LOCUS       NM_001309809             869 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cytochrome c oxidase assembly protein 16 (Cox16),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001309809
VERSION     NM_001309809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132391.3 and AK087666.1.
            
            On Jun 16, 2015 this sequence version replaced NM_001309809.1.
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform 3 which is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088794.1, AK087666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC132391.3         10139-10165
            28-695              AK087666.1         2-669
            696-869             AC132391.3         136251-136424
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.6 cM"
     gene            1..869
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="cytochrome c oxidase assembly protein 16"
                     /db_xref="GeneID:66272"
                     /db_xref="MGI:MGI:1913522"
     exon            1..241
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..406
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cytochrome c oxidase assembly protein COX16 homolog,
                     mitochondrial"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly protein COX16
                     homolog, mitochondrial isoform 3"
                     /protein_id="NP_001296738.1"
                     /db_xref="CCDS:CCDS83976.1"
                     /db_xref="GeneID:66272"
                     /db_xref="MGI:MGI:1913522"
                     /translation="MIAPAVLRALRKNKTLRYGVPMLLLVVGGSFGLREFSQIRYDAV
                     TIKIDPELEKKLKVNKITLESEYERLLCLLCRQ"
     exon            242..313
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            314..376
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            377..869
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      672..677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="hexamer: AATAAA"
     regulatory      685..690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="hexamer: TATAAA"
     polyA_site      697
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="major polyA site"
     polyA_site      726
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
     regulatory      840..845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      861
                     /gene="Cox16"
                     /gene_synonym="1810020G14Rik; 1810055I05Rik"
ORIGIN      
        1 ggaagcagaa gtgcgttaag gccaatcgtt tccgtttgcc tcggggaggc ttatcaggcg
       61 tggacctggc acccaaagcc tgcgctgagt ctacaacttc gcctgagacg tgttgcgggc
      121 cgcgctgggc tcgctctgga agcggctgac taagcaggcc gcaccttctg ccatgattgc
      181 gcccgctgtg ttgcgagctc tgcgtaagaa caagactcta cgctatggag ttcccatgtt
      241 gttgctggtt gttggaggtt cttttggtct tcgtgaattt tcacaaatcc ggtacgatgc
      301 tgtgacaatt aagattgatc ctgaattgga gaaaaaattg aaagtgaata aaataacttt
      361 agagtcagag tatgagaggc tgttatgttt attgtgcaga caatgataat ccaccagaga
      421 agtattgcca caagcaagcc gtccaagtac aatcacagac agcgactcta cacaaggaac
      481 agagaatgaa gtcagagggc acacaaagga acagggagaa agtcagtctc agttaatcat
      541 cttgatcttg ataagtttct cctgcaagca cacttagctt tcagaaatgg tagagaagtt
      601 agatgtccag tcttacttag cggtgaccaa caacagtaaa aaacagtctt ataaaatttg
      661 tctcccacaa aaataaacta tatatataaa aatgttatga tgttctcagt gttccattgg
      721 acacaagcct ttttttcctg tctctttttt ctttctttct tttttttttt cagtatgaaa
      781 aatgaggtat actgggactt aagaggtagt agtgtgtttt gattgtacaa catagaggaa
      841 ataaagaata acttcatcag atatggaaa
//
