LOCUS       NM_009943                678 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 6A2 (Cox6a2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_009943
VERSION     NM_009943.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 678)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 678)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 678)
  AUTHORS   Malwade,S., Gasthaus,J., Bellardita,C., Andelic,M., Moric,B.,
            Korshunova,I., Kiehn,O., Vasistha,N.A. and Khodosevich,K.
  TITLE     Identification of Vulnerable Interneuron Subtypes in 15q13.3
            Microdeletion Syndrome Using Single-Cell Transcriptomics
  JOURNAL   Biol Psychiatry 91 (8), 727-739 (2022)
   PUBMED   34838304
REFERENCE   4  (bases 1 to 678)
  AUTHORS   Khadimallah,I., Jenni,R., Cabungcal,J.H., Cleusix,M., Fournier,M.,
            Beard,E., Klauser,P., Knebel,J.F., Murray,M.M., Retsa,C.,
            Siciliano,M., Spencer,K.M., Steullet,P., Cuenod,M., Conus,P. and
            Do,K.Q.
  TITLE     Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as
            biomarkers of parvalbumin interneurons, psychopathology, and
            neurocognition in schizophrenia
  JOURNAL   Mol Psychiatry 27 (2), 1192-1204 (2022)
   PUBMED   34686767
  REMARK    GeneRIF: Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony
            as biomarkers of parvalbumin interneurons, psychopathology, and
            neurocognition in schizophrenia.
REFERENCE   5  (bases 1 to 678)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   6  (bases 1 to 678)
  AUTHORS   Schmidt,T.R., Jaradat,S.A., Goodman,M., Lomax,M.I. and
            Grossman,L.I.
  TITLE     Molecular evolution of cytochrome c oxidase: rate variation among
            subunit VIa isoforms
  JOURNAL   Mol Biol Evol 14 (6), 595-601 (1997)
   PUBMED   9190060
REFERENCE   7  (bases 1 to 678)
  AUTHORS   Makris,G.J. and Lomax,M.I.
  TITLE     The gene encoding the heart/muscle isoform of cytochrome c oxidase
            subunit VIII maps to mouse chromosome 7
  JOURNAL   Mamm Genome 8 (6), 453-454 (1997)
   PUBMED   9166597
REFERENCE   8  (bases 1 to 678)
  AUTHORS   Bachman,N.J., Riggs,P.K., Siddiqui,N., Makris,G.J., Womack,J.E. and
            Lomax,M.I.
  TITLE     Structure of the human gene (COX6A2) for the heart/muscle isoform
            of cytochrome c oxidase subunit VIa and its chromosomal location in
            humans, mice, and cattle
  JOURNAL   Genomics 42 (1), 146-151 (1997)
   PUBMED   9177785
REFERENCE   9  (bases 1 to 678)
  AUTHORS   Wan,B. and Moreadith,R.W.
  TITLE     Structural characterization and regulatory element analysis of the
            heart isoform of cytochrome c oxidase VIa
  JOURNAL   J Biol Chem 270 (44), 26433-26440 (1995)
   PUBMED   7592858
REFERENCE   10 (bases 1 to 678)
  AUTHORS   Grossman,L.I., Rosenthal,N.H., Akamatsu,M. and Erickson,R.P.
  TITLE     Cloning, sequence analysis, and expression of a mouse cDNA encoding
            cytochrome c oxidase subunit VIa liver isoform
  JOURNAL   Biochim Biophys Acta 1260 (3), 361-364 (1995)
   PUBMED   7873616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU842968.1, AK002506.1 and BF472154.1.
            
            On Dec 22, 2005 this sequence version replaced NM_009943.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF472154.1, CJ041966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BU842968.1         1-50
            51-480              AK002506.1         2-431
            481-678             BF472154.1         364-561
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.04 cM"
     gene            1..678
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /note="cytochrome c oxidase subunit 6A2"
                     /db_xref="GeneID:12862"
                     /db_xref="MGI:MGI:104649"
     exon            1..144
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..365
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 6A2, mitochondrial;
                     cytochrome c oxidase polypeptide VIa-heart; subunit VIaH
                     (heart-type); cytochrome c oxidase subunit VIa polypeptide
                     2"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6A2, mitochondrial
                     precursor"
                     /protein_id="NP_034073.2"
                     /db_xref="CCDS:CCDS21891.1"
                     /db_xref="GeneID:12862"
                     /db_xref="MGI:MGI:104649"
                     /translation="MALPLKVLSRSMASAAKGDHGGAGANTWRLLTFVLALPGVALCS
                     LNCWMHAGHHERPEFIPYHHLRIRTKPFAWGDGNHTLFHNPHVNPLPTGYEHP"
     exon            145..281
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /inference="alignment:Splign:2.1.0"
     exon            282..659
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      462..467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /note="hexamer: AATAAA"
     polyA_site      480
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /note="major polyA site"
     regulatory      635..640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
                     /note="hexamer: AATACA"
     polyA_site      656
                     /gene="Cox6a2"
                     /gene_synonym="CoxVIaH; VIaH"
ORIGIN      
        1 ggggaggaga gcctctcgac tgggtgaagg agacagagaa ggacagtgcc attcctagcc
       61 tccctttgac aatggctctg cctctaaagg tcctgagccg gagcatggcc agcgcagcca
      121 aaggagacca tggaggggca ggagccaaca cctggcgcct cctgaccttt gtgctggctc
      181 ttcccggcgt agccctctgc tcccttaact gctggatgca cgctggccac cacgagcgcc
      241 cagagttcat cccgtatcac cacctccgca tccgaaccaa gcccttcgcc tggggggacg
      301 gcaaccacac gcttttccac aatccccacg tcaatccttt gcccaccggt tatgagcacc
      361 cttgatgtct cagcagacac gctctgccag caatcttcaa attggccttc tgcacaccgg
      421 ctctgagagc ccctgaggtt ccagtggaca gttccaagct caataaaggt gtggaagttt
      481 tgtgtcctct ggctctttgg gaacagcatg gtggaagggg ctgggcaggc tcttgggcag
      541 ttggtatctg ggttccagtt attttttttt atataaggaa aatgtgatgt ttccacctgc
      601 attttcattt tattttttaa aaatttatac aagcaataca ttgaatattg agcatattaa
      661 aaaaaaaaaa aaaaaaaa
//
