LOCUS       NM_009945                754 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 7A2 (Cox7a2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_009945
VERSION     NM_009945.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Chen,L., Jia,J.M., Zhong,W., Zhang,Y.L., Lu,J., Wang,H.W., Zhou,Z.,
            Wang,M.X., Xin,Z.C. and Guo,Y.L.
  TITLE     [P70S6K is involved in the inhibition of testosterone production in
            TM3 mouse Leydig cells overexpressing Cox7a2]
  JOURNAL   Zhonghua Nan Ke Xue 17 (4), 291-295 (2011)
   PUBMED   21548202
  REMARK    GeneRIF: Cox7a2 decreased P70S6K phosphorylation, reduced StAR
            expression and consequently inhibited LH-induced testosterone
            biosynthesis in the TM3 Leydig cells.
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Chen,L., Xin,Z.C., Li,X., Tian,L., Yuan,Y.M., Liu,G., Jiang,X.J.
            and Guo,Y.L.
  TITLE     Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells
  JOURNAL   Asian J Androl 8 (5), 589-594 (2006)
   PUBMED   16752004
  REMARK    GeneRIF: Cox7a2 inhibited lutropin-induced StAR protein expression,
            and consequent testosterone production
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Garg,N., Popov,V.L. and Papaconstantinou,J.
  TITLE     Profiling gene transcription reveals a deficiency of mitochondrial
            oxidative phosphorylation in Trypanosoma cruzi-infected murine
            hearts: implications in chagasic myocarditis development
  JOURNAL   Biochim Biophys Acta 1638 (2), 106-120 (2003)
   PUBMED   12853116
  REMARK    GeneRIF: The protein level for COX7AL was decreased early during
            the acute phase.
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Jaradat,S.A., Ko,M.S. and Grossman,L.I.
  TITLE     Tissue-specific expression and mapping of the Cox7ah gene in mouse
  JOURNAL   Genomics 49 (3), 363-370 (1998)
   PUBMED   9615220
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583-4]
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Hoog,C.
  TITLE     Isolation of a large number of novel mammalian genes by a
            differential cDNA library screening strategy
  JOURNAL   Nucleic Acids Res 19 (22), 6123-6127 (1991)
   PUBMED   1659684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN838002.1 and CN670202.1.
            
            On Dec 23, 2005 this sequence version replaced NM_009945.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN670202.1, CX236205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               CN838002.1         4-542
            540-754             CN670202.1         403-617
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.82 cM"
     gene            1..754
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /note="cytochrome c oxidase subunit 7A2"
                     /db_xref="GeneID:12866"
                     /db_xref="MGI:MGI:1316715"
     exon            1..214
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..448
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit VIIa-L; cytochrome c
                     oxidase subunit 7A2, mitochondrial; cytochrome c oxidase
                     subunit VIIa-liver/heart; cytochrome c oxidase subunit
                     VIIa 3; cytochrome c oxidase subunit VIIa 2"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7A2, mitochondrial
                     precursor"
                     /protein_id="NP_034075.2"
                     /db_xref="CCDS:CCDS23366.1"
                     /db_xref="GeneID:12866"
                     /db_xref="MGI:MGI:1316715"
                     /translation="MLRNLLALRQIAQRTISTTSRRHFENKVPEKQKLFQEDNGMPVH
                     LKGGASDALLYRATMALTLGGTAYAIYLLAMAAFPKKQN"
     exon            215..304
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /inference="alignment:Splign:2.1.0"
     exon            305..389
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /inference="alignment:Splign:2.1.0"
     exon            390..754
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /note="major polyA site"
     regulatory      614..619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
                     /note="hexamer: AATAAA"
     polyA_site      634
                     /gene="Cox7a2"
                     /gene_synonym="Cox7a3; COX7AL; CoxVIIa-L"
ORIGIN      
        1 agacgggccg ctgcgagaag tcgctctggc tcgccttccg ctctctatgg tcgggagcgc
       61 gagcccctcc tcttcccgga acgagccctc ttgctcgacg cgcgcgcagc gctaggaggg
      121 agttccgttt ccggtctggt ggctttcgat ttttggcgtt cagtagtcgc ggttggtggg
      181 taacaaccga gccaagatgt tgcggaatct gctggccctt cgtcagattg cccagaggac
      241 catcagcacc acttcacgaa ggcattttga aaacaaggtt ccagagaaac aaaagctgtt
      301 tcaggaggat aatgggatgc cagttcatct gaaaggcggg gcatctgatg ccctcctcta
      361 cagagccaca atggctctga cgcttggtgg cacagcctat gccatctatc tgttagctat
      421 ggctgcattt cccaagaagc agaactaatg tcgtcatccc agtcttcacg tggttcagtt
      481 tcatcaacgc tcgatggacc aggaatctga tgagtaactg agctcttctt tggggatcaa
      541 tatttattga tgtgtattaa ctgctgccaa taaagcaatc cttaaccatt ttgtgtctcc
      601 cttttcactt gagaataaat tcctggtaat accattttgt gtcagcagtt ggcaaatctt
      661 agataagaaa aaaatttaaa agttgtttgt ccacaagttt atctaaagca ccattgtcat
      721 ggtaatgtgt attcactttt agcagctagg gata
//
