LOCUS       NM_007749                449 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 7C (Cox7c), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_007749 XM_903175
VERSION     NM_007749.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 449)
  AUTHORS   Cohen,B., Altman,T., Golani-Armon,A., Savulescu,A.F., Ibraheem,A.,
            Mhlanga,M.M., Perlson,E. and Arava,Y.S.
  TITLE     Co-transport of the nuclear-encoded Cox7c mRNA with mitochondria
            along axons occurs through a coding-region-dependent mechanism
  JOURNAL   J Cell Sci 135 (16) (2022)
   PUBMED   35833493
  REMARK    GeneRIF: Co-transport of the nuclear-encoded Cox7c mRNA with
            mitochondria along axons occurs through a coding-region-dependent
            mechanism.
REFERENCE   4  (bases 1 to 449)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   5  (bases 1 to 449)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   6  (bases 1 to 449)
  AUTHORS   Wang,Q. and Latham,K.E.
  TITLE     Requirement for protein synthesis during embryonic genome
            activation in mice
  JOURNAL   Mol Reprod Dev 47 (3), 265-270 (1997)
   PUBMED   9170106
REFERENCE   7  (bases 1 to 449)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
REFERENCE   8  (bases 1 to 449)
  AUTHORS   Taylor,K.D. and Piko,L.
  TITLE     Mitochondrial biogenesis in early mouse embryos: expression of the
            mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and
            subunit 9 (P1) of H(+)-ATP synthase
  JOURNAL   Mol Reprod Dev 40 (1), 29-35 (1995)
   PUBMED   7535541
REFERENCE   9  (bases 1 to 449)
  AUTHORS   Mann,M., Latham,K.E. and Varmuza,S.
  TITLE     Identification of genes showing altered expression in
            preimplantation and early postimplantation parthenogenetic embryos
  JOURNAL   Dev Genet 17 (3), 223-232 (1995)
   PUBMED   8565329
REFERENCE   10 (bases 1 to 449)
  AUTHORS   Akamatsu,M. and Grossman,L.I.
  TITLE     Nucleotide sequence of a cDNA for mouse cytochrome c oxidase
            subunit VIIc
  JOURNAL   Nucleic Acids Res 18 (12), 3645 (1990)
   PUBMED   2163523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB696274.1, AK131871.1 and AV056265.1.
            
            On Apr 21, 2006 this sequence version replaced NM_007749.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY135818.1, BU531618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN02415133,
                                           SAMN02415134 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BB696274.1         11-18
            9-422               AK131871.1         5-418
            423-449             AV056265.1         263-289
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..449
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /note="cytochrome c oxidase subunit 7C"
                     /db_xref="GeneID:12867"
                     /db_xref="MGI:MGI:103226"
     exon            1..195
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..312
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 7C, mitochondrial;
                     cytochrome c oxidase polypeptide VIIc; cytochrome c
                     oxidase subunit VIIc"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7C, mitochondrial
                     precursor"
                     /protein_id="NP_031775.1"
                     /db_xref="CCDS:CCDS26668.1"
                     /db_xref="GeneID:12867"
                     /db_xref="MGI:MGI:103226"
                     /translation="MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWRLLAMMTVY
                     FGSGFAAPFFIVRHQLLKK"
     exon            196..338
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            339..449
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      411..416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /note="hexamer: AATAAA"
     polyA_site      431
                     /gene="Cox7c"
                     /gene_synonym="Cox7c1; COXVIIc"
                     /note="major polyA site"
ORIGIN      
        1 atcttccctt tcggtcttcg cgctctgccg agcaaggtcg tgtagaaagg ggagttaggt
       61 ggtacggcca tttcttccgc cttccgtgtc tgcggccctc gcagaacttc cagcagcgac
      121 atgttgggcc agagtatccg gaggttcacg acctccgtgg tccgtcgcag ccactatgag
      181 gagggtccgg ggaagaattt gccattttca gtggaaaaca agtggcggtt gctggctatg
      241 atgaccgtgt actttggatc tgggtttgcc gcacctttct ttatagtaag acaccagcta
      301 cttaaaaaat aaggatattt aattcatccc tttaacagaa tgaagaaagt ttaagagatg
      361 atctgaaaat tggattaaac tcttgaactc ttatactaga aaaaattgta aataaactaa
      421 tgacataaag attcaatgcc tcgtctctg
//
