LOCUS       NM_001164804            3887 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus coronin, actin binding protein 2A (Coro2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001164804
VERSION     NM_001164804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Suo,D., Park,J., Harrington,A.W., Zweifel,L.S., Mihalas,S. and
            Deppmann,C.D.
  TITLE     Coronin-1 is a neurotrophin endosomal effector that is required for
            developmental competition for survival
  JOURNAL   Nat Neurosci 17 (1), 36-45 (2014)
   PUBMED   24270184
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   3  (bases 1 to 3887)
  AUTHORS   Huang,W., Ghisletti,S., Saijo,K., Gandhi,M., Aouadi,M., Tesz,G.J.,
            Zhang,D.X., Yao,J., Czech,M.P., Goode,B.L., Rosenfeld,M.G. and
            Glass,C.K.
  TITLE     Coronin 2A mediates actin-dependent de-repression of inflammatory
            response genes
  JOURNAL   Nature 470 (7334), 414-418 (2011)
   PUBMED   21331046
  REMARK    GeneRIF: findings uncover a CORO2A-actin-dependent mechanism for
            the de-repression of inflammatory response genes that can be
            differentially regulated by phosphorylation and by nuclear receptor
            signalling pathways that control immunity and homeostasis
REFERENCE   4  (bases 1 to 3887)
  AUTHORS   de Hostos,E.L.
  TITLE     The coronin family of actin-associated proteins
  JOURNAL   Trends Cell Biol 9 (9), 345-350 (1999)
   PUBMED   10461187
  REMARK    Review article
REFERENCE   5  (bases 1 to 3887)
  AUTHORS   Okumura,M., Kung,C., Wong,S., Rodgers,M. and Thomas,M.L.
  TITLE     Definition of family of coronin-related proteins conserved between
            humans and mice: close genetic linkage between coronin-2 and
            CD45-associated protein
  JOURNAL   DNA Cell Biol 17 (9), 779-787 (1998)
   PUBMED   9778037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683884.26, AK030971.1, AK054394.1 and AW912496.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and uses a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (2) is
            shorter at the N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.352594.1,
                                           SRR7345562.3478379.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL683884.26        213011-213123       c
            114-358             AK030971.1         70-314
            359-1540            AK054394.1         360-1541
            1541-3683           AK030971.1         1498-3640
            3684-3881           AW912496.1         11-208              c
            3882-3887           AL683884.26        148131-148136       c
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.87 cM"
     gene            1..3887
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /note="coronin, actin binding protein 2A"
                     /db_xref="GeneID:107684"
                     /db_xref="MGI:MGI:1345966"
     exon            1..113
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            114..314
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            315..431
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            432..581
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            582..761
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            762..878
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            879..983
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1080
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1193
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1284
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1556
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..3887
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /note="hexamer: AACAAA"
     polyA_site      1882
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /note="major polyA site"
     regulatory      3858..3863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /note="hexamer: AATAAA"
     polyA_site      3881
                     /gene="Coro2a"
                     /gene_synonym="9030208C03Rik; IR10"
                     /note="major polyA site"
ORIGIN      
        1 gccgggctgc gcggggaggc ggcggcactg ggcgcgggga ctcggcgggc ggcgcgaagc
       61 gcggagcggg agccggagcc gccgccgccg ccacctgcgc ggcagccaac aagatgtcat
      121 ggcaccccca gtaccgcagc tccaagttcc gtcatgtcta cggcaagccc gccagcaaag
      181 agaactgcta cgactctgtg cccatcacac gcagcgtcca cgacaaccac ttctgtgccg
      241 tgaaccccca cttcatcgct gtggtcactg aatgtgccgg cgggggcgcc ttccttgtca
      301 tccccctgca ccagacggga aagttggacc ctcactaccc caaagtctgt gggcacagag
      361 ggaacgtctt ggacatcaaa tggaatcctt tcaatgactt tgagattgcc tcctgttctg
      421 aagatgccac gattaagatc tggaacatcc ccaagcaact gttgacaagg aacctcacaa
      481 cctacaggaa ggagctgatc ggccatgctc gcagggtggg gctggtggag tggcacccca
      541 caactgccaa cattctcttc agtgctggct atgactacaa ggtgatggtg tggaacctgg
      601 acacaaagga ttctgtcatt gctgggccag tgaagacaat caactgtcac caagatgtga
      661 tcctctccat gtcctttaac accaacggca gcctgctggc caccacctgt aaggaccgca
      721 agattcggat tgttgacccc cgactaggga ttgtcctcca ggaagccagc tacaaggggc
      781 accgcgccaa caaagtactg ttcctgggga gcctcaagaa gctgctatcc acgggtacct
      841 cccgctggaa caaccggcag atggccctgt gggaccagga aaacctttct gtgcccctta
      901 cagaggaaga cctggatggc tcttctggtg tgctgttccc cttctttgac tcggacacca
      961 gcatgctgta cattgtgggg aagggagacg ggaacatccg ctactatgag gtaagcatgg
     1021 agaaacctca cctgacctac ctgaccgagt accgctccta caacccacag aaggggatcg
     1081 gtatcatgcc aaagagaggt ctcgatgtgt cttcctgcga gatcttccgc ttctataaac
     1141 tgatcacaac caaaagcctc atcgagccag tgtccatgat tgtaccccga aggtcagaat
     1201 cctaccaaga ggacatctac ccgcccaccg cagcggccca gccctccctg acggctcatg
     1261 agtggctcag cgggatgaac agagggccta tcatgatgtc ccttagaccc ggctccgagc
     1321 tgctggactc ccagacactg cctccagaga gacccctctc caattctatg gtccaagttt
     1381 cacctcagcc cttagaaccc atgaaacagc cggccgaaga cggtgaccag gcgcccttct
     1441 ctctactgga agagaagcta gcaaagtgga ccgcagagca tcatctggga gagaagtcct
     1501 gcctcactaa tggctttgat gttttcgaat gctccccacc aaagacagaa aatgagctgc
     1561 tgcagatgtt ctaccggcaa caggaggaga tccggaggct ccgggagctg ttaatccaga
     1621 gagaagtcca gaccaagcag ctggaactag agatcaaaaa cctgcggatg gccttaggac
     1681 agctctgagc agtgctctcc tccacccttg ccctcaggga caccgatagg ctctgtggag
     1741 agagagagag agagagagag agagagagag agagagagag agagagagag agaggtccag
     1801 caccgagccg aaattcactg agaacaacca ctatttctat attttatacc aggaaaacaa
     1861 aactctcagt tgctgaaaga gatcccagtg ggacgtggtg ccgctttcct gtcgccttct
     1921 ccaatctgca gttcctgccc tggctggttt agattatacc ctaccttctg ctggattctg
     1981 gttttaaggg ttggtgagga gctatgacct cccagagtga agatttggcc caattctaaa
     2041 ccacaggcag gcagccaaac ccatccttcc aaccagaatc agccacatgt gggtagatcg
     2101 tcccataggt ggggacacag acctcagagc tgagtccatg tctgttgact acaagagggc
     2161 aggaacggac ttccacccag ggtatctaaa gtcctctggg aggtaggggg gcccagcact
     2221 ggatgtggca aagccccatg gccagccacc agtaagggct ctggttcact gcactgggtg
     2281 agaaaatggc acctggtctg aaagcctgcg accctccctt gtgtgtcttg tgcctggttc
     2341 tgaggctctt ttctttcttg gtgcaaaaca agcctagctg gtgcctgaga acttgagaca
     2401 aggcttacca caggaggtac ccactccccc atacctcctg gacaagcaga cagagttccc
     2461 ccctcccccc ttcccctctg gacagatagt ttcccccatc actcagggtc atgctggagc
     2521 tcaagcgaga atttcagggg ctatccaggc taacaggttc tgacccacat cgtccattag
     2581 caccccactg gatgcacata ctgatgacca gacctgccca ctaaagctga ccctacagtg
     2641 gagggtacgg ccctctgaac aagctgcctg agtggcttct gttcatggga atggagacgc
     2701 ttttagctag catcctactg ctgtgttggc aatggaagca gtacaaagct gactcgcaca
     2761 cgaccacgtc actcaccgtc gctggtatct gcacacacca gggtcctgtg ctccttggtt
     2821 tattctccat ccctacacta cactgggact ctatgcccgg cgatgagcta gctatgctcg
     2881 ccttccttgt gctcccgagt atggcaggga tctggagctc ctgggatggc gcgctctctc
     2941 tcctttcatt tgtgaccagc atgtcagtct gtaaagctcc aaccccatgc tcagaaggca
     3001 ggagggccac atagtgaaga caccagccca aaaccactgg ctgcctctta tgtgtggcta
     3061 ggggtggggt ccagtgagct tcccatcaaa tctctgtaca acaccatccc ctcaaaaaaa
     3121 agctatcccc actgtaaggg acccagaccc agacctcaca ttcaggaaca ggtcacaggt
     3181 ggctatgaac aaaattatat gttgtttctt gttctgttgg gttttttttt acatctagaa
     3241 taaattattt aaattatttc atagcaaggg agagggatat ttgtcatctt ttttttcttt
     3301 tgaagatttt gtcatatttt tttaagatta tgtttttatg ttcttgggct aatggagcaa
     3361 cactgccccc tgacacagtg accacccaag cagcaaagcc gccctcggct ccttccttct
     3421 tgccttggga gctttctttc tgatgactca ggaactttgt gtgaatgagg gagaacgctt
     3481 ggagatgagc ttgtacccac cttagctcta caataattct gcttcctaga acaaaacttg
     3541 aggttgtatc ccagagggaa acgggaatca agatacggac ctatgctttt catatgaaac
     3601 cgtgcctgaa gccgtttgag tgattgtttg aatgtttctt aaattccttg tacctttgta
     3661 aaaaagtaaa taaaaaaata attaagaaat aaaagttaaa atagacacag aatcgtgcaa
     3721 tgtaagaata tgacaatcta ctgtgggtgg taattcctgc ctgtaatccc agttcatgga
     3781 aggctgaggc aggaagattg aaaattccag accagcttgg gcaaaggagt ctaagactct
     3841 gcctcaacca aaataataat aaataataac accagactcg atattgc
//
