LOCUS       NM_175484               3626 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coronin, actin binding protein, 2B (Coro2b), mRNA.
ACCESSION   NM_175484 XM_981162 XM_981205 XM_981238 XM_981266
VERSION     NM_175484.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Chen,Y., Xu,Z., Chen,J., Qiu,Y., Yuan,L., Liu,P., Duan,J., Chen,L.
            and Chen,Y.
  TITLE     Coronin 2B Regulates Neuronal Migration via Rac1-Dependent
            Multipolar-Bipolar Transition
  JOURNAL   J Neurosci 43 (2), 211-220 (2023)
   PUBMED   36639906
  REMARK    GeneRIF: Coronin 2B Regulates Neuronal Migration via Rac1-Dependent
            Multipolar-Bipolar Transition.
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Chen,Y., Xu,J., Zhang,Y., Ma,S., Yi,W., Liu,S., Yu,X., Wang,J. and
            Chen,Y.
  TITLE     Coronin 2B regulates dendrite outgrowth by modulating actin
            dynamics
  JOURNAL   FEBS Lett 594 (18), 2975-2987 (2020)
   PUBMED   32692409
  REMARK    GeneRIF: Coronin 2B regulates dendrite outgrowth by modulating
            actin dynamics.
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Schwarz,A., Moller-Hackbarth,K., Ebarasi,L., Unnersjo Jess,D.,
            Zambrano,S., Blom,H., Wernerson,A., Lal,M. and Patrakka,J.
  TITLE     Coro2b, a podocyte protein downregulated in human diabetic
            nephropathy, is involved in the development of protamine
            sulphate-induced foot process effacement
  JOURNAL   Sci Rep 9 (1), 8888 (2019)
   PUBMED   31221975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Gobe,C., Elzaiat,M., Meunier,N., Andre,M., Sellem,E., Congar,P.,
            Jouneau,L., Allais-Bonnet,A., Naciri,I., Passet,B., Pailhoux,E. and
            Pannetier,M.
  TITLE     Dual role of DMXL2 in olfactory information transmission and the
            first wave of spermatogenesis
  JOURNAL   PLoS Genet 15 (2), e1007909 (2019)
   PUBMED   30735494
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Rogg,M., Yasuda-Yamahara,M., Abed,A., Dinse,P., Helmstadter,M.,
            Conzelmann,A.C., Frimmel,J., Sellung,D., Biniossek,M.L., Kretz,O.,
            Grahammer,F., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     The WD40-domain containing protein CORO2B is specifically enriched
            in glomerular podocytes and regulates the ventral actin
            cytoskeleton
  JOURNAL   Sci Rep 7 (1), 15910 (2017)
   PUBMED   29162887
  REMARK    GeneRIF: CORO2B is a novel podocyte enriched protein influencing
            cytoskeletal plasticity and stress adaptation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Cheverud,J.M., Lawson,H.A., Bouckaert,K., Kossenkov,A.V.,
            Showe,L.C., Cort,L., Blankenhorn,E.P., Bedelbaeva,K.,
            Gourevitch,D., Zhang,Y. and Heber-Katz,E.
  TITLE     Fine-mapping quantitative trait loci affecting murine external ear
            tissue regeneration in the LG/J by SM/J advanced intercross line
  JOURNAL   Heredity (Edinb) 112 (5), 508-518 (2014)
   PUBMED   24569637
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Suo,D., Park,J., Harrington,A.W., Zweifel,L.S., Mihalas,S. and
            Deppmann,C.D.
  TITLE     Coronin-1 is a neurotrophin endosomal effector that is required for
            developmental competition for survival
  JOURNAL   Nat Neurosci 17 (1), 36-45 (2014)
   PUBMED   24270184
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Xu,B., Hsu,P.K., Stark,K.L., Karayiorgou,M. and Gogos,J.A.
  TITLE     Derepression of a neuronal inhibitor due to miRNA dysregulation in
            a schizophrenia-related microdeletion
  JOURNAL   Cell 152 (1-2), 262-275 (2013)
   PUBMED   23332760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087414.1, BB647296.1 and BC062649.1.
            
            On Jun 1, 2007 this sequence version replaced NM_175484.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087414.1, AK047527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AK087414.1         2-74
            74-365              BB647296.1         11-302
            366-2809            AK087414.1         367-2810
            2810-3626           BC062649.1         2542-3358
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.71 cM"
     gene            1..3626
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /note="coronin, actin binding protein, 2B"
                     /db_xref="GeneID:235431"
                     /db_xref="MGI:MGI:2444283"
     exon            1..392
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1820
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /note="E130012P22"
                     /codon_start=1
                     /product="coronin-2B"
                     /protein_id="NP_780693.2"
                     /db_xref="CCDS:CCDS23264.2"
                     /db_xref="GeneID:235431"
                     /db_xref="MGI:MGI:2444283"
                     /translation="MTVTKMSWRPQYRSSKFRNVYGKAANREHCFDGIPITKNVHDNH
                     FCAVNARFLAIVTESAGGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNI
                     IASCSEDTSVRIWEIPDGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDY
                     KVLIWNLDIGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEA
                     NCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSMPMIEEEIDGLSGLLFP
                     FYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSA
                     CEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIYPMTPGTEPALTPDEWLGGINRDP
                     VLMSLKEGYKKSSKVVFKAPIREKKSVVVNGIDLLENVPPRTENELLRMFFRQQDEIR
                     RLKEELAQKDIRLRQLQLELKNLRNNPKNC"
     exon            393..593
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..710
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..860
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1025
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1142
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1247
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1344
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1457
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1548
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1688
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..3610
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3587..3592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="Coro2b"
                     /gene_synonym="CLIPINC; E130012P22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgacttcac cgggcgcccg gagccaacgc ggcaccgaag gccgggtccc cgcccacggc
       61 cccggccgca ggtgccagga gcccgagggg gcagcgcctg gacgcgcggg gctggggacc
      121 gtcaggcgcc cggactgcac tcccgcctct gcctccgcct cctctttgta gcgagtcccc
      181 ggtcggtcct ccccgccccc cgcgcggccc gccgcccgcc tttcttcctg cctcgccttc
      241 ctgcggcgcg gcggcctcat ctattataga tgctcggccg cggctgacat cagccagcgg
      301 cctcccgagc gcgcggtccc cagcccggcc cagccgcctg ccgccgcccg cgcccagccc
      361 caccgcccgc tttctgtatg actgtcacaa agatgtcctg gcgaccgcag taccgcagtt
      421 ccaagtttcg gaacgtgtat gggaaagcgg ccaacaggga gcactgcttt gacgggatcc
      481 ccatcaccaa gaatgtacat gacaaccact tctgtgcagt caacgcccgc ttcctggcca
      541 tagtcactga gagcgcagga ggtggctcct tcctcgtcat ccccctggag cagacaggca
      601 gaatcgagcc aaactacccc aaggtatgcg gtcatcaggg caacgtgctg gacatcaaat
      661 ggaacccctt cattgacaac atcatcgcct cttgctccga ggacacttcg gtgcggatct
      721 gggagatccc tgacggtggg ctgaagcgga acatgaccga ggcgctcctg gagctccacg
      781 gacacagccg ccgtgtgggg ctggttgagt ggcaccccac gaccaacaac attctcttca
      841 gcgctggcta tgactacaag gtcctcatct ggaacctgga cataggcgag ccagtgaaaa
      901 tgattgactg ccacaccgac gtgatcctct gcatgtcctt caatacagac ggcagcctgc
      961 tcaccaccac atgcaaggac aagaagctgc gtgtgattga accccgatcc ggccgtgttc
     1021 tacaggaggc aaactgcaaa aaccacagag tgaatcgggt agtgttcctg ggcaacatga
     1081 agcggctcct cacgacaggg gtctccaggt ggaacacaag acagatcgcc ctctgggacc
     1141 aggaggatct gtccatgcca atgatcgaag aagaaattga tggactctca ggcctcctgt
     1201 tcccattcta tgatgctgat acccacatgc tctacctggc tggaaagggg gatggaaaca
     1261 tccggtacta tgagatcagc acggagaagc cctacctgag ctacctcatg gagttccgct
     1321 ccccagcccc acagaaaggc ctaggtgtca tgcccaagca tgggttggat gtgtctgcct
     1381 gcgaggtctt ccgcttctac aagctggtga ccctcaaggg cctgattgaa cccatctcca
     1441 tgattgtacc ccggaggtca gattcctacc aggaggacat ttatcccatg acaccaggca
     1501 cagagccagc gctgacccct gatgaatggc tgggaggcat caaccgagat cccgtgctga
     1561 tgtctctgaa ggaaggctat aagaagtctt caaaagtggt atttaaggcc cccatcagag
     1621 aaaagaagag cgttgtcgtc aacggcatag atttattaga aaatgtccca cccaggacag
     1681 agaatgagct cctcaggatg ttctttaggc agcaggatga gattcgaagg ctgaaggagg
     1741 agctggcaca gaaggacatc cggctccgtc agctccagct cgaactgaaa aacctgcgca
     1801 acaaccccaa gaactgctag ccccgcctcg ggctgtgtta gccccgcctt gggctgagta
     1861 agccccgcct cgggctgttt tccaagccga tctctccgtt gtttttactg gtccctaaac
     1921 tgcctcttat ctgtagagcc cagagacagg gcctggactg gagctgggga ccagttggta
     1981 gaccctacct accacctcaa gaactggaag ctgacctttg acctcctgac ttcatgctaa
     2041 catcggtccc ccagcctctc ctggaaagcc cacccctgac tggctgcggc ttctccttgc
     2101 agccccaaga gccaggcttt cccccttggc tcccggcaag tctcctcaga gggacaggat
     2161 gagtgggatt acagcctggt ttagatcttg aatgtgtccc ctgcagaggg gctgccagga
     2221 cctatctaca caggaaccag tcgctctgac cccagcattc cttctgaaac acagagaggg
     2281 ctggattgtg gggagagcgc tctgcccacc ttctgcctcc ttctgctcct gctgccgagc
     2341 aagctcaagt catctcaccc aatggttgag cgcctggcag cccgcccttt tctttctgaa
     2401 ctccctccca cccctttgtc ttcagggaat gaagaggatg tgctccatgg ccataatgac
     2461 cctttgccta cctaccctgt ggttctcttc aaagctcttt tacaccactt ttccatttaa
     2521 ttcgtgaagc aggcagagta aggattagtg tccctacctg tcaaatgaca gaaccgaggg
     2581 gtcactcaga gggtcagcag cagaccaagt acccttggta tccagagctt tcggccaggg
     2641 cccttcccac tgtattgaga tgccaatccc cttgtgggct tccccagaaa gagacctgga
     2701 agccacttcc actgtctgcc caacaccagt agtgccaaca cgcaggctga ggctctcaca
     2761 ctcagtgccc tggaccctcc tggcctgcgc tccttgctct cactctctgc tggggggggg
     2821 gggggggctc catctgacag tgaggcctct tcctggaagc tgaggcagag agaaagaata
     2881 gagtttggcc cttgggcagg cagagcaaga tggcttccag ggacgctctg cctgtgtctc
     2941 cctccacccc gctcccttcc cactcccaac cctgctatct cagccacttt cagccttaca
     3001 cacacaggat gaccacagcc actccaccca catagcactt taaagtttac ccaggttttt
     3061 gacacataga tctcaccgac tcgtgcatct gccctacttt acagtgaagg taaccaggaa
     3121 atggccctct gcacgcagct ctgggatgcg gcatctcttt ggtcctctac acgcttgctt
     3181 tagcccctct cccctccctc tctccattct ccacctaaca catggagctc aaaagcactg
     3241 gtgtcaggac agtcaccgcc ctttgggtag aggagatgtg gggacctcgg tcaccggctg
     3301 ggatctgcta tacataggac acttcttgcc tgcccaccct gcaaaacttc ccaactgcag
     3361 atgccctcca ggcgagctga ggtgagattt ccccagccct ggggcctctc ctctccaacc
     3421 accgacgttc cccactccca gcgtgctaaa gcgagttctc ctccccacca ccacagctag
     3481 actgtcagct ctcatctccc ctccacactt ctggaatttt ctttctctcc attgaccttt
     3541 gtggtcttct gtgattattt atgctgcctc ccaaggttag aattgaaata aaatgttttc
     3601 aggttatcaa aaaaaaaaaa aaaaaa
//
