LOCUS       NM_009942                584 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 5B (Cox5b), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_009942
VERSION     NM_009942.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 584)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 584)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   4  (bases 1 to 584)
  AUTHORS   Basta,J.M., Singh,A.P., Robbins,L., Stout,L., Pherson,M. and
            Rauchman,M.
  TITLE     The core SWI/SNF catalytic subunit Brg1 regulates nephron
            progenitor cell proliferation and differentiation
  JOURNAL   Dev Biol 464 (2), 176-187 (2020)
   PUBMED   32504627
REFERENCE   5  (bases 1 to 584)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 584)
  AUTHORS   Basu,A., Lenka,N., Mullick,J. and Avadhani,N.G.
  TITLE     Regulation of murine cytochrome oxidase Vb gene expression in
            different tissues and during myogenesis. Role of a YY-1
            factor-binding negative enhancer
  JOURNAL   J Biol Chem 272 (9), 5899-5908 (1997)
   PUBMED   9038208
REFERENCE   7  (bases 1 to 584)
  AUTHORS   Taylor,K.D. and Piko,L.
  TITLE     Mitochondrial biogenesis in early mouse embryos: expression of the
            mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and
            subunit 9 (P1) of H(+)-ATP synthase
  JOURNAL   Mol Reprod Dev 40 (1), 29-35 (1995)
   PUBMED   7535541
REFERENCE   8  (bases 1 to 584)
  AUTHORS   Basu,A. and Avadhani,N.G.
  TITLE     Structural organization of nuclear gene for subunit Vb of mouse
            mitochondrial cytochrome c oxidase
  JOURNAL   J Biol Chem 266 (23), 15450-15456 (1991)
   PUBMED   1651332
REFERENCE   9  (bases 1 to 584)
  AUTHORS   Basu,A. and Avadhani,N.G.
  TITLE     Nucleotide sequence of cDNA for nuclear encoded subunit Vb of mouse
            cytochrome-c oxidase
  JOURNAL   Biochim Biophys Acta 1087 (1), 98-100 (1990)
   PUBMED   2169317
REFERENCE   10 (bases 1 to 584)
  AUTHORS   Nielsen,P.J., Ayane,M. and Kohler,G.
  TITLE     Nucleotide sequence of cDNA encoding mouse cytochrome c oxidase
            subunit Va
  JOURNAL   Nucleic Acids Res 17 (16), 6723 (1989)
   PUBMED   2550898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075429.1, AK135174.1 and BU757937.1.
            
            On Aug 19, 2006 this sequence version replaced NM_009942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF741094.1, BG808840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CJ075429.1         6-77
            73-566              AK135174.1         2-495
            567-584             BU757937.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.38 cM"
     gene            1..584
                     /gene="Cox5b"
                     /note="cytochrome c oxidase subunit 5B"
                     /db_xref="GeneID:12859"
                     /db_xref="MGI:MGI:88475"
     exon            1..203
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..490
                     /gene="Cox5b"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase polypeptide Vb; cytochrome c
                     oxidase subunit Vb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 5B, mitochondrial"
                     /protein_id="NP_034072.2"
                     /db_xref="CCDS:CCDS14886.1"
                     /db_xref="GeneID:12859"
                     /db_xref="MGI:MGI:88475"
                     /translation="MASRLLRGVGALAAQALRAHGPRGAAVTRSMASGGGVPTDEEQA
                     TGLEREIMIAAQKGLDPYNMLPPKAASGTKEDPNLVPSISNKRIVGCICEEDNCTVIW
                     FWLHKGESQRCPNCGTHYKLVPHQMAH"
     exon            204..277
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     exon            278..377
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     exon            378..569
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      535..540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox5b"
                     /note="hexamer: AATAAA"
     polyA_site      569
                     /gene="Cox5b"
                     /note="major polyA site"
ORIGIN      
        1 agcggaagac tgaccgggcg ttgttagact cccaccaacg gaagtcccgc ccatcttgct
       61 cagcctgttc ccggaagtgc atctgcttgt ctcgggcgag atggcttcaa ggttacttcg
      121 cggagtgggc gctttggcgg cgcaggccct gagggcccac ggcccccgtg gcgcggccgt
      181 gacccgctcc atggcttctg gaggtggtgt ccccactgat gaggagcagg ctactgggct
      241 ggagagggag atcatgatag cagcacagaa gggactggac ccatacaata tgctacctcc
      301 aaaggcagct tcaggcacca aggaagaccc taatctagtc ccgtccatca gcaacaagag
      361 aatagtgggc tgcatctgtg aagaggacaa ctgtactgtc atctggtttt ggctgcacaa
      421 aggcgagagt cagcgatgcc ccaactgtgg aacccattac aagctggtgc cccaccaaat
      481 ggcccactga gcccctgtgt tatcttttca gaatgtaaag aaaaacttct ctctaataaa
      541 gattagccat tgcactggct cctcccataa aaaaaaaaaa aaaa
//
