LOCUS       NM_028071               1642 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus coactosin like F-actin binding protein 1 (Cotl1),
            mRNA.
ACCESSION   NM_028071
VERSION     NM_028071.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1642)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1642)
  AUTHORS   Scheller,I., Stritt,S., Beck,S., Peng,B., Pleines,I., Heinze,K.G.,
            Braun,A., Otto,O., Ahrends,R., Sickmann,A., Bender,M. and
            Nieswandt,B.
  TITLE     Coactosin-like 1 integrates signaling critical for shear-dependent
            thrombus formation in mouse platelets
  JOURNAL   Haematologica 105 (6), 1667-1676 (2020)
   PUBMED   31582545
  REMARK    GeneRIF: Coactosin-like 1 integrates signaling critical for
            shear-dependent thrombus formation in mouse platelets.
REFERENCE   4  (bases 1 to 1642)
  AUTHORS   Li,G., Yin,Y., Chen,J., Fan,Y., Ma,J., Huang,Y., Chen,C., Dai,P.,
            Chen,S. and Zhao,S.
  TITLE     Coactosin-like protein 1 inhibits neuronal migration during mouse
            corticogenesis
  JOURNAL   J Vet Sci 19 (1), 21-26 (2018)
   PUBMED   28385010
  REMARK    GeneRIF: Cotl1 overexpression impaired migration of both early- and
            late-born neurons during mouse corticogenesis. Moreover, Cotl1
            overexpression delayed, rather than blocked, neuronal migration in
            late-born neurons.
REFERENCE   5  (bases 1 to 1642)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1642)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 1642)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   8  (bases 1 to 1642)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   9  (bases 1 to 1642)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 1642)
  AUTHORS   Doucet,J., Provost,P., Samuelsson,B. and Radmark,O.
  TITLE     Molecular cloning and functional characterization of mouse
            coactosin-like protein
  JOURNAL   Biochem Biophys Res Commun 290 (2), 783-789 (2002)
   PUBMED   11785969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200873.1, AK151690.1 and AK196452.1.
            
            On Mar 27, 2008 this sequence version replaced NM_028071.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148854.1, BC010249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               BY200873.1         5-412
            409-1628            AK151690.1         371-1590
            1629-1642           AK196452.1         8-21                c
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.42 cM"
     gene            1..1642
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /note="coactosin like F-actin binding protein 1"
                     /db_xref="GeneID:72042"
                     /db_xref="MGI:MGI:1919292"
     exon            1..256
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..608
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /note="coactosin-like 1"
                     /codon_start=1
                     /product="coactosin-like protein"
                     /protein_id="NP_082347.1"
                     /db_xref="CCDS:CCDS22712.1"
                     /db_xref="GeneID:72042"
                     /db_xref="MGI:MGI:1919292"
                     /translation="MATKIDKEACRAAYNLVRDDGSAVIWVTFRYDGATIVPGDQGAD
                     YQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGEDVSGLQRAKTGTDKTLVK
                     EVVQNFAKEFVISDRKELEEDFIRSELKKAGGANYDAQSE"
     exon            257..339
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /inference="alignment:Splign:2.1.0"
     exon            340..497
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1639
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /note="hexamer: AGTAAA"
     polyA_site      1636
                     /gene="Cotl1"
                     /gene_synonym="1810074P22Rik; 2010004C08Rik; Clp"
                     /note="major polyA site"
ORIGIN      
        1 ttcacgggag tggagtcccc gcgcgcgctc tggctctgca gtaaccgcgg gcctctctcc
       61 gaggacctta gcttgctgtt gcgagcggcc acctcccctg cccactctcg gagcccgctc
      121 gactctcgta gcggatcagg gacgcgttca ctggttccgg cagtgtcctc gcggcggcca
      181 tggccacgaa gatcgacaag gaggcgtgtc gcgcggcgta caacttagtg cgggacgacg
      241 gctcggcggt catctgggtg actttcagat acgacggcgc caccattgtc cccggcgatc
      301 agggagcaga ttaccagcac ttcatccagc agtgcacaga tgatgtccgg ctgttcgcct
      361 ttgtgcgctt caccaccggc gacgccatga gcaaaagatc caagtttgcc ctcatcacat
      421 ggatcgggga ggacgtgagt ggactgcagc gtgccaagac ggggaccgac aagacgctgg
      481 tgaaggaggt ggtccagaat tttgcaaagg aatttgtgat cagcgaccgg aaggagctag
      541 aggaagactt catcaggagc gagctgaaga aggctggggg ggccaactac gacgctcagt
      601 cagagtagct acagccccac agcccagagc catctgcctg ctccgccaag gaggagactg
      661 ccgcctcacg tcaccagccc accagggagg agaagccatg agaggcacca gcgccaccag
      721 tgtgtccaac cctccccttc cctctccccc ctgtggcccc tctcaagctc accaagcatc
      781 attctttgag acccgccccc ccttttgttt taaagaagtc attttggtgc cagggtcatg
      841 cataccatct gatcccagaa gcctctctgt cactggccct ggacctggca tttacccctg
      901 ccgtcaccgt ggcctgcctg gtctaagcta ccctggcctt gagttgctga ggcctggtca
      961 ggtgccaccc cagcttgacc tggctgtttc ctgctagccc tacgccggcc accaatacca
     1021 ggagctgtgc acaccttaca gccttcatga gctcccatgc gcgcgcatgc tcctcagagc
     1081 ccatagatgt ggccccaggc ctcacccctg tcctgttcag agtggccttg agctgtccct
     1141 ctggtagaca ctgcttggca gtaacaggtt taggtctggc gtggaccgag tgtgaagtga
     1201 caaatttgcc ttaaatcttg cctggcagtg gctctgccac gtggtctaaa ctaccctttt
     1261 ggcgaagcct ttctgaagcc tgagaggtct gagtctggct gggggggggg ggggggggga
     1321 gttcagggtc aacctcaggg cctccagggt gacaaggatg gaaaggtccc ctgcaaacag
     1381 ggaggctggc ataggcctca gggcacctgg aaggcagcaa cggttggaat cttagtctgc
     1441 aaattccaaa gatggctttg tttgcttttg aagacagctg aggcgggctt ggctcctcga
     1501 gagcactcga agatggttct ttccctccct cctcgctctt attactctgg ggaaggatgc
     1561 tgcaccgggc tgggctgtga ggaccatctc tggcattccg acagtttaca gaagtaaatg
     1621 tgtttttcaa gaaaaatgaa aa
//
