LOCUS       NM_009944                393 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome c oxidase subunit 7A1 (Cox7a1), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009944
VERSION     NM_009944.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 393)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   3  (bases 1 to 393)
  AUTHORS   Chae,S.A., Son,J.S., de Avila,J.M., Du,M. and Zhu,M.J.
  TITLE     Maternal exercise improves epithelial development of fetal
            intestine by enhancing apelin signaling and oxidative metabolism
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (5), R728-R738 (2022)
   PUBMED   36189989
REFERENCE   4  (bases 1 to 393)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 393)
  AUTHORS   Holzman,M.A., Ryckman,A., Finkelstein,T.M., Landry-Truchon,K.,
            Schindler,K.A., Bergmann,J.M., Jeannotte,L. and Mansfield,J.H.
  TITLE     HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal
            Muscle Patterning and in Brown Adipocyte Differentiation
  JOURNAL   Front Cell Dev Biol 9, 632303 (2021)
   PUBMED   33732701
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 393)
  AUTHORS   Garg,N., Popov,V.L. and Papaconstantinou,J.
  TITLE     Profiling gene transcription reveals a deficiency of mitochondrial
            oxidative phosphorylation in Trypanosoma cruzi-infected murine
            hearts: implications in chagasic myocarditis development
  JOURNAL   Biochim Biophys Acta 1638 (2), 106-120 (2003)
   PUBMED   12853116
  REMARK    GeneRIF: A significasnt decrease in COX7AH polypeptide was observed
            in the myocardium of infected mice at 110 dpi, the repression being
            amplified with chronic disease development (330 dpi).
REFERENCE   7  (bases 1 to 393)
  AUTHORS   Vizirianakis,I.S., Pappas,I.S. and Tsiftsoglou,A.S.
  TITLE     Differentiation-dependent repression of c-myc, B22, COX II and COX
            IV genes in murine erythroleukemia (MEL) cells
  JOURNAL   Biochem Pharmacol 63 (5), 1009-1017 (2002)
   PUBMED   11911854
  REMARK    Erratum:[Biochem Pharmacol 2002 May 15;63(10):1919]
REFERENCE   8  (bases 1 to 393)
  AUTHORS   Huttemann,M., Kadenbach,B. and Grossman,L.I.
  TITLE     Mammalian subunit IV isoforms of cytochrome c oxidase
  JOURNAL   Gene 267 (1), 111-123 (2001)
   PUBMED   11311561
REFERENCE   9  (bases 1 to 393)
  AUTHORS   Arthur,J.S., Greer,P.A. and Elce,J.S.
  TITLE     Structure of the mouse calpain small subunit gene
  JOURNAL   Biochim Biophys Acta 1388 (1), 247-252 (1998)
   PUBMED   9774740
REFERENCE   10 (bases 1 to 393)
  AUTHORS   Jaradat,S.A., Ko,M.S. and Grossman,L.I.
  TITLE     Tissue-specific expression and mapping of the Cox7ah gene in mouse
  JOURNAL   Genomics 49 (3), 363-370 (1998)
   PUBMED   9615220
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079950.1 and BC060974.1.
            
            On Dec 22, 2005 this sequence version replaced NM_009944.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060974.1, BU555231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AK079950.1         2-358
            358-393             BC060974.1         336-371
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.31 cM"
     gene            1..393
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="cytochrome c oxidase subunit 7A1"
                     /db_xref="GeneID:12865"
                     /db_xref="MGI:MGI:1316714"
     exon            1..75
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..303
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /EC_number="7.1.1.9"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cytochrome c oxidase subunit 7A1,
                     mitochondrial; cytochrome c oxidase subunit VIIa-H;
                     cytochrome c oxidase subunit VIIa-M; cytochrome c oxidase
                     subunit VIIa-heart; cytochrome c oxidase subunit
                     VIIa-muscle; cytochrome c oxidase subunit VIIa 1"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7A1, mitochondrial
                     isoform 2 precursor"
                     /protein_id="NP_034074.1"
                     /db_xref="CCDS:CCDS21081.1"
                     /db_xref="GeneID:12865"
                     /db_xref="MGI:MGI:1316714"
                     /translation="MRALRVSQALVRSFSSSTRSHLENRVAEKQKLFQADNDLPVHLK
                     GGGMDNVLYRLTMTLTLGGTAYCLYCLGWASFPHKK"
     exon            76..162
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     exon            163..247
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     exon            248..366
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      337..342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="hexamer: AATAAA"
     polyA_site      366
                     /gene="Cox7a1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="major polyA site"
ORIGIN      
        1 aaagtgctgc acgtccttgg gcgaagaggg gaggtgactc ggagctgctg aggacgcaaa
       61 atgagggccc tacgggtctc ccaggctctg gtccggtctt ttagctcatc taccagaagc
      121 cacttagaaa accgtgtggc agagaagcag aagctcttcc aggccgacaa tgacctccca
      181 gtacacttga aaggcggggg aatggacaac gtcctgtaca gactgaccat gacgctgact
      241 ctggggggca ctgcctactg cttatactgc ttgggctggg cctccttccc ccacaagaag
      301 tgacaccaag aagcttggag gacttggaca aacatcaata aatatgctaa tctcttgaga
      361 acccaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
