LOCUS       NM_053091                727 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus cytochrome c oxidase subunit 4I2 (Cox4i2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_053091
VERSION     NM_053091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 727)
  AUTHORS   Moreno-Dominguez,A., Colinas,O., Arias-Mayenco,I., Cabeza,J.M.,
            Lopez-Ogayar,J.L., Chandel,N.S., Weissmann,N., Sommer,N.,
            Pascual,A. and Lopez-Barneo,J.
  TITLE     Hif1alpha-dependent mitochondrial acute O2 sensing and signaling to
            myocyte Ca2+ channels mediate arterial hypoxic vasodilation
  JOURNAL   Nat Commun 15 (1), 6649 (2024)
   PUBMED   39103356
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 727)
  AUTHORS   Zanini,F., Che,X., Suresh,N.E., Knutsen,C., Klavina,P., Xie,Y.,
            Domingo-Gonzalez,R., Liu,M., Kum,A., Jones,R.C., Quake,S.R.,
            Alvira,C.M. and Cornfield,D.N.
  TITLE     Hyperoxia prevents the dynamic neonatal increases in lung
            mesenchymal cell diversity
  JOURNAL   Sci Rep 14 (1), 2033 (2024)
   PUBMED   38263350
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 727)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 727)
  AUTHORS   Delavallee,L., Mathiah,N., Cabon,L., Mazeraud,A.,
            Brunelle-Navas,M.N., Lerner,L.K., Tannoury,M., Prola,A.,
            Moreno-Loshuertos,R., Baritaud,M., Vela,L., Garbin,K., Garnier,D.,
            Lemaire,C., Langa-Vives,F., Cohen-Salmon,M., Fernandez-Silva,P.,
            Chretien,F., Migeotte,I. and Susin,S.A.
  TITLE     Mitochondrial AIF loss causes metabolic reprogramming,
            caspase-independent cell death blockade, embryonic lethality, and
            perinatal hydrocephalus
  JOURNAL   Mol Metab 40, 101027 (2020)
   PUBMED   32480041
REFERENCE   5  (bases 1 to 727)
  AUTHORS   Moreno-Dominguez,A., Ortega-Saenz,P., Gao,L., Colinas,O.,
            Garcia-Flores,P., Bonilla-Henao,V., Aragones,J., Huttemann,M.,
            Grossman,L.I., Weissmann,N., Sommer,N. and Lopez-Barneo,J.
  TITLE     Acute O2 sensing through HIF2alpha-dependent expression of atypical
            cytochrome oxidase subunits in arterial chemoreceptors
  JOURNAL   Sci Signal 13 (615) (2020)
   PUBMED   31848220
  REMARK    GeneRIF: Acute O2 sensing through HIF2alpha-dependent expression of
            atypical cytochrome oxidase subunits in arterial chemoreceptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 727)
  AUTHORS   Horvat,S., Beyer,C. and Arnold,S.
  TITLE     Effect of hypoxia on the transcription pattern of subunit isoforms
            and the kinetics of cytochrome c oxidase in cortical astrocytes and
            cerebellar neurons
  JOURNAL   J Neurochem 99 (3), 937-951 (2006)
   PUBMED   16981895
  REMARK    GeneRIF: the presence of the COX isoform IV-2 suppresses the
            sensitivity of COX to its allosteric regulator ATP and overrules
            the regulation of COX by the cellular energy level
REFERENCE   7  (bases 1 to 727)
  AUTHORS   Takahashi,Y., Kako,K., Kashiwabara,S., Takehara,A., Inada,Y.,
            Arai,H., Nakada,K., Kodama,H., Hayashi,J., Baba,T. and Munekata,E.
  TITLE     Mammalian copper chaperone Cox17p has an essential role in
            activation of cytochrome C oxidase and embryonic development
  JOURNAL   Mol Cell Biol 22 (21), 7614-7621 (2002)
   PUBMED   12370308
REFERENCE   8  (bases 1 to 727)
  AUTHORS   Putcha,G.V., Harris,C.A., Moulder,K.L., Easton,R.M., Thompson,C.B.
            and Johnson,E.M. Jr.
  TITLE     Intrinsic and extrinsic pathway signaling during neuronal
            apoptosis: lessons from the analysis of mutant mice
  JOURNAL   J Cell Biol 157 (3), 441-453 (2002)
   PUBMED   11980919
REFERENCE   9  (bases 1 to 727)
  AUTHORS   Huttemann,M., Kadenbach,B. and Grossman,L.I.
  TITLE     Mammalian subunit IV isoforms of cytochrome c oxidase
  JOURNAL   Gene 267 (1), 111-123 (2001)
   PUBMED   11311561
REFERENCE   10 (bases 1 to 727)
  AUTHORS   STEIN,K.F. and HUBER,S.A.
  TITLE     Morphology and behavior of Waltzertype mice
  JOURNAL   J Morphol 106, 197-203 (1960)
   PUBMED   13834122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731857.9.
            
            On Nov 17, 2006 this sequence version replaced NM_053091.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF271382.1, EL961657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL731857.9         110105-110156       c
            53-137              AL731857.9         109090-109174       c
            138-302             AL731857.9         107155-107319       c
            303-434             AL731857.9         103560-103691       c
            435-727             AL731857.9         99292-99584         c
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..727
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /note="cytochrome c oxidase subunit 4I2"
                     /db_xref="GeneID:84682"
                     /db_xref="MGI:MGI:2135755"
     exon            1..52
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..571
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase, subunit IVb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 4 isoform 2,
                     mitochondrial isoform 2 precursor"
                     /protein_id="NP_444321.1"
                     /db_xref="CCDS:CCDS16898.1"
                     /db_xref="GeneID:84682"
                     /db_xref="MGI:MGI:2135755"
                     /translation="MFSRAARSLVMRTGLRTRGTGTHSPGDAAGSQRRMTPYVDCYAQ
                     RSYPMPDEPFCTELSEEQRALKEKEKGSWTQLSQAEKVALYRLQFHETFAEMNHRSNE
                     WKTVMGCVFFFIGFTALVIWWQRVYVFPKKVVTLTEERKAQQLQRLLDMKSNPIQGLA
                     AHWDYEKKEWKK"
     exon            53..137
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..302
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..434
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..727
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /note="hexamer: AATAAA"
     polyA_site      724
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /note="major polyA site"
ORIGIN      
        1 agtcactcag cagggcagct ctggatagtt ccgccgcctc cagcttgcaa ttatgttttc
       61 cagagctgcc cggagtctgg taatgaggac aggactcaga actagaggga cagggacaca
      121 cagcccagga gatgctgctg gcagccagag gaggatgacc ccctacgttg actgctacgc
      181 ccagcgctcc tatcccatgc cggatgagcc cttctgcaca gagctcagcg aggagcagcg
      241 ggccctgaag gagaaagaga agggcagctg gacccagctg agccaagcag agaaggtggc
      301 cttgtaccgg ctccagttcc atgaaacctt cgcagagatg aaccatcgct ccaacgaatg
      361 gaagacagtg atgggctgcg tcttcttctt cattggattc acggctctgg tgatttggtg
      421 gcagcgagtc tatgtgttcc ctaagaaggt tgtcaccctg acggaagaac ggaaagccca
      481 acagctccag cgcctcctgg acatgaagag caaccccata cagggcctgg ctgcccactg
      541 ggattatgaa aagaaggagt ggaaaaagtg accaacgtcc cacgtctgcc gccagcccct
      601 gcaaactgct tctgcagccc aggagacaat catcccctcc cctcccctcc cctccctcct
      661 cctcctgagt cctgtctcca ctcccttctc caataaaagc agcctgcttt gttctgcttg
      721 caaactc
//
