LOCUS       NM_007748                538 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 6A1 (Cox6a1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_007748
VERSION     NM_007748.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 538)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 538)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 538)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 538)
  AUTHORS   Duteil,D., Tosic,M., Lausecker,F., Nenseth,H.Z., Muller,J.M.,
            Urban,S., Willmann,D., Petroll,K., Messaddeq,N., Arrigoni,L.,
            Manke,T., Kornfeld,J.W., Bruning,J.C., Zagoriy,V., Meret,M.,
            Dengjel,J., Kanouni,T. and Schule,R.
  TITLE     Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose
            Tissue
  JOURNAL   Cell Rep 17 (4), 1008-1021 (2016)
   PUBMED   27760309
REFERENCE   5  (bases 1 to 538)
  AUTHORS   Doucet-Beaupre,H., Gilbert,C., Profes,M.S., Chabrat,A., Pacelli,C.,
            Giguere,N., Rioux,V., Charest,J., Deng,Q., Laguna,A., Ericson,J.,
            Perlmann,T., Ang,S.L., Cicchetti,F., Parent,M., Trudeau,L.E. and
            Levesque,M.
  TITLE     Lmx1a and Lmx1b regulate mitochondrial functions and survival of
            adult midbrain dopaminergic neurons
  JOURNAL   Proc Natl Acad Sci U S A 113 (30), E4387-E4396 (2016)
   PUBMED   27407143
REFERENCE   6  (bases 1 to 538)
  AUTHORS   Giesen,K., Plum,L., Kluge,R., Ortlepp,J. and Joost,H.G.
  TITLE     Diet-dependent obesity and hypercholesterolemia in the New Zealand
            obese mouse: identification of a quantitative trait locus for
            elevated serum cholesterol on the distal mouse chromosome 5
  JOURNAL   Biochem Biophys Res Commun 304 (4), 812-817 (2003)
   PUBMED   12727230
REFERENCE   7  (bases 1 to 538)
  AUTHORS   Huttemann,M., Arnold,S., Lee,I., Muhlenbein,N., Linder,D.,
            Lottspeich,F. and Kadenbach,B.
  TITLE     Turkey cytochrome c oxidase contains subunit VIa of the liver type
            associated with low efficiency of energy transduction
  JOURNAL   Eur J Biochem 267 (7), 2098-2104 (2000)
   PUBMED   10727950
REFERENCE   8  (bases 1 to 538)
  AUTHORS   Guerra,C., Koza,R.A., Walsh,K., Kurtz,D.M., Wood,P.A. and
            Kozak,L.P.
  TITLE     Abnormal nonshivering thermogenesis in mice with inherited defects
            of fatty acid oxidation
  JOURNAL   J Clin Invest 102 (9), 1724-1731 (1998)
   PUBMED   9802886
REFERENCE   9  (bases 1 to 538)
  AUTHORS   Schmidt,T.R., Jaradat,S.A., Goodman,M., Lomax,M.I. and
            Grossman,L.I.
  TITLE     Molecular evolution of cytochrome c oxidase: rate variation among
            subunit VIa isoforms
  JOURNAL   Mol Biol Evol 14 (6), 595-601 (1997)
   PUBMED   9190060
REFERENCE   10 (bases 1 to 538)
  AUTHORS   Grossman,L.I., Rosenthal,N.H., Akamatsu,M. and Erickson,R.P.
  TITLE     Cloning, sequence analysis, and expression of a mouse cDNA encoding
            cytochrome c oxidase subunit VIa liver isoform
  JOURNAL   Biochim Biophys Acta 1260 (3), 361-364 (1995)
   PUBMED   7873616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117735.8.
            
            On Dec 4, 2019 this sequence version replaced NM_007748.4.
            
            CCDS Note: The coding region has been updated to start at a
            downstream in-frame start codon that is supported by conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052816.1, CF739427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC117735.8         131287-131406
            121-263             AC117735.8         131538-131680
            264-538             AC117735.8         134319-134593
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.06 cM"
     gene            1..538
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /note="cytochrome c oxidase subunit 6A1"
                     /db_xref="GeneID:12861"
                     /db_xref="MGI:MGI:103099"
     exon            1..120
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..347
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase polypeptide VIa-liver; subunit
                     VIaL (liver-type); cytochrome c oxidase subunit VIa
                     polypeptide 1"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6A1, mitochondrial"
                     /protein_id="NP_031774.2"
                     /db_xref="CCDS:CCDS19590.1"
                     /db_xref="GeneID:12861"
                     /db_xref="MGI:MGI:103099"
                     /translation="MASAVLSASRVSRPLGRALPGLRRPMSSGAHGEEGSARMWKALT
                     YFVALPGVGVSMLNVFLKSRHEEHERPPFVAYPHLRIRTKPFPWGDGNHTLFHNPHVN
                     PLPTGYEDE"
     exon            121..263
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /inference="alignment:Splign:2.1.0"
     exon            264..538
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      518..523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /note="hexamer: AATAAA"
     polyA_site      538
                     /gene="Cox6a1"
                     /gene_synonym="VIaL"
                     /note="major polyA site"
ORIGIN      
        1 gtagttccat gatggcgtcg gcggtgctgt cagcgtctcg ggtctctcgg ccgctgggcc
       61 gggccctccc cgggttgagg cggcccatgt cgagtggcgc ccacggcgag gagggttcag
      121 ctcggatgtg gaaggccctc acctacttcg tggcgctgcc cggggtggga gtgagcatgc
      181 tcaacgtgtt cctcaagtcg cggcacgaag agcacgagag acccccgttc gttgcctacc
      241 ctcacctgcg catcaggacc aagcccttcc cctggggaga cggtaaccat accctcttcc
      301 acaaccctca tgtgaaccca cttccgaccg gctatgaaga tgagtaaaga gaacctggcc
      361 tcccccaggc aacaaaggga ccacagcact ggttttggac ccttactctg tgtggaccac
      421 gaaaaccctt tggatgctaa gctcgtgtct cctttcctca gatggcgacc attactctga
      481 tcttccatcc cttctgcttg taagaggaga tgccttaaat aaataactta aactcaga
//
