LOCUS       NM_016869               4890 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus corin, serine peptidase (Corin), transcript variant 1,
            mRNA.
ACCESSION   NM_016869
VERSION     NM_016869.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4890)
  AUTHORS   Zhou T, Zhang S, Du C, Wang K, Gu X, Sun S, Zhang X, Niu Y, Wang C,
            Liu M, Dong N and Wu Q.
  TITLE     Renal Corin Is Essential for Normal Blood Pressure and Sodium
            Homeostasis
  JOURNAL   Int J Mol Sci 23 (19), 11251 (2022)
   PUBMED   36232551
  REMARK    GeneRIF: Renal Corin Is Essential for Normal Blood Pressure and
            Sodium Homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4890)
  AUTHORS   El Abdellaoui-Soussi F, Yunes-Leites PS, Lopez-Maderuelo D,
            Garcia-Marques F, Vazquez J, Redondo JM and Gomez-Del Arco P.
  TITLE     Interplay between the Chd4/NuRD Complex and the Transcription
            Factor Znf219 Controls Cardiac Cell Identity
  JOURNAL   Int J Mol Sci 23 (17), 9565 (2022)
   PUBMED   36076959
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4890)
  AUTHORS   Xu J, Liu H, Lan Y and Jiang R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4890)
  AUTHORS   He M, Zhou T, Niu Y, Feng W, Gu X, Xu W, Zhang S, Wang Z, Zhang Y,
            Wang C, Dong L, Liu M, Dong N and Wu Q.
  TITLE     The protease corin regulates electrolyte homeostasis in eccrine
            sweat glands
  JOURNAL   PLoS Biol 19 (2), e3001090 (2021)
   PUBMED   33591965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4890)
  AUTHORS   Harshuk-Shabso S, Dressler H, Niehrs C, Aamar E and
            Enshell-Seijffers D.
  TITLE     Fgf and Wnt signaling interaction in the mesenchymal niche
            regulates the murine hair cycle clock
  JOURNAL   Nat Commun 11 (1), 5114 (2020)
   PUBMED   33037205
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4890)
  AUTHORS   Chan JC, Knudson O, Wu F, Morser J, Dole WP and Wu Q.
  TITLE     Hypertension in mice lacking the proatrial natriuretic peptide
            convertase corin
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 785-790 (2005)
   PUBMED   15637153
  REMARK    GeneRIF: data establish corin as the physiological pro-ANP
            convertase and indicate that corin deficiency may contribute to
            hypertensive heart disease (pro-ANP convertase corin)
REFERENCE   7  (bases 1 to 4890)
  AUTHORS   Pan J, Hinzmann B, Yan W, Wu F, Morser J and Wu Q.
  TITLE     Genomic structures of the human and murine corin genes and
            functional GATA elements in their promoters
  JOURNAL   J Biol Chem 277 (41), 38390-38398 (2002)
   PUBMED   12154094
  REMARK    GeneRIF: These data indicate that the GATA element and its binding
            to GATA-4 are essential for cardiac expression of the human and
            murine corin genes.
REFERENCE   8  (bases 1 to 4890)
  AUTHORS   Wu F, Yan W, Pan J, Morser J and Wu Q.
  TITLE     Processing of pro-atrial natriuretic peptide by corin in cardiac
            myocytes
  JOURNAL   J Biol Chem 277 (19), 16900-16905 (2002)
   PUBMED   11884416
  REMARK    GeneRIF: Processing of pro-atrial natriuretic peptide by corin in
            cardiac myocytes.
REFERENCE   9  (bases 1 to 4890)
  AUTHORS   Yan W, Sheng N, Seto M, Morser J and Wu Q.
  TITLE     Corin, a mosaic transmembrane serine protease encoded by a novel
            cDNA from human heart
  JOURNAL   J Biol Chem 274 (21), 14926-14935 (1999)
   PUBMED   10329693
REFERENCE   10 (bases 1 to 4890)
  AUTHORS   Tomita Y, Kim DH, Magoori K, Fujino T and Yamamoto TT.
  TITLE     A novel low-density lipoprotein receptor-related protein with type
            II membrane protein-like structure is abundant in heart
  JOURNAL   J Biochem 124 (4), 784-789 (1998)
   PUBMED   9756624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB013874.1 and BC093485.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_016869.4.
            
            On Mar 19, 2008 this sequence version replaced NM_016869.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB013874.1, BC138339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1223              AB013874.1         1-1223
            1224-3530           BC093485.1         1000-3306
            3531-3668           AB013874.1         3531-3668
            3669-4890           BC093485.1         3445-4666
FEATURES             Location/Qualifiers
     source          1..4890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..4890
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /note="corin, serine peptidase"
                     /db_xref="GeneID:53419"
                     /db_xref="MGI:MGI:1349451"
     exon            1..327
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..3402
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     atrial natriuretic peptide-converting enzyme;
                     pro-ANP-converting enzyme; low density lipoprotein
                     receptor-related protein 4; low density
                     lipoprotein-related protein 4"
                     /codon_start=1
                     /product="atrial natriuretic peptide-converting enzyme
                     isoform 1"
                     /protein_id="NP_058565.2"
                     /db_xref="CCDS:CCDS19330.1"
                     /db_xref="GeneID:53419"
                     /db_xref="MGI:MGI:1349451"
                     /translation="MGRVSFSVRVSSVRRARCSCPGRCYLSCRVPPTTALRALNGLGC
                     AGVPGETAGGAVGPGPLGTRGFLSGSKFQAPGSWKDCFGAPPAPDVLRADRSVGEGCP
                     QKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKRVYFKSNDSEPLVTDGEARV
                     PGVIPVNTVYYENTGAPSLPPSQSTPAWTPRAPSPEDQSHRNTSTCMNITHSQCQILP
                     YHSTLAPLLPIVKNMDMEKFLKFFTYLHRLSCYQHILLFGCSLAFPECVVDGDDRHGL
                     LPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRDHTETNSSVRKSCFSLQQEHGKQ
                     SLCGGGESFLCTSGLCVPKKLQCNGYNDCDDWSDEAHCNCSKDLFHCGTGKCLHYSLL
                     CDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCHSQ
                     GLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDSQTPCPEGEQGCLGSSCVESCAGS
                     SLCDSDSSLSNCSQCEPITLELCMNLPYNHTHYPNYLGHRTQKEASISWESSLFPALV
                     QTNCYKYLMFFACTILVPKCDVNTGQRIPPCRLLCEHSKERCESVLGIVGLQWPEDTD
                     CNQFPEESSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENC
                     GCKERALWECPFNKQCLKHTLICDGFPDCPDSMDEKNCSFCQDNELECANHECVPRDL
                     WCDGWVDCSDSSDEWGCVTLSKNGNSSSLLTVHKSAKEHHVCADGWRETLSQLACKQM
                     GLGEPSVTKLIPGQEGQQWLRLYPNWENLNGSTLQELLVYRHSCPSRSEISLLCSKQD
                     CGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEG
                     REDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINET
                     SYVRPVCLPSPEEYLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKT
                     ITNRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYS
                     NVSYFVGWIERQIYIQTFLQKKSQG"
     exon            328..469
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            470..670
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            671..878
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1063
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1177
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1285
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1396
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1513
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1621
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1853
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1999
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2107
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2221
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2332
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2462
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2576
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2626
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2801
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3073
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3207
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..4863
                     /gene="Corin"
                     /gene_synonym="Lrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagtcccca ggcagacggt ccctcactcc tgtggcttgg cgtcggagac gctggcagtc
       61 atgggcaggg tttccttcag cgttcgggtc agctccgtgc ggagagcccg ctgctcttgt
      121 cctgggcgat gctacctctc ctgcagagtc cctccaacca ccgccctccg tgcactgaac
      181 ggtcttggct gcgcgggggt tccgggggag actgcaggtg gagccgtcgg acccggcccc
      241 ttggggaccc gtggcttcct ctccgggtcc aagttccagg ctcccggcag ctggaaggat
      301 tgctttggag ccccgcctgc tccagacgtc ttgagagcag acaggagcgt gggcgagggc
      361 tgtcctcaga agctggtgac tgctaacttg ctgcgcttcc tcctgctggt gctcatcccc
      421 tgcatctgcg ccctcatcgt gctgctggcc atcctgctgt cctttgtggg aacattaaaa
      481 agggtttatt tcaaatcaaa tgacagtgaa cctttggtca ctgatgggga agctcgagtg
      541 cctggtgtta ttcctgtaaa tacagtttat tatgagaaca caggggcgcc ctctctgccc
      601 cccagccagt ccactccagc ctggacaccg agagctcctt ctccagagga ccagagtcac
      661 aggaacacaa gcacctgcat gaacatcact cacagccagt gtcaaattct gccctaccac
      721 agcacgttgg cacctctctt gccaattgtc aaaaacatgg acatggagaa gttcctcaag
      781 ttcttcacgt acctccatcg cctcagttgc tatcaacata tcctgctctt cggctgtagc
      841 ctcgccttcc ctgagtgcgt tgttgatggc gatgacaggc atggtcttct accctgtaga
      901 tctttctgtg aggctgcaaa agaaggatgc gaatctgtcc tgggaatggt gaactcctcc
      961 tggccggatt ccctcagatg ctctcagttt agggaccaca ctgagactaa cagcagtgtc
     1021 agaaagagct gcttctcact gcagcaggaa catggaaagc aatcactctg tggagggggc
     1081 gagagcttcc tgtgtaccag cgggctctgc gtccccaaga agctgcagtg taacggctat
     1141 aatgactgtg atgactggag cgacgaggcg cattgcaact gcagcaagga tctgtttcac
     1201 tgtggcacag gcaagtgcct ccattacagc ctcttgtgtg atgggtacga tgactgtggg
     1261 gacctgagtg acgagcaaaa ctgtgattgt aatctcacaa aagagcatcg ctgtggagat
     1321 gggcgctgca ttgcggctga gtgggtgtgc gatggggacc atgactgtgt ggacaagtct
     1381 gatgaggtca actgctcttg tcacagccag ggcctggtgg aatgcagaag tggacagtgc
     1441 atccctagca ccttccagtg tgatggggac gaagactgta aggatgggag tgacgaggag
     1501 aactgcagtg acagtcagac gccatgtcca gaaggagaac agggatgcct tggcagttcc
     1561 tgcgtcgaat cctgtgctgg tagctctctg tgtgactcag acagcagcct gagtaactgc
     1621 agtcaatgtg agcccatcac tttggaactc tgcatgaatt tgccctacaa ccatacacat
     1681 tatccaaatt accttggcca cagaactcaa aaggaagcgt ccatcagctg ggagtcatcc
     1741 cttttccctg cccttgtaca aaccaactgt tacaaatacc tcatgttttt cgcttgcacc
     1801 attttggttc caaagtgtga tgtgaataca ggacaacgca tcccgccttg cagactcctg
     1861 tgtgagcact ccaaagagcg ctgtgagtct gttctgggaa tcgttggcct gcagtggcct
     1921 gaagacaccg actgcaatca atttccagag gaaagttcag acaatcaaac ttgcctcctg
     1981 cccaatgaag atgtggaaga atgctctccg agtcacttca aatgccgctc gggacgatgc
     2041 gttctgggct ccaggagatg tgacggccag gctgactgtg acgacgacag tgacgaggag
     2101 aactgtggtt gtaaagagag agctctttgg gaatgtccat ttaataagca atgtctgaag
     2161 catacattaa tctgcgatgg gtttccagat tgtccagaca gtatggatga aaaaaactgc
     2221 tcattttgcc aagacaatga gctggaatgt gccaaccatg agtgtgtgcc gcgtgacctt
     2281 tggtgcgacg gatgggtcga ctgctcagac agttctgatg aatggggctg tgtgaccctc
     2341 tctaaaaatg ggaactcctc ctcattgctg actgttcaca aatctgcaaa ggaacaccac
     2401 gtgtgtgctg acggctggcg ggagacgttg agtcagctgg cctgcaagca gatgggttta
     2461 ggagaaccgt ctgtgaccaa gctgatccca ggacaggaag gccagcagtg gctgaggttg
     2521 taccccaact gggagaatct caatgggagc accttgcagg agctgctggt atacaggcac
     2581 tcctgcccaa gcagaagtga gatttccctt ctgtgctcca agcaagactg tggccgccgc
     2641 cctgctgccc gaatgaacaa gaggatcctt gggggtcgga ctagtcgtcc tgggaggtgg
     2701 ccgtggcagt gctctctgca gagtgaaccc agtggacata tctgtggctg tgtcctcatt
     2761 gccaagaagt gggtcctgac agttgcccat tgctttgaag ggagagaaga cgctgatgtt
     2821 tggaaagtgg tatttggcat aaacaacctg gaccatccat caggcttcat gcagacccgc
     2881 tttgtgaaga ccatcctgct acatccccgt tacagtcgag cagtggtaga ctatgatatc
     2941 agcgtggtgg agctgagcga tgatatcaat gagacaagct acgtcagacc tgtctgccta
     3001 cccagtccgg aggagtatct agaaccagat acgtactgct acatcacagg ctggggccac
     3061 atgggcaata aaatgccctt taagctgcag gagggagagg tccgcattat ccctctggag
     3121 cagtgccagt cctattttga catgaagacc atcaccaatc ggatgatctg tgctggctat
     3181 gagtctggca ccgtggactc ctgcatggga gacagcggtg ggcctctggt ttgtgaacga
     3241 cccggaggac agtggacatt atttggttta acttcatggg gctccgtctg cttttccaaa
     3301 gttctgggac ctggagtgta cagcaatgtg tcttactttg tgggctggat tgaaagacaa
     3361 atatatatcc agacctttct ccaaaagaaa tcccaaggat aatcagagac tttgtgggga
     3421 aacctacatg gagaatgacc ctctgaaaca gaagcttgtc ctgccaagag ctgtacgaac
     3481 aggcgtttca cggacaggac gctcaacatg caccgcaaga tctctcctgt ttgtgctaga
     3541 tgagttttac tcaggcttta atctctttca acattatcat ttattaattt catgaatcct
     3601 tttaaaagca cagagcaaag taggttttgt tattttgcta ggctaacctt gaatgtagtg
     3661 tgcaattatc aacccataga gacatttgga gctctagggt aacaagttat agaaagctcc
     3721 ttttattact actacaagac acacacggag atacacgctg actgatctcc agtttctgct
     3781 taagcccagt ggcttagggg gcacatttca gaactgatct tggagactgg cttttaattt
     3841 gtagaaagcc aagagaatat atatgctttt attatttact ctactcttct aaataacttg
     3901 aagaaatcat gaaagacaga gaaaggaccc acagtgttga tctagacagt tgaagttgca
     3961 agaatgtaaa attctctagc caaccaaact aacactctga agtaagtaga attctatcct
     4021 ttctgtattc aaattaagct taaaatctcc accagatttg ttcccgttac tgggaatttt
     4081 cggagtatgt cacttagatg actgtgatgt caaaagccag gtcaatcctt gaggaaataa
     4141 tttgtttgct tatgtgggaa tgaataagaa tctttccatt ccgcaaaaca cacaaattaa
     4201 aaaggagaaa aaaattaaat aacattccac acccaattaa ttctgaaaat tagtctgctt
     4261 gtattcaccc aaaacagaaa agttacagaa atatatttca aagtgcagca aaatgttgca
     4321 tggagtatat aacattttgc aatttccccc tcatgatgtc taacatccgg tattgccatt
     4381 tgcctcattg ataattaaaa ctaaatttta aggatgcttt taagcactgg gccactttat
     4441 gggaatcaat ttccaaagca attagtggtt acaagtattt tttcccacta aaaagtttca
     4501 aaacacaaac cttcatacta aattaattag ccagacatga actatgtaac atgcaaatgc
     4561 ctttttgaac aagtaggatg cactgctaaa cttcaccagc aaccaaactg cctcagtatt
     4621 gcttacaggg actacctgca attttatatg tgtattttgt actctttttc tagatagttc
     4681 aaatgcaaaa cattgtttca acccctattc tccatgttgt tcacctcttg tcctggaatt
     4741 tgttacaaag tgtgtgtagc aaatgattgt actgcggtca ggactatatg aaggtttagg
     4801 accatcgggt cggttttgtt ataattgttg gcacataatt aataaaatat ttttagcatt
     4861 ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
