LOCUS       NM_007745                690 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus cortistatin (Cort), mRNA.
ACCESSION   NM_007745 XM_905725
VERSION     NM_007745.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 690)
  AUTHORS   Qiu C, Li J, Luo D, Chen X, Qu R, Liu T, Li F and Liu Y.
  TITLE     Cortistatin protects against inflammatory airway diseases through
            curbing CCL2 and antagonizing NF-kappaB signaling pathway
  JOURNAL   Biochem Biophys Res Commun 531 (4), 595-601 (2020)
   PUBMED   32811643
  REMARK    GeneRIF: Cortistatin protects against inflammatory airway diseases
            through curbing CCL2 and antagonizing NF-kappaB signaling pathway.
            Erratum:[Biochem Biophys Res Commun. 2020 Nov 19;532(4):683-684.
            PMID: 33012512]
REFERENCE   2  (bases 1 to 690)
  AUTHORS   Zhang X and Meeks JP.
  TITLE     Paradoxically Sparse Chemosensory Tuning in Broadly Integrating
            External Granule Cells in the Mouse Accessory Olfactory Bulb
  JOURNAL   J Neurosci 40 (27), 5247-5263 (2020)
   PUBMED   32503886
REFERENCE   3  (bases 1 to 690)
  AUTHORS   Maynard KR, Kardian A, Hill JL, Mai Y, Barry B, Hallock HL, Jaffe
            AE and Martinowich K.
  TITLE     TrkB Signaling Influences Gene Expression in Cortistatin-Expressing
            Interneurons
  JOURNAL   eNeuro 7 (1) (2020)
   PUBMED   31941661
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 690)
  AUTHORS   Harris JA, Mihalas S, Hirokawa KE, Whitesell JD, Choi H, Bernard A,
            Bohn P, Caldejon S, Casal L, Cho A, Feiner A, Feng D, Gaudreault N,
            Gerfen CR, Graddis N, Groblewski PA, Henry AM, Ho A, Howard R, Knox
            JE, Kuan L, Kuang X, Lecoq J, Lesnar P, Li Y, Luviano J,
            McConoughey S, Mortrud MT, Naeemi M, Ng L, Oh SW, Ouellette B, Shen
            E, Sorensen SA, Wakeman W, Wang Q, Wang Y, Williford A, Phillips
            JW, Jones AR, Koch C and Zeng H.
  TITLE     Hierarchical organization of cortical and thalamic connectivity
  JOURNAL   Nature 575 (7781), 195-202 (2019)
   PUBMED   31666704
REFERENCE   5  (bases 1 to 690)
  AUTHORS   Hill JL, Jimenez DV, Mai Y, Ren M, Hallock HL, Maynard KR, Chen HY,
            Hardy NF, Schloesser RJ, Maher BJ, Yang F and Martinowich K.
  TITLE     Cortistatin-expressing interneurons require TrkB signaling to
            suppress neural hyper-excitability
  JOURNAL   Brain Struct Funct 224 (1), 471-483 (2019)
   PUBMED   30377803
  REMARK    GeneRIF: BDNF, signaling through TrkB receptors on
            cortistatin-expressing cells, promotes excitatory drive onto these
            cells. Loss of excitatory drive onto CST-expressing cells that lack
            TrkB receptors may contribute to observed hyperexcitability and
            epileptogenesis.
REFERENCE   6  (bases 1 to 690)
  AUTHORS   Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C,
            Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A and de
            Lecea L.
  TITLE     Cortistatin overexpression in transgenic mice produces deficits in
            synaptic plasticity and learning
  JOURNAL   Mol Cell Neurosci 30 (3), 465-475 (2005)
   PUBMED   16182561
REFERENCE   7  (bases 1 to 690)
  AUTHORS   Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L and Criado JR.
  TITLE     Overexpression of the human beta-amyloid precursor protein
            downregulates cortistatin mRNA in PDAPP mice
  JOURNAL   Brain Res 1023 (1), 157-162 (2004)
   PUBMED   15364032
  REMARK    GeneRIF: Cortistatin mRNA concentration in the hippocampus and
            dentate gyrus is significantly increased in aged non-transgenic
            (Tg) mice compared with young non-Tg mice.
REFERENCE   8  (bases 1 to 690)
  AUTHORS   Trabucchi M, Tostivint H, Lihrmann I, Sollars C, Vallarino M, Dores
            RM and Vaudry H.
  TITLE     Polygenic expression of somatostatin in the sturgeon Acipenser
            transmontanus: molecular cloning and distribution of the mRNAs
            encoding two somatostatin precursors
  JOURNAL   J Comp Neurol 443 (4), 332-345 (2002)
   PUBMED   11807842
REFERENCE   9  (bases 1 to 690)
  AUTHORS   Calbet M, Guadano-Ferraz A, Spier AD, Maj M, Sutcliffe JG,
            Przewlocki R and de Lecea L.
  TITLE     Cortistatin and somatostatin mRNAs are differentially regulated in
            response to kainate
  JOURNAL   Brain Res Mol Brain Res 72 (1), 55-64 (1999)
   PUBMED   10521599
REFERENCE   10 (bases 1 to 690)
  AUTHORS   de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE,
            Frankel WN and Sutcliffe JG.
  TITLE     Cloning, mRNA expression, and chromosomal mapping of mouse and
            human preprocortistatin
  JOURNAL   Genomics 42 (3), 499-506 (1997)
   PUBMED   9205124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731655.8, AK013496.1 and
            AW122642.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by NM_007745.5.
            
            On Nov 25, 2015 this sequence version replaced NM_007745.3.
            
            Summary: This gene encodes a member of the somatostatin family of
            multifunctional peptides attributed with neurohormone,
            neurotransmitter/modulator and autocrine/paracrine actions. The
            encoded preproprotein undergoes proteolytic processing to generate
            a mature functional peptide that can bind to somatostatin
            receptors. Mice lacking the encoded protein exhibit elevated levels
            of growth hormone in the plasma without major changes in somatic
            growth and have exacerbated nociceptive responses to neuropathic
            and inflammatory pain sensitization. Transgenic mice overexpressing
            the encoded protein in neurons do not express long-term
            potentiation in the dentate gyrus and exhibit deficits in synaptic
            plasticity and learning. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW490859.1, AK013496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL731655.8         6660-6681           c
            23-520              AK013496.1         3-500
            521-690             AW122642.1         1-170               c
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.89 cM"
     gene            1..690
                     /gene="Cort"
                     /gene_synonym="CST; PCST"
                     /note="cortistatin"
                     /db_xref="GeneID:12854"
                     /db_xref="MGI:MGI:109538"
     exon            1..237
                     /gene="Cort"
                     /gene_synonym="CST; PCST"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..447
                     /gene="Cort"
                     /gene_synonym="CST; PCST"
                     /codon_start=1
                     /product="cortistatin preproprotein"
                     /protein_id="NP_031771.1"
                     /db_xref="CCDS:CCDS18953.1"
                     /db_xref="GeneID:12854"
                     /db_xref="MGI:MGI:109538"
                     /translation="MMGGRGTGGKWPSAFGLLLLWGVAASALPLESGPTGQDSVQEAT
                     EGRSGLLTFLAWWHEWASQASSSTPVGGGTPGLSKSQERPPPQQPPHLDKKPCKNFFW
                     KTFSSCK"
     exon            238..677
                     /gene="Cort"
                     /gene_synonym="CST; PCST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggcgtg taggttttca atgaacgagt gcagaccccc aagcaggtgg tgctagagct
       61 taaaacacca cagaagagac cctcgtccac caagcacaga cctcagcacg tccgaggatg
      121 atgggtggcc gaggcacagg aggcaagtgg ccctcagcct tcgggctgct gctgctctgg
      181 ggggtcgcag cctccgccct tcccctggag agtggcccta ctggccagga cagtgtgcag
      241 gaagccaccg aggggaggag cggccttctg actttccttg cctggtggca cgagtgggct
      301 tcccaagcca gctccagcac ccccgtcgga gggggtaccc ccgggctgtc caagagccag
      361 gaaaggccac ccccccaaca gcccccacac ctggataaaa agccctgcaa gaacttcttc
      421 tggaaaacct tctcctcgtg caagtaaccc caccctgggc atagcaccct ggccaccctg
      481 tgagatgcca acgagacctg aataaagact gtcaatcagc ggggagcttt cttcttatgt
      541 cagctttgcc tcccctgccc tgtgagaatc attggtttca gtaatgctcg ctaccgacaa
      601 caggtcaact aagggattgg agattcagtg accccctcca aataaaatgg tggtggctct
      661 tgctccaatc agcagaaaaa aaaaaaaaaa
//
