LOCUS       NM_001412248            1734 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coronin, actin binding protein 1A (Coro1a), transcript
            variant 4, mRNA.
ACCESSION   NM_001412248
VERSION     NM_001412248.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Deng,X., Liu,B., Jiang,Q., Li,G., Li,J. and Xu,K.
  TITLE     CREBH promotes autophagy to ameliorate NASH by regulating Coro1a
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166914 (2024)
   PUBMED   37837948
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Wang,F., Tan,P., Zhang,P., Ren,Y., Zhou,J., Li,Y., Hou,S., Li,S.,
            Zhang,L., Ma,Y., Wang,C., Tang,W., Wang,X., Huo,Y., Hu,Y., Cui,T.,
            Niu,C., Wang,D., Liu,B., Lan,Y. and Yu,J.
  TITLE     Single-cell architecture and functional requirement of alternative
            splicing during hematopoietic stem cell formation
  JOURNAL   Sci Adv 8 (1), eabg5369 (2022)
   PUBMED   34995116
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Fei,X., Li,Z., Yang,D., Kong,X., Lu,X., Shen,Y., Li,X., Xie,S.,
            Wang,J., Zhao,Y., Sun,Y., Zhang,J., Ye,Z., Wang,J. and Cai,Z.
  TITLE     Neddylation of Coro1a determines the fate of multivesicular bodies
            and biogenesis of extracellular vesicles
  JOURNAL   J Extracell Vesicles 10 (12), e12153 (2021)
   PUBMED   34623756
  REMARK    GeneRIF: Neddylation of Coro1a determines the fate of
            multivesicular bodies and biogenesis of extracellular vesicles.
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Okumura,M., Kung,C., Wong,S., Rodgers,M. and Thomas,M.L.
  TITLE     Definition of family of coronin-related proteins conserved between
            humans and mice: close genetic linkage between coronin-2 and
            CD45-associated protein
  JOURNAL   DNA Cell Biol 17 (9), 779-787 (1998)
   PUBMED   9778037
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Vidal,S., Kono,D.H. and Theofilopoulos,A.N.
  TITLE     Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr
            mice
  JOURNAL   J Clin Invest 101 (3), 696-702 (1998)
   PUBMED   9449705
REFERENCE   8  (bases 1 to 1734)
  AUTHORS   Kimura,S., Hirasawa,T., Nakamura,K., Yagi,H., Matsumoto,M.,
            Makino,S. and Harada,M.
  TITLE     Genetic control of peripheral T-cell deficiency in the cataract
            Shionogi (CTS) mouse linked to chromosome 7
  JOURNAL   Immunogenetics 47 (3), 278-280 (1998)
   PUBMED   9435347
REFERENCE   9  (bases 1 to 1734)
  AUTHORS   Yagi,H., Matsumoto,M., Nakamura,M., Makino,S., Suzuki,R., Harada,M.
            and Itoh,T.
  TITLE     Defect of thymocyte emigration in a T cell deficiency strain (CTS)
            of the mouse
  JOURNAL   J Immunol 157 (8), 3412-3419 (1996)
   PUBMED   8871639
REFERENCE   10 (bases 1 to 1734)
  AUTHORS   Yagi,H., Nagata,M., Takeuchi,M., Watanabe,A., Arimura,A.,
            Hashimoto,S., Makino,S. and Harada,M.
  TITLE     Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in
            vivo T cell-mediated immune response
  JOURNAL   Immunol Invest 19 (5-6), 493-505 (1990)
   PUBMED   2074115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124505.4.
            
            Summary: This gene encodes a member of the WD repeat coronin
            family. The encoded protein may bind actin and interact with
            microtubules. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.847891.1,
                                           SRR13422600.124163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC124505.4         44737-44955         c
            220-439             AC124505.4         43744-43963         c
            440-562             AC124505.4         42774-42896         c
            563-692             AC124505.4         42558-42687         c
            693-877             AC124505.4         42286-42470         c
            878-997             AC124505.4         42058-42177         c
            998-1102            AC124505.4         41760-41864         c
            1103-1248           AC124505.4         41508-41653         c
            1249-1306           AC124505.4         41352-41409         c
            1307-1522           AC124505.4         41025-41240         c
            1523-1734           AC124505.4         40542-40753         c
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1734
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /note="coronin, actin binding protein 1A"
                     /db_xref="GeneID:12721"
                     /db_xref="MGI:MGI:1345961"
     exon            1..219
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            220..439
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1627
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /note="clipin-A; coronin-like protein A; coronin-like
                     protein p57; tryptophan aspartate-containing coat protein;
                     coronin-like actin binding protein; coronin 1"
                     /codon_start=1
                     /product="coronin-1A"
                     /protein_id="NP_001399177.1"
                     /db_xref="GeneID:12721"
                     /db_xref="MGI:MGI:1345961"
                     /translation="MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNP
                     KFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSE
                     DCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWD
                     VGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPH
                     EGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFD
                     PDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEI
                     ARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISL
                     KDGYVPPKSRELRVNRGLDSARRRATPEPSGTPSSDTVSRLEEDVRNLNAIVQKLQER
                     LDRLEETVQAK"
     exon            440..562
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            563..692
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            693..877
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            878..997
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1102
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1248
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1306
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1522
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1734
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="Coro1a"
                     /gene_synonym="Clabp; Lmb3; p57; TACO"
                     /note="major polyA site"
ORIGIN      
        1 acatcttccg cccctacctt ggattgggct ttccttctcc caaatccaga ctgctcactg
       61 gggtcttgtg tccccttcct gtcttggaga cttcactcag gcacttcacc tgcttttatt
      121 tttaatagac ctgggagcct ccttggtgat accggggtgt gcgaggactg gagtcccagc
      181 acgaaggggc tgagtccccc attaaggcag agcagatggt ttacaatctg tatccttcag
      241 gatgagccgg caggtggttc gctccagcaa attccgccac gtgtttggac agccagccaa
      301 ggctgaccag tgctatgagg atgtgcgcgt ctcacaaacc acttgggaca gtggcttctg
      361 cgctgtcaac cccaagttca tggctctgat ctgtgaggcc agtgggggag gggccttcct
      421 ggtgctaccc ctaggcaaga ctggacgagt agacaagaac gtgcccctgg tctgcggcca
      481 cactgcccct gtgctagaca tcgcctggtg tccacacaat gacaatgtca ttgccagtgg
      541 ctctgaggac tgcacagtta tggtgtggga gatcccggat gggggcctgg tgctgccctt
      601 gcgggagcct gtcatcacct tggagggcca caccaagagg gttggcatcg tggcctggca
      661 ccccacagcc cagaatgtgc ttctcagcgc aggttgtgac aatgtgatcc tggtgtggga
      721 cgtgggcact ggggcagctg tgctgacgct gggcccggat gtgcacccgg acacaatcta
      781 cagcgtggac tggagccggg acggtgctct catctgcacc tcctgccgtg acaagcgagt
      841 tcgtgtcatc gagcctcgca aaggcactgt tgtggctgaa aaggaccgtc cccatgaggg
      901 gactcggcca gtgcacgctg tgtttgtgtc agaagggaag attctaacca cgggtttcag
      961 tcgcatgagt gagcggcagg tggcgctgtg ggacacaaag cacctggagg agccactgtc
     1021 cctgcaggag ctggacacaa gcagcggagt cctgctacct ttttttgatc ctgataccaa
     1081 cattgtctac ctctgtggca agggtgacag ctctatccgg tattttgaga tcacttctga
     1141 ggctccgttc ctgcattatc tttccatgtt cagttccaag gagtctcagc gtggtatggg
     1201 ctacatgccc aaacgtggcc tggaagtgaa taagtgtgag attgccagat tctataagct
     1261 tcatgagcgg aagtgtgagc ccattgccat gacagtgcct agaaagtcgg acctgttcca
     1321 ggaggacctg tatccgccca ctgcaggacc cgaccctgcc ctcacagctg aggaatggct
     1381 gggtggtcgg gatgctggcc ccctcctcat ttccctcaag gatggctacg tgcccccaaa
     1441 gagcagggag ctgagggtca acaggggcct ggacagcgct cgcagaagag ctacaccaga
     1501 gcccagcggc acgcccagct cggataccgt gtcaaggctg gaggaggacg tgaggaatct
     1561 gaacgccata gtgcaaaagc tacaagagcg cctggacagg ctggaggaga ctgttcaggc
     1621 caagtagaac cccagagccc tcatctgggg ccagccatcc cctctgctcc caccccaccc
     1681 tcaggccata tggtgaataa gacgaaaata ataaaacggc tttattttct ggta
//
