LOCUS       NM_007751                383 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 8B (Cox8b), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_007751
VERSION     NM_007751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 383)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 383)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 383)
  AUTHORS   Song,Z., Xiaoli,A.M., Li,Y., Siqin,G., Wu,T., Strich,R.,
            Pessin,J.E. and Yang,F.
  TITLE     The conserved Mediator subunit cyclin C (CCNC) is required for
            brown adipocyte development and lipid accumulation
  JOURNAL   Mol Metab 64, 101548 (2022)
   PUBMED   35863637
REFERENCE   4  (bases 1 to 383)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 383)
  AUTHORS   Fonseca,T.L., Russo,S.C., Luongo,C., Salvatore,D. and Bianco,A.C.
  TITLE     Inactivation of Type 3 Deiodinase Results in Life-long Changes in
            the Brown Adipose Tissue Transcriptome in the Male Mouse
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35238380
REFERENCE   6  (bases 1 to 383)
  AUTHORS   Rajakumari,S., Wu,J., Ishibashi,J., Lim,H.W., Giang,A.H., Won,K.J.,
            Reed,R.R. and Seale,P.
  TITLE     EBF2 determines and maintains brown adipocyte identity
  JOURNAL   Cell Metab 17 (4), 562-574 (2013)
   PUBMED   23499423
REFERENCE   7  (bases 1 to 383)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 383)
  AUTHORS   Makris,G.J. and Lomax,M.I.
  TITLE     The gene encoding the heart/muscle isoform of cytochrome c oxidase
            subunit VIII maps to mouse chromosome 7
  JOURNAL   Mamm Genome 8 (6), 453-454 (1997)
   PUBMED   9166597
REFERENCE   9  (bases 1 to 383)
  AUTHORS   Bachman,N.J., Riggs,P.K., Siddiqui,N., Makris,G.J., Womack,J.E. and
            Lomax,M.I.
  TITLE     Structure of the human gene (COX6A2) for the heart/muscle isoform
            of cytochrome c oxidase subunit VIa and its chromosomal location in
            humans, mice, and cattle
  JOURNAL   Genomics 42 (1), 146-151 (1997)
   PUBMED   9177785
REFERENCE   10 (bases 1 to 383)
  AUTHORS   Hegeman,A.D., Brown,J.S. and Lomax,M.I.
  TITLE     Sequence of the cDNA for the heart/muscle isoform of mouse
            cytochrome c oxidase subunit VIII
  JOURNAL   Biochim Biophys Acta 1261 (2), 311-314 (1995)
   PUBMED   7711081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE626379.1 and AA511205.1.
            
            On Oct 19, 2007 this sequence version replaced NM_007751.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE626379.1, BY766873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               BE626379.1         1-350
            351-383             AA511205.1         305-337
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.11 cM"
     gene            1..383
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /note="cytochrome c oxidase subunit 8B"
                     /db_xref="GeneID:12869"
                     /db_xref="MGI:MGI:105958"
     exon            1..215
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..317
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 8B, mitochondrial;
                     cytochrome c oxidase polypeptide VIII-heart; cytochrome c
                     oxidase subunit 8-1; cytochrome c oxidase subunit VIII-H;
                     cytochrome c oxidase subunit 8H; COX VIII-H; cytochrome c
                     oxidase subunit VIIIb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 8B, mitochondrial
                     precursor"
                     /protein_id="NP_031777.1"
                     /db_xref="CCDS:CCDS21991.1"
                     /db_xref="GeneID:12869"
                     /db_xref="MGI:MGI:105958"
                     /translation="MPRLPPILRLLQAPAKFTVVPKAHVSAKPAKTPTSAVEQAVGIS
                     AIVVGFMVPAGWVLAHLESYKKSSAA"
     exon            216..363
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      342..347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /note="hexamer: ATTAAA"
     polyA_site      363
                     /gene="Cox8b"
                     /gene_synonym="Cox8h; CoxVIII-H"
                     /note="major polyA site"
ORIGIN      
        1 cagctataaa aagccccagc tggctaccta agtggtcaga ggacgtgcag cggacattca
       61 gggtgcctct ttggggccaa ggaaggagtg cgaccccgag aatcatgcca aggctccccc
      121 ctatcctgcg gctgctccaa gcgcctgcga agttcacagt ggttcccaaa gcccatgtct
      181 ctgccaagcc agccaaaact cccacttccg ccgtggagca ggctgtgggg atctcagcca
      241 tagtcgttgg cttcatggtt ccagcaggat gggtcttagc ccacttggag agctataaaa
      301 agagctccgc agcatgaagt tgcacatccc tgagagattt cattaaacat gtccatctgc
      361 ctaaaaaaaa aaaaaaaaaa aaa
//
