LOCUS       NM_001017429             436 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus cytochrome c oxidase assembly protein 17, copper
            chaperone (Cox17), mRNA.
ACCESSION   NM_001017429 XM_001481074
VERSION     NM_001017429.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Guhathakurta,S., Erdogdu,N.U., Hoffmann,J.J., Grzadzielewska,I.,
            Schendzielorz,A., Seyfferth,J., Martensson,C.U., Corrado,M.,
            Karoutas,A., Warscheid,B., Pfanner,N., Becker,T. and Akhtar,A.
  TITLE     COX17 acetylation via MOF-KANSL complex promotes mitochondrial
            integrity and function
  JOURNAL   Nat Metab 5 (11), 1931-1952 (2023)
   PUBMED   37813994
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Zhu,S.Y., Zhou,W.Q., Niu,Y.Y., Zheng,C., Liu,X., Zhang,Y.Y. and
            Yu,C.
  TITLE     COX17 restricts renal fibrosis development by maintaining
            mitochondrial copper homeostasis and restoring complex IV activity
  JOURNAL   Acta Pharmacol Sin 44 (10), 2091-2102 (2023)
   PUBMED   37217601
  REMARK    GeneRIF: COX17 restricts renal fibrosis development by maintaining
            mitochondrial copper homeostasis and restoring complex IV activity.
REFERENCE   3  (bases 1 to 436)
  AUTHORS   Duteil,D., Tosic,M., Lausecker,F., Nenseth,H.Z., Muller,J.M.,
            Urban,S., Willmann,D., Petroll,K., Messaddeq,N., Arrigoni,L.,
            Manke,T., Kornfeld,J.W., Bruning,J.C., Zagoriy,V., Meret,M.,
            Dengjel,J., Kanouni,T. and Schule,R.
  TITLE     Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose
            Tissue
  JOURNAL   Cell Rep 17 (4), 1008-1021 (2016)
   PUBMED   27760309
REFERENCE   4  (bases 1 to 436)
  AUTHORS   Takahashi,Y., Kako,K., Kashiwabara,S., Takehara,A., Inada,Y.,
            Arai,H., Nakada,K., Kodama,H., Hayashi,J., Baba,T. and Munekata,E.
  TITLE     Mammalian copper chaperone Cox17p has an essential role in
            activation of cytochrome C oxidase and embryonic development
  JOURNAL   Mol Cell Biol 22 (21), 7614-7621 (2002)
   PUBMED   12370308
  REMARK    GeneRIF: cox17 has a role in activating cytochrome c oxidase in
            mice
REFERENCE   5  (bases 1 to 436)
  AUTHORS   Takahashi,Y., Kako,K., Arai,H., Ohishi,T., Inada,Y., Takehara,A.,
            Fukamizu,A. and Munekata,E.
  TITLE     Characterization and identification of promoter elements in the
            mouse COX17 gene
  JOURNAL   Biochim Biophys Acta 1574 (3), 359-364 (2002)
   PUBMED   11997103
  REMARK    GeneRIF: Sp1, NRF-1 and NRF-2 are involved in basal transcription,
            similar to the transcription mechanism of other CCO-related genes
REFERENCE   6  (bases 1 to 436)
  AUTHORS   Takahashi,Y., Kako,K., Ohmura,K., Tsumori,K., Ohmasa,Y.,
            Kashiwabara,S., Baba,T. and Munekatat,E.
  TITLE     Genomic structure of mouse copper chaperone, COX17
  JOURNAL   DNA Seq 12 (5-6), 305-318 (2001)
   PUBMED   11913776
REFERENCE   7  (bases 1 to 436)
  AUTHORS   Kako,K., Tsumori,K., Ohmasa,Y., Takahashi,Y. and Munekata,E.
  TITLE     The expression of Cox17p in rodent tissues and cells
  JOURNAL   Eur J Biochem 267 (22), 6699-6707 (2000)
   PUBMED   11054125
REFERENCE   8  (bases 1 to 436)
  AUTHORS   Punter,F.A., Adams,D.L. and Glerum,D.M.
  TITLE     Characterization and localization of human COX17, a gene involved
            in mitochondrial copper transport
  JOURNAL   Hum Genet 107 (1), 69-74 (2000)
   PUBMED   10982038
REFERENCE   9  (bases 1 to 436)
  AUTHORS   Nishihara,E., Furuyama,T., Yamashita,S. and Mori,N.
  TITLE     Expression of copper trafficking genes in the mouse brain
  JOURNAL   Neuroreport 9 (14), 3259-3263 (1998)
   PUBMED   9831461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048668.1 and BG792513.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001481074.1, NM_001017429.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048668.1, CB945506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               BC048668.1         1-425
            426-436             BG792513.1         358-368
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.77 cM"
     gene            1..436
                     /gene="Cox17"
                     /note="cytochrome c oxidase assembly protein 17, copper
                     chaperone"
                     /db_xref="GeneID:12856"
                     /db_xref="MGI:MGI:1333806"
     exon            1..209
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..294
                     /gene="Cox17"
                     /note="cytochrome c oxidase, subunit XVII assembly protein
                     homolog"
                     /codon_start=1
                     /product="cytochrome c oxidase copper chaperone"
                     /protein_id="NP_001017429.1"
                     /db_xref="CCDS:CCDS28165.1"
                     /db_xref="GeneID:12856"
                     /db_xref="MGI:MGI:1333806"
                     /translation="MPGLAAASPAPPEAQEKKPLKPCCACPETKKARDACIIEKGEEH
                     CGHLIEAHKECMRALGFKI"
     exon            210..298
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
     exon            299..436
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      402..407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox17"
                     /note="hexamer: ATTAAA"
     polyA_site      425
                     /gene="Cox17"
                     /note="major polyA site"
ORIGIN      
        1 gtcccccttc gattgactgc ggaagtggag acagacggct cagggtagtc ggagtttggg
       61 agctttgcgc gtgtgcgctc atagttgctt tcgcctggaa agatgccggg actggcggcc
      121 gctagccctg ccccgcccga ggctcaggag aagaagccac tgaagccctg ctgtgcctgc
      181 ccggaaacca agaaggcgcg tgatgcgtgc atcattgaga aaggagaaga acactgtgga
      241 catctcattg aagcccacaa ggagtgcatg agggcactgg gatttaagat atgacgtggt
      301 ggcctacttt gtgaatgaat aatccttgaa gaatgaagaa gattaaatat tttggaagtt
      361 ctttggagaa ctttgataaa tggataaagt atttataatt tattaaaaaa cagaaggaaa
      421 gaaaatatgc tgaacc
//
