LOCUS       NM_026452               1697 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus coenzyme Q9 (Coq9), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_026452 XM_911664
VERSION     NM_026452.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Gonzalez-Garcia,P., Diaz-Casado,M.E., Hidalgo-Gutierrez,A.,
            Jimenez-Sanchez,L., Bakkali,M., Barriocanal-Casado,E., Escames,G.,
            Chiozzi,R.Z., Vollmy,F., Zaal,E.A., Berkers,C.R., Heck,A.J.R. and
            Lopez,L.C.
  TITLE     The Q-junction and the inflammatory response are critical
            pathological and therapeutic factors in CoQ deficiency
  JOURNAL   Redox Biol 55, 102403 (2022)
   PUBMED   35863266
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Rodriguez-Hidalgo,M., Luna-Sanchez,M., Hidalgo-Gutierrez,A.,
            Barriocanal-Casado,E., Mascaraque,C., Acuna-Castroviejo,D.,
            Rivera,M., Escames,G. and Lopez,L.C.
  TITLE     Reduction in the levels of CoQ biosynthetic proteins is related to
            an increase in lifespan without evidence of hepatic mitohormesis
  JOURNAL   Sci Rep 8 (1), 14013 (2018)
   PUBMED   30228311
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Luna-Sanchez,M., Diaz-Casado,E., Barca,E., Tejada,M.A.,
            Montilla-Garcia,A., Cobos,E.J., Escames,G., Acuna-Castroviejo,D.,
            Quinzii,C.M. and Lopez,L.C.
  TITLE     The clinical heterogeneity of coenzyme Q10 deficiency results from
            genotypic differences in the Coq9 gene
  JOURNAL   EMBO Mol Med 7 (5), 670-687 (2015)
   PUBMED   25802402
  REMARK    GeneRIF: The presence of a truncated version of COQ9 protein in
            Coq9(R239X) mice destabilizes the coenzyme Q10-synthesizing
            multiprotein complex.
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Lohman,D.C., Forouhar,F., Beebe,E.T., Stefely,M.S., Minogue,C.E.,
            Ulbrich,A., Stefely,J.A., Sukumar,S., Luna-Sanchez,M., Jochem,A.,
            Lew,S., Seetharaman,J., Xiao,R., Wang,H., Westphall,M.S.,
            Wrobel,R.L., Everett,J.K., Mitchell,J.C., Lopez,L.C., Coon,J.J.,
            Tong,L. and Pagliarini,D.J.
  TITLE     Mitochondrial COQ9 is a lipid-binding protein that associates with
            COQ7 to enable coenzyme Q biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (44), E4697-E4705 (2014)
   PUBMED   25339443
  REMARK    GeneRIF: Mitochondrial COQ9 is a lipid-binding protein that
            associates with COQ7 to enable coenzyme Q biosynthesis.
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Garcia-Corzo,L., Luna-Sanchez,M., Doerrier,C., Garcia,J.A.,
            Guaras,A., Acin-Perez,R., Bullejos-Peregrin,J., Lopez,A.,
            Escames,G., Enriquez,J.A., Acuna-Castroviejo,D. and Lopez,L.C.
  TITLE     Dysfunctional Coq9 protein causes predominant encephalomyopathy
            associated with CoQ deficiency
  JOURNAL   Hum Mol Genet 22 (6), 1233-1248 (2013)
   PUBMED   23255162
  REMARK    GeneRIF: Lack of a functional Coq9 protein causes predominant
            encephalomyopathy and CoQ deficiency.
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Quinzii,C.M., Garone,C., Emmanuele,V., Tadesse,S., Krishna,S.,
            Dorado,B. and Hirano,M.
  TITLE     Tissue-specific oxidative stress and loss of mitochondria in
            CoQ-deficient Pdss2 mutant mice
  JOURNAL   FASEB J 27 (2), 612-621 (2013)
   PUBMED   23150520
  REMARK    GeneRIF: Although Pdss2 mutant mice manifest widespread CoQ(9)
            deficiency and mitochondrial respiratory chain abnormalities, only
            affected organs show increased ROS production, oxidative stress,
            mitochondrial DNA depletion, and reduced citrate synthase activity.
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Parrado-Fernandez,C., Lopez-Lluch,G., Rodriguez-Bies,E.,
            Santa-Cruz,S., Navas,P., Ramsey,J.J. and Villalba,J.M.
  TITLE     Calorie restriction modifies ubiquinone and COQ transcript levels
            in mouse tissues
  JOURNAL   Free Radic Biol Med 50 (12), 1728-1736 (2011)
   PUBMED   21447381
  REMARK    GeneRIF: Calorie restriction modifies ubiquinone and COQ transcript
            levels in mouse tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129606.4.
            
            On Jun 14, 2018 this sequence version replaced NM_026452.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036386.1, AK158979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC129606.4         91027-91111
            86-236              AC129606.4         95232-95382
            237-372             AC129606.4         97391-97526
            373-515             AC129606.4         102739-102881
            516-600             AC129606.4         103129-103213
            601-705             AC129606.4         104465-104569
            706-861             AC129606.4         105729-105884
            862-915             AC129606.4         106219-106272
            916-1697            AC129606.4         106728-107509
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.89 cM"
     gene            1..1697
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /note="coenzyme Q9"
                     /db_xref="GeneID:67914"
                     /db_xref="MGI:MGI:1915164"
     exon            1..85
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..951
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /note="ubiquinone biosynthesis protein COQ9,
                     mitochondrial; coenzyme Q9 homolog"
                     /codon_start=1
                     /product="ubiquinone biosynthesis protein COQ9,
                     mitochondrial precursor"
                     /protein_id="NP_080728.1"
                     /db_xref="CCDS:CCDS22550.1"
                     /db_xref="GeneID:67914"
                     /db_xref="MGI:MGI:1915164"
                     /translation="MAATAAVSGVLGRLGWRLLQLRCLPVARCRPALVPRAFHTAVGF
                     RSSEEQKQQPPHSSSQQHSETQGPEFSRPPPRYTDQSGEEEEDYESEEQLQHRILTAA
                     LEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGSDGSELILHFVTQCNARLNQVLEEEQ
                     KLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILLLPHNIPPSLNLLTSM
                     VDDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLENRINDAM
                     NMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR"
     exon            86..236
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..372
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..515
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            516..600
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..705
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            706..861
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..915
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1697
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="Coq9"
                     /gene_synonym="2310005O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 acttccaaga tggcggcgac agcagccgtg tctggtgtcc tcggccgctt gggctggagg
       61 ctcctgcagc tgcggtgcct gcccgtggcc cgctgccgac cagctctggt gccacgtgcc
      121 ttccacactg ccgtggggtt ccggtcttca gaagagcaga agcagcagcc tccccactct
      181 tcttctcagc agcattctga gacacagggg cccgagtttt cccgtccacc ccccaggtac
      241 acagaccaga gtggagagga ggaagaggac tatgagagtg aggagcagct acagcaccgc
      301 atcttgacag cagccctaga gtttgtgcct gcccatggct ggactgcaga ggccattgct
      361 gaaggagccc agtccttggg tctctccagc gcagcagcca gcatgtttgg gagcgatggc
      421 agtgagctga ttctgcactt tgtgacccag tgcaatgctc gcctcaacca ggtgctggaa
      481 gaggagcaga agctggtgca actgggccag gcagagaaga ggaagacaga ccagttcctg
      541 agggatgcag tggaaaccag actgagaatg ctgatcccct acattgagca ctggccccgg
      601 gccctcagca tcctcctgct ccctcacaac atcccaccca gcctgaactt gctcaccagc
      661 atggtggatg acatgtggca ttacgctggg gaccagtcca ctgactttaa ctggtacacc
      721 cgccgtgcag tgctggccgg catctacaac acaacagagc tggtgatgat gcaggattcc
      781 tccccagact ttgaagatac gtggcgcttc ctggaaaacc ggattaatga tgcaatgaac
      841 atgggccaca cggctaagca ggtgaagtcc acgggagagg cactggtgca aggactgatg
      901 ggtgcagcgg tcacgctcaa gaacctgacg ggtctaaacc agcgtcggtg agagaaggga
      961 accatgtgcc tgggaggagc agcagtagat atgaagggct ttgacaagat gggccaccca
     1021 ttgaacagga tgttaatgag aacacactga agaacttgga gtcgtatgac agccacaagg
     1081 ctggaaatca caatgcactt gctgccgttc tgacctggga ctgggccact tcttcagttc
     1141 ctaatgccag gcctggcctc ctgatgcctt ttgcattgca gctgtgtgtt tgaaaactga
     1201 gactcacatc caaggtttca aaccacaaaa ccttggcatg actctgccat ggtgtcacag
     1261 gcatcttgat catgtcttga ccatagaatt gctctctagg agctgggcat ggtgacctac
     1321 gtctgtattc tcagcactca ggagactgct acagcaggat tgagagatca gaggcaggct
     1381 tgtctttgta gagaattaca agcctgcttg agctacagag tgtgatcctg tcaaaatccc
     1441 ctgagaaata ttcttagggg ctcacaacca aggtccggag gcaacacata gtgggagctc
     1501 ttccccagca cagggcagac agtgctcaca aacatttgcc actggccatt gtctctggat
     1561 cccctcagaa agctgcctcc cctaggcagg tgccttttgg acagttgtgc tgagcctggc
     1621 atcacagaca ccagcatgca cttcaggatc attagtgtat ttagaatctg taaaaataat
     1681 aaatatgttt gaaacaa
//
