LOCUS       NM_178379               2921 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus heme A:farnesyltransferase cytochrome c oxidase
            assembly factor 10 (Cox10), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_178379
VERSION     NM_178379.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Spate,E., Zhou,B., Sun,T., Kusch,K., Asadollahi,E., Siems,S.B.,
            Depp,C., Werner,H.B., Saher,G., Hirrlinger,J., Mobius,W., Nave,K.A.
            and Goebbels,S.
  TITLE     Downregulated expression of lactate dehydrogenase in adult
            oligodendrocytes and its implication for the transfer of glycolysis
            products to axons
  JOURNAL   Glia 72 (8), 1374-1391 (2024)
   PUBMED   38587131
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Southwell,N., Primiano,G., Nadkarni,V., Attarwala,N., Beattie,E.,
            Miller,D., Alam,S., Liparulo,I., Shurubor,Y.I., Valentino,M.L.,
            Carelli,V., Servidei,S., Gross,S.S., Manfredi,G., Chen,Q. and
            D'Aurelio,M.
  TITLE     A coordinated multiorgan metabolic response contributes to human
            mitochondrial myopathy
  JOURNAL   EMBO Mol Med 15 (7), e16951 (2023)
   PUBMED   37222423
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Wculek,S.K., Heras-Murillo,I., Mastrangelo,A., Mananes,D.,
            Galan,M., Miguel,V., Curtabbi,A., Barbas,C., Chandel,N.S.,
            Enriquez,J.A., Lamas,S. and Sancho,D.
  TITLE     Oxidative phosphorylation selectively orchestrates tissue
            macrophage homeostasis
  JOURNAL   Immunity 56 (3), 516-530 (2023)
   PUBMED   36738738
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Zhang,H., Li,B., Huang,Q., Lopez-Giraldez,F., Tanaka,Y., Lin,Q.,
            Mehta,S., Wang,G., Graham,M., Liu,X., Park,I.H., Eichmann,A.,
            Min,W. and Zhou,J.H.
  TITLE     Mitochondrial dysfunction induces ALK5-SMAD2-mediated
            hypovascularization and arteriovenous malformations in mouse
            retinas
  JOURNAL   Nat Commun 13 (1), 7637 (2022)
   PUBMED   36496409
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Nsiah,N.Y. and Inman,D.M.
  TITLE     Destabilizing COXIV in Muller Glia Increases Retinal Glycolysis and
            Alters Scotopic Electroretinogram
  JOURNAL   Cells 11 (23), 3756 (2022)
   PUBMED   36497016
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Vempati,U.D., Diaz,F., Barrientos,A., Narisawa,S., Mian,A.M.,
            Millan,J.L., Boise,L.H. and Moraes,C.T.
  TITLE     Role of cytochrome C in apoptosis: increased sensitivity to tumor
            necrosis factor alpha is associated with respiratory defects but
            not with lack of cytochrome C release
  JOURNAL   Mol Cell Biol 27 (5), 1771-1783 (2007)
   PUBMED   17210651
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Diaz,F., Fukui,H., Garcia,S. and Moraes,C.T.
  TITLE     Cytochrome c oxidase is required for the assembly/stability of
            respiratory complex I in mouse fibroblasts
  JOURNAL   Mol Cell Biol 26 (13), 4872-4881 (2006)
   PUBMED   16782876
  REMARK    GeneRIF: The levels of respiratory complex I were markedly reduced
            in COX10 knockout clones.
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Diaz,F., Thomas,C.K., Garcia,S., Hernandez,D. and Moraes,C.T.
  TITLE     Mice lacking COX10 in skeletal muscle recapitulate the phenotype of
            progressive mitochondrial myopathies associated with cytochrome c
            oxidase deficiency
  JOURNAL   Hum Mol Genet 14 (18), 2737-2748 (2005)
   PUBMED   16103131
  REMARK    GeneRIF: Mice lacking COX10 in skeletal muscle recapitulate the
            phenotype of progressive mitochondrial myopathies associated with
            cytochrome c oxidase deficiency.
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Antonicka,H., Leary,S.C., Guercin,G.H., Agar,J.N., Horvath,R.,
            Kennaway,N.G., Harding,C.O., Jaksch,M. and Shoubridge,E.A.
  TITLE     Mutations in COX10 result in a defect in mitochondrial heme A
            biosynthesis and account for multiple, early-onset clinical
            phenotypes associated with isolated COX deficiency
  JOURNAL   Hum Mol Genet 12 (20), 2693-2702 (2003)
   PUBMED   12928484
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Glerum,D.M. and Tzagoloff,A.
  TITLE     Isolation of a human cDNA for heme A:farnesyltransferase by
            functional complementation of a yeast cox10 mutant
  JOURNAL   Proc Natl Acad Sci U S A 91 (18), 8452-8456 (1994)
   PUBMED   8078902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY078593.1, AK149999.1 and AL603889.5.
            
            On Feb 2, 2010 this sequence version replaced NM_178379.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154668.1, BC038046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY078593.1         1-13
            14-1386             AK149999.1         4-1376
            1387-2921           AL603889.5         141258-142792       c
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 39.47 cM"
     gene            1..2921
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /note="heme A:farnesyltransferase cytochrome c oxidase
                     assembly factor 10"
                     /db_xref="GeneID:70383"
                     /db_xref="MGI:MGI:1917633"
     exon            1..137
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1426
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /EC_number="2.5.1.141"
                     /note="cytochrome c oxidase assembly protein 10; heme O
                     synthase; COX10 homolog, cytochrome c oxidase assembly
                     protein, heme A: farnesyltransferase"
                     /codon_start=1
                     /product="protoheme IX farnesyltransferase, mitochondrial"
                     /protein_id="NP_848466.1"
                     /db_xref="CCDS:CCDS24839.1"
                     /db_xref="GeneID:70383"
                     /db_xref="MGI:MGI:1917633"
                     /translation="MAASPHTISSRLLTGSVGGCIWYLERRAIQGLPHRVTRLFRNVS
                     NQWVTLQHLSFLKRMYVTQLHRGLSQRVKPKPEPPASPFLEHTSSGQARADEDELPSF
                     PAPSRPLSRKPNEELVELEATSIVDHSLDTAKEKKEERQWKEMKLHTDDLPGILARLS
                     KIKLTALVVSTTSAGFALAPGPFDWSCFLLTSLGTGLASCAANSINQFFEVPFDSNMN
                     RTKNRPLVRGQISPLLAVSFATCCAVPGVALLTWGVNPLTGALGVFNIFLYTCCYTPL
                     KRVSITNTWVGAVVGAIPPVMGWTAATGSLDAGALLLGGILYSWQFPHFNALSWGLRE
                     DYSRGGYCMMSVTHPALCRRVALRHCLALIALSTAAPVLDITTWVFPVISLPINLYIS
                     YLGFRFYVDADRRSSRKLFFCSLWHLPLLLLLMLTCKQRPGQEGDKGEAPS"
     exon            138..271
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            272..590
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..715
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            716..786
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1019
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..2921
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="Cox10"
                     /gene_synonym="2410004F01Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcactcagag ggcgggctag caagatggcg gcgcccagga gccggtgagg tgagaggcgt
       61 cctggggtcc tggggactgc tgcaccagta cgttatggcc gcgtccccgc acaccatttc
      121 ctcgcgcctc ctcacaggct cagtaggagg atgtatctgg tatttagaga gaagagctat
      181 acagggattg ccacacaggg tcacacgtct gttcaggaat gtcagtaatc agtgggtcac
      241 gctccagcac ttgagcttcc tcaagcgcat gtatgtcaca cagctgcaca ggggccttag
      301 ccagcgagtc aaaccaaagc cagagccacc ggcgtctcct ttccttgaac acacgtcttc
      361 agggcaggct agagcggacg aggatgagct gccgtctttc ccagcaccca gtcggcctct
      421 gtcccggaag ccaaatgagg agttggtgga gctggaggcg acctccatag tggaccattc
      481 cctcgacaca gccaaagaga aaaaggaaga aaggcagtgg aaagagatga aacttcacac
      541 tgatgatctg cctggcattt tggccaggct gtccaagatc aaactcacag ctcttgtggt
      601 aagcaccact tcagcaggct ttgcactggc tccaggccct ttcgactggt cctgcttcct
      661 gcttacatcc cttggaaccg gcctcgcatc ctgtgctgcc aactccatca atcagttttt
      721 tgaggtgccg ttcgactcaa acatgaatag aacaaagaac aggcctctgg ttcgagggca
      781 gataagccca ttgctagccg tgtcttttgc cacctgctgt gctgtgccag gagtggccct
      841 tctgacctgg ggagtgaatc cactcacagg ggccttgggg gtcttcaaca ttttcctgta
      901 tacctgttgt tacacaccac tgaagagggt cagcatcacc aatacctggg ttggagccgt
      961 ggttggagcc atccctcctg tcatgggctg gacggccgcc actggaagcc ttgatgctgg
     1021 agcgcttctt ctgggaggga tcctgtactc ctggcaattc ccccacttca atgccctgag
     1081 ctggggcctc cgtgaagact actcccgagg aggctactgt atgatgtccg tcacccatcc
     1141 agccctctgc cggcgggtgg cactgcgcca ctgcctggcc ctgattgctc tgtcgactgc
     1201 tgccccggtc ctggacatca ccacctgggt cttccctgtc atctccctcc ccatcaacct
     1261 gtacatttcc tacctcggct tccgcttcta cgtggacgca gaccgcagga gctcaaggaa
     1321 actgttcttc tgcagcctgt ggcacctgcc gctgctcctg ctgctcatgc tcacctgtaa
     1381 gcagcggccc gggcaggagg gggacaaggg agaggctccg agctgagagc cagccggtct
     1441 gtggggaaca tgagagcaga cacctgcaga cagacacacg gacagcactg ccctgggcca
     1501 gcaggaagcg tattttggtg attctggcaa agagagttgg atggtgtcag ctggtggcag
     1561 atcatctggt gctgtgtcgt cacttcccag tccttttaat attaatatcc aaactgcttc
     1621 ccaaacaaga aagggactag catatggggt cagtacaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aagaatattt cttctcctgg aaagtcttta tgcatctttc cctccagccc tgtgttctct
     1741 cacccacatg atatatatgc acatcctcct ccctccaccc caggccagcc ccgcccccaa
     1801 cacacacaca cacacacaca cacgcacgtg cgcgcgtgca tactcaccac ctggaggcca
     1861 ctgtggtcat tgctcaaaca ggtgagtgct tgtgacccaa cctctgtagt tccgcatctg
     1921 gaagctccca cacacttcct cagaagaaca catagtgtgg ctacagcacc ccttctctgc
     1981 cagtaagatg gggcctgcct agcttcctct accctaccag tgttctcaac cacacattcc
     2041 ctgaagtaac acaacacctg gcctgggctg cccactggga gtggggattc caaacggttg
     2101 cctgcagatc cctggccaca ttgccagcac acaccaccac gtccaatccc accccaaacc
     2161 aggagttcag aaaccccagg aaatatgcca cgtgttcatc atgctctcag gcatggtctc
     2221 agcatttcct tttggaaggg catcactcag cataacctga gggagagggt gagctgcgtc
     2281 agcaaccatt ttatgctcac ttatctcttt cgtgcaaacc acatttctac actggtacct
     2341 cctaagtcca gaagttggcc tccgtgccca gtggtgttca gagagggcag cagggctcct
     2401 agtggccatg ggtccagctc tggaactcca tggcctctgg tgtaaaatgc agggacctgt
     2461 aggtcttcgg actgttgcgt actccccagg gctagagagc aatgctgcct taaaattgtg
     2521 gagctgccag agtttgagtt ccttgatctc ccagggtgct gggccccgtc aggattccct
     2581 ccagggcttt aagccacaca gaaaacggtt cttgaatttg gactgtcctc tcaaaatgtg
     2641 gaagaaaggc tttggccgtg accaaaggga gagcacttgc ttagctctgg gctcgggttt
     2701 gaacttaaca ccaccacaaa aggtggggag gatggtgtcc agagtgcctg cagacagtgt
     2761 gcccggtacc tctgtctacc ttttgtaacg ttaccgcctg gctgtgtcct gtggtaacag
     2821 ggaatggcga tgtctgcaaa gagcatctag gacttgttgc ggccttaaag tctgtaaagt
     2881 gtgttgattc tcctcctgct gcaataaaac agttaaaaga a
//
