruloplasmin levels exacerbate retinal degeneration in a
            hereditary hemochromatosis model
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37439255
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Hadziahmetovic,M., Dentchev,T., Song,Y., Haddad,N., He,X., Hahn,P.,
            Pratico,D., Wen,R., Harris,Z.L., Lambris,J.D., Beard,J. and
            Dunaief,J.L.
  TITLE     Ceruloplasmin/hephaestin knockout mice model morphologic and
            molecular features of AMD
  JOURNAL   Invest Ophthalmol Vis Sci 49 (6), 2728-2736 (2008)
   PUBMED   18326691
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Hahn,P., Qian,Y., Dentchev,T., Chen,L., Beard,J., Harris,Z.L. and
            Dunaief,J.L.
  TITLE     Disruption of ceruloplasmin and hephaestin in mice causes retinal
            iron overload and retinal degeneration with features of age-related
            macular degeneration
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13850-13855 (2004)
   PUBMED   15365174
  REMARK    GeneRIF: Ceruloplasmin ane hephaestin are critical for CNS iron
            homeostasis and that loss of Cp and Heph in the mouse leads to
            age-dependent retinal neurodegeneration.
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Harris,Z.L., Durley,A.P., Man,T.K. and Gitlin,J.D.
  TITLE     Targeted gene disruption reveals an essential role for
            ceruloplasmin in cellular iron efflux
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10812-10817 (1999)
   PUBMED   10485908
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Morton,D.L.
  TITLE     Changing concepts of cancer surgery: surgery as immunotherapy
  JOURNAL   Am J Surg 135 (3), 367-371 (1978)
   PUBMED   343622
  REMARK    GeneRIF: The mouse ceruloplasmin gene has been mapped to chromosome
            3.
            Review article
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Voller,A. and Bidwell,D.E.
  TITLE     Enzyme-immunoassays for antibodies in measles, cytomegalovirus
            infections and after rubella vaccination
  JOURNAL   Br J Exp Pathol 57 (2), 243-247 (1976)
   PUBMED   178338
  REMARK    GeneRIF: The mouse ceruloplasmin gene has been mapped to chromosome
            3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079442.24.
            
            Summary: The protein encoded by this gene is a copper-containing
            glycoprotein found soluble in the serum and GPI-anchored in other
            tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an
            important role in iron homeostasis. In humans mutations of this
            gene cause aceruloplasminemia, which is characterized by retinal
            degeneration, diabetes, anemia and neurological symptoms. In mouse
            deficiency of this gene in combination with a deficiency of its
            homolog hephaestin causes retinal degeneration and serves as a
            pathophysiological model for aceruloplasminemia and age-related
            macular degeneration. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.51808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC079442.24        132008-132188       c
            182-429             AC079442.24        124910-125157       c
            430-636             AC079442.24        122989-123195       c
            637-810             AC079442.24        121224-121397       c
            811-1065            AC079442.24        119407-119661       c
            1066-1237           AC079442.24        118354-118525       c
            1238-1377           AC079442.24        116683-116822       c
            1378-1530           AC079442.24        115508-115660       c
            1531-1727           AC079442.24        114379-114575       c
            1728-1878           AC079442.24        112191-112341       c
            1879-2091           AC079442.24        110365-110577       c
            2092-2299           AC079442.24        108639-108846       c
            2300-2439           AC079442.24        107335-107474       c
            2440-2568           AC079442.24        105916-106044       c
            2569-2675           AC079442.24        103771-103877       c
            2676-2892           AC079442.24        101862-102078       c
            2893-3032           AC079442.24        101365-101504       c
            3033-3198           AC079442.24        100219-100384       c
            3199-3303           AC079442.24        83866-83970         c
            3304-4514           AC079442.24        79687-80897         c
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.1 cM"
     gene            1..4514
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="ceruloplasmin"
                     /db_xref="GeneID:12870"
                     /db_xref="MGI:MGI:88476"
     exon            1..181
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3290
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /EC_number="1.11.1.9"
                     /EC_number="1.16.3.1"
                     /EC_number="1.11.1.27"
                     /EC_number="1.16.3.4"
                     /note="isoform e precursor is encoded by transcript
                     variant 7; ferroxidase; cuproxidase ceruloplasmin;
                     ferroxidase ceruloplasmin; glutathione peroxidase
                     ceruloplasmin; glutathione-dependent peroxiredoxin
                     ceruloplasmin"
                     /codon_start=1
                     /product="ceruloplasmin isoform e precursor"
                     /protein_id="NP_001396577.1"
                     /db_xref="GeneID:12870"
                     /db_xref="MGI:MGI:88476"
                     /translation="MKFLLLSTFIFLYSSLALARDKHYFIGITEAVWDYASGTEEKKL
                     ISVDTEQSNFYLQNGPDRIGRKYKKALYFEYTDGTFSKTIDKPAWLGFLGPVIKAEVE
                     DKVYVHLKNLASRIYTFHAHGVTYTKEYEAVYPDNTTDFQRADDKVLPGQQYVYVLHA
                     NEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLYKEKEKNIDQEFVLM
                     FSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAA
                     DRVKWYLFGMGNEVDVHSAFFHGQALTSRNYQTDIINLFPATLIDAYMVAQNPGVWML
                     SCQNLNHLKAGLQAFFQVRDCNKPSPEDNIQDRHVRHYYIAAEEVIWNYAPSGTDIFT
                     GENLTALESDSRVFFEQGATRIGGSYKKMAYREYTDGSFTNRKQRGPDEEHLGILGPV
                     IWAEVGDTIKVTFHNKGQHPLSIQPMGVSFTAENEGTYYGPPGRSSQQASHVAPKETF
                     TYEWTVPKEMGPTYADPVCLSKMYYSGVDPTKDIFTGLIGPMKICKKGSLLADGRQKD
                     VDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQ
                     PGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMNP
                     DTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDFTVYLGERTYYVAAVEVEWDYSP
                     SRAWEKELHHLQEQNVSNVFLDKEEFFIGSKYKKVVYRQFTDSSFREQVKRRAEDEHL
                     GILGPPIHANVGDKVKVVFKNMATRPYSIHAHGVKTESSTVVPTLPGEVRTYTWQIPE
                     RSGAGREDSACIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFSPKKKMEFFLLFL
                     VFDENESWYLDDNIKTYSEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKDE
                     VNWYVMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDLFPGTYQTLEMFPQTPGTWL
                     LHCHVTDHVHAGMATTYTVLPVEQVSSQSYRMTWNILYTLLISIIILFQMSTKE"
     exon            182..429
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            430..636
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            637..810
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1065
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1237
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1377
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1530
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1727
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1878
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2091
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2299
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2439
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2568
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2675
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2892
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3032
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3198
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3303
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..4514
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="hexamer: AATATA"
     polyA_site      3559
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
     regulatory      4495..4500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="hexamer: ATTAAA"
     polyA_site      4514
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="major polyA site"
ORIGIN      
        1 actttattgc atcgtgggct ccgagaggga gaaaaatgaa gtttttgctg cttagcacat
       61 ttatattttt gtatagttcc ttagccttgg caagagataa gcattatttc attggaatta
      121 ctgaagcagt ctgggactat gcttctggca ctgaagaaaa gaaacttatt tcagttgaca
      181 cggaacagtc caatttctat cttcaaaatg gtccagatcg tattggaaga aaatataaga
      241 aggcccttta ttttgagtac acagatggca cctttagtaa gactatagac aaaccagcct
      301 ggctagggtt tttaggccct gtcatcaaag ctgaagttga agataaagtt tatgttcact
      361 taaagaacct tgcctctagg atctacactt ttcatgcaca tggggtaacg tacaccaagg
      421 agtatgaggc cgtctaccct gacaacacca ctgattttca acgggctgat gacaaagtgc
      481 ttcccggaca acagtatgtg tatgtgctgc atgccaatga gccaagtcct ggagagggag
      541 acagcaattg tgtgaccagg atttaccact cccatgttga tgctccaaaa gatattgcat
      601 caggactcat aggacctcta atactctgta aaaaaggttc tctatataag gaaaaagaga
      661 aaaatattga ccaagaattt gtactaatgt tctctgtggt ggatgaaaat ctcagctggt
      721 atctggaaga taacatcaaa accttctgct ctgaacccga gaaagttgat aaagacaatg
      781 aagacttcca ggaaagcaac aggatgtact ctataaatgg atatacattt ggaagcctcc
      841 cagggctctc gatgtgtgca gcagacagag tgaagtggta cctttttggt atgggtaatg
      901 aagttgatgt gcattcagct ttctttcatg gccaagccct gaccagcagg aactatcaaa
      961 ccgatataat caacctgttc cctgccaccc taattgatgc ttatatggtg gcccagaatc
     1021 ctggagtctg gatgctcagt tgccagaacc taaaccatct gaaagctggg ttgcaggcct
     1081 ttttccaggt tcgtgactgt aacaagccct cgccagagga taatatccaa gataggcatg
     1141 tgagacacta ttacattgct gctgaggagg tcatctggaa ttatgctcct tctgggacgg
     1201 acatcttcac tggagagaat ttaacagctc tggaaagtga ttcaagggta ttttttgagc
     1261 aaggtgccac aagaattggt ggctcttata aaaaaatggc atatcgtgag tacacagatg
     1321 gttccttcac aaaccgaaaa caaagaggcc ctgatgagga acatcttgga atcctaggtc
     1381 ctgtcatttg ggcagaagta ggagacacca ttaaagtcac ctttcataac aaaggacagc
     1441 atcctctcag cattcagcca atgggagtaa gtttcactgc agaaaatgag ggaacatact
     1501 atggcccacc aggtcgctcc tcacagcaag cctcccatgt ggctcccaaa gaaaccttta
     1561 catacgaatg gactgtcccc aaagaaatgg gacccactta tgcagatcct gtgtgcctat
     1621 ctaagatgta ctactctggc gttgacccca ccaaagatat atttactggg cttattgggc
     1681 caatgaaaat atgcaagaaa ggcagcttac ttgctgatgg gagacagaaa gatgtagaca
     1741 aagagttcta cttgtttccc acagtgtttg atgagaatga gagtttactc ttagatgata
     1801 atatcaggat gttcacaact gcacctgatc aagtggataa ggaagatgaa gactttcagg
     1861 agtctaataa gatgcactcc atgaatgggt tcatgtatgg caatcagcct ggcctcaata
     1921 tgtgtctagg agaatccatc gtgtggtatt tgttcagcgc tggaaatgag gctgatgtgc
     1981 atgggatata cttttcagga aatacttatc tgtctaaagg agaaagaaga gacactgcaa
     2041 acctattccc tcataaaagt ctcacccttc tcatgaaccc tgacacaaaa gggacttttg
     2101 atgttgagtg ccttacaacg gatcactaca caggtggcat gaagcaaaaa tacactgtga
     2161 accagtgcca gcggcagttt gaagatttca ctgtctacct tggagaaagg acctactatg
     2221 tggcagccgt agaggtggaa tgggattact caccaagcag ggcctgggaa aaggagctgc
     2281 atcatttgca agagcaaaat gtttcaaatg tatttttgga taaagaagag tttttcatag
     2341 gctcaaagta caagaaggtt gtgtatcgcc agtttactga cagctcattc agagaacagg
     2401 tgaagagacg agccgaagac gagcacttgg gcatccttgg gccaccaatt catgcaaatg
     2461 ttggagacaa agttaaagtt gtctttaaaa atatggcaac caggccatat tcaatacatg
     2521 cccatggggt gaaaacagag agttctacag ttgttccaac gttaccaggt gaagttcgaa
     2581 cttatacatg gcaaattcca gaaagatcag gggctggaag agaggattca gcttgtatcc
     2641 catgggctta ttactcaact gtggatcgag ttaaggatct ctatagtggg ctaataggcc
     2701 cattgattgt ttgtcggaag tcttatgtga aagtattcag tcctaaaaag aaaatggagt
     2761 ttttccttct gtttctagta tttgatgaga atgaatcttg gtacttagat gataacatca
     2821 aaacatactc tgaacaccct gagaaagtaa acaaagacaa cgaggaattc ctagaaagca
     2881 ataaaatgca tgctattaat gggaaaatgt ttggaaacct acaaggcctc acaatgcacg
     2941 tgaaagatga agtcaactgg tatgtgatgg gaatgggcaa tgaaatagac ctgcacactg
     3001 tacacttcca cggccacagc ttccaataca agcacagggg agtatacagt tctgatgtct
     3061 ttgacctttt ccctggaaca taccaaaccc tagaaatgtt tccccaaaca cctggaacct
     3121 ggttactcca ctgccacgtg actgaccatg tccatgctgg gatggcaact acctacactg
     3181 ttttaccagt agaacaagta tcatctcaga gttacaggat gacctggaac atcctctata
     3241 cactactaat cagcatcatt attttattcc aaatgtctac caaggagtag ccaggaaaat
     3301 aaggtgtttt cacgtctatt ctaaacagga aggcagttgt acagctcatt cgcctgcagc
     3361 aagaccagtc cctcagctca gaggcttcgt ctcagcagtt ccacccagaa gccagcattc
     3421 caaagcaaag ctcctaactg tgatcaatta tagatttttg cccctcaaaa agctatactc
     3481 taaattaaca agacatgtgc tatcacaaca catttaaatt gtttactata cttcaatata
     3541 ctgcatattt taaaagtaag agaggcattt ttatttacct gtaatttcag aaggtcgtct
     3601 gtgtaatttt tatcagctaa ggaatcagat gtcgttaaca catgaaccca tggatttact
     3661 aggccataat gactgcaggc atttatctga aacattacag aaatgcatca caagccaaat
     3721 acagcaagag caaaacaagt catctcttca tccattcact aactctctgc cacatcgtag
     3781 attcagttgc acactctcct aggagaagga agctttgcag acgtatttcc ctggaaaagt
     3841 gtgtagtctt gctgctttcg tatcaaataa tctgcaataa atatttccta atattttgaa
     3901 atttaaaaat attctacaga agtgctttca agcaaaatat ataagtgaat agaatagaat
     3961 agaatagaat agaatagaat agaatagaat agaatagaac agaacagaat agaatagtat
     4021 tactcctaag ataagagtgg aaatgatttt tgggggtgag aaaatatcct tttaagttct
     4081 catgatgact gtcatggagt atccttaatc caagaaatta cactggtgac ctttgcactc
     4141 atggtgcagt gcccacagca gtcatagcaa caggagtcta tggaaaccag agcagtatgg
     4201 gagggtgacc aaggctgtcg cagttgccta caacacacct gaagcctaag cgtggccctg
     4261 acaggaaaga gaacagtgca gtaggccctt gcctcagccc tttcaaaact gcttgaggca
     4321 acccttctga agaaagcctc tcatatgctg ggacactgca aggtggtaat aaaggagtat
     4381 ggctgtattc tttattttca gggtgtgaaa tttgagttgg tcgggtctca tgtgtagccc
     4441 tggctggcct ggaactcaca gagatccccc tgcccctgcc ttctgagtgg taagattaaa
     4501 ggtgtgtgcc atga
//
