LOCUS       NM_001276248            6507 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus ceruloplasmin (Cp), transcript variant 3, mRNA.
ACCESSION   NM_001276248
VERSION     NM_001276248.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6507)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 6507)
  AUTHORS   Anderson,B.D., Lee,T., Bell,B., Song,Y. and Dunaief,J.L.
  TITLE     Low ceruloplasmin levels exacerbate retinal degeneration in a
            hereditary hemochromatosis model
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37439255
REFERENCE   4  (bases 1 to 6507)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   5  (bases 1 to 6507)
  AUTHORS   Hadziahmetovic,M., Dentchev,T., Song,Y., Haddad,N., He,X., Hahn,P.,
            Pratico,D., Wen,R., Harris,Z.L., Lambris,J.D., Beard,J. and
            Dunaief,J.L.
  TITLE     Ceruloplasmin/hephaestin knockout mice model morphologic and
            molecular features of AMD
  JOURNAL   Invest Ophthalmol Vis Sci 49 (6), 2728-2736 (2008)
   PUBMED   18326691
REFERENCE   6  (bases 1 to 6507)
  AUTHORS   Hahn,P., Qian,Y., Dentchev,T., Chen,L., Beard,J., Harris,Z.L. and
            Dunaief,J.L.
  TITLE     Disruption of ceruloplasmin and hephaestin in mice causes retinal
            iron overload and retinal degeneration with features of age-related
            macular degeneration
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13850-13855 (2004)
   PUBMED   15365174
  REMARK    GeneRIF: Ceruloplasmin ane hephaestin are critical for CNS iron
            homeostasis and that loss of Cp and Heph in the mouse leads to
            age-dependent retinal neurodegeneration.
REFERENCE   7  (bases 1 to 6507)
  AUTHORS   Harris,Z.L., Durley,A.P., Man,T.K. and Gitlin,J.D.
  TITLE     Targeted gene disruption reveals an essential role for
            ceruloplasmin in cellular iron efflux
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10812-10817 (1999)
   PUBMED   10485908
REFERENCE   8  (bases 1 to 6507)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   9  (bases 1 to 6507)
  AUTHORS   Morton,D.L.
  TITLE     Changing concepts of cancer surgery: surgery as immunotherapy
  JOURNAL   Am J Surg 135 (3), 367-371 (1978)
   PUBMED   343622
  REMARK    GeneRIF: The mouse ceruloplasmin gene has been mapped to chromosome
            3.
            Review article
REFERENCE   10 (bases 1 to 6507)
  AUTHORS   Voller,A. and Bidwell,D.E.
  TITLE     Enzyme-immunoassays for antibodies in measles, cytomegalovirus
            infections and after rubella vaccination
  JOURNAL   Br J Exp Pathol 57 (2), 243-247 (1976)
   PUBMED   178338
  REMARK    GeneRIF: The mouse ceruloplasmin gene has been mapped to chromosome
            3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079442.24.
            
            On Jul 21, 2022 this sequence version replaced NM_001276248.1.
            
            Summary: The protein encoded by this gene is a copper-containing
            glycoprotein found soluble in the serum and GPI-anchored in other
            tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an
            important role in iron homeostasis. In humans mutations of this
            gene cause aceruloplasminemia, which is characterized by retinal
            degeneration, diabetes, anemia and neurological symptoms. In mouse
            deficiency of this gene in combination with a deficiency of its
            homolog hephaestin causes retinal degeneration and serves as a
            pathophysiological model for aceruloplasminemia and age-related
            macular degeneration. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043248.1, SRR17253011.5470103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC079442.24        132008-132188       c
            182-429             AC079442.24        124910-125157       c
            430-639             AC079442.24        122989-123198       c
            640-813             AC079442.24        121224-121397       c
            814-1068            AC079442.24        119407-119661       c
            1069-1240           AC079442.24        118354-118525       c
            1241-1380           AC079442.24        116683-116822       c
            1381-1533           AC079442.24        115508-115660       c
            1534-1730           AC079442.24        114379-114575       c
            1731-1881           AC079442.24        112191-112341       c
            1882-2094           AC079442.24        110365-110577       c
            2095-2302           AC079442.24        108639-108846       c
            2303-2442           AC079442.24        107335-107474       c
            2443-2571           AC079442.24        105916-106044       c
            2572-2678           AC079442.24        103771-103877       c
            2679-2895           AC079442.24        101862-102078       c
            2896-3035           AC079442.24        101365-101504       c
            3036-3201           AC079442.24        100219-100384       c
            3202-3306           AC079442.24        83866-83970         c
            3307-6507           AC079442.24        79687-82887         c
FEATURES             Location/Qualifiers
     source          1..6507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.1 cM"
     gene            1..6507
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="ceruloplasmin"
                     /db_xref="GeneID:12870"
                     /db_xref="MGI:MGI:88476"
     exon            1..181
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3293
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /EC_number="1.11.1.9"
                     /EC_number="1.16.3.1"
                     /EC_number="1.11.1.27"
                     /EC_number="1.16.3.4"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; ferroxidase; cuproxidase ceruloplasmin;
                     ferroxidase ceruloplasmin; glutathione peroxidase
                     ceruloplasmin; glutathione-dependent peroxiredoxin
                     ceruloplasmin"
                     /codon_start=1
                     /product="ceruloplasmin isoform c precursor"
                     /protein_id="NP_001263177.1"
                     /db_xref="CCDS:CCDS71227.1"
                     /db_xref="GeneID:12870"
                     /db_xref="MGI:MGI:88476"
                     /translation="MKFLLLSTFIFLYSSLALARDKHYFIGITEAVWDYASGTEEKKL
                     ISVDTEQSNFYLQNGPDRIGRKYKKALYFEYTDGTFSKTIDKPAWLGFLGPVIKAEVE
                     DKVYVHLKNLASRIYTFHAHGVTYTKEYEGAVYPDNTTDFQRADDKVLPGQQYVYVLH
                     ANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLYKEKEKNIDQEFVL
                     MFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCA
                     ADRVKWYLFGMGNEVDVHSAFFHGQALTSRNYQTDIINLFPATLIDAYMVAQNPGVWM
                     LSCQNLNHLKAGLQAFFQVRDCNKPSPEDNIQDRHVRHYYIAAEEVIWNYAPSGTDIF
                     TGENLTALESDSRVFFEQGATRIGGSYKKMAYREYTDGSFTNRKQRGPDEEHLGILGP
                     VIWAEVGDTIKVTFHNKGQHPLSIQPMGVSFTAENEGTYYGPPGRSSQQASHVAPKET
                     FTYEWTVPKEMGPTYADPVCLSKMYYSGVDPTKDIFTGLIGPMKICKKGSLLADGRQK
                     DVDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGN
                     QPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMN
                     PDTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDFTVYLGERTYYVAAVEVEWDYS
                     PSRAWEKELHHLQEQNVSNVFLDKEEFFIGSKYKKVVYRQFTDSSFREQVKRRAEDEH
                     LGILGPPIHANVGDKVKVVFKNMATRPYSIHAHGVKTESSTVVPTLPGEVRTYTWQIP
                     ERSGAGREDSACIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFSPKKKMEFFLLF
                     LVFDENESWYLDDNIKTYSEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKD
                     EVNWYVMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDLFPGTYQTLEMFPQTPGTW
                     LLHCHVTDHVHAGMATTYTVLPVEQVSSQSYRMTWNILYTLLISIIILFQMSTKE"
     exon            182..429
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            430..639
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            640..813
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1068
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1240
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1380
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1533
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1730
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1881
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2094
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2302
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2442
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2571
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2678
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2895
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3035
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3201
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3306
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..6507
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5528..5533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="hexamer: AATATA"
     polyA_site      5552
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
     regulatory      6488..6493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="hexamer: ATTAAA"
     polyA_site      6507
                     /gene="Cp"
                     /gene_synonym="D3Ertd555e"
                     /note="major polyA site"
ORIGIN      
        1 actttattgc atcgtgggct ccgagaggga gaaaaatgaa gtttttgctg cttagcacat
       61 ttatattttt gtatagttcc ttagccttgg caagagataa gcattatttc attggaatta
      121 ctgaagcagt ctgggactat gcttctggca ctgaagaaaa gaaacttatt tcagttgaca
      181 cggaacagtc caatttctat cttcaaaatg gtccagatcg tattggaaga aaatataaga
      241 aggcccttta ttttgagtac acagatggca cctttagtaa gactatagac aaaccagcct
      301 ggctagggtt tttaggccct gtcatcaaag ctgaagttga agataaagtt tatgttcact
      361 taaagaacct tgcctctagg atctacactt ttcatgcaca tggggtaacg tacaccaagg
      421 agtatgaggg agccgtctac cctgacaaca ccactgattt tcaacgggct gatgacaaag
      481 tgcttcccgg acaacagtat gtgtatgtgc tgcatgccaa tgagccaagt cctggagagg
      541 gagacagcaa ttgtgtgacc aggatttacc actcccatgt tgatgctcca aaagatattg
      601 catcaggact cataggacct ctaatactct gtaaaaaagg ttctctatat aaggaaaaag
      661 agaaaaatat tgaccaagaa tttgtactaa tgttctctgt ggtggatgaa aatctcagct
      721 ggtatctgga agataacatc aaaaccttct gctctgaacc cgagaaagtt gataaagaca
      781 atgaagactt ccaggaaagc aacaggatgt actctataaa tggatataca tttggaagcc
      841 tcccagggct ctcgatgtgt gcagcagaca gagtgaagtg gtaccttttt ggtatgggta
      901 atgaagttga tgtgcattca gctttctttc atggccaagc cctgaccagc aggaactatc
      961 aaaccgatat aatcaacctg ttccctgcca ccctaattga tgcttatatg gtggcccaga
     1021 atcctggagt ctggatgctc agttgccaga acctaaacca tctgaaagct gggttgcagg
     1081 cctttttcca ggttcgtgac tgtaacaagc cctcgccaga ggataatatc caagataggc
     1141 atgtgagaca ctattacatt gctgctgagg aggtcatctg gaattatgct ccttctggga
     1201 cggacatctt cactggagag aatttaacag ctctggaaag tgattcaagg gtattttttg
     1261 agcaaggtgc cacaagaatt ggtggctctt ataaaaaaat ggcatatcgt gagtacacag
     1321 atggttcctt cacaaaccga aaacaaagag gccctgatga ggaacatctt ggaatcctag
     1381 gtcctgtcat ttgggcagaa gtaggagaca ccattaaagt cacctttcat aacaaaggac
     1441 agcatcctct cagcattcag ccaatgggag taagtttcac tgcagaaaat gagggaacat
     1501 actatggccc accaggtcgc tcctcacagc aagcctccca tgtggctccc aaagaaacct
     1561 ttacatacga atggactgtc cccaaagaaa tgggacccac ttatgcagat cctgtgtgcc
     1621 tatctaagat gtactactct ggcgttgacc ccaccaaaga tatatttact gggcttattg
     1681 ggccaatgaa aatatgcaag aaaggcagct tacttgctga tgggagacag aaagatgtag
     1741 acaaagagtt ctacttgttt cccacagtgt ttgatgagaa tgagagttta ctcttagatg
     1801 ataatatcag gatgttcaca actgcacctg atcaagtgga taaggaagat gaagactttc
     1861 aggagtctaa taagatgcac tccatgaatg ggttcatgta tggcaatcag cctggcctca
     1921 atatgtgtct aggagaatcc atcgtgtggt atttgttcag cgctggaaat gaggctgatg
     1981 tgcatgggat atacttttca ggaaatactt atctgtctaa aggagaaaga agagacactg
     2041 caaacctatt ccctcataaa agtctcaccc ttctcatgaa ccctgacaca aaagggactt
     2101 ttgatgttga gtgccttaca acggatcact acacaggtgg catgaagcaa aaatacactg
     2161 tgaaccagtg ccagcggcag tttgaagatt tcactgtcta ccttggagaa aggacctact
     2221 atgtggcagc cgtagaggtg gaatgggatt actcaccaag cagggcctgg gaaaaggagc
     2281 tgcatcattt gcaagagcaa aatgtttcaa atgtattttt ggataaagaa gagtttttca
     2341 taggctcaaa gtacaagaag gttgtgtatc gccagtttac tgacagctca ttcagagaac
     2401 aggtgaagag acgagccgaa gacgagcact tgggcatcct tgggccacca attcatgcaa
     2461 atgttggaga caaagttaaa gttgtcttta aaaatatggc aaccaggcca tattcaatac
     2521 atgcccatgg ggtgaaaaca gagagttcta cagttgttcc aacgttacca ggtgaagttc
     2581 gaacttatac atggcaaatt ccagaaagat caggggctgg aagagaggat tcagcttgta
     2641 tcccatgggc ttattactca actgtggatc gagttaagga tctctatagt gggctaatag
     2701 gcccattgat tgtttgtcgg aagtcttatg tgaaagtatt cagtcctaaa aagaaaatgg
     2761 agtttttcct tctgtttcta gtatttgatg agaatgaatc ttggtactta gatgataaca
     2821 tcaaaacata ctctgaacac cctgagaaag taaacaaaga caacgaggaa ttcctagaaa
     2881 gcaataaaat gcatgctatt aatgggaaaa tgtttggaaa cctacaaggc ctcacaatgc
     2941 acgtgaaaga tgaagtcaac tggtatgtga tgggaatggg caatgaaata gacctgcaca
     3001 ctgtacactt ccacggccac agcttccaat acaagcacag gggagtatac agttctgatg
     3061 tctttgacct tttccctgga acataccaaa ccctagaaat gtttccccaa acacctggaa
     3121 cctggttact ccactgccac gtgactgacc atgtccatgc tgggatggca actacctaca
     3181 ctgttttacc agtagaacaa gtatcatctc agagttacag gatgacctgg aacatcctct
     3241 atacactact aatcagcatc attattttat tccaaatgtc taccaaggag tagccaggaa
     3301 aataagcaaa aattcccaga aaagggtgaa gggaatatgc agaaactgag gcattatgag
     3361 aagtctacaa agcagaggca cggatgagag ggaagatcaa tggcatagaa cagattttca
     3421 acataattat agaaaactcc cagaataagg aaaaccacaa ccatatagac acacagaaca
     3481 ccaactagaa gaagaaaaga agttccccat ggaacataag ttaaaacact aaatatacac
     3541 aacacagagg atactgaaag cagcaagaga aaggacacaa gtcccatgca aaggcaaaca
     3601 caccaggaaa ctgctgatgg aggctgaaca ccagcagagt ctggtgcaat gcaccccaaa
     3661 ggaccacaga cgccaaatca gacttcttta cccagcaacg ctctctgcca tagttgaaga
     3721 aagaaagttt tcatgataga aacaggttaa aggaatgtat ccaccaagcc agccccgctg
     3781 agaatactag aacctgaaga tactttagac tgaagagagg ataagcaagc ccaaaaggcc
     3841 acataaagaa aacaagtgaa gccatctaac aagaacacgg aataagacaa agaacacagc
     3901 agaattcccc cacaaacaca cacaacaaaa ttacagcaat caacaaaccc ttttcaatac
     3961 taactttaag tattggcttc aacttcccaa tcaaaagaaa atgttgaatg gaatgattaa
     4021 gtaacaaaaa tccatctttt gttacataca gagattttaa atgatcactg aattataccg
     4081 tttgattgtg attataaatg tgcttagaag ttatatcagt aaaattttca tagcctatta
     4141 cacgtacaac tttatttgct tcactgttct gtgtgttggg aggacaaggt ccgattctgt
     4201 ctcccacatt tactgtactt ctcagactga gctatcaaat gaacaaacaa gccgctaaca
     4261 cctcagggct tgcagtgtct atatgtacta gagataagag acaatgaaag aatctccttt
     4321 agtgatatat tgttgtagtt aactaataaa ttactgaggc tggacttgaa ttcatgattc
     4381 ttctgtctca gccttccaag tgctagaatt ataagcatgt acaaccatac ccgattctgg
     4441 tgattttaat agaagaatat aggccacagt ctggaaactg agtctaaaca ctctagcctc
     4501 ctgattttcc ttccccaacc cacccccaac tcaacagctg tctctatgtt ctataaagtc
     4561 cacattttga ccaatttcta aagtttaaac caggaattat acaccccaat cgtaaaaagc
     4621 tcatggagaa gaaaatgcct aagggcctct gggtatggta taagactcga gaacctcagc
     4681 gtctggatga gaagctgtgg agataagagt ggtgcagact gaacacgctg tgcactgctc
     4741 agacagagcc atcagcatct ggcagaccag gcctcaggaa cagtacaggg cacaggtggc
     4801 cagtactcct gaatttttca agagtaacgt ttaactcaga attcctaaca tgaaatattg
     4861 atttctatat gtggcttgct acagtgagta aacagaagaa aagaaaagaa aagaaaagaa
     4921 aagaaaagaa aagaaaagaa aagaaaagaa aagaaaagaa aagaaaagaa aaggaaagaa
     4981 aagaaaagga aagaaaaaga aaggtgaaaa ttatattcag cccttgggcc aacaaatggt
     5041 attaaaagat acattcagcc cggcctggcc taccatgtcc catgcagaaa cagttagaat
     5101 tcctatacca taattgtgtc cctcaattct tttgaaacct tctcttctgg ggtcagatac
     5161 gactactttg acatattatt cataaggcag atggtattgg ttcagtgggt atgaagtcta
     5221 cattgtgcta agccacatta aacaaagctc atacttacaa aagatcccta tacatttgga
     5281 cactttttcc ccacaggtgt tttcacgtct attctaaaca ggaaggcagt tgtacagctc
     5341 attcgcctgc agcaagacca gtccctcagc tcagaggctt cgtctcagca gttccaccca
     5401 gaagccagca ttccaaagca aagctcctaa ctgtgatcaa ttatagattt ttgcccctca
     5461 aaaagctata ctctaaatta acaagacatg tgctatcaca acacatttaa attgtttact
     5521 atacttcaat atactgcata ttttaaaagt aagagaggca tttttattta cctgtaattt
     5581 cagaaggtcg tctgtgtaat ttttatcagc taaggaatca gatgtcgtta acacatgaac
     5641 ccatggattt actaggccat aatgactgca ggcatttatc tgaaacatta cagaaatgca
     5701 tcacaagcca aatacagcaa gagcaaaaca agtcatctct tcatccattc actaactctc
     5761 tgccacatcg tagattcagt tgcacactct cctaggagaa ggaagctttg cagacgtatt
     5821 tccctggaaa agtgtgtagt cttgctgctt tcgtatcaaa taatctgcaa taaatatttc
     5881 ctaatatttt gaaatttaaa aatattctac agaagtgctt tcaagcaaaa tatataagtg
     5941 aatagaatag aatagaatag aatagaatag aatagaatag aatagaatag aacagaacag
     6001 aatagaatag tattactcct aagataagag tggaaatgat ttttgggggt gagaaaatat
     6061 ccttttaagt tctcatgatg actgtcatgg agtatcctta atccaagaaa ttacactggt
     6121 gacctttgca ctcatggtgc agtgcccaca gcagtcatag caacaggagt ctatggaaac
     6181 cagagcagta tgggagggtg accaaggctg tcgcagttgc ctacaacaca cctgaagcct
     6241 aagcgtggcc ctgacaggaa agagaacagt gcagtaggcc cttgcctcag ccctttcaaa
     6301 actgcttgag gcaacccttc tgaagaaagc ctctcatatg ctgggacact gcaaggtggt
     6361 aataaaggag tatggctgta ttctttattt tcagggtgtg aaatttgagt tggtcgggtc
     6421 tcatgtgtag ccctggctgg cctggaactc acagagatcc ccctgcccct gccttctgag
     6481 tggtaagatt aaaggtgtgt gccatga
//
