LOCUS       NM_139130               2400 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coronin 6 (Coro6), transcript variant B, mRNA.
ACCESSION   NM_139130 XM_126105
VERSION     NM_139130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   de Groot,N.E., van den Hoogenhof,M.M.G., Najafi,A., van der
            Made,I., van der Velden,J., Beqqali,A., Pinto,Y.M. and
            Creemers,E.E.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Yang,J., Hung,L.H., Licht,T., Kostin,S., Looso,M., Khrameeva,E.,
            Bindereif,A., Schneider,A. and Braun,T.
  TITLE     RBM24 is a major regulator of muscle-specific alternative splicing
  JOURNAL   Dev Cell 31 (1), 87-99 (2014)
   PUBMED   25313962
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Chen,Y., Ip,F.C., Shi,L., Zhang,Z., Tang,H., Ng,Y.P., Ye,W.C.,
            Fu,A.K. and Ip,N.Y.
  TITLE     Coronin 6 regulates acetylcholine receptor clustering through
            modulating receptor anchorage to actin cytoskeleton
  JOURNAL   J Neurosci 34 (7), 2413-2421 (2014)
   PUBMED   24523531
  REMARK    GeneRIF: these findings demonstrate that Coronin 6 is a critical
            regulator of AChR clustering at the postsynaptic region of the
            neuromuscular junction
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607072.15.
            
            On Feb 15, 2019 this sequence version replaced NM_139130.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145575.1, AB070895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AL607072.15        45528-45727
            201-323             AL607072.15        47283-47405
            324-453             AL607072.15        47812-47941
            454-635             AL607072.15        48035-48216
            636-755             AL607072.15        49367-49486
            756-860             AL607072.15        49883-49987
            861-1006            AL607072.15        50078-50223
            1007-1064           AL607072.15        50527-50584
            1065-1295           AL607072.15        50674-50904
            1296-2400           AL607072.15        50996-52100
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.58 cM"
     gene            1..2400
                     /gene="Coro6"
                     /note="coronin 6"
                     /db_xref="GeneID:216961"
                     /db_xref="MGI:MGI:2183448"
     exon            1..200
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1418
                     /gene="Coro6"
                     /note="isoform B is encoded by transcript variant B;
                     coronin, actin binding protein 6; clipin E; coronin
                     6/clipin E type D; coronin-like protein E"
                     /codon_start=1
                     /product="coronin-6 isoform B"
                     /protein_id="NP_624356.1"
                     /db_xref="CCDS:CCDS25079.1"
                     /db_xref="GeneID:216961"
                     /db_xref="MGI:MGI:2183448"
                     /translation="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSAFCAVNP
                     KFLAIIVEAGGGGAFIVLPLAKTGRVDKNYPLVTGHTGPVLDIDWCPHNDNVIASASD
                     DTTVMVWQIPDYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWN
                     VGTGEVLLSLDDIHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKSQVVAERFAAHE
                     GMRPMRAVFTRLGHIFTTGFTRMSQRELGLWDPNNFEEPVALQEMDTSNGVLLPFYDP
                     DSSIVYLCGKGDSSIRYFEITEEPPFVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIA
                     RFYKLHERKCEPIIMTVPRKSDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLK
                     EGYVPPKHRELRVTKRNILDVRPPASPRRSQSASEAPLSQHTLETLLEEIKALRDRVQ
                     AQEERITALENMLCELVDGTD"
     exon            201..323
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            324..453
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            454..635
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            636..755
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            756..860
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1006
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1064
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1295
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..2400
                     /gene="Coro6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatgagccg gcgtgttgtt cggcagagca agttccgcca cgtgtttggt caggcagcaa
       61 aggctgacca ggcctatgag gacatccggg tatccaaggt cacatgggac agcgccttct
      121 gtgccgtcaa ccccaaattt ctagccatta ttgtggaggc tggaggtgga ggtgccttca
      181 ttgtcctgcc tctggccaag acaggacgag tggataagaa ctacccactg gtcactgggc
      241 acactggccc tgtgctggac attgactggt gcccacacaa tgacaacgtc atcgccagtg
      301 cctcagatga caccacagtc atggtgtggc agattccaga ctacacccct gtaagaaaca
      361 tcacagaacc tgtcatcaca ctcgagggcc actccaagcg tgtgggcatc ctgtcttggc
      421 atcctactgc caggaatgtc ctgctcagtg cagggggtga taatgtgatc atcatctgga
      481 atgtgggcac tggggaggta ctgctgagcc tggacgacat acaccctgac gtcatccaca
      541 gcgtgtgttg gaacagcaat ggtagcctgc tagccaccac ctgcaaggac aagaccttgc
      601 gcatcattga cccccggaag agtcaagtgg ttgcggagag gtttgcagcc cacgagggga
      661 tgagacccat gcgggctgtc ttcacgcggc tgggtcatat cttcaccacg ggattcaccc
      721 gcatgagcca gcgagagcta ggcctgtggg acccgaacaa tttcgaagag ccagtggccc
      781 tgcaggagat ggacacaagc aacggagtgt tactaccatt ctacgatcct gactccagca
      841 tcgtctactt gtgtggcaag ggtgacagta gcattcggta ctttgaaatt acggaagaac
      901 cacctttcgt gcattatctg aacacattta gcagcaaaga accgcaacgg ggtatgggtt
      961 tcatgcccaa gcggggactg gatgtcagca aatgtgaaat cgccaggttc tacaagctgc
     1021 acgaacgaaa gtgtgaaccc atcatcatga ctgtaccgcg aaagtcagac ctgttccagg
     1081 atgacctata cccagacacg cctggccctg agcctgccct ggaagctgat gagtggctat
     1141 caggtcagga tgcagaacct gtgctcattt cgctgaagga aggctacgtt ccccccaaac
     1201 accgtgagct tcgggtcacc aaacgcaaca tcctagatgt gcgcccgccg gccagtcctc
     1261 ggcgcagcca gtccgccagc gaggccccct tgtcgcagca caccctggag acattgctgg
     1321 aggagataaa ggccctccga gatcgagtgc aggcccaaga ggagcgcatc actgcgttgg
     1381 aaaacatgct ctgtgagctg gtggacggca cagactagca ctgcctacgc gctgcaaagc
     1441 tctgcacact gcagactcaa tggggcaggg cgcaccgact ggcagcaccg gcttttggtc
     1501 tggaactctg caccctgcct cgtggggttg gaatcagggg agggatcaga aaagaaactc
     1561 catctcccac aagaggcctg aacacacaga tcttaagtgg cagggactga gctccgtact
     1621 aggtccccaa acattgcaag atcaggcctc ggggaagcct ggggtaatgt ggccttagca
     1681 gtggtgcttc atggtgaggt ggtgtccctc tctgtccctt accctgggca ggggaagtgc
     1741 ttagtattag cgtgatcctg gggatgctga ggggcctagg cctgacctca caggaatggc
     1801 gattcaacag atatccccag aacctcagga aatttccaat atttctccta ataagcagca
     1861 ccctgtttct attgccagaa gagcttaacc cactggcttc aaccataatt ctatggcaga
     1921 gggctcttcc catcttctca cttccaaaga cggcagcttc ttggagacaa acagacccca
     1981 ccagagaaat ctcaggagaa caggcacacg gaagcaggtt caacacacac acacacacac
     2041 acacacacac acacacacac acacacacac acacaccagc actctgctga ctcttataga
     2101 aacactgagg cattactaat gaaatacttc actaagtaca agtctgtgcc tcctgcacag
     2161 aaagccaata tgctgccccc attccccaag gcaccatgag ggaaccaggc cttgcccaaa
     2221 ctagggggca cctcagtcct ttttggaaaa ctgaggagac ctagcaaatg caagctggac
     2281 tgaggaccca tcaggcagct ttttatccca ggtcatccat ctttgcattg aggttcccaa
     2341 gaccccaccc acctcccacc cctgtgggca cttctcccca ataaagttaa gtagaaatgc
//
