LOCUS       NM_009941                762 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009941 XM_006530638
VERSION     NM_009941.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 762)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 762)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 762)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   4  (bases 1 to 762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 762)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 762)
  AUTHORS   Labosky,P.A., Winnier,G.E., Sasaki,H., Blessing,M. and Hogan,B.L.
  TITLE     The chromosomal mapping of four genes encoding winged helix
            proteins expressed early in mouse development
  JOURNAL   Genomics 34 (2), 241-245 (1996)
   PUBMED   8661058
REFERENCE   7  (bases 1 to 762)
  AUTHORS   Adams,M.E., Dwyer,T.M., Dowler,L.L., White,R.A. and Froehner,S.C.
  TITLE     Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome
            localization, and homology with a discs large domain
  JOURNAL   J Biol Chem 270 (43), 25859-25865 (1995)
   PUBMED   7592771
REFERENCE   8  (bases 1 to 762)
  AUTHORS   Taylor,K.D. and Piko,L.
  TITLE     Mitochondrial biogenesis in early mouse embryos: expression of the
            mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and
            subunit 9 (P1) of H(+)-ATP synthase
  JOURNAL   Mol Reprod Dev 40 (1), 29-35 (1995)
   PUBMED   7535541
REFERENCE   9  (bases 1 to 762)
  AUTHORS   Carter,R.S. and Avadhani,N.G.
  TITLE     Cloning and characterization of the mouse cytochrome c oxidase
            subunit IV gene
  JOURNAL   Arch Biochem Biophys 288 (1), 97-106 (1991)
   PUBMED   1654830
REFERENCE   10 (bases 1 to 762)
  AUTHORS   Grossman,L.I. and Akamatsu,M.
  TITLE     Nucleotide sequence of a mouse cDNA for subunit IV of cytochrome c
            oxidase
  JOURNAL   Nucleic Acids Res 18 (21), 6454 (1990)
   PUBMED   2173832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY250039.1, AK012583.1 and BE992841.1.
            
            On or before Jun 11, 2014 this sequence version replaced
            XM_006530638.1, NM_009941.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA450881.1, BU562590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BY250039.1         3-67
            66-742              AK012583.1         3-679
            743-762             BE992841.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 69.99 cM"
     gene            1..762
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /note="cytochrome c oxidase subunit 4I1"
                     /db_xref="GeneID:12857"
                     /db_xref="MGI:MGI:88473"
     exon            1..131
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..642
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /EC_number="7.1.1.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome c oxidase polypeptide IV; cytochrome c oxidase,
                     subunit IVa; cytochrome c oxidase subunit IV"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 4 isoform 1,
                     mitochondrial isoform 1"
                     /protein_id="NP_034071.2"
                     /db_xref="GeneID:12857"
                     /db_xref="MGI:MGI:88473"
                     /translation="MLRGSVLVFRLRAPFFRSRAPQGVEGGRGGRLGSGGRMLASRAL
                     SLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTMLSASQKALKEK
                     EKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKS
                     YVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK"
     exon            132..205
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..373
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..505
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..744
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      721..726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /note="hexamer: AATAAA"
     polyA_site      742
                     /gene="Cox4i1"
                     /gene_synonym="COX; COX IV-1; Cox4; Cox4a; COXIV; IV-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttccc tgattcccgc gatgcttcgc ggctccgtct tggtcttccg gttgcgggcc
       61 ccgttcttcc ggtcgcgagc accccagggt gtagagggcg gtcgcggcgg tcgcctgggc
      121 agcggtggca gaatgttggc ttccagagcg ctgagcctga ttggcaagag agccatttct
      181 acttcggtgt gccttcgagc acatgggagt gttgtgaaga gtgaagacta tgctttcccc
      241 acttacgctg atcggcgtga ctaccccttg cctgatgtgg cccatgtcac gatgctgtct
      301 gccagccaga aggcgctgaa ggagaaggag aaggccgact ggagcagcct ttccagggat
      361 gagaaagttc agttgtaccg catccagttt aacgagagct tcgccgagat gaacaggggc
      421 accaatgaat ggaagacagt tgtgggcatg gccatgttct tcattggctt cactgcgctc
      481 gttctgattt gggagaagag ctatgtgtat ggccccatcc ctcatacttt cgatcgtgac
      541 tgggtggcca tgcagaccaa gcgaatgctg gacatgaagg ccaaccccat tcagggcttc
      601 tccgccaagt gggactatga caagaatgag tggaagaagt gagagcccgc tgcctgccgg
      661 ctccctgcct ccctcactcc ctcggcatgc tggaagctgc cgtatccaat ggtccatgct
      721 aataaaagac cagtttacgt ggtgaaaaaa aaaaaaaaaa aa
//
