LOCUS       NM_007747                707 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 5A (Cox5a), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_007747
VERSION     NM_007747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 707)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 707)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   3  (bases 1 to 707)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 707)
  AUTHORS   Ponce,J.M., Coen,G., Spitler,K.M., Dragisic,N., Martins,I.,
            Hinton,A. Jr., Mungai,M., Tadinada,S.M., Zhang,H., Oudit,G.Y.,
            Song,L.S., Li,N., Sicinski,P., Strack,S., Abel,E.D., Mitchell,C.,
            Hall,D.D. and Grueter,C.E.
  TITLE     Stress-Induced Cyclin C Translocation Regulates Cardiac
            Mitochondrial Dynamics
  JOURNAL   J Am Heart Assoc 9 (7), e014366 (2020)
   PUBMED   32248761
REFERENCE   5  (bases 1 to 707)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   6  (bases 1 to 707)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   7  (bases 1 to 707)
  AUTHORS   Nielsen,P.J., Ayane,M. and Kohler,G.
  TITLE     Nucleotide sequence of cDNA encoding mouse cytochrome c oxidase
            subunit Va
  JOURNAL   Nucleic Acids Res 17 (16), 6723 (1989)
   PUBMED   2550898
REFERENCE   8  (bases 1 to 707)
  AUTHORS   Droste,M., Schon,E. and Kadenbach,B.
  TITLE     Nucleotide sequence of cDNA encoding subunit Va from rat heart
            cytochrome c oxidase
  JOURNAL   Nucleic Acids Res 17 (11), 4375 (1989)
   PUBMED   2544858
REFERENCE   9  (bases 1 to 707)
  AUTHORS   Rizzuto,R., Nakase,H., Zeviani,M., DiMauro,S. and Schon,E.A.
  TITLE     Subunit Va of human and bovine cytochrome c oxidase is highly
            conserved
  JOURNAL   Gene 69 (2), 245-256 (1988)
   PUBMED   2853101
REFERENCE   10 (bases 1 to 707)
  AUTHORS   Wright,R.M., Ko,C., Cumsky,M.G. and Poyton,R.O.
  TITLE     Isolation and sequence of the structural gene for cytochrome c
            oxidase subunit VI from Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 259 (24), 15401-15407 (1984)
   PUBMED   6210289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY259203.1, AK018723.1 and CO044753.1.
            
            On Aug 12, 2006 this sequence version replaced NM_007747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF578606.1, BU848057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY259203.1         2-67
            67-689              AK018723.1         2-624
            690-707             CO044753.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.05 cM"
     gene            1..707
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /note="cytochrome c oxidase subunit 5A"
                     /db_xref="GeneID:12858"
                     /db_xref="MGI:MGI:88474"
     exon            1..184
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..537
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 5A, mitochondrial;
                     cytochrome c oxidase polypeptide Va; cytochrome c oxidase
                     subunit Va"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 5A, mitochondrial
                     precursor"
                     /protein_id="NP_031773.2"
                     /db_xref="CCDS:CCDS23223.1"
                     /db_xref="GeneID:12858"
                     /db_xref="MGI:MGI:88474"
                     /translation="MLAAALRRCTAAAAARGLLHPASAPSPAAAVCSIRCYSHGSHET
                     DEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAV
                     RILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV"
     exon            185..301
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /inference="alignment:Splign:2.1.0"
     exon            302..423
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /inference="alignment:Splign:2.1.0"
     exon            424..547
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /inference="alignment:Splign:2.1.0"
     exon            548..693
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      666..671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /note="hexamer: AATAAA"
     polyA_site      693
                     /gene="Cox5a"
                     /gene_synonym="CcOX"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctgcgt gagtccggcc cccgcgaact gctgtaccgc ccgcgagctc acaccggctt
       61 ctcgtcagcc tcagccagtg cgctgtggtc gccgtcatgc tcgccgctgc cctccgtcgc
      121 tgtaccgcag ccgcggctgc ccgaggcctc ctgcaccccg cctcggctcc cagccccgcc
      181 gccgctgtct gttccattcg ctgctattct catgggtcac acgagacaga tgaggagttt
      241 gatgctcgct gggtgacata tttcaacaag ccagacattg atgcctggga attgcgtaaa
      301 gggatgaata cacttgttgg ctatgatctg gttcctgagc ccaaaatcat tgatgctgca
      361 ttgcgagcat gtagacggtt aaatgatttt gctagtgctg ttcgcatctt ggaggttgtt
      421 aaggacaaag caggacctca taaggaaatc tatccctatg tcatccagga acttagacca
      481 actttaaatg aattgggaat ctccactcca gaggagctgg gccttgacaa agtgtaaact
      541 cccttcgatg ggcttcctaa ggacttaact gctattgcta cttgattgaa acagttgcct
      601 ggaaatgttt tatttgaaca aattttcctt tgagtatcaa accatgtaat agtaacttgg
      661 actttaataa agggaaatga gtttgaactg aaaaaaaaaa aaaaaaa
//
