LOCUS       NM_009187               1100 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 7A2 like (Cox7a2l),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009187
VERSION     NM_009187.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Mitchell,J.S., Spanier,J.A., Dwyer,A.J., Knutson,T.P.,
            Alkhatib,M.H., Qian,G., Weno,M.E., Chen,Y., Shaheen,Z.R.,
            Tucker,C.G., Kangas,T.O., Morales,M.S., Silva,N., Kaisho,T.,
            Farrar,M.A. and Fife,B.T.
  TITLE     CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin
            A adopt a distinct effector fate and are pathogenic in autoimmune
            diabetes
  JOURNAL   Immunity 57 (10), 2399-2415 (2024)
   PUBMED   39214091
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Sung,C.Y.W., Hayase,N., Yuen,P.S.T., Lee,J., Fernandez,K., Hu,X.,
            Cheng,H., Star,R.A., Warchol,M.E. and Cunningham,L.L.
  TITLE     Macrophage depletion protects against cisplatin-induced ototoxicity
            and nephrotoxicity
  JOURNAL   Sci Adv 10 (30), eadk9878 (2024)
   PUBMED   39047106
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Sirbulescu,R.F., Nicholson,K., Kawai,K., Hilton,O.M., Sobell,D.,
            Jin,G., Verrill,D.E., Dwyer,L.J., Xiong,Y., Bachanova,P., Kim,S.E.,
            Gallup,S., Gelevski,D., Daley,H., Hernandez Rodriguez,D.E.,
            Negre,H., Sturtevant,O., Nikiforow,S., Ritz,J., Chen,Y.B.,
            Reeves,P.M., Sluder,A.E., Berry,J.D., Sadri-Vakili,G., Cudkowicz,M.
            and Poznansky,M.C.
  TITLE     Allogeneic B cell immunomodulatory therapy in amyotrophic lateral
            sclerosis
  JOURNAL   FASEB J 38 (13), e23796 (2024)
   PUBMED   38967302
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 1100)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1100)
  AUTHORS   Segade,F., Hurle,B., Claudio,E., Ramos,S. and Lazo,P.S.
  TITLE     Identification of an additional member of the cytochrome c oxidase
            subunit VIIa family of proteins
  JOURNAL   J Biol Chem 271 (21), 12343-12349 (1996)
   PUBMED   8647836
REFERENCE   9  (bases 1 to 1100)
  AUTHORS   Segade,F., Claudio,E., Wrobel,K., Ramos,S. and Lazo,P.S.
  TITLE     Isolation of nine gene sequences induced by silica in murine
            macrophages
  JOURNAL   J Immunol 154 (5), 2384-2392 (1995)
   PUBMED   7868905
REFERENCE   10 (bases 1 to 1100)
  AUTHORS   Mixter,P.F., Russell,J.Q., Durie,F.H. and Budd,R.C.
  TITLE     Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking
            beta 2-microglobulin
  JOURNAL   J Immunol 154 (5), 2063-2074 (1995)
   PUBMED   7868883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122624.1, AK133520.1 and BP769290.1.
            
            On Apr 18, 2009 this sequence version replaced NM_009187.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB595474.1, BC085296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               BY122624.1         1-314
            315-1063            AK133520.1         315-1063
            1064-1100           BP769290.1         1-37                c
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 53.02 cM"
     gene            1..1100
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /note="cytochrome c oxidase subunit 7A2 like"
                     /db_xref="GeneID:20463"
                     /db_xref="MGI:MGI:106015"
     exon            1..130
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /inference="alignment:Splign:2.1.0"
     exon            131..259
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /inference="alignment:Splign:2.1.0"
     exon            260..1080
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /note="hexamer: AATAAA"
     polyA_site      1069
                     /gene="Cox7a2l"
                     /gene_synonym="COX7AR; COX7RP; EB1; Scaf1; SIG-81; SIG81;
                     Silg81"
                     /note="major polyA site"
ORIGIN      
        1 ggtccttttc tagggcggtc gcacaggcag cggcggtgcg aagcgggcct ccgccaacat
       61 gtactacaag tttagcagtt tcacgcagaa gttggctgga gcttgggctt cggaagccta
      121 caccccgcag gggttaaagc cagtttccac agaagcacca cctatcatat ttgccacacc
      181 aaccaaactg acctccagtg tgacagcata tgattattct gggaagaaca aagttccaga
      241 gctgcagaag tttttccaga aggctgatgg tttccacctg aaacgaggcc ttccagacca
      301 aatgctttac cggaccacca tggctctgac actgggaggg accatctact gcctgatcgc
      361 cctctacatg gcctcgcagc ccagaaacaa atgagcttgc ctgtggagga ctggttcact
      421 ttgtggcaca aaccctttga atcctcacgt ttcatgtttt ccacttggat agtctactta
      481 acattttgca aacaaaggaa aagataagaa tacattgttt tgatttgttt atggtgtgca
      541 gatggcctgt cagatgtcag agctggtttg acagttaaaa ctattgttta aggaaatgtc
      601 actgagccat cactgagctg tgcttctgct cctgatttcc ctggagttct gcaggaaagt
      661 tgctctccag ctcattcgtg gccagccgtg ctcagggcct cgggactcag gcggtgtctg
      721 agcgggaagc gaagcgcgga agccttttgg agtgtaggtg tgattgagga aggaaaacaa
      781 aagccagcgg acaggtggtg aagtgagggc tgagttagcc accctaggga ttgctccgcc
      841 ttgcagaaaa cattgagagg aatgatagca acctgcctct atttgtgggc agttggtttc
      901 aaagggttgt gtgtctcgcc cagaacctag ggaaatgggt gtttgttcca tcgtgggagg
      961 agcacctgtc agtgctgcac attagacagc tgtgtcagga gttctccttt aataatgctg
     1021 tggctttacg ttatgattga ccggactgcg gaataaacac tggaatgaag atgtttttag
     1081 aaaaaaaaaa aaaaaaaaaa
//
