LOCUS       NP_031771                109 aa            linear   ROD 14-FEB-2025
DEFINITION  cortistatin isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_031771 XP_910818
VERSION     NP_031771.1
DBSOURCE    REFSEQ: accession NM_007745.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 109)
  AUTHORS   Chen,H.Y., Phan,B.N., Shim,G., Hamersky,G.R., Sadowski,N.,
            O'Donnell,T.S., Sripathy,S.R., Bohlen,J.F., Pfenning,A.R. and
            Maher,B.J.
  TITLE     Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the
            density and connectivity of distinct inhibitory interneuron
            subtypes
  JOURNAL   Mol Psychiatry 28 (11), 4679-4692 (2023)
   PUBMED   37770578
REFERENCE   2  (residues 1 to 109)
  AUTHORS   Castillo-Gonzalez,J., Ruiz,J.L., Serrano-Martinez,I.,
            Forte-Lago,I., Ubago-Rodriguez,A., Caro,M., Perez-Gomez,J.M.,
            Benitez-Troncoso,A., Andres-Leon,E., Sanchez-Navarro,M., Luque,R.M.
            and Gonzalez-Rey,E.
  TITLE     Cortistatin deficiency reveals a dysfunctional brain endothelium
            with impaired gene pathways, exacerbated immune activation, and
            disrupted barrier integrity
  JOURNAL   J Neuroinflammation 20 (1), 226 (2023)
   PUBMED   37794493
  REMARK    GeneRIF: Cortistatin deficiency reveals a dysfunctional brain
            endothelium with impaired gene pathways, exacerbated immune
            activation, and disrupted barrier integrity.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 109)
  AUTHORS   Qiu,C., Li,J., Luo,D., Chen,X., Qu,R., Liu,T., Li,F. and Liu,Y.
  TITLE     Cortistatin protects against inflammatory airway diseases through
            curbing CCL2 and antagonizing NF-kappaB signaling pathway
  JOURNAL   Biochem Biophys Res Commun 531 (4), 595-601 (2020)
   PUBMED   32811643
  REMARK    GeneRIF: Cortistatin protects against inflammatory airway diseases
            through curbing CCL2 and antagonizing NF-kappaB signaling pathway.
            Erratum:[Biochem Biophys Res Commun. 2020 Nov 19;532(4):683-684.
            doi: 10.1016/j.bbrc.2020.09.069.. PMID: 33012512]
REFERENCE   4  (residues 1 to 109)
  AUTHORS   Zhang,X. and Meeks,J.P.
  TITLE     Paradoxically Sparse Chemosensory Tuning in Broadly Integrating
            External Granule Cells in the Mouse Accessory Olfactory Bulb
  JOURNAL   J Neurosci 40 (27), 5247-5263 (2020)
   PUBMED   32503886
REFERENCE   5  (residues 1 to 109)
  AUTHORS   Maynard,K.R., Kardian,A., Hill,J.L., Mai,Y., Barry,B.,
            Hallock,H.L., Jaffe,A.E. and Martinowich,K.
  TITLE     TrkB Signaling Influences Gene Expression in Cortistatin-Expressing
            Interneurons
  JOURNAL   eNeuro 7 (1) (2020)
   PUBMED   31941661
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 109)
  AUTHORS   Tallent,M.K., Fabre,V., Qiu,C., Calbet,M., Lamp,T., Baratta,M.V.,
            Suzuki,C., Levy,C.L., Siggins,G.R., Henriksen,S.J., Criado,J.R.,
            Roberts,A. and de Lecea,L.
  TITLE     Cortistatin overexpression in transgenic mice produces deficits in
            synaptic plasticity and learning
  JOURNAL   Mol Cell Neurosci 30 (3), 465-475 (2005)
   PUBMED   16182561
REFERENCE   7  (residues 1 to 109)
  AUTHORS   Winsky-Sommerer,R., Spier,A.D., Fabre,V., de Lecea,L. and
            Criado,J.R.
  TITLE     Overexpression of the human beta-amyloid precursor protein
            downregulates cortistatin mRNA in PDAPP mice
  JOURNAL   Brain Res 1023 (1), 157-162 (2004)
   PUBMED   15364032
  REMARK    GeneRIF: Cortistatin mRNA concentration in the hippocampus and
            dentate gyrus is significantly increased in aged non-transgenic
            (Tg) mice compared with young non-Tg mice.
REFERENCE   8  (residues 1 to 109)
  AUTHORS   Trabucchi,M., Tostivint,H., Lihrmann,I., Sollars,C., Vallarino,M.,
            Dores,R.M. and Vaudry,H.
  TITLE     Polygenic expression of somatostatin in the sturgeon Acipenser
            transmontanus: molecular cloning and distribution of the mRNAs
            encoding two somatostatin precursors
  JOURNAL   J Comp Neurol 443 (4), 332-345 (2002)
   PUBMED   11807842
REFERENCE   9  (residues 1 to 109)
  AUTHORS   Calbet,M., Guadano-Ferraz,A., Spier,A.D., Maj,M., Sutcliffe,J.G.,
            Przewlocki,R. and de Lecea,L.
  TITLE     Cortistatin and somatostatin mRNAs are differentially regulated in
            response to kainate
  JOURNAL   Brain Res Mol Brain Res 72 (1), 55-64 (1999)
   PUBMED   10521599
REFERENCE   10 (residues 1 to 109)
  AUTHORS   de Lecea,L., Ruiz-Lozano,P., Danielson,P.E., Peelle-Kirley,J.,
            Foye,P.E., Frankel,W.N. and Sutcliffe,J.G.
  TITLE     Cloning, mRNA expression, and chromosomal mapping of mouse and
            human preprocortistatin
  JOURNAL   Genomics 42 (3), 499-506 (1997)
   PUBMED   9205124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731655.8.
            
            On Dec 7, 2005 this sequence version replaced XP_910818.1.
            
            Summary: This gene encodes a member of the somatostatin family of
            multifunctional peptides attributed with neurohormone,
            neurotransmitter/modulator and autocrine/paracrine actions. The
            encoded preproprotein undergoes proteolytic processing to generate
            a mature functional peptide that can bind to somatostatin
            receptors. Mice lacking the encoded protein exhibit elevated levels
            of growth hormone in the plasma without major changes in somatic
            growth and have exacerbated nociceptive responses to neuropathic
            and inflammatory pain sensitization. Transgenic mice overexpressing
            the encoded protein in neurons do not express long-term
            potentiation in the dentate gyrus and exhibit deficits in synaptic
            plasticity and learning. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW490859.1, AK013496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.89 cM"
     Protein         1..109
                     /product="cortistatin isoform 1 preproprotein"
                     /calculated_mol_wt=9097
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56469.1)"
                     /calculated_mol_wt=2534
     Region          64..97
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P56469.1)"
     Region          91..108
                     /region_name="Somatostatin"
                     /note="Somatostatin/Cortistatin family; pfam03002"
                     /db_xref="CDD:367290"
     mat_peptide     96..109
                     /product="Cortistatin-14. /id=PRO_0000033158"
                     /note="propagated from UniProtKB/Swiss-Prot (P56469.1)"
                     /calculated_mol_wt=1723
     CDS             1..109
                     /gene="Cort"
                     /gene_synonym="CST; PCST"
                     /coded_by="NM_007745.5:30..359"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS18953.1"
                     /db_xref="GeneID:12854"
                     /db_xref="MGI:MGI:109538"
ORIGIN      
        1 mmggrgtggk wpsafgllll wgvaasalpl esgptgqdsv qeategrsgl ltflawwhew
       61 asqassstpv gggtpglsks qerpppqqpp hldkkpcknf fwktfssck
//
