LOCUS       NM_144874               4798 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus cytochrome c oxidase assembly protein 15 (Cox15),
            mRNA.
ACCESSION   NM_144874
VERSION     NM_144874.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4798)
  AUTHORS   Dogan,S.A., Cerutti,R., Beninca,C., Brea-Calvo,G., Jacobs,H.T.,
            Zeviani,M., Szibor,M. and Viscomi,C.
  TITLE     Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy
  JOURNAL   Cell Metab 28 (5), 764-775 (2018)
   PUBMED   30122554
REFERENCE   3  (bases 1 to 4798)
  AUTHORS   Civiletto,G., Varanita,T., Cerutti,R., Gorletta,T., Barbaro,S.,
            Marchet,S., Lamperti,C., Viscomi,C., Scorrano,L. and Zeviani,M.
  TITLE     Opa1 overexpression ameliorates the phenotype of two mitochondrial
            disease mouse models
  JOURNAL   Cell Metab 21 (6), 845-854 (2015)
   PUBMED   26039449
REFERENCE   4  (bases 1 to 4798)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4798)
  AUTHORS   Viscomi,C., Bottani,E., Civiletto,G., Cerutti,R., Moggio,M.,
            Fagiolari,G., Schon,E.A., Lamperti,C. and Zeviani,M.
  TITLE     In vivo correction of COX deficiency by activation of the
            AMPK/PGC-1alpha axis
  JOURNAL   Cell Metab 14 (1), 80-90 (2011)
   PUBMED   21723506
REFERENCE   6  (bases 1 to 4798)
  AUTHORS   Zhu,R., Ji,Y., Xiao,L. and Matin,A.
  TITLE     Testicular germ cell tumor susceptibility genes from the consomic
            129.MOLF-Chr19 mouse strain
  JOURNAL   Mamm Genome 18 (8), 584-595 (2007)
   PUBMED   17671812
REFERENCE   7  (bases 1 to 4798)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 4798)
  AUTHORS   Antonicka,H., Mattman,A., Carlson,C.G., Glerum,D.M., Hoffbuhr,K.C.,
            Leary,S.C., Kennaway,N.G. and Shoubridge,E.A.
  TITLE     Mutations in COX15 produce a defect in the mitochondrial heme
            biosynthetic pathway, causing early-onset fatal hypertrophic
            cardiomyopathy
  JOURNAL   Am J Hum Genet 72 (1), 101-114 (2003)
   PUBMED   12474143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141888.4, AK048099.1 and AK051792.1.
            
            On Dec 10, 2009 this sequence version replaced NM_144874.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051792.1, AK048099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC141888.4         83005-83023
            20-2107             AK048099.1         2-2089
            2108-4798           AK051792.1         2006-4696
FEATURES             Location/Qualifiers
     source          1..4798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..4798
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /note="cytochrome c oxidase assembly protein 15"
                     /db_xref="GeneID:226139"
                     /db_xref="MGI:MGI:1920112"
     exon            1..179
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1331
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /EC_number="1.17.99.9"
                     /note="cytochrome c oxidase assembly protein COX15
                     homolog; COX15 homolog, cytochrome c oxidase assembly
                     protein"
                     /codon_start=1
                     /product="heme A synthase COX15"
                     /protein_id="NP_659123.2"
                     /db_xref="CCDS:CCDS29836.1"
                     /db_xref="GeneID:226139"
                     /db_xref="MGI:MGI:1920112"
                     /translation="MQRLLLPSLRALTGSRNVGLLVPRVASRTQCGSSCGSQRPLRPG
                     QYSTITEVALQSGKGTVSLPSRAAERAVGRWLLVCSGTVAGAVILGGVTRLTESGLSM
                     VDWHLIKEMKPPTSQEEWEAEFQKYQQFPEFKILNHDMTLAEFKFIWYMEYSHRMWGR
                     AVGLAYILPAAYFWRKGWLNRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKPESYDI
                     PRVSQYRLAAHLGSALVLYCASLWTSLSLLLPQHKLPETRQLLWLRRFAGGTAGLVFL
                     TALSGAFVAGLDAGLVYNSFPKMGESWIPEDLLTFSPVLKNVFENPTMVQFDHRLLGV
                     TSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYAQVALGISTLLMYVPTPLAATHQS
                     GSLALLSGALWLMNELRRVPK"
     exon            180..370
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            371..493
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            494..680
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            681..848
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            849..930
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1085
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1199
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..4798
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2910..2915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /note="hexamer: AATAAA"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /note="hexamer: ATTAAA"
     polyA_site      2932
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
                     /note="major polyA site"
     polyA_site      2947
                     /gene="Cox15"
                     /gene_synonym="2900026G05Rik; HAS"
ORIGIN      
        1 gcctgacccg gaagtgcttg ttctttcggg agcggagaag cggaccgcag ctcgctgggg
       61 cgctccggca gtggcgctgt actgtcagca tgcaacggtt gctccttccg tccctgaggg
      121 ccttgacggg gagccgcaat gtcgggctcc tggtccctag ggtggcgtcc agaacacagt
      181 gtggcagcag ctgtggcagc cagcgtcctc tgaggccagg acagtacagc accatcactg
      241 aagtggctct gcaatccgga aaagggacag tgtcccttcc ttcgagggca gccgagcggg
      301 cggtgggccg atggcttctg gtgtgcagtg ggacagtggc tggagcagtt attctgggag
      361 gagtgaccag gttgacagag tctggcctct caatggtaga ctggcatctg ataaaggaga
      421 tgaagccgcc cacaagccag gaagagtggg aagcagagtt ccaaaagtac cagcaatttc
      481 cagaatttaa aatcctgaac catgacatga cgctggcgga attcaagttt atctggtaca
      541 tggaatactc acaccggatg tgggggcgag ctgtaggcct tgcatacatc ctgcctgctg
      601 cctacttttg gagaaagggt tggctcaacc gtggcatgaa aggacgtgtt ctcgccctct
      661 gtggcttagt ctgtttccag ggtctgttgg gttggtatat ggtgaaaagt ggattggaag
      721 aaaaaccaga gtcctatgac atccctcggg tcagtcagta ccgcctcgca gcccacctgg
      781 ggtcagcact ggttctctac tgtgccagtc tgtggacctc cctgtcactg ctactgcctc
      841 agcacaagtt accagaaact cggcagctcc tgtggttgag acggtttgct ggtggcacag
      901 caggcctggt gttcctcacg gctctctcag gggcttttgt ggcagggctg gatgctggcc
      961 tcgtttacaa ctccttcccc aaaatgggag aatcttggat cccagaggac ctcctgacct
     1021 tctcccctgt cctgaagaat gtttttgaga atcctaccat ggttcagttt gatcacaggc
     1081 ttctgggagt cacgtctgtc actgccatta cagtgctcta tttcctgtcc cggagaatcc
     1141 cccttcctcg aagaaccaag atggcagcag tgactctgct agctttggca tatgcacagg
     1201 tggccctggg cattagcact ctgcttatgt acgtccccac tccgctggct gccacacacc
     1261 agtcaggctc cttggctctg ctcagtggtg ccctttggct catgaatgaa ctccgaagag
     1321 tccctaaata attctcagag gatcatttcc taggactgga actgccttgg aaactcatca
     1381 ccaaacacaa gaacttagcc ttttctaaga cggtggtatt gacatgccac atggtttcca
     1441 aattggtcaa gtcattcaga actgttctga gatgggcact ggaccacgaa cattactaag
     1501 gtgtgcttat accagaggtt tcctttaaaa ctctgctaca taaacaagga tctgccattt
     1561 gctgcttcat aagaggcggg ctgacttctt agatcttggt ttctatgtcc tgcccactag
     1621 tcaggcttct ggtgacagtg acagattcag gaacacgtgc ccctgtggag ctactcgacc
     1681 agttggctgg tgactgcatg ttagtttgtt accaaggtct aaaattgtca tattttctgg
     1741 ttttgataag cagctaacta gctaggtttg tgaagtgaat attcttttat gcatatgtgt
     1801 gtttgtgtta atatatgcca tgtgtgtacg ggtgcccatg gaggccaggg aaggtgctgg
     1861 gtccctggag ctggacttaa aggtgatttt aatatgcctg atacgggtgc tagtaaccaa
     1921 acacgggtcc tctggaagag cagcaggcac ttttaacagc taagccatct ctccagccct
     1981 ggagtgtata ttattaaaat taaatgttga caatttcaag ttttaaaaaa tatatggagg
     2041 cttaacatgt ctgacctgag gttgcacatt tgcagtttct gaacaagatg atcaggtttt
     2101 tttttttaac tctaataatt attctgtgag tctcggtgta tcctaaagga tactgttctt
     2161 agctagtctt agcaaaaaca aacgcacatg tgtttcactc ctcaagtccc aggccctgct
     2221 gggcttgtgt tattgcacaa aagaggttcc ctcaacctca gaacaagact catcctagac
     2281 ctaagcgatc acaaggcctc tgaacaggac tgggctgggt tgaagttctg ccagcttgtt
     2341 cccattccct ccgaatcgct accgcaccta ccgtgcctca tttaacctgt tgggcctgtg
     2401 tcagcagggt agaaactccg ctagacagga gccttccaag aaggggacca gggcagcttg
     2461 cacaccctct gcttcccaac tccaaatccg cactcttcag ttagaagcaa tcagcacagg
     2521 gctggagggt ccagccagag accactcgga accggtttat agtcacccca agcacatggc
     2581 aactggagtc agctcaagtc tcagatattt tgctgcaggt ttttgtttgt ttgtttgttt
     2641 gtactacagt taagcatgtt cggaacagat ccaatattta gctgtttaac tgctttatgg
     2701 tatatatata tatatatata tatatataca catacataca cacacacaca cacacacaca
     2761 cacaccctaa atacacccta atacaattat tgatttatgc cccaaatgtc tatttcagaa
     2821 aaatccattg cacacttaaa ggattaaata atttctttta atgttttcaa cagtctgtcc
     2881 acaattctgt caattgtttt taatttataa ataaaggtaa ttaaaacatg tattttcagt
     2941 cagctaaccc aggatttttg tttgggattg attaggccat taactcttat gacatcattt
     3001 aatttttcta agaatttact tattattgtg tgtgcatgta catgacaggg gatatgcatt
     3061 gtacatgcac gtgcatgcag agaaaagggg acaactcctg cgagttggtt ctctccttct
     3121 gtctttgtgt ggcgattgct ttgtaccgct gagctgtctc actggctcag gtttgcgtct
     3181 ttaacctgca ctgagatctg gtttcctgcg gcagggtcag tgagactgcc tgaagtgaag
     3241 ttggttgcaa agaccagctc tgataatcag gagtttagaa tagcagttta cctgcagccc
     3301 tcctggtctt ggggtgaatg gggggttcta tgtgggcata tgccacacag agccacataa
     3361 gacgctgcac attttctaga gctccacatc tatcagaata ttaagaacta ttccatgaaa
     3421 tttaagaatt ccacaaaaat tcgtttttcc accgcctggc tgacaaaatt cttaacgtaa
     3481 agcatgtaaa aagagccgcc tcagccaccg gaagcagggc ggtcccaaag cctttgtcct
     3541 taaggtcatg ggtcacagtg gaaggagccg tagccactgc agagaccgtg ctaaaggtag
     3601 aaatcctgga ggagatgtag tgtatactcc agcttcaact aaacggacag tgtgggacag
     3661 cgtggaagga gaacttgaac agaaacctga ccggttggag ggcccgggat ccctgctggc
     3721 agaggcgggc ttgagtaaag gggcagagcc gaaatcaggc tggactcacc aggaccccct
     3781 tcaaactgtg cggtagctca gattgagaat gtcctccaag ggccatctgt taaaggcttg
     3841 gtcctcatgg tggcatcgtt gggaatggtg ggaccctcgt ggccaagctt cctagaaggt
     3901 cttcacatca ttggaggatg agtgagactc ccaactccat cctttcttgc atcctggtca
     3961 tgagctaagc atccactctg cgtcacatgc ctgctgcaac gtacacttca ctgcgggctc
     4021 agagcagagg gacacttgac tactgagttg accatctaca gctgtgagcc agaacaaccc
     4081 gttctctgta taaacgatct caagtgtttg gttacagtaa acggactagc agcctggggg
     4141 tgggggtggg agtcaggggt ctggtagtaa ttgtcctgct ttaaggagag gctcaggaat
     4201 agacacatct tcaagcttgt ctgacatgca ggcatggtta aacagcctat gactcagaac
     4261 attttcaact caagttttca tgccatggaa gcaatggcct ggttcatatt tgaaaaactg
     4321 gaagccctta tagcatgagc aataattcca ttttacaata taaaaaaagt ctttttattg
     4381 ctccgatttc cagaaatgaa aatggtctgc tggtgtgtgg ttctcctctg tccttctaat
     4441 gatagtatta acaaacaaaa ataatgaact actaggccaa ggggaaatat gaaacccttc
     4501 aaagacagcc gatggggata taaaacaaga caaagctggc ttaaaataga accttaacaa
     4561 gcctcccacc aaaacagaaa gcctggaatg gacaggaacc cacgcagggt acaacagctt
     4621 ttccagttcg atcacatcca agttaggagg agggtgaagg tcaaggacag agccacccac
     4681 catacagacc attacctaaa agtatttgat ttcaatcatt gttttgcaat catggtttac
     4741 aaaaatattt gttattctgt attgttagtc aaaggtgcca aaacttggtt cttagtcc
//
