LOCUS       NM_199008               2259 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome c oxidase assembly protein 11, copper
            chaperone (Cox11), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_199008
VERSION     NM_199008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Barallobre,M.J., Perier,C., Bove,J., Laguna,A., Delabar,J.M.,
            Vila,M. and Arbones,M.L.
  TITLE     DYRK1A promotes dopaminergic neuron survival in the developing
            brain and in a mouse model of Parkinson's disease
  JOURNAL   Cell Death Dis 5 (6), e1289 (2014)
   PUBMED   24922073
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Aslanukov,A., Bhowmick,R., Guruju,M., Oswald,J., Raz,D., Bush,R.A.,
            Sieving,P.A., Lu,X., Bock,C.B. and Ferreira,P.A.
  TITLE     RanBP2 modulates Cox11 and hexokinase I activities and
            haploinsufficiency of RanBP2 causes deficits in glucose metabolism
  JOURNAL   PLoS Genet 2 (10), e177 (2006)
   PUBMED   17069463
  REMARK    GeneRIF: RanBP2 associates in vitro and in vivo and colocalizes
            with the mitochondrial metallochaperone, Cox11, and the pacemaker
            of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK143937.1.
            
            On Jul 23, 2006 this sequence version replaced NM_199008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143937.1, AK172067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 55.45 cM"
     gene            1..2259
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="cytochrome c oxidase assembly protein 11, copper
                     chaperone"
                     /db_xref="GeneID:69802"
                     /db_xref="MGI:MGI:1917052"
     exon            1..369
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..834
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="COX11 homolog, cytochrome c oxidase assembly
                     protein"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly protein COX11,
                     mitochondrial"
                     /protein_id="NP_950173.1"
                     /db_xref="CCDS:CCDS25243.1"
                     /db_xref="GeneID:69802"
                     /db_xref="MGI:MGI:1917052"
                     /translation="MGGLWCPGWRLVASCGRGWRQPGWSGRTVVNAELVLRPGWDGLG
                     GAERGLRRLGTWKRPCGVRGPATQPPRRPRSSNPFQRAQEDEWRRRNKTVLTYVAAAA
                     VGMLGASYAAVPLYRLYCQTTGLGGSAVAGHSSDQIENMVPVKDRVIKVTFNADVHAS
                     LQWNFRPQQTEIYVVPGETALAFYKAKNPTDKPVIGISTYNVVPFEAGQYFNKIQCFC
                     FEEQRLNPQEEVDMPVFFYIDPEFAEDPRMVNVDLITLSYTFFEAKEGHKLPVPGYN"
     exon            370..525
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..651
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            652..2259
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1218
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="major polyA site"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
     regulatory      2153..2158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
                     /note="hexamer: AACAAG"
     polyA_site      2170
                     /gene="Cox11"
                     /gene_synonym="2010004I09Rik"
ORIGIN      
        1 ggggttatgg gagggctctg gtgtccggga tggaggttgg tggcttcgtg tggccggggc
       61 tggaggcagc ccgggtggtc agggcggact gtggtgaacg cagagctggt gcttaggccc
      121 gggtgggatg ggctcggagg cgcggagcgg ggtctgagac gcctcgggac atggaagcgc
      181 ccgtgcgggg tccgggggcc cgcgacgcag ccgccacggc ggccgaggag cagcaaccct
      241 ttccagcgcg cgcaggagga cgagtggcgg cggcggaaca agacggtgct cacctacgtg
      301 gccgcggccg ccgtgggcat gctgggggcc tcctacgccg cggtgcccct ctatcggctc
      361 tactgccaga ctactggact tggaggatca gcagtggccg ggcactcctc agaccagatc
      421 gagaacatgg tgcctgtcaa ggaccgggtc attaaggtca ccttcaatgc tgacgttcat
      481 gccagtctcc agtggaactt cagacctcag caaacagaga tctatgtggt accaggagag
      541 actgcactgg cattttataa agctaagaat cctactgaca aaccagtaat tggaatttct
      601 acatataatg ttgtaccgtt tgaagctgga cagtatttca ataagataca gtgcttctgt
      661 tttgaagaac aaaggcttaa tccacaagaa gaagtagata tgccagtgtt tttctacatt
      721 gatcctgaat ttgcagaaga tccaagaatg gtgaatgtcg acctcatcac tctttcttac
      781 actttttttg aagcaaagga agggcacaag ttgccagttc caggctataa ttgaagcagc
      841 tcccaaggcc tgcttcagat ttgtgatttt tggaaaatca tgtattgctt tctcagaaga
      901 gaaatattct atagtaatgt attttaaagc cttgtatttt aaatggtttt acctttcttt
      961 ctttctttgc accttcattt atcccactta agactgaaag aacaagttca aaactcagtc
     1021 tgtggtgaaa agatgctgct atcctgtgat ggtgcttaag ggtaggaaac aaacacagct
     1081 ctgttttaag taatagaata tgaatattgt tcatattcca agcctgaaga atatatgact
     1141 gcccaagtgt gactattaaa aactgcatca tgggccaggg atatgaatca gtgggttaaa
     1201 taaagtgttt gccacatagg cctgacaact tgatttctat tcccggaacc agccttaaaa
     1261 gagtgactac agtagctcct acctgtaatc ccagagttct tacagtgagc tgggaggtgg
     1321 agccaggaga atcatcttgc ctgtatatgc atgctctggc tgcccacaca cagatataaa
     1381 ctgctttaac agttcagttt aagtcctcct gaagtattag cccttcacat ctataataat
     1441 gtatctgaaa acttcgaaac agaatcgaca tgcaactgtt tagttcatag gcatgctggt
     1501 tgctgttttc cttcagtata aactgacacc atttaaaaat tttaaaattt atcttcttaa
     1561 tatgtgggga ggatgaatgc tacccatgct gcagcagaca atgggcaagc tgtgggagac
     1621 agctttctct cactgtgagg gtctcaggaa tcaggggagc acgtgccttc accggcagag
     1681 ctttctctgg ctgacccaac agtgtggagg aggagacact tgctccaagt ttgccttctg
     1741 agtgcaagtg tgcctttttc tgttaagctt gagggctgtt ttattccgag tactgactag
     1801 ataatcattt ggaaatgacg gaatcatgat ctaacagaaa attacacctg ctagtctaag
     1861 ctagcattta ccaccataaa tccaagttca ttaacatcat gtaagggtaa aattgtgaag
     1921 atttactgac ataaaagctc attaaactag aagacaaaac aacaacacaa ctgacaaatt
     1981 aatagtaatt taattttatg taaatgatgc attgtccagt tttccaagag tcattgtttc
     2041 aaatcagaat gtgaattata ataaaaggca agaatgttaa acattacata ggactaacta
     2101 catcttaggc cacctgatgc agtggcctac tcaggcactt gaaatataat taaacaagtc
     2161 tttcaagcaa ttctaaacca aaatgttatt tataaacaag tacaaactga attgtacatt
     2221 cagattcagt taaataaagg cactcatttt cttcctttc
//
