LOCUS       NM_183405                568 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 6B2 (Cox6b2), transcript
            variant 1, mRNA.
ACCESSION   NM_183405
VERSION     NM_183405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 568)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 568)
  AUTHORS   Shimada,K., Lu,Y. and Ikawa,M.
  TITLE     Disruption of testis-enriched cytochrome c oxidase subunit COX6B2
            but not COX8C leads to subfertility
  JOURNAL   Exp Anim 73 (1), 1-10 (2024)
   PUBMED   37423748
  REMARK    GeneRIF: Disruption of testis-enriched cytochrome c oxidase subunit
            COX6B2 but not COX8C leads to subfertility.
REFERENCE   3  (bases 1 to 568)
  AUTHORS   Saha,S., Bose,R., Chakraborty,S. and Ain,R.
  TITLE     Tipping the balance toward stemness in trophoblast: Metabolic
            programming by Cox6B2
  JOURNAL   FASEB J 36 (11), e22600 (2022)
   PUBMED   36250984
REFERENCE   4  (bases 1 to 568)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 568)
  AUTHORS   Huttemann,M., Jaradat,S. and Grossman,L.I.
  TITLE     Cytochrome c oxidase of mammals contains a testes-specific isoform
            of subunit VIb--the counterpart to testes-specific cytochrome c?
  JOURNAL   Mol Reprod Dev 66 (1), 8-16 (2003)
   PUBMED   12874793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY152400.1, AK160152.1 and AW123567.1.
            
            [WARNING] On Jan 31, 2025 this sequence was replaced by
            NM_183405.3.
            
            On Feb 1, 2014 this sequence version replaced NM_183405.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 3. Variants 1 through 3 encode the same isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU743708.1, CN839626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AY152400.1         1-71
            72-550              AK160152.1         2-480
            551-568             AW123567.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.75 cM"
     gene            1..568
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /note="cytochrome c oxidase subunit 6B2"
                     /db_xref="GeneID:333182"
                     /db_xref="MGI:MGI:3044182"
     exon            1..142
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..268
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..423
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome c oxidase subunit VIb polypeptide 2"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6B2 isoform 1"
                     /protein_id="NP_899664.1"
                     /db_xref="CCDS:CCDS39738.1"
                     /db_xref="GeneID:333182"
                     /db_xref="MGI:MGI:3044182"
                     /translation="MLGVQAQKPPPGQWTTPPFDPRFPNQNQTRNCYQNFLDYHRCVK
                     TMNRRGKSTQPCEYYFRVFHSLCPISWVQRWNEQIKQGTFPGKI"
     exon            269..369
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..553
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      532..537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /note="hexamer: AATAAA"
     polyA_site      553
                     /gene="Cox6b2"
                     /gene_synonym="1700067P11Rik; COXVIB2"
                     /note="major polyA site"
ORIGIN      
        1 gactccctgg gagccagcca atccggcctg agggtcgtat tttttctccc gtgctcttgg
       61 gaccagccct cattctcaaa ctaaaggcac gggtggattc cgcagccctg gtgttccagc
      121 tactttggct cacttcagtc tggaattgct acttggatgt tgggtgttca agcccagaag
      181 ccccctccgg gccaatggac aacgccgccc tttgatccgc gcttccctaa ccagaaccag
      241 acgcgtaact gctaccagaa ttttctggac taccaccggt gtgtgaagac catgaatcgc
      301 cgcggaaaga gcacacaacc ctgcgagtac tatttccgtg tattccattc actgtgtccc
      361 atcagctggg tgcagcgctg gaatgagcag atcaagcagg gaactttccc gggcaaaata
      421 tgaccttgca cttgagcgct gctcccctgg cgtcatcaac ccctagtggc tgtcctttca
      481 tcaagcccca gcctgggtca ccccctccct ccactttgtc tttgtgccac aaataaagtt
      541 attgtgctgc taaaaaaaaa aaaaaaaa
//
